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| 1 | Intravenous immune globulin suppresses angiogenesis in mice and humans显示文摘Human intravenous immune globulin(IVIg),a purified IgG fraction composed of~60%IgG1 and obtained from the pooled plasma of thousands of donors,is clinically used for a wide range of diseases.The biological actions of IVIg are incompletely understood and have been attributed both to the polyclonal antibodies therein and also to their IgG(IgG)Fc regions.Recently,we demonstrated that multiple therapeutic human IgG1 antibodies suppress angiogenesis in a target-independent manner via FcγRI,a high-affinity receptor for IgG1.Here we show that IVIg possesses similar anti-angiogenic activity and inhibited blood vessel growth in five different mouse models of prevalent human diseases,namely,neovascular age-related macular degeneration,corneal neovascularization,colorectal cancer,fibrosarcoma and peripheral arterial ischemic disease.Angioinhibition was mediated by the Fc region of IVIg,required FcγRI and had similar potency in transgenic mice expressing human FcγRs.Finally,IVIg therapy administered to humans for the treatment of inflammatory or autoimmune diseases reduced kidney and muscle blood vessel densities.These data place IVIg,an agent approved by the US Food and Drug Administration,as a novel angioinhibitory drug in doses that are currently administered in the clinical setting.In addition,they raise the possibility of an unintended effect of IVIg on blood vessels. | Reo Yasuma Valeria Cicatiello Takeshi Mizutani Laura Tudisco Younghee Kim Valeria Tarallo Sasha Bogdanovich Yoshio Hirano Nagaraj Kerur Shengjian Li Tetsuhiro Yasuma Benjamin J Fowler Charles B Wright Ivana Apicella Adelaide Greco Arturo Brunetti Balamurali K Ambati Sevim Barbasso Helmers Ingrid E Lundberg Ondrej Viklicky Jeanette HW Leusen J Sjef Verbeek Bradley D Gelfand Ana Bastos-Carvalho Sandro De Falco Jayakrishna Ambati | 2016 | Signal Transduction and Targeted Therapy2016，1，1： | 3 |
| 2 | Cestode infeslations: hydatid disease and cysticercosis显示文摘 | Brunetti E White AC Jr | 2012 | Infect Dis Clin North Am2012，26，2： | 1 |
| 3 | Expert consensus for the di- agnoses and treatment and of cystic alveolar echinococcosis in humans显示文摘 | Brunetti E Kern P Vuitton DA | 2009 | Acta Trop2009，114，1： | 1 |
| 4 | Clinical management of hep- atic abscesses in HIV patients 显示文摘 | llice C Brunetti E Bruno R | 2000 | Am J Gastroenterol2000，9，： | 1 |
| 5 | Speciation and lability of Ag-,Ag Cl-,and Ag2S-nanoparticles in soil determined by X-ray absorption spectroscopy and diffusive gradients in thin films显示文摘 | SEKINE R BRUNETTI G DONNER E | 2014 | Environmental Science&Technology2014，，46： | 1 |
| 6 | Perspectives on the contribution of genetics to the pathogenesis of type 2 diabetes mellitus 显示文摘 | Brunetti A Chiefari E Foti D | 2011 | Recenti Prog Med2011，102，12： | 1 |
| 7 | Selective B-cell depletion with rit- uximab for the treatment of patients with acquired hemophilia 显示文摘 | Stasi R Brunetti M Stipa E | 2004 | Blood2004，103，12： | 1 |
| 8 | Expert consensus for the diagnosis and treatment of cystic and alveolar echinococcosis in humans显示文摘 | Brunetti E Kern P Vuitton DA | 2010 | Acta Trop2010，114，1： | 1 |
| 9 | Description of Illex argentinus beaks and rostral length relationships with size and weight of squids 显示文摘 | Ivanovic M L Brunetti N E | 1997 | Rev Inv Des Pes1997，11，： | 1 |
| 10 | Expert consensus for the diagnosis and treatment of cystic and alveolar eehinoeoc- cosis in humans显示文摘 | Brunetti E Kern P Vuitton DA | 2010 | Acta Trop2010，114，1： | 1 |
| 11 | Distribution and abundance of early life stages of squid(Illex argentinus) in the Southwest Atlantic显示文摘 | BRUNETTI N E IVANOVIC M L | 1992 | ICES J Mar Sci Symp1992，，49： | 1 |
| 12 | A possible role for nitric oxide but not for prostaglandin E2 in basal and interleukin-l-? -induced PRL release in vitro 显示文摘 | Ragazzoni E Proziosi P | 1995 | Life Sci1995，56，15： | 1 |
| 13 | Distribution and abundance of early life stages of squid (lllex argentinus) in the south -west Atlantic显示文摘 | BRUNETTI N E IVANOVIC M L | 1992 | ICES J Mar Sci1992，49，： | 1 |
| 14 | Expression of cyclin-dependent kinases and CDC25a phosphatase is related with recurrences and survival in women with peri-and post-menopausa/ breast cancer显示文摘 | Bonin S Brunetti D Benedetti E | 2006 | Virchows Arch2006，448，5： | 1 |
| 15 | Treatment of Viral Myocarditis Caused by Coxsaekievirus B显示文摘 | Brunetti L de Santis E R | 2008 | Am J Health Syst Pharm2008，65，2： | 1 |
| 16 | Second revision of the Oriental Stratiomyidae显示文摘 | Brunetti E | 1923 | Records of the Indian Museum1923，25，1： | 1 |
| 17 | Expert consensus for the diagnosis and treatment of cystic and alveolar echinococcosis in humans显示文摘 | Brunetti E Kern P Vuitton DA | 2010 | Acta tropica2010，114，1： | 1 |
| 18 | Comment on percutaneous treatment of liver hydatid cysts 显示文摘 | Brunetti E Filice C Meroni V | 2006 | A JR Am J Roentgenol2006，186，4： | 1 |
| 19 | Carbon nanotube cathodes for electron gun显示文摘 | Ulisse G Brunetti F Tamburri E | 2013 | IEEE Electron Device Letters2013，34，5： | 1 |
| 20 | Selective B-cell depletion with rituximab for the treatment of patients with acquired hemophilia显示文摘 | Stasi R Brunetti M Stipa E | 2004 | Blood2004，103，12： | 1 |
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