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| 1 | Correlation of endoscopic disease severity with pediatric ulcerative colitis activity index score in children and young adults with ulcerative colitis显示文摘AIM To investigate of pediatric ulcerative colitis activity index(PUCAI) in ulcerative colitis correlate with mucosal inflammation and endoscopic assessment of disease activity(Mayo endoscopic score).METHODS We reviewed charts from ulcerative colitis patients who had undergone both colonoscopy over 3 years. Clinical assessment of disease severity within 35 d(either before or after) the colonoscopy were included. Patients were excluded if they had significant therapeutic interventions(such as the start of corticosteroids or immunosuppressive agents) between the colonoscopy and the clinical assessment. Mayoendoscopic score of the rectum and sigmoid were done by two gastroenterologists. Inter-observer variability in Mayo score was assessed.RESULTS We identified 99 patients(53% female, 74% pancolitis) that met inclusion criteria. The indications for colonoscopy included ongoing disease activity(62%), consideration of medication change(10%), assessment of medication efficacy(14%), and cancer screening(14%). Based on PUCAI scores, 33% of patients were in remission, 39% had mild disease, 23% had moderate disease, and 4% had severe disease. There was 'moderate-substantial' agreement between the two reviewers in assessing rectal Mayo scores(kappa = 0.54, 95%CI: 0.41-0.68). CONCLUSION Endoscopic disease severity(Mayo score) assessed by reviewing photographs of pediatric colonoscopy has moderate inter-rater reliability, and agreement was less robust in assessing patients with mild disease activity. Endoscopic disease severity generally correlates with clinical disease severity as measured by PUCAI score. However, children with inflamed colons can have significant variation in their reported clinical symptoms. Thus, assessment of both clinical symptoms and endoscopic disease severity may be required in future clinical studies. | Basavaraj Kerur Heather J Litman Julia Bender Stern Sarah Weber Jenifer R Lightdale Paul A Rufo Athos Bousvaros | 2017 | World Journal of Gastroenterology2017，23，18： | 5 |
| 2 | Innate and adaptive immune connections in inflammatory bowel diseases显示文摘 | Rakoff-Nahoum S Bousvaros A | 2010 | Curr Opin Gastroenterol2010，26，6： | 1 |
| 3 | Efficacy of probiotic use in acute diarrhea in children:a meta-analysis显示文摘 | Huang JS Bousvaros A Lee JW | 2002 | Dig Dis Sci2002，47，1： | 1 |
| 4 | Imaging of neuroblastoma:an overview显示文摘 | Bousvaros A Kirks DR Grossman H | 1986 | Pediatr Radiol1986，16，2： | 1 |
| 5 | Intraduodenal hematoma complicating intestinal biopsy显示文摘 | Celina Guzman Athos Bousvaros Carlo Buonomo Samuel Nurko | 1998 | The American Journal of Gastroenterology1998，，： | 1 |
| 6 | Effica- cy of probiotic use in acute diarrhea in children: a meta-analysis显示文摘 | Huang J S Bousvaros A Lee JW Diaz A D avidson E J | 2002 | Dig Dis Sci2002，47，： | 1 |
| 7 | A randomized, double-blind trial of Lactobacillus GG versus placebo in addition to standard maintenance therapy for children with Crohn's disease 显示文摘 | Bousvaros A Guandalini S Baldassano RN | 2005 | Inflamm Bowel Dis2005，11，： | 1 |
| 8 | Davidson efficacy of probiotic use in acute diarrhea in children 显示文摘 | Huang JS Bousvaros A Lee JW | 2002 | Digest Dis Sci2002，47，： | 1 |
| 9 | Differentiating ulcerative olitis from Crohn diease in children and young adults:report of a working group of the North American Society for pediatric gastroenterology,hepatology and nutrition and the Crohn's and colitis foundation of America显示文摘 | Bousvaros A Antonioli DA Colletti RB | | 0，，05： | 1 |
| 10 | Extraintestinal Manifestations of Pediatric Inflammatory Bowel Disease and Their Relation to Disease Type and Severity显示文摘 | Jennifer L Dotson Jeffrey S Hyams James Markowitz Neal S LeLeiko David R Mack Jonathan S Evans Marian D Pfefferkorn Anne M Griffiths Anthony R Otley Athos Bousvaros Subra Kugathasan Joel R Rosh David Keljo Ryan S Carvalho Gitit Tomer Petar Mamula Marsha H | 2010 | Journal of Pediatric Gastroenterology and Nutrition2010，，2： | 1 |
| 11 | Nutritional concerns in pediatric inflammatory bowel disease patients 显示文摘 | Kappelman MD Bousvaros A | 2008 | Mol Nutr Food Res2008，52，8： | 1 |
| 12 | Growth Abnormalities Persist in Newly Diagnosed Children With Crohn Disease Despite Current Treatment Paradigms显示文摘 | Marian Pfefferkorn Georgine Burke Anne Griffiths James Markowitz Joel Rosh David Mack Anthony Otley Subra Kugathasan Jonathan Evans Athos Bousvaros M Susan Moyer Robert Wyllie Maria Oliva-Hemker Ryan Carvalho Wallace Crandall David Keljo TD Walters Neal L | 2009 | Journal of Pediatric Gastroenterology and Nutrition2009，，2： | 1 |
| 13 | The Prevalence and Geographic Distribution of Crohn’s Disease and Ulcerative Colitis in the United States显示文摘 | Michael D. Kappelman Sheryl L. Rifas–Shiman Ken Kleinman Dan Ollendorf Athos Bousvaros Richard J. Grand Jonathan A. Finkelstein | 2007 | Clinical Gastroenterology and Hepatology2007，，： | 1 |
| 14 | Varicella vaccination in children with inflammatory bowel disease receiving immunosuppressive therapy显示文摘 | Lu Y Bousvaros A | 2010 | J Pediatr Gastroenterol Nutr2010，50，5： | 1 |
| 15 | Challenges and progress in pediatric inflammatory bowel disease显示文摘 | Rufo PA Bousvaros A | 2007 | Curt Opin Gastroenterol2007，23，4： | 1 |
| 16 | Clinical, biological, and histologic parameters as predictors of relapse in ulcerative colitis显示文摘 | Alain Bitton Mark A. Peppercorn Donald A. Antonioli John L. Niles Samir Shah Athos Bousvaros Bernard Ransil Gary Wild Albert Cohen Michael D. deB Edwardes Anthony C. Stevens | 2001 | Gastroenterology2001，，1： | 1 |
| 17 | Impaired intestinal iron absorption in Crohn' s disease correlates with disease activity and markers of inflammation 显示文摘 | Semrin G Fishman DS Bousvaros A | 2006 | Inflamm Bowel Dis2006，12，12： | 1 |
| 18 | Imaging of neuroblastoma: an overview显示文摘 | Bousvaros A Kirks DR Grossman H | 1986 | Pediatr Radiol1986，16，2： | 1 |
| 19 | Current therapy of inflammatory bowel disease in children 显示文摘 | Rufo PA Bousvaros A | 2006 | Pediatr Drugs2006，8，5： | 1 |
| 20 | <ce:link locator='fx1'/> The Prevalence and Geographic Distribution of Crohn’s Disease and Ulcerative Colitis in the United States显示文摘 | Michael D. Kappelman Sheryl L. Rifas–Shiman Ken Kleinman Dan Ollendorf Athos Bousvaros Richard J. Grand Jonathan A. Finkelstein | 2007 | Clinical Gastroenterology and Hepatology2007，，12： | 1 |
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