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| 1 | 氯乙烯作业工人职业接触评定与健康危害调查显示文摘[目的 ]评估氯乙烯累积接触剂量和氯乙烯职业危害的关系。[方法 ]选取某厂 2 3 8名职业接触氯乙烯人群和 2 12名非接触人群 ,登录该厂历年氯乙烯浓度监测资料 ,以及工人健康监护资料 ,将暴露人群按累积接触剂量分为未接触组和低、中、高接触组 ,比较接触组间和接触组与对照组间工人的症状和体征方面的差异。[结果 ]神经症、肝B超异常及咽部刺激症状随氯乙烯累积接触剂量的升高 ,发生率有升高的趋势 (P <0 0 1) ,与对照组比较也有显著性差异。[结论 ]咽部刺激症状和肝脏的损害均与接触氯乙烯有明显的关系。提示在我国的卫生标准范围内 ,氯乙烯仍可能产生一定的健康危害。 | 任雪峰 柴尚健 万俊香 帕尔哈提 吴翠娥 夏昭林 David Christiani | 2001 | 劳动医学2001，18，1： | 20 |
| 2 | East meets West:ethnic differences in epidemiology and clinical behaviors of lung cancer between East Asians and Caucasians显示文摘Lung cancer is the leading cause of cancer death worldwide,with large variation of the incidence and mortality across regions.Although the mortality of lung cancer has been decreasing,or steady in the US,it has been increasing in Asia for the past two decades.Smoking is the leading cause of lung cancer,and other risk factors such as indoor coal burning,cooking fumes,and infections may play important roles in the development of lung cancer among Asian never smoking women.The median age of diagnosis in Asian patients with lung cancer is generally younger than Caucasian patients,particularly among never-smokers.Asians and Caucasians may have different genetic susceptibilities to lung cancer,as evidenced from candidate polymorphisms and genome-wide association studies.Recent epidemiologic studies and clinical trials have shown consistently that Asian ethnicity is a favorable prognostic factor for overall survival in non-small cell lung cancer(NSCLC),independent of smoking status.Compared with Caucasian patients with NSCLC,East Asian patients have a much higher prevalence of epidermal growth factor receptor(EGFR) mutation(approximately 30% vs.7%,predominantly among patients with adenocarcinoma and never-smokers),a lower prevalence of K-Ras mutation(less than 10% vs.18%,predominantly among patients with adenocarcinoma and smokers),and higher proportion of patients who are responsive to EGFR tyrosine kinase inhibitors.The ethnic differences in epidemiology and clinical behaviors should be taken into account when conducting global clinical trials that include different ethnic populations. | Wei Zhou David C. Christiani | 2011 | Chinese Journal of Cancer2011，30，5： | 19 |
| 3 | 棉纺织工人棉尘及内毒素暴露对肺功能慢性影响的研究显示文摘目的探索棉尘及其内毒素长期暴露对棉纺织工人肺功能慢性改变的影响。方法选择某市棉纺织厂的447名棉纺工人及作为对照组的472名丝绸纺织工人,从1981年开始,分别于1986、1992、1996、2001和2006年进行为期25年的跟踪调查,以第一秒用力呼气容积(FEV1)的慢性改变作为肺功能改变的主要指标,采用广义估计方程估计累积棉尘中内毒素暴露对棉纺织工人慢性肺功能改变的影响。结果棉纺织工人内毒素暴露与FEV1降低间存在约5年的滞后期,棉纺织工人5年滞后累积内毒素暴露量每增加1 000 EU/m3,可使慢性FEV1每年减少0.99 ml(P<0.05),每停止暴露1年可以使FEV1恢复7.12 ml(P<0.05)。结论棉纺织工人的长期棉尘及内毒素暴露会造成肺功能的慢性降低;累积内毒素暴露与工人FEV1降低间存在滞后效应,而近期的累积内毒素暴露与工人FEV1慢性降低间关系不显著。 | 石晶 Christiani DC 戴和莲 杭晶卿 张洪熙 金龙哲 丁辉 | 2011 | 环境与健康杂志2011，28，2： | 6 |
| 4 | 谷胱甘肽S-转移酶P1基因多态性与慢性阻塞性肺疾病的关系显示文摘目的 明确谷胱甘肽S 转移酶P1(GSTP1)基因多态性与中国人慢性阻塞性肺疾病(COPD)易感性的关系。方法 对COPD进行分子流行病学初步研究 ,采用病例对照研究设计 ,用聚合酶链反应 限制性片段长度多态性 (PCR RFLP)分析的方法检测 10 0对年龄、性别匹配的COPD患者和健康对照者GSTP1外显子 5基因多态性 ,用Logistic回归计算比值比 (OR)和 95 %可信区间 (CI)。结果 经调整年龄、性别、体重指数和吸烟年支数 ,COPD组和对照组GSTP1基因多态性没有明显差异(P值均 >0 0 5 )。结论 GSTP1基因多态性与中国COPD的易感性可能没有明显关系。 | 肖丹 王辰 杜敏捷 庞宝森 张洪玉 肖白 刘敬忠 翁心植 苏丽 David C Christiani | 2003 | 中华结核和呼吸杂志2003，26，9： | 5 |
| 5 | Ethnic differences in the prevalence of the homozygous deleted genotype of glutathione Stransferase theta显示文摘 | Nelson HH Wiencke JK Christiani DC | 1995 | Carcinogenesis1995，16，： | 2 |
| 6 | EGFR-targeted therapies in lung cancer:predictors of response and toxicity显示文摘 | Heist RS Christiani D | | 0，，01： | 1 |
| 7 | Reproductive hormone profile along pesticide factory workers显示文摘 | Padungtod C Lasley B L Christiani D C | 1998 | J Occup Env Med1998，40，12： | 1 |
| 8 | Asbestos exposure, manganese superoxide dismutase (MnSOD) genotype, and lung cancer risk显示文摘 | WANG L I NEUBERG D CHRISTIANI D C | 2004 | J Occup Environ Med2004，46，6： | 1 |
| 9 | Body weight, alcohol consumption and liver enzyme activity 4-year follow-up study显示文摘 | Lee DH Ha MH Christiani DC | 2001 | Int J Epidemiol2001，30，4： | 1 |
| 10 | Body weight,alcohol consumption and liver enzyme activity--a 4-year follow-study显示文摘 | Lee DH Ha MH Christiani DC | 2001 | Int J Epidemiol2001，30，4： | 1 |
| 11 | The Association Between Personal Measurements of Environmental Exposure to Particulates and Heart Rate Variability显示文摘 | Shannon R. Magari Joel Schwartz Paige L. Williams Russ Hauser Thomas J. Smith David C. Christiani | 2002 | Epidemiology2002，，3： | 1 |
| 12 | International Lung Cancer Consortium: Pooled Analysis of Sequence Variants in DNA Repair and Cell Cycle Pathways显示文摘 | HUNG R J CHRISTIANI D C RISCH A | 2008 | Cancer Epiderniol Biomarkers Prev2008，17，11： | 1 |
| 13 | International Lung Cancer Consortium:pooled analysis of sequence variants in DNA repair and cell cycle pathways显示文摘 | Hung RJ Christiani DC Risch A | 2008 | Cancer Epidemiol Biomarkers Prey2008，17，11： | 1 |
| 14 | Carcinogen exposure,p53 alteration,and k-ras mutation in synchronous multiple primary lung carcinoma显示文摘 | Wang X Christiani DC Mark EJ | 1999 | Cancer1999，85，8： | 1 |
| 15 | Exposure response relationships between occupational exposures and chronic respiratory illness:a community-based study 显示文摘 | Xu X Christiani DC Dockery DW | 1992 | Am Rev Respir Dis1992，146，2： | 1 |
| 16 | EGFR-targeted therapies in lung cancer: predictors of response and toxicity 显示文摘 | Heist RS Christiani D | 2009 | Pharmacogenomics2009，10，1： | 1 |
| 17 | Gamma-glutamyltransferase and diabetes—a 4 year follow-up study显示文摘 | D.-H. Lee MD M.-H. Ha J.-H. Kim D. C. Christiani M. D. Gross M. Steffes R. Blomhoff D. R. Jacobs | 2003 | Diabetologia2003，，3： | 1 |
| 18 | Molecular epidemiology of non-small cell lung cancer 显示文摘 | Liu G Zhou W Christiani DC | 2005 | Semin Respir Crit Care Med2005，26，3： | 1 |
| 19 | Utility of the WHO neurobehavioral core test battery in Chinese workers: a metal-analysis 显示文摘 | Zhou W Liang Y Christiani D | 2002 | Environ Res2002，88，2： | 1 |
| 20 | Cotton dust exposure, acrossshift drop in FEV1, and five-year change in lung function 显示文摘 | Christiani DC Ye TT Wegman DH | 1994 | Am J Respir Crit Care Med1994，150，： | 1 |
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