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| 1 | Nat Biotechnol:将人星形胶质细胞重编程为多巴胺能神经元,有助治疗帕金森病显示文摘帕金森病是一种主要影响运动系统的神经退行性疾病。它的特征在于大脑中的多巴胺能神经元(dopaminergic neuron)渐进性丧失。尽管当前的疗法旨在补充多巴胺水平,但是没有一种疗法能够恢复这些丢失的细胞。如今。在一项新的研究中,来自瑞典、奥地利、西班牙和美国的研究人员开发出一种方法:将神经胶质细胞(glialcell)转化为活性的多巴胺能神经元,并且所产生的多巴胺能神经元能够部分恢复帕金森病模式小鼠的运动功能。这项概念验证研究可能为开发出一种治疗这种疾病的新方法铺平道路。 | Pia Rivetti di Val Cervo, Elisa Martín-Montañez, Enrique M Toledo, Gioele La Manno, Sara Padrell Sánchez, Sten Linnarsson Ernest Arenas Roman A Romanov, Christian Pifl Tibor Harkany Roman A Romanov, Giada Spigolon, Débora Masini, Michael Feyder, Tibor Harkany Gilberto Fisone Elisa Martín-Montañez Yi-Han Ng Marius Wernig | 2017 | 现代生物医学进展2017，17，17： | 11 |
| 2 | Research advances on the multiple uses of Moringa oleifera: a sustainable alternative for socially neglected population显示文摘Moringa oleifera Lam(Moringaceae) is a plant with high nutritional and medicinal value. Native to India, it is now widely distributed throughout tropical and subtropical regions of the world. Its different parts are sources of proteins, vitamins and minerals and present different pharmacological and biotechnological potential. Moreover, M. oleifera seeds are widely used in water and effluent treatment, for their coagulation, flocculation and sedimentation properties, their ability of improving water quality, by reducing organic matter and microbial load, with special applicability in intensive animal production systems, such as aquaculture. In addition, due to its high nutritional value and several medicinal properties, this tree may act as a nutritional and medical alternative for socially neglected populations. In this context, this review gathers information on M. oleifera, emphasizing its chemical constituents, nutritional, pharmacological and antimicrobial properties, applications in the treatment of water effluents, and ecological and social aspects. | Raimunda Samia Nogueira Brilhante Jamille Alencar Sales Vandbergue Santos Pereira Débora de Souza Collares Maia Castelo-Branco Rossana de Aguiar Cordeiro Célia Maria de Souza Sampaio Manoel de Araújo Neto Paiva Joao Bosco Feitosa dos Santos JoséJúlio CostaSidrim Marcos Fábio Gadelha Rocha | 2017 | Asian Pacific Journal of Tropical Medicine2017，10，7： | 10 |
| 3 | Enamel microabrasion: An overview of clinical and scientific considerations显示文摘Superficial stains and irregularities of the enamelare generally what prompt patients to seek dental intervention to improve their smile. These stains or defects may be due to hypoplasia, amelogenesis imperfecta, mineralized white spots, or fluorosis, for which enamel microabrasion is primarily indicated. Enamel microabrasion involves the use of acidic and abrasive agents, such as with 37% phosphoric acid and pumice or 6% hydrochloric acid and silica, applied to the altered enamel surface with mechanical pressure from a rubber cup coupled to a rotatory mandrel of a lowrotation micromotor. If necessary, this treatment can be safely combined with bleaching for better esthetic results. Recent studies show that microabrasion is a conservative treatment when the enamel wear is minimal and clinically imperceptible. The most important factor contributing to the success of enamel microabrasion is the depth of the defect, as deeper, opaque stains, such as those resulting from hypoplasia, cannot be resolved with microabrasion, and require a restorative approach. Surface enamel alterations that result from microabrasion, such as roughness and microhardness, are easily restored by saliva. Clinical studies support the efficacy and longevity of this safe and minimally invasive treatment. The present article presents the clinical and scientific aspects concerning the microabrasion technique, and discusses the indications for and effects of the treatment, including recent works describing microscopic and clinical evaluations. | Núbia Inocencya Pavesi Pini Daniel Sundfeld-Neto Flavio Henrique Baggio Aguiar Renato Herman Sundfeld Luis Roberto Marcondes Martins José Roberto Lovadino Débora Alves Nunes Leite Lima | 2015 | World Journal of Clinical Cases2015，3，1： | 6 |
| 4 | Transcranial direct current stimulation in psychiatric disorders显示文摘The interest in non-invasive brain stimulation techniques is increasing in recent years. Among these techniques, transcranial direct current stimulation(t DCS) has been the subject of great interest among researchers because of its easiness to use, low cost, benign profile of side effects and encouraging results of research in the field. This interest has generated several studies and randomized clinical trials, particularly in psychiatry. In this review, we provide a summary of the development of the technique and its mechanism of action as well as a review of the methodological aspects of randomized clinical trials in psychiatry, including studies in affective disorders, schizophrenia, obsessive compulsive disorder, child psychiatry and substance use disorder. Finally,we provide an overview of t DCS use in cognitive enhancement as well as a discussion regarding its clinical use and regulatory and ethical issues. Although many promising results regarding t DCS efficacy were described, the total number of studies is still low, highlighting the need of further studies aiming to replicate these findings in larger samples as to provide a definite picture regarding t DCS efficacy in psychiatry. | Gabriel Tortella Roberta Casati Luana V M Aparicio Antonio Mantovani Natasha Senco Giordano D’Urso Jerome Brunelin Fabiana Guarienti Priscila Mara Lorencini Selingardi Débora Muszkat Bernardo de Sampaio Pereira Junior Leandro Valiengo Adriano H Moffa Marcel Simis Lucas Borrione André R Brunoni | 2015 | World Journal of Psychiatry2015，5，1： | 6 |
| 5 | What exists beyond cag A and vacA? Helicobacter pylori genes in gastric diseases显示文摘Helicobacter pylori(H. pylori) infection is present in more than half the world's population and has been associated with several gastric disorders, such as gastritis, peptic ulceration, and gastric adenocarcinoma.The clinical outcome of this infection depends on host and bacterial factors where H. pylori virulence genes seem to play a relevant role. Studies of cag A and vac A genes established that they were determining factors in gastric pathogenesis. However, there are gastric cancer cases that are cag A-negative. Several other virulence genes have been searched for, but these genes remain less well known that cag A and vac A. Thus, this review aimed to establish which genes have been suggested as potentially relevant virulence factors for H. pylori-associated gastrointestinal diseases. We focused on the cag-pathogenicity island, genes with adherence and motility functions, and ice A based on the relevance shown in several studies in the literature. | Débora Menezes da Costa Eliane dos Santos Pereira Silvia Helena Barem Rabenhorst | 2015 | World Journal of Gastroenterology2015，21，37： | 6 |
| 6 | Autoimmune hepatitis in childhood: The role of genetic and immune factors显示文摘Autoimmune hepatitis (AIH) is a rare chronic inflammatory disease of the liver, which affects a group of patients who lost their immunological tolerance to antigens of the liver. It is clinically characterized by hypergammaglobulinemia, elevated liver enzymes, presence of autoantibodies and histological changes. Although being rare in children, it represents a serious cause of chronic hepatic disease that can lead to cirrhosis and hepatic failure. Clinical findings, exclusion of more common liver disorders and the detection of antibodies antinuclear antibodies, smooth muscle antibodies and anti-LKM1 are usually enough for diagnosis on clinical practice. The pathogenic mechanisms that lead to AIH remain obscure, but some research findings suggest the participation of immunologic and genetic factors. It is not yet knew the triggering factor or factors that stimulate inflammatory response. Several mechanisms proposed partially explain the immunologic findings of AIH. The knowledge of immune factors evolved might result in better markers of prognosis and response to treatment. In this review, we aim to evaluate the findings of research about genetic and immune markers and their perspectives of application in clinical practice especially in pediatric population. | Priscila Menezes Ferri Liu Débora Marques de Miranda Eleonora Druve Tavares Fagundes Alexandre Rodrigues Ferreira Ana Cristina Simoes e Silva | 2013 | World Journal of Gastroenterology2013，19，28： | 3 |
| 7 | Diagnostic criteria for autoimmune hepatitis in children: A challenge for pediatric hepatologists显示文摘Autoimmune hepatitis (AIH) is a progressive inflammatory liver disorder that is rare in children and adolescents. AIH has a broad clinical spectrum and a quick response to treatment with corticosteroids and immunosuppressive medication. The available diagnosis criteria have limitations and should be evaluated in pediatric populations. Recently, some studies reported that the 2008 simplified diagnostic criteria for AIH could be used in children with high sensibility and specificity. In addition, the authors reported that globulin and immunoglobulin G levels can be used interchangeably for diagnostic purposes. They also demonstrated that the 2008 simplified criteria fail in identifying patients with fulminant hepatic failure. Here, we discuss the limitations of the use of these criteria in pediatric patients and the requirement of more studies to improve the diagnosis of AIH in children. | Priscila Menezes Ferri Alexandre Rodrigues Ferreira Débora Marques Miranda Ana Cristina Sim■es e Silva | 2012 | World Journal of Gastroenterology2012，18，33： | 3 |
| 8 | Clinical hematological and biochemical parameters in Swiss,BALB/c,C57BL/6 and B6D2F1 Mus musculus显示文摘Background:Animal models are widely used in scientific research in order to obtain information from a whole organism under a specific set of experimental conditions.Various lineages of mice have been used to investigate diseases and new therapeutic strategies,and,consequently,hematological and biochemical tests in these laboratory animals are essential to validate scientific studies.Our study seeks to establish reference values for hematological and biochemical parameters of four lineages of mice.Methods:We evaluated the hematological and biochemical profiles of 20 males and 20 females from the lineages Swiss(heterogeneous),BALB/c and C57BL/6(isogenic),and B6D2F1(hybrid),totaling 160 mice.Analysis were standardized using the systems pocH-100iV Diff™for 19 hematological parameters and VITROS®350 for 12 biochemical parameters.Results:Results are shown as means and standard deviation,grouped by lineage and genre.Comparing the values obtained in this study with the values from previous studies,some variations were detected,which could be explained by differences in methodologies or individual variability.Conclusion:Thus our study shows that knowledge and disclosure of the values of physiological parameters of laboratory animals is necessary,and emphasises the importance of considering variations influenced by gender,lineage and genotype in the choice of the best experimental model. | Giorgio Silva-Santana Juliet Cunha Bax Débora Cristina Silva Fernandes Daniela Tendler Leibel Bacellar Cleber Hooper Alexandre Alves Souza Oliveira Dias Cristina Barbosa Silva Aline Moreira de Souza Simone Ramos Ricardo Alexandre Santos Thainara Ramos Pinto Mariana Antunes Ramão Ana Luíza Mattos-Guaraldi | 2020 | Animal Models and Experimental Medicine2020，3，4： | 2 |
| 9 | 钙质土壤颗粒对酸雨的影响:巴西贝洛奥里藏特都市区显示文摘这篇论文描述了巴西贝洛奥里藏特(Belo Horizonte)都市区(RMBH)的酸雨特征。这是一个受工业和机动车辆释放出来的二氧化硫(SO_2)和氮氧化物(NO_2)的影响的地区,并且盛行的风是从石灰质开发较集中的喀斯特地区吹来的。能够中和大气中人类产生的酸的碱性钙质尘土的供应可以控制RMBH的雨水的酸度。雨水是由三个监测站在日常的基础上,用大容积的容器收集的。收集时间是从1993年10月~1994年2月。pH容积加权平均值的范围是在4.98~5.27之间。Ca^(2+)是主要的离子,其次为SO__4^(2-)、NH_4^+和NO_3离子。降雨的酸度与SO_4^(2-):Ca^(2)和NO_3:Ca~(2+_比率的相关性很高。在干季,这些钙粒子连续释放进入大气,结果,穿过这一带大气的第一次降雨的酸度就比较低。然而,在连绵不断的雨季,雨水的酸度就日益增强。这样的结果表明钙粒子对RMBH大气中的酸有很强的中和能力。 | Débora Vallory Figuerêdo 雷利卿 | 1999 | AMBIO-人类环境杂志1999，28，6： | 2 |
| 10 | RNA interference therapeutics for cancer:challenges and opportunities(review)显示文摘 | Bora RS Gupta D Mukkur TK | 2012 | Mol Med Rep2012，6，1： | 1 |
| 11 | Coronary intervention for acute coronary syndrome in a 51 -year-old man with immune thrombocytope- nic purpura: a case report显示文摘 | Bora D Meltem A Fadime B | 2014 | J Med Case Rep2014，8，： | 1 |
| 12 | Clinical and histomorphometric characteristics of three different families with hereditary gingival fibromatosis显示文摘 | Jorge Kather Miguel Angel Castillo Salgado Ulisses Fernando Lodi Salgado José Roberto Cortelli Débora Pallos | 2008 | Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology2008，，3： | 1 |
| 13 | Simultaneous determination of pesticides and 5-hydroxymethylfurfural in honey by the modified QuEChERS method and liquid chromatography coupled to tandem mass spectrometry显示文摘 | Débora Tomasini Maicon R.F. Sampaio Sergiane S. Caldas Jaqueline G. Buffon Fábio A. Duarte Ednei G. Primel | 2012 | Talanta2012，，： | 1 |
| 14 | Air stable ligandless heterogeneous catalyst systems based on Pd and Au supported in SiO 2 and MCM-41 for Suzuki–Miyaura cross-coupling in aqueous medium显示文摘 | Marcelo Gomes Speziali Anderson Gabriel Marques da Silva Débora Michelini Vaz de Miranda Adriano Lisboa Monteiro Patricia Alejandra Robles-Dutenhefner | 2013 | Applied Catalysis A General2013，，： | 1 |
| 15 | Reliability tests of pulse width modulation(PWM)valves for flow rate control of anhydrous ammonia显示文摘 | Bora G C Schrock M D Oard D L | 2005 | Applied Engineering in Agriculture2005，21，6： | 1 |
| 16 | Superoxide dismutase, glutathione peroxidase activities and the hydroperoxide concentration are modified in the hippocampus of epileptic rats显示文摘 | Maria I. Bellissimo Débora Amado Dulcinéia S.P. Abdalla Edimar C. Ferreira Esper A. Cavalheiro Maria da Gra?a Naffah-Mazzacoratti | 2001 | Epilepsy Research2001，，2： | 1 |
| 17 | A reconfigurable plasma antenna显示文摘 | Kumar R Bora D | 2010 | Journal of Applied Physics2010，107，05： | 1 |
| 18 | Sleep deprivation induced by the modified multiple platform technique: quantification of sleep loss and recovery显示文摘 | Ricardo Borges Machado Débora C Hipólide Ana Amélia Benedito-Silva Sergio Tufik | 2004 | Brain Research2004，，1： | 1 |
| 19 | Lipotoxicity: Effects of Dietary Saturated and Transfatty Acids显示文摘 | Débora Estadella Claudia M. da Penha Oller do Nascimento Lila M. Oyama Eliane B. Ribeiro Ana R. Damaso Aline de Piano Fábio Santos Lira | 2013 | Mediators of Inflammation2013，，： | 1 |
| 20 | Clarification of fruit juices by fungal pectinases显示文摘 | Ivana Greice Sandri Roselei Claudete Fontana Débora Menim Barfknecht Mauricio Moura da Silveira | 2011 | LWT - Food Science and Technology2011，，10： | 1 |
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