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| 1 | Pancreatic head cancer in patients with chronicpancreatitis显示文摘BACKGROUND: Chronic pancreatitis (CP) is a risk factor of pancreatic adenocarcinoma (PA). The discovery of a pancreatic head lesion in CP frequently leads to a pancreaticoduo denectomy (PD) which preceded by a multidisciplinary meeting(MM). The aim of this study was to evaluate the relevance between this indication of PD and the definitive pathological results.METHODS: Between 2000 and 2010, all patients with CP who underwent PD for suspicion of PA without any histological proof were retrospectively analyzed. The operative decision has always been made at an MM. The definitive pathological finding was retrospectively confronted with the decision made at an MM, and patients were classified in two groups according to this concordance (group 1) or not (group 2). Clinical and biological parameters were analyzed, preoperative imaging were reread and confronted to pathological findings in order to identify predictive factors of malignant degeneration.RESULTS: During the study period, five of 18 (group 1) patients with CP had PD were histologically confirmed to have PA, and the other 13 (group 2) did not have PA. The median age was52.5 ±8.2 years (gender ratio 3.5). The main symptoms were pain (94.4%) and weight loss (72.2%). There was no patient's death. Six (33.3%) patients had a major complication (ClavienDindo classification ≥3). There was no statistical difference in clinical and biological parameters between the two groups. The rereading of imaging data could not detect efficiently all patients with PA.CONCLUSIONS: Our results confirmed the difficulty in detecting malignant transformation in patients with CP before surgery and therefore an elevated rate of unnecessary PD was found. A uniform imaging protocol is necessary to avoid PD as a less invasive treatment could be proposed. | Aude Merdrignac Laurent Sulpice Michel Rayar Tanguy Rohou Emmanuel Quéhen Ayman Zamreek Karim Boudjema Bernard Meunier | 2014 | Hepatobiliary & Pancreatic Diseases International2014，13，2： | 6 |
| 2 | Volumetric Changes after 90 Y Radioembolization for Hepatocellular Carcinoma in Cirrhosis: An Option to Portal Vein Embolization in a Preoperative Setting?显示文摘 | Julien Edeline Laurence Lenoir Karim Boudjema Yan Rolland Anne Boulic Fanny Le Du Marc Pracht Jean-Luc Raoul Bruno Clément Etienne Garin Eveline Boucher | 2013 | Annals of Surgical Oncology2013，，8： | 3 |
| 3 | A Neuro-fuzzy-sliding Mode Controller Using Nonlinear Sliding Surface Applied to the Coupled Tanks System显示文摘The aim of this paper is to develop a neuro-fuzzy-sliding mode controller (NFSMC) with a nonlinear sliding surface for a coupled tank system. The main purpose is to eliminate the chattering phenomenon and to overcome the problem of the equivalent control computation. A first-order nonlinear sliding surface is presented, on which the developed sliding mode controller (SMC) is based. Mathematical proof for the stability and convergence of the system is presented. In order to reduce the chattering in SMC, a fixed boundary layer around the switch surface is used. Within the boundary layer, where the fuzzy logic control is applied, the chattering phenomenon, which is inherent in a sliding mode control, is avoided by smoothing the switch signal. Outside the boundary, the sliding mode control is applied to drive the system states into the boundary layer. Moreover, to compute the equivalent controller, a feed-forward neural network (NN) is used. The weights of the net are updated such that the corrective control term of the NFSMC goes to zero. Then, this NN also alleviates the chattering phenomenon because a big gain in the corrective control term produces a more serious chattering than a small gain. Experimental studies carried out on a coupled tank system indicate that the proposed approach is good for control applications. | Ahcene Boubakir Fares Boudjema Salim Labiod | 2009 | International Journal of Automation and computing2009，6，1： | 3 |
| 4 | Iron metabolism imbalance at the time of listing increases overall and infectious mortality after liver transplantation显示文摘BACKGROUND Liver transplantation(LT)is the best treatment for patients with liver cancer or end stage cirrhosis,but it is still associated with a significant mortality.Therefore identifying factors associated with mortality could help improve patient management.The impact of iron metabolism,which could be a relevant therapeutic target,yield discrepant results in this setting.Previous studies suggest that increased serum ferritin is associated with higher mortality.Surprisingly iron deficiency which is a well described risk factor in critically ill patients has not been considered.AIM To assess the impact of pre-transplant iron metabolism parameters on posttransplant survival.METHODS From 2001 to 2011,553 patients who underwent LT with iron metabolism parameters available at LT evaluation were included.Data were prospectively recorded at the time of evaluation and at the time of LT regarding donor and recipient.Serum ferritin(SF)and transferrin saturation(TS)were studied as continuous and categorical variable.Cox regression analysis was used to determine mortality risks factors.Follow-up data were obtained from the local and national database regarding causes of death.RESULTS At the end of a 95-mo median follow-up,196 patients were dead,38 of them because of infections.In multivariate analysis,overall mortality was significantly associated with TS>75%[HR:1.73(1.14;2.63)],SF<100μg/L[HR:1.62(1.12;2.35)],hepatocellular carcinoma[HR:1.58(1.15;2.26)],estimated glomerular filtration rate(CKD EPI Cystatin C)[HR:0.99(0.98;0.99)],and packed red blood cell transfusion[HR:1.05(1.03;1.08)].Kaplan Meier curves show that patients with low SF(<100μg/L)or high SF(>400μg/L)have lower survival rates at 36 mo than patients with normal SF(P=0.008 and P=0.016 respectively).Patients with TS higher than 75%had higher mortality at 12 mo(91.4%±1.4%vs 84.6%±3.1%,P=0.039).TS>75%was significantly associated with infection related death[HR:3.06(1.13;8.23)].CONCLUSION Our results show that iron metabolism imbalance(either deficiency or overload)is associated with post-transplant overall and infectious mortality.Impact of iron supplementation or depletion should be assessed in prospective study. | Elodie Fallet Michel Rayar Amandine Landrieux Christophe Camus Pauline Houssel-Debry Caroline Jezequel Ludivine Legros Thomas Uguen Martine Ropert-Bouchet Karim Boudjema Dominique Guyader Edouard Bardou-Jacquet | 2020 | World Journal of Gastroenterology2020，26，16： | 2 |
| 5 | Indication of liver transplantation in severe alcoholic liver cirrhosis: quantitative evaluation and optimal timing显示文摘 | Bartholomeus Johannes Veldt Fabrice Lainé Anne Guillygomarc’h Laurence Lauvin Karim Boudjema Michel Messner Pierre Brissot Yves Deugnier Romain Moirand | 2002 | Journal of Hepatology2002，，1： | 2 |
| 6 | Enteral Nutrition Reduces Delayed Gastric Emptying After Standard Pancreaticoduodenectomy with Child Reconstruction显示文摘 | Michel Rayar Laurent Sulpice Bernard Meunier Karim Boudjema | 2012 | Journal of Gastrointestinal Surgery2012，，5： | 2 |
| 7 | Possible involvement of Von Willebrand factorin pancreatic graft thrombosis after kidney-pancreas transoplantation:a retrospectivestudy显示文摘 | Kessler L Wiesel ML Boudjema K | 1998 | Clin Transplant1998，12，1： | 1 |
| 8 | Corticosteroid-free immunosuppression with tacrolimus following induction with daclizumab= a large randomized clinical study 显示文摘 | Boillot O Mayer DA Boudjema K | 2005 | Liver Transpl2005，11，1： | 1 |
| 9 | Possible involvement of von willebrand factor in pancreatic graft thrombosis after kidney - pancreas transplantation: a retrospective study显示文摘 | Kessler L Wiesel ML Boudjema K | 1998 | Clin Transplant1998，12，1： | 1 |
| 10 | Hepcidin Levels in Humans are Correlated with Hepatic Iron Stores, Hemoglobin Levels,and Hepatic Function显示文摘 | Detivaud L Nemeth E Boudjema K | 2005 | Blood2005，106，2： | 1 |
| 11 | Hepcidin levels in humans are correlated with hepatic iron stores, hemoglobin levels, and hepatic function显示文摘 | Detivaud L Nemeth E Boudjema K | 2005 | Biood2005，106，： | 1 |
| 12 | Auxiliary versus orthotopic liver transplantation for acute liver failure显示文摘 | van HOEK B de BOER J BOUDJEMA K | 1999 | J Hepatol1999，30，4： | 1 |
| 13 | Hepcidin levels in humans are correlated with hepatic iron stores, hemoglobin levels, and hepatic function显示文摘 | Detivaud L Nemeth E Boudjema K | 2005 | Blood2005，106，： | 1 |
| 14 | Epithelial cell adhesion molecule is a prognosis marker for intrahepatic cholangiocarcinoma显示文摘 | Laurent Sulpice Michel Rayar Bruno Turlin Eveline Boucher Pascale Bellaud Mireille Desille Bernard Meunier Bruno Clément Karim Boudjema Cédric Coulouarn | 2014 | Journal of Surgical Research2014，，： | 1 |
| 15 | Effect of oxidized and reduced glutathione in heart preservation显示文摘 | BOUDJEMA K VANFULIK T M LINDELL S L | 1990 | J Transplantation1990，50，8： | 1 |
| 16 | Randomized Trial of Choledochocholedochostomy With or Without a T Tube in Orthotopic Liver Transplantation显示文摘 | Olivier Scatton Bernard Meunier Daniel Cherqui Olivier Boillot Alain Sauvanet Karim Boudjema Bernard Launois Pierre-Louis Fagniez Jacques Belghiti Philippe Wolff Didier Houssin Olivier Soubrane | 2001 | Annals of Surgery2001，，3： | 1 |
| 17 | Hepcidin levels in humans are correlated with hepatic iron stores,hemoglo bin levels,and hepatic function显示文摘 | Detivaud L Nemeth E Boudjema K | | 0，，： | 1 |
| 18 | Role of Preoperative Optimization of the Liver for Resection in Patients with Hilar Cholangiocarcinoma Type III显示文摘 | Stéphane Grandadam MD Philippe Compagnon MD PhD Alexis Arnaud MD Damien Olivié MD Yannick Malledant MD Bernard Meunier MD Bernard Launois MD FACS Karim Boudjema MD | 2010 | Annals of Surgical Oncology2010，，12： | 1 |
| 19 | Hepcidin levels in humans are correlated with hepatic iron stores, hemoglobin levels, and hepatic function 显示文摘 | Detivaud L Nemeth E Boudjema K | 2005 | Blood2005，106，2： | 1 |
| 20 | Corticosteroid-free immunosuppression with tacrelimus following induction with daclizum-ab:a large randomized clinical study显示文摘 | BOILLOT O MAYER DA BOUDJEMA K | 2005 | Liver Trauspl2005，11，1： | 1 |
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