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| 1 | Advances in adjuvant systemic therapy for non-small-cell lung cancer显示文摘Non-small-cell lung cancer remains a leading cause of death around the world. For most cases, the only chance of cure comes from resection for localised disease, however relapse rates remain high following surgery. Data has emerged over recent years regarding the utility of adjuvant chemotherapy for improving disease-free and overall survival of patients following curative resection. This paper reviews the clinical trials that have been conducted in this area along with the studies integrating radiation therapy in the adjuvant setting. The role of prognostic gene signatures are reviewed as well as ongoing clinical trials including those incorporating biological or targeted therapies. | David Leong Rajat Rai Brandon Nguyen Andrew Lee Desmond Yip | 2014 | World Journal of Clinical Oncology2014，5，4： | 7 |
| 2 | Factors associated with refractory pain in emergency patients admitted to emergency general surgery显示文摘BACKGROUND: Oligoanalgesia in emergency departments (EDs) is multifactorial. A previousstudy reported that emergency providers did not adequately manage patients with severe paindespite objective findings for surgical pathologies. Our study aims to investigate clinical andlaboratory factors, in addition to providers’ interventions, that might have been associated witholigoanalgesia in a group of ED patients with moderate and severe pains due to surgical pathologies.METHODS: We conducted a retrospective study of adult patients who were transferred directlyfrom referring EDs to the emergency general surgery (EGS) service at a quaternary academic centerbetween January 2014 and December 2016. Patients who were intubated, did not have adequaterecords, or had mild pain were excluded. The primary outcome was refractory pain, which wasdefi ned as pain reduction <2 units on the 0–10 pain scale between triage and ED departure.RESULTS: We analyzed 200 patients, and 58 (29%) had refractory pain. Patients with refractory painhad signifi cantly higher disease severity, serum lactate (3.4±2.0 mg/dL vs. 1.4±0.9 mg/dL, P=0.001), and lessfrequent pain medication administration (median [interquartile range], 3 [3–5] vs. 4 [3–7], P=0.001), whencompared to patients with no refractory pain. Multivariable logistic regression showed that the number of painmedication administration (odds ratio [OR] 0.80, 95% confi dence interval [95% CI] 0.68–0.98) and ED serumlactate levels (OR 3.80, 95% CI 2.10–6.80) were signifi cantly associated with the likelihood of refractory pain.CONCLUSIONS: In ED patients transferring to EGS service, elevated serum lactate levelswere associated with a higher likelihood of refractory pain. | William Gilliam Jackson FBarr Brandon Bruns Brandon Cave Jordan Mitchell Tina Nguyen Jamie Palmer Mark Rose Safura Tanveer Chris Yum Quincy K.Tran | 2021 | World Journal of Emergency Medicine2021，12，1： | 2 |
| 3 | Modeling cardiac arrest and resuscitation in the domestic pig显示文摘Cardiac arrest remains a leading cause of death and permanent disability worldwide. Although many victims are initially resuscitated, they often succumb to the extensive ischemia-reperfusion injury inflicted on the internal organs, especially the brain. Cardiac arrest initiates a complex cellular injury cascade encompassing reactive oxygen and nitrogen species, Ca2+ overload, ATP depletion, pro- and anti-apoptotic proteins, mitochondrial dysfunction, and neuronal glutamate excitotoxity, which injures and kills cells, compromises function of internal organs and ignites a destructive systemic inflammatory response. The sheer complexity and scope of this cascade challenges the development of experimental models of and effective treatments for cardiac arrest. Many experimental animal preparations have been developed to decipher the mechanisms of damage to vital internal organs following cardiac arrest and cardiopulmonary resuscitation(CPR), and to develop treatments to interrupt the lethal injury cascades. Porcine models of cardiac arrest and resuscitation offer several important advantages over other species, and outcomes in this large animal are readily translated to the clinical setting. This review summarizes porcine cardiac arrest-CPR models reported in the literature, describes clinically relevant phenomena observed during cardiac arrest and resuscitation in pigs, and discusses numerous methodological considerations in modeling cardiac arrest/CPR. Collectively, published reports show the domestic pig to be a suitable large animal model of cardiac arrest which is responsive to CPR, defibrillatory countershocks and medications, and yields extensive information to foster advances in clinical treatment of cardiac arrest. | Brandon H Cherry Anh Q Nguyen Roger A Hollrah Albert H Olivencia-Yurvati Robert T Mallet | 2015 | World Journal of Critical Care Medicine2015，4，1： | 2 |
| 4 | MITOMAP: a hu?man mitochondrial genome database-2004 update显示文摘 | Brandon MC Lott MT Nguyen KC et a1 | 2005 | Nucleic Acids Res2005，33，： | 1 |
| 5 | MITOMAP : ahuman mitochondrial genome database-2004 update显示文摘 | Brandon MC Lott MT Nguyen KC | 2005 | NucleicAcids Res2005，33，： | 1 |
| 6 | MITOMAP: a human mitochondrial genome database- 2004 update显示文摘 | Brandon MC Lott MT Nguyen KC Spolim S Navathe SB Baldi P | 2005 | Nucleic Acids Res2005，33，： | 1 |
| 7 | MITOMAP:a h- uman mitoehondrial genome database-2004 update显示文摘 | Brandon M C Lott M T Nguyen K C | 2005 | Nu- cleic Acids Res2005，33，： | 1 |
| 8 | MITO-MAP:a human mitochondrial genome database-2004 update 显示文摘 | Brandon MC Lott MT Nguyen KC | 2005 | Nucleic Acids Res2005，33，： | 1 |
| 9 | MITOMAP: a human mitochondrial genome database-2004 update显示文摘 | Brandon MC Lott MT Nguyen KC | 2005 | Nucleic Acids Research2005，33，11： | 1 |
| 10 | Arterial stiffness, oxidative stress, and smoke exposure in wildland firefighters显示文摘 | Denise M. Gaughan Paul D. Siegel Michael D. Hughes Chiung‐Yu Chang Brandon F. Law Corey R. Campbell Jennifer C. Richards Stefanos F. Kales Marcia Chertok Lester Kobzik Phuong‐son Nguyen Carl R. O’Donnell Max Kiefer Gregory R. Wagner David C. Christiani | 2014 | Am. J. Ind. Med2014，，7： | 1 |
| 11 | MITOMAP: a human mitochon-drial genome disease-2004 update 显示文摘 | Brandon MC Lott MT Nguyen KC | 2005 | Nucleic Acids Res2005，33，： | 1 |
| 12 | MITOMAP:a human mitochondrial genome database-2004 update显示文摘 | BRANDON M C LOTT M T NGUYEN K C | 2005 | Nucleic Acids Res2005，33，： | 1 |
| 13 | Systematic review on reoperative bariatric surgery显示文摘 | Stacy A. Brethauer Shanu Kothari Kara Kallies Ranjan Sudan Brandon Williams Wayne J. English Matthew Brengman Marina Kurian Matthew Hutter Lloyd Stegemann Ninh T. Nguyen Jaime Ponce John M. Morton | 2014 | Surgery for Obesity and Related Diseases2014，，： | 1 |
| 14 | MITOMAP:a human mitochon-drial genome database?2004 update显示文摘 | Brandon MC Lott MT Nguyen KC | 2005 | Nucleic Acids Res2005，33，： | 1 |
| 15 | MITOMAP: a human mitochondrial genome database-2004 update显示文摘 | Brandon M C Lott M T Nguyen K C | 2005 | Nucleic Acids Res2005，33，： | 1 |
| 16 | Experimental study of effects of fore- body geometry on high angle of attack stability显示文摘 | Brandon J M Nguyen L T | 1988 | Journal of Aircraft1988，25，7： | 1 |
| 17 | OSP-03大洋边缘和大洋岛屿沉积物块体运移及其影响:何时?何地?起因?(二)——墨西哥湾陆坡Ursa盆地斜坡失稳的触发因素显示文摘Ursa盆地水深1000m,位于密西西比峡谷的东部隆起上,是研究大型无震滑坡现象的超级天然实验室。近期的研究表明,本地区有记载的地震活动有可能是由浅层重力滑动而不是深层构造作用导致的。在Ursa盆地,块体运移沉积物广泛存在,其时空关系在多波束以及地震反射资料中都有显示。2005年6月,综合大洋钻探项目(IODP)308航次在靠近全新世大滑坡以及泥火山型流体溢出构造附近钻了三个孔,钻穿了更新世-全新世一系列块体运移沉积物,采集了这几个钻孔的测井、沉积学以及土工资料, | Roger Urgeles Jacques Locat Peter B. Flemings Brandon Dugan Nguyen Thi Thanh Binh Derek E. Sawye 杨丽娟(译) 闫章存(校对) | 2009 | 海洋地质2009，，1： | 0 |
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