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| 1 | The role of regulatory T cells in immune dysfunction during sepsis显示文摘BACKGROUND: Although regulatory T cells(Tregs) are key to the maintenance of immunologic homeostasis and tolerance, little is known about Treg-mediated immunosuppression in the stage of sepsis. This article aimed to review the current literature on the role of Tregs in the pathophysiology of septic response, attempting to investigate the role of Tregs in immune dysfunction during sepsis.DATA SOURCES: A literature search was conducted in January 2014 using the China National Knowledge Infrastructure and Pub Med. Articles on the role of Tregs in immune dysfunction during sepsis were identified.RESULTS: The identified articles indicated that Treg levels can be used for the assessment of the course of sepsis. The inhibition of Treg activity can promote the recovery of immune function.CONCLUSION: Since the mechanism of Tregs is complex during the sepsis, more studies are needed. | Chao Cao Tao Ma Yan-fen Chai Song-tao Shou | 2015 | World Journal of Emergency Medicine2015，6，1： | 21 |
| 2 | Temporal and Spatial Variations of Abundance of Phycocyaninand Phycoerythrin-Rich Synechococcus in Pearl River Estuary and Adjacent Coastal Area显示文摘Three surveys were carried out in Pearl River Estuary and adjacent coastal area in May, August, and November, 2013, to investigate the temporal and spatial variations of abundance of phycoerythrin-rich Synechococcus(PE-rich SYN) and phycocyanin-rich Synechococcus(PC-rich SYN). The effects of environmental factors on the alternation of the different Synechococcus groups were also elucidated. PE-rich SYN was detected in three surveys, whereas PC-rich SYN was detected in May and August, but not in November. The highest abundances of PE-rich SYN and PC-rich SYN were recorded in August and May, with mean values of 74.17×103 and 189.92×103 cells m L-1, respectively. From May to November, the relative abundance of PE-rich SYN increased, whereas that of PC-rich SYN declined. PE-rich and PC-rich SYN presented similar horizontal distributions with high abundance in the southern estuary in May, and in the western estuary in August. The abundances of PE-rich and PC-rich SYN were high at 27–32℃and salinity of 10–20. PC-rich SYN was not detected at < 24℃, and PC:PE-rich SYN decreased in abundance with salinity increase. When less than 20 mg L-1, suspended particulate matter(SPM) was helpful for Synechococcus growth. PE-rich SYN decreased in abundance when the concentration of dissolved inorganic nitrogen increased in May and November, and the concentration of phosphate increased in November. However, PC-rich SYN abundance and nutrients showed no correlation. Principal component analysis and regression analysis indicated that PE-rich SYN significantly correlated with the principal components that were affected by environmental factors. | JIANG Tao CHAI Chao WANG Jifang ZHANG Ling CEN Jingyi LU Songhui | 2016 | Journal of Ocean University of China2016，15，5： | 6 |
| 3 | Effects of land-use types on the vertical distribution of fractions of oxidizable organic carbon on the Loess Plateau, China显示文摘The oxidizability of soil organic carbon(SOC_) influences soil quality and carbon sequestration. Four fractions of oxidizable organic carbon(very labile(C_1), labile(C_2), less labile(C_3) and non-labile(C_4)) reflect the status and composition of SOC_ and have implications for the change and retention of SOC_. Studies of the fractions of oxidizable organic carbon(OC_) have been limited to shallow soil depths and agroecosystems. How these fractions respond at deep soil depths and in other types of land-use is not clear. In this study, we evaluated the vertical distributions of the fractions of oxidizable organic carbon to a soil depth of 5.0 m in 10 land-use types in the Zhifanggou Watershed on the Loess Plateau, C_hina. Along the soil profile, C_1 contents were highly variable in the natural grassland and shrubland I(C_aragana microphylla), C_2 and C_4 contents were highly variable in the natural grassland and two terraced croplands, respectively, and C_3 contents varied little. Among the land-use types, natural grassland had the highest C__1 and C_2 contents in the 0–0.4 m layers, followed by shrubland I in the 0–0.1 m layer. Natural grassland had the highest C_4 contents in the 1.0–4.5 m layers. Natural grassland and shrubland I thus contributed to improve the oxidizability of SOC_ in shallow soil, and the deep soil of natural grassland has a large potential to sequester SOC_ on the Loess Plateau. | SUN Caili XUE Sha CHAI Zongzheng ZHANG Chao LIU Guobin | 2016 | Journal of Arid Land2016，8，2： | 5 |
| 4 | Synthesis and fungicidal activity of novel strobilurin analogues containing substituted N-phenylpyrimidin-2-amines显示文摘包含代替的 N-phenylpyrimidin-2-amines 的很多新奇 strobilurin 类似物被综合。这些新混合物的结构被 1 H NMR,红外和元素的分析。在温室的生物评估证明几混合物在 25 mg/L 举办好杀菌剂活动。 | Hui Chao Li Bao Shan Chai Zhi Nian Li Ji Chun Yang Chang Ling Liu | 2009 | Chinese Chemical Letters2009，20，11： | 4 |
| 5 | Effects of nitrogen and phosphorus concentrations on the bioaccumulation of polybrominated diphenyl ethers by Prorocentrum donghaiense显示文摘The growth, cellular total lipids, bioaccumulation amount, and bioaccumulation factors (BAFs) of 2,4,4 ′ -tribromodiphenyl ether (BDE28), 2,2 ′ ,4,4 ′ -tetrabromodiphenyl ether (BDE47), and 2,2 ′ ,4,4 ′ ,5-pentabromodiphenyl ether (BDE99) in a semi-continuous culture of Prorocentrum donghaiense were studied in relation to nitrate (0, 128, and 512 μmol/L) and phosphate (0, 8, and 32 μmol/L) concentrations. The BDE28, BDE47, and BDE99 content per cell under 0 μmol N/L were 3.77 × 10 6 , 3.95 × 10 6 , and 4.32 × 10 6 ng/cell, respectively, which were significantly higher than those under 128 and 512 μmol N/L. A nearly 5-fold increase in polybrominated diphenyl ether (PBDE) content per algal cell was found between 0 and 8 μmol P/L and between 8 and 32 μmol P/L. With increasing N and P concentrations, the PBDE content per volume of algal culture and the accumulation percentage of available PBDEs declined slightly. The BAFs for the PBDEs based on lipids showed that the logBAF lip under 0 μmol N/L was higher than those under 128 and 512 μmol N/L. The logBAF lip under 0 μmol P/L was higher than that under 8 μmol P/L but lower than that under 32 μmol P/L. Correlation analysis indicated a significant negative correlation between nutrient concentration and cellular total lipids, as well as the PBDE content per cell. The results indicate that different N and P concentrations change the total lipids content of P. donghaiense, thereby resulting in varying PBDE accumulation. | Chao Chai Xundong Yin Wei Ge Jinye Wang | 2013 | Journal of Environmental Sciences2013，25，2： | 4 |
| 6 | Selective feeding of bay scallop Argopecten irradians on phytoplankton community revealed by HPLC analysis of phytopigments in Bohai Sea, China显示文摘Understanding the feeding selectivity on phytoplankton by shellfi sh is currently a big challenge. In order to investigate the feeding behavior of bay scallop ( Argopecten irradians ) on phytoplankton, we compared its compositions of phytopigments in digestive glands with those in the surrounding seawater, and conducted fi ve consecutive investigations between July and November 2016 in a bay scallop culture area along coast of Qinghuangdao City, northwest of the Bohai Sea, China. Phytopigments in four-size fractionated phytoplankton of seawater (micro-(20-200 μm);nano(L)-[10-20 μm];nano(S)-[2.7-10 μm], and pico-[<2.7 μm]) and digestive glands of A . irradians were examined to investigate the selective feeding of A . irradians . Results show that fucoxanthin and peridinin constituted the major part of taxonomically diagnostic carotenoids (TDCs) in the micro- and nano(L)-phytoplankton in seawater. Compared with total phytoplankton biomass of seawater (TPB, sum of the four sizes), a substantial decrease of fucoxanthin proportion to total DCs in digestive glands was observed while that of peridinin, 19′-butanoyloxyfucoxanthin, alloxanthin and 19′-hexanoyloxy-fucoxanthin showed an obvious increase when those pigments were mainly confi ned to micro-sized phytoplankton (20-200 μm). However, zeaxanthin and prasinoxanthin were mainly confi ned to nano(s)- and pico-phytoplankton, of which the proportions in digestive glands were usually lower in TPB. The contribution of lutein to total DCs in digestive glands (with an average of 7.23%) increased compared with TPB of seawater (with an average of 0.63%) during all fi ve sampling times. | JIANG Tao WANG Longhua ZHANG Fuchong FANG Xiao LU Lin ZHANG Jihong WANG Wei QU Keming CHAI Chao | 2019 | Journal of Oceanology and Limnology2019，37，5： | 4 |
| 7 | Phosphonate-Decorated Covalent Organic Frameworks for Actinide Extraction: A Breakthrough Under Highly Acidic Conditions显示文摘Although solid-phase extraction is a useful approach for metal ion separation from aqueous solutions,existing sorbents suffer from low extraction effici-encies and/or instability when in contact with strong acidic media.We report here the first study on rational design and fabrication of phosphonate-decorated covalent organic frameworks,COF-IHEP1 and COF-IHEP2,for efficient and selective extraction of of uranium(VI)[U(VI)]and plutonium(IV)[Pu(IV)]from highly acidic solutions. | Jipan Yu Liyong Yuan Shuai Wang Jianhui Lan Lirong Zheng Chao Xu Jing Chen Lin Wang Zhiwei Huang Wuqing Tao Zhirong Liu Zhifang Chai John K.Gibson Weiqun Shi | 2019 | CCS Chemistry2019，1，3： | 3 |
| 8 | Satellite group autonomous operation mechanism and planning algorithm for marine target surveillance显示文摘In terms of fast response problem of unanticipated marine target, it is necessary to design the satellite-ground-combined operation mechanism and planning algorithm for autonomous task planning. Firstly, based on the autonomous operation and task planning of remote sensing satellite group, it is divided into two parts: ground planning and satellite autonomous planning. Secondly,the satellite-ground-combined operation mechanism and operation flow for task planning are proposed after fully considering the resource characteristics and task demand characteristics of the ground and satellite. The satellite autonomous task planning algorithm based on extended contract net is designed. Through the simulation operation of the self-developed distributed simulation demonstration software, it shows that the operation mechanism can coordinate and cooperate effectively between the satellite autonomous task planning and ground planning. It can give full play to the advantages of the ground computing resources, reflect the control intention, make full use of the real-time feature and flexibility of the satellite calculation, and respond fast to the unanticipated task. Besides, it has solved problems of the untimely response of ground control on unanticipated observation task, the limitation of satellite computing resources and satellite-ground planning and coordination, which can effectively improve the responsiveness of remote sensing satellite to the observation task of maritime unanticipated target. | Chao ZHANG Jinyong CHEN Yanbin LI Yuqing LI Weijie CHAI | 2019 | Chinese Journal of Aeronautics2019，32，4： | 2 |
| 9 | Nutrient characteristics in the Yangtze River Estuary and the adjacent East China Sea before and after impoundment of the Three Gorges Dam显示文摘 | Chao Chai Zhiming Yu Zhiliang Shen Xiuxian Song Xihua Cao Yun Yao | 2009 | Science of the Total Environment2009，，16： | 2 |
| 10 | Interstitial copper-doped edge contact for n-type carrier transport in black phosphorus显示文摘Black phosphorus(BP)has been shown as a promising two-dimensional(2D)material for electronic devices owing to its high carrier mobility.To realize complementary electronic circuits with 2D materials,it is important to fabricate both n-type and p-type transistors with the same channel material.By engineering the contact region with copper(Cu)-doped BP,here we demonstrate an n-type carrier transport in BP field-effect transistors(FETs),which usually exhibit strongly p-type characteristics.Cu metal atoms are found to severely penetrate into the BP flakes,which forms interstitial Cu(Cuint)-doped edge contact and facilitates the electron transport in BP.Our BP FETs in backgated configuration exhibit n-type dominant characteristics with a high electron mobility of^138 cm^2 V^−1 s^−1 at room temperature.The Schottky barrier height for electrons is relatively low because of the edge contact between Cuint-doped BP and pristine BP channel.The contact doping of BP by highly mobile Cu atoms gives rise to n-type transport property of BP FETs.Furthermore,we demonstrate a p-n junction on the same BP flake with asymmetric contact.This strategy on contact engineering can be further extended to other 2D materials. | Ziyuan Lin Jingli Wang Xuyun Guo Jiewei Chen Chao Xu Mingqiang Liu Bilu Liu Ye Zhu Yang Chai | 2019 | InfoMat2019，1，2： | 2 |
| 11 | Molecular cloning,sequence analysis,and chromosomal localization of the human protease inhibitor 4(kallistatin)gene(PI4)显示文摘 | Chai KX Ward DC Chao J | 1994 | Genomics1994，23，2： | 1 |
| 12 | Synthesis and biological activities of N-dichloroacetyl-2-n-propyl-1-oxa-4-aza-spiro-4, 5-decane显示文摘The title compound was synthesized and characterized by IR, 1HNMR and elemental analysis. The preliminary biological test showed that the compound protected maize against injury by imazethapyr to some extent. | YE Fei CHAI Chao | 2007 | Journal of Northeast Agricultural University(English Edition)2007，14，1： | 1 |
| 13 | Morphological and Microstructunal Aspects of Metal Dusting on 304L stainless steel with Different Surface Treatments显示文摘 | LIN CHAO YI CHANG CHAI HAO TSAI WEN TA | 2004 | Oxidation of Metals2004，62，34： | 1 |
| 14 | Downregulation of miR-491-5p promotes neovascularization after traumatic brain injury显示文摘Micro RNA-491-5 p(miR-491-5 p) plays an important role in regulating cell proliferation and migration;however,the effect of miR-491-5 p on neovascularization after traumatic brain injury remains poorly understood.In this study,a controlled cortical injury model in C57 BL/6 mice and an oxygen-glucose deprivation model in microvascular endothelial cells derived from mouse brain were established to simulate traumatic brain injury in vivo and in vitro,respectively.In the in vivo model,quantitative real-time-polymerase chain reaction results showed that the expression of miR-491-5 p increased or decreased following the intracerebroventricular injection of an miR-491-5 p agomir or antagomir,respectively,and the expression of miR-491-5 p decreased slightly after traumatic brain injury.To detect the neuroprotective effects of miR-491-p,neurological severity scores,Morris water maze test,laser speckle techniques,and immunofluorescence staining were assessed,and the results revealed that miR-491-5 p downregulation alleviated neurological dysfunction,promoted the recovery of regional cerebral blood flow,increased the number of lectin-stained microvessels,and increased the survival of neurons after traumatic brain injury.During the in vitro experiments,the potential mechanism of miR-491-5 p on neovascularization was explored through quantitative real-time-polymerase chain reaction,which showed that miR-491-5 p expression increased or decreased in brain microvascular endothelial cells after transfection with an miR-491-5 p mimic or inhibitor,respectively.Dual-luciferase reporter and western blot assays verified that metallothionein-2 was a target gene for miR-491-5 p.Cell counting kit 8(CCK-8) assay,flow cytometry,and 2′,7′-dichlorofluorescein diacetate(DCFH-DA) assay results confirmed that the downregulation of miR-491-5 p increased brain microvascular endothelial cell viability,reduced cell apoptosis,and alleviated oxidative stress under oxygen-glucose deprivation conditions.Cell scratch assay,Transwell assay,tube formation assay,and western blot assay results demonstrated that miR-491-5 p downregulation promoted the migration,proliferation,and tube formation of brain microvascular endothelial cells through a metallothionein-2-dependent hypoxia-inducible factor-1α/vascular endothelial growth factor pathway.These findings confirmed that miR-491-5 p downregulation promotes neovascularization,restores cerebral blood flow,and improves the recovery of neurological function after traumatic brain injury.The mechanism may be mediated through a metallothionein-2-dependent hypoxia-inducible factor-1α/vascular endothelial growth factor signaling pathway and the alleviation of oxidative stress.All procedures were approved by Ethics Committee of the First Affiliated Hospital of Chongqing Medical University,China(approval No.2020-304) on June 22,2020. | Wei Tang Zong-Duo Guo Wei-Na Chai Dong-Lin Du Xiao-Min Yang Lang Cao Hong Chen Chao Zhou Chong-Jie Cheng Xiao-Chuan Sun Zhi-Jian Huang Jian-Jun Zhong | 2022 | Neural Regeneration Research2022，17，3： | 1 |
| 15 | The Experts Consensus for Patient Management of Neurosurgical Critical Care Unit in China (2015)显示文摘 | Zhao, Ji-Zong Zhou, Ding-Biao Zhou, Liang-Fu Wang, Ren-Zhi Zhang, Jian-Ning Wang, Shuo Li, Xin-Gang Hua-Feng Liu, Jian Jiang, Jiyao Zhang, Sai Zhang, Jun-Ting Zhang, Jian-Min Hou, Lijun Hong, Tao Yuan, Xian-Rui Gao, Guo-Dong Kang, De-Zhi You, Chao Bao, Shengde Qi, Song-Tao Zhao, Shi-Guang Zhao, Yuan-Li Hu, Jin Cui, Li-ying Peng, Bin Liu, Da-Wei Guo, Shu-Bin Lin, Yuan-Xiang Sun, Shi-Zhong Gao, Liang Jiang, Rong-Cai Shi, Guang-Zhi Chai, Wen-Zhao Wang, Ning Zhao, Yuan-Li Wei, Jun-Ji | 2015 | Chinese Medical Journal2015，，9： | 1 |
| 16 | The status andcharacteristics of eutrophication in the Yangtze River ( Changjiang)estuary and the adjacent East China Sea, China 显示文摘 | CHAI Chao YU Zhiming SONG Xiuxian | 2006 | Hydrobiologia2006，563，1： | 1 |
| 17 | The Status and Characteristics of Eutrophication in the Yangtze River (Changjiang) Estuary and the Adjacent East China Sea, China显示文摘 | Chao Chai Zhiming Yu Xiuxian Song Xihua Cao | 2006 | Hydrobiologia2006，，1： | 1 |
| 18 | Estimation of Resistance of Starch/Polyvinyl Alcohol Blends toPermeation By organic Solvents显示文摘 | Chao Keh-Ping Chow Jing-Dong Chai Wan-Lan | 2012 | Carbohydrate Polymers2012，89，2： | 1 |
| 19 | Nutrient characteristics in the Yangtze River Estuary and adjacent East China Sea before and after impoundment of the Three Gorges Dam显示文摘 | Chao Chai Zhiming Yu Zhiliang Shen | 2009 | Science of Total En- vironment2009，407，： | 1 |
| 20 | Larva fish assemblage structure in three-dimensional floating wetlands and non-floating wetlands in the Changjiang River estuary显示文摘Fish populations have declined in many estuarine and freshwater ecosystems in part due to the loss of habitat in recent decades.Reconstructing lost habitat for larvae fish is a potential method for recovering larvae fish populations.Three-dimensional artificial floating wetlands(AFWs)on which Phragmites australis was planted were experimentally deployed to recover the lost habitat in the Changjiang(Yangtze)River estuary from May to July 2018.The AFW area was characterized by slow velocity,high transparency,low dissolved oxygen,and relatively constant water temperature.The total individuals of larvae fish in the AFW area(12122 in total)was higher than that in the non-AFW area(1250 in total),and the densities of most larvae fish species were higher in the AFW habitat than in the non-AFW area.The distributions of larvae fish species were positively influenced by habitat type because they were strongly related to the negative part of the first axis of the redundancy analysis,and Cyprinus carpio and Cyprinus auratus were inclined to habitat in the slow velocity and high transparency AFW habitat area.These results indicate that larvae fish species are inclined to inhabit the AFW habitat.The use of three-dimensional P.australis AFWs would be a potential method for enhancing the habitat of larvae fish in the degraded habitats along the estuary. | Xiaofeng HUANG Feng ZHAO Chao SONG Yi CHAI Qian WANG Ping ZHUANG | 2021 | Journal of Oceanology and Limnology2021，39，2： | 1 |
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