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| 1 | Highly active antiretroviral therapy dysregulates proliferation and differentiation of human pre-adipocytes显示文摘AIM To investigate the mechanism(s) by which potential effects of multi-drug highly-active antiretroviral therapy contributes to lipodystrophy syndrome. METHODS Preadipocytes from healthy donors were assessed for proliferation and differentiation in the presence of nucleoside reverse transcriptase inhibitors(NRTIs), nonnucleoside reverse transcriptase inhibitors(NNRTIs), and protease inhibitors(PIs) individually and in combination. Effects on proliferation were assessed with a 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide assay and effects on differentiation were assessed from glycerol-3-phosphate dehydrogenase(GPDH) activity and quantitation of Oil Red O staining for intracellular lipid. Data were analyzed with a randomized block ANOVA with post-hoc Fisher's Least Significant Difference test. RESULTS Preadipocyte proliferation was inhibited by a combination of NNRTI + NRTI(14% at 48 h, P < 0.001) and PI + NRTI(19% at 48 h, P < 0.001) with additional suppression when ritonavir(RTV) was added(26% at 48 h). The drug combination of atazanavir(ATV) + RTV + emtricitabine(FTC) + tenofovir(TDF) had the greatest inhibitory effect on proliferation at 48 h. Preadipocyte differentiation was most significantly reduced by the efavirenz + FTC + TDF assessed either by GPDH activity(64%) or lipid accumulation(39%), P < 0.001. Combining NRTIs with a PI(ATV + FTC + TDF) significantly suppressed differentiation(GPDH activity reduced 29%, lipid accumulation reduced by 19%, P < 0.01). This effect was slightly greater when a boosting amount of RTV was added(ATV + FTC + TDF + RTV, P < 0.001). CONCLUSION Although combination antiretroviral therapy is clinically more efficacious than single drug regimens, it also has a much greater inhibitory effect on preadipocyte proliferation and differentiation. | Eyone Jones Pavel Mazirka Margaret A McNurlan Frank Darras Marie C Gelato Giuseppe Caso | 2017 | World Journal of Virology2017，6，3： | 3 |
| 2 | Effect of dynamic myocardial dyssynchrony on mitral regurgitation during supine bicycle exercise stress echoeardiography in patients with idiopathic dilated cardiomyopathy and 'narrow' QRS显示文摘 | D'Andrea A Caso P Cuomo S | 2007 | Eur Heart J2007，28，8： | 1 |
| 3 | High diastolic blood pressure is a risk factor for in-hospital mortality in complete MCA stroke patients 显示文摘 | Caso V Agnelli G Alberti A | 2012 | Neurol Sci2012，33，3： | 1 |
| 4 | Association hetween left ventricular structure and cardiac performance during effort in two morphological forms of athlete's heart显示文摘 | D'Andrea A Limongelli G Caso P | | 0，，： | 1 |
| 5 | Mild hyperhomocysteinemia is a risk factor in all etiological subtypes of stroke显示文摘 | Parnetti L Caso V Santucci A | 2004 | Neurol Sci2004，25，1： | 1 |
| 6 | Association between left atrial myocardial function and exercise capacity in patients with either idiopathic or ischemic dilated cardiomyopathy: a two-di- mensional speckle strain study 显示文摘 | D' Andrea A Caso P Romano S | 2009 | Int J Cardiol2009，132，3： | 1 |
| 7 | Association between lett atrial myocardial function and exercise capacity in patients with either idiopathic or ischemic dilated cardiomyopathy:a two-dimensionals peckle strain study显示文摘 | Dp Andrea A Caso P Romano S | 2009 | Int J Cardiol2009，132，3： | 1 |
| 8 | Effect of dynamic myocardial dyssynchrony on mitral regurgitation during supine bicycle exercise stress echocardiography in patients with idiopathic dilated cardiomyopathy and'narrow'QRS显示文摘 | D'Andrea A Caso P Cuomo S | 2007 | Eur Heart J2007，28，8： | 1 |
| 9 | Right ventricular myocardial dysfunction in adult patients late after repair of tetralogy of fallot显示文摘 | D'Andrea A Caso P Sarubbi B | 2004 | Int J Cardiol2004，94，： | 1 |
| 10 | Association between left atri- al myocardial function and exercise capacity in patients with either idiopathicor ischemic dilated cardiomyopathy: a two-dimensional speckle strain study 显示文摘 | D'Andrea A Caso P Romano S | 2009 | Int J Cardio12009，132，3： | 1 |
| 11 | Usefulness of Doppler tissue imaging for the assessment of righe and left ventriclar myocardiacl function in patients with dual-chamber pacing显示文摘 | D' Andrrea A Duccschi V Caso P | 2001 | Int J Cardiol2001，81，1： | 1 |
| 12 | Different effects of cardiac re- synchronization therapy on left atrial function in patients with either idiopathic or ischaemic dilated cardiomyopathy: a two-dimensional speckle strain study显示文摘 | D'Andrea A Caso P Romano S | 2007 | Eur Heart J2007，28，22： | 1 |
| 13 | Mild hyperhomocysteinemia is a risk-factor in all etiological subtypes of stroke显示文摘 | Parnetti L Caso V Santucci A | 2004 | Neurol Sci2004，25，： | 1 |
| 14 | Changes in writing self-efficacy and writing products and processes through specific training in the self-efficacy beliefs of students with learning disabilities 显示文摘 | Garcia J N & de Caso A M | 2006 | Learning Disabilities : A Contem- porary Journal2006，，2： | 1 |
| 15 | Involvement of IL-1β in acute stress-induced worsening of cerebral ischaemia in rats显示文摘 | Javier R. Caso María A. Moro Pedro Lorenzo Ignacio Lizasoain Juan C. Leza | 2007 | European Neuropsychopharmacology2007，，9： | 1 |
| 16 | Association between left atrial myocardial function and exercise capacity in patients with either idiopathic or ischemic dilated cardiomyopathy: a two di- mensional speckle strain study 显示文摘 | D'Andrea A Caso P Romano S | 2009 | Int J Cardiol2009，132，3： | 1 |
| 17 | Association between intraventricular myocardial systolic dyssynchrony and ven- tricular arrhythmias in patients with hypertrophic cardiomy- opathy 显示文摘 | D'Andrea A Caso P Severino S | 2005 | Echocardiography2005，22，7： | 1 |
| 18 | Mild hyperhomocysteinemia is a risk-factor in all etiological subtypes of stroke 显示文摘 | Parnetti L Caso V Santucci A | 2004 | Neuro Sci2004，25，3： | 1 |
| 19 | Effect of dynamic myocardial dyssynchrony on mitral regurgitation during supine bicycle exercise stress echocardiography in patients with idiopathic dilated cardiomyopathy and 'narrow' QRS显示文摘 | D'Andrea A Caso P Cuomo S | 2007 | Eur Heart J2007，28，8： | 1 |
| 20 | Mild hyperhomocysteinemia is a risk-factor in all etiological subtypes of stroke 显示文摘 | Pametti L Caso V Santucci A | 2004 | Neurol Sci2004，25，1： | 1 |
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