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| 1 | Morphological study on colonic pathology in ulcerative colitis treated by moxibustion显示文摘AIM To observe the therapeutic effect ofmoxibustion on ulcerative colitis and itsinfluence on the colonic mucosal morphology.METHODS Forty-six patients with ulcerativecolitis were randomly divided into themoxibustion with herbal medicine underneathgroup and the western medicine group.Thirtypatients were treated with the abovemoxibustion and 16 patients with Salicylayefapyridine(SASP).The colonic mucosa of 13patients in the moxibustion group was observedby colonoscopy before and after the treatment.Mucin was also analyzed by H.E and AB-PASstaining.RESULTS Seventeen patients were clinicallycured,12 were improved and 1 unchanged in themoxibustion group.In the control group,5patients were clinically cured,7 improved and 4unchanged.Thirteen patients with active UCwere taken as the subjects for histopathologicanalysis in this study.The colonic mucosallesions were remarkably improved and thecharacteristic of the mucin also changed.Inmost sections,the chronic inflammation ofmucosa was geatly ameliorated(P<0.01).Theinflammatory cell infiltratation much decreased and neutrophils,disapeared in most sections(P<0.001).The goblet cells significantlyincreased(P<0.001);crypt paracrypt abscessor mucosal ulceration was seen(P<0.001).CONCLUSION The rate of cure of ulcerative colitis by moxibustion with herbal medicine beneath is superior to that by SASP. This sort of moxibustion can effectively improve the colonic mucosal lesions and restore the proportion of mucoprotein to near normal. | Huan Gan Wu Li Bin Zhou Da Ren Shi Shi Min Liu Hui Rong Liu Bi Meng Zhang Han Ping Chen Lin Shan Zhang | 2000 | World Journal of Gastroenterology2000，6，6： | 28 |
| 2 | APC and K-ras gene mutation in aberrant crypt foci of human colon显示文摘AIM To study the genetic alteration in ACF andto define the possibility that ACF may be a veryearly morphological lesion with molecularchanges, and to explore the relationshipbetween ACF and colorectal adenoma evencarcinoma.METHODS DNA from 35 CRC, 15 adenomas, 34ACF and 10 normal mucus was isolated by meansof microdissection. Direct gene sequencing of K-ras gene including codon 12, 13 and 61 as well asthe mutation cluster region (MCR) of APC genewas performed.RESULTS K-ras gene mutation frequency inACF, adenoma and carcinoma was 17.6% (6/34), 13.3% (2/ 15), and 14.3% (5/ 35)respectively, showing no difference ( P > 0.05)in K-fas gene mutation among three pathologicprocedures. The K-ras gene mutation inadenoma, carcinoma and 4 ACF restricted incodon 12 (GGT→GAT), but the other 2 mutationsfrom ACF located in codon 13 (GGC→GAC). K-res gene mutation was found more frequently inolder patients and patients with polypoidcancer. No mutation in codon 61 was found in thethree tissue types. Mutation rate of APO gene inadenoma and carcinoma was 22.9% (8/35) and26.7% (4/ 15), which was higher than ACF(2.9%) (P < 0.05). APC gene mutation incarcinoma was not correlated with age ofpatients, location, size and differentiation oftumor.CONCLUSION ACF might be a very earlymorphological lesion in the tumorogenesis ofcolorectal tumor. The morphological feature andgene mutation status was different in ACF andadenoma. ACF is possibly putative'microadenoma' that might be the precursor ofadenoma. In addition, the development of asubgroup of colorectal carcinomas mightundergo a way of 'normal epithelium→ ACF→carcinomas'. | Ping Yuan~1 Meng Hong Sun~2 Jin Sheng Zhang~1 Xiong Zeng Zhu~2 Da Ren Shi~2 ~1Department of Pathology,Medical College of Fudan University,~2Department of Pathology,Cancer Hospital/Cancer Institute,Fudan University,Shanghai 200032,ChinaDr.Ping Yuan Studying Province.studying in Medical College of Fudan University,worked in Department of Pathology,Wannan Medical College,having eighteen papers published. | 2001 | World Journal of Gastroenterology2001，7，3： | 20 |
| 3 | Preliminary study on the production of transgenic mice harboring hepatitis B virus X gene显示文摘INTRODUCTIONDespiteoverwhelmingepidemiologicalevidencelinkingpersistentHepatitisBVirus(HBV)infectionandthedevelopmentofhepato... | ZHU Huan Zhang 1, CHENG Guo Xiang 2, CHEN Jian Qu 2, KUANG Shu Yuan 3, CHENG Yong 2, ZHANG Xin Li 1, Ll Hou Da 2, XU Shao Fu 2, SHI Jing Quan 1, QIAN Geng Sun 3 and GU Jian Ren 3 | 1998 | World Journal of Gastroenterology1998，4，6： | 14 |
| 4 | Association between ApoE Polymorphism and Type 2 Diabetes: A Meta-Analysis of 59 Studies显示文摘Objective To identify the important risk factors for type 2 Diabetes Mellitus(T2 DM) and develop effective strategies to address the problem of T2 DM. Our study aimed to evaluate the association between apolipoprotein E(Apo E) genetic polymorphism and type 2 diabetes, and to provide clues for the etiology of T2 DM.Methods Based on the criteria of inclusion and exclusion, we extracted, pooled, analyzed and assessed the case-control studies of Apo E polymorphism and T2 DM published in Pub Med, Web of Science,Medline, Wan Fang, VIP, and CNKI databases by R soft-ware(version 3.4.3). We used Random-effect models when heterogeneity was present in between-study, and fixed-effect models otherwise.Results We had 59 studies covering 6,872 cases with T2 DM and 8,250 controls, and compared the alleles and genotypes of Apo E between cases and controls. When we conducted a comparison between Apo E ε4 and ε3 alleles, we produced a pooled OR of 1.18(95% CI: 1.09-1.28;P < 0.001). Apo E ε2/ε2 genotype displayed a possible association with T2 DM(OR = 1.46;95% CI: 1.11-1.93;P = 0.007), ε3/ε4 genotype showed a 1.11-fold risk(OR = 1.11;95% CI: 1.01-1.22;P = 0.039) and ε4/ε4 genotype had a1.71-fold risk of developing T2 DM(OR = 1.71;95% CI: 1.33-2.19;P < 0.001) when they were compared with ε3/ε3 genotype.Conclusions There is an association between Apo E polymorphism and T2 DM: allele ε4 and genotypes(ε2/ε2, ε3/ε4, and ε4/ε4) are associated with the increased risk for the development of T2 DM, and they may be risk factors for T2 DM. | CHEN Da Wei SHI Ji Kang LI Yun YANG Yu REN Shu Ping | 2019 | Biomedical and Environmental Sciences2019，32，11： | 4 |
| 5 | Formation Sequence of Interface Intermetallic Phases of Cold Rolling Cu/Al Clad Metal Sheet in Annealing Process显示文摘 | Ji Xing Lin Jun Ping Zhang Li Yuan Niu Da Ren Sun Zi Mu Shi Yong Li Guang Yu Li | 2013 | Materials Science Forum2013，，749： | 1 |
| 6 | Methyl jasmonate induces ganoderic acid biosynthesis in the basidiomycetous fungus Ganoderma lu cidum显示文摘 | Ang Ren Lei Qin Liang Shi Xin Dong Da Shuai Mu Yu Xiang Li Ming Wen Zhao | 2010 | Bioresource Technology2010，101，： | 1 |
| 7 | Selective Reduction of α,β-Unsaturated Amides with NaBH_4/BiCl_3 System显示文摘SelectiveReductionofα,β-UnsaturatedAmideswithNaBH_4/BiCl_3SystemSelectiveReductionofα,β-UnsaturatedAmideswithNaBH_4/BiCl_3Syste... | Ping Da REN Shi Feng PAN Ting Wei DONG Shi Hui WU(Department of Chemistry,Fudan University,Shanghai 200433) | 1996 | Chinese Chemical Letters1996，7，9： | 1 |
| 8 | Synthesis of a silica monolith with textural pores and ordered mesopores显示文摘 | SHI Z G FENG Y Q xu L DA S L REN Y Y | 2004 | Microporous and Mesoporous Materials2004，68，： | 1 |
| 9 | FACILE AND SELECTIVE REDUCTION OF NTIROARENES IN THE PRESENCE OF NITRILES WITH NaBH_4-BiCl_3 SYSTEM显示文摘FACILEANDSELECTIVEREDUCTIONOFNTIROARENESINTHEPRESENCEOFNITRILESWITHNaBH_4-BiCl_3SYSTEM￥PingDaREN,ShiFengPAN,TingWeiDONG,ShiHui... | Ping Da REN, Shi Feng PAN, Ting Wei DONG, Shi Hui WU (Department of Chemistry, Fudan University, Shanghai 200433) | 1995 | Chinese Chemical Letters1995，6，7： | 1 |
| 10 | Comparative analysis of window operating behavior in three different open-plan offices in Nanjing显示文摘Research on the window operating behavior of offices is of great significance for reducing building energy con-sumption and improving indoor comfort.The open-plan office is a common office form that involves a large number of people and a complex staffcomposition.The window operating behaviors in open-plan offices are also random and various.This study took three open-plan offices with different situations(area,office type,staffcomposition,etc.)as an example,which provides a new perspective on how people behave differently when opening or closing windows.The window operating behaviors in two typical seasons(summer and transition seasons)were recorded and analyzed.The occupants’schedules and influencing factors of window operating behavior were investigated by questionnaire surveys.In addition,the indoor environmental parameters,occu-pancy situation,and on-offstatuses of windows and air conditioning were acquired through field measurements.Furthermore,the differences in window operating behaviors in the three open-plan offices were compared from the perspectives of influencing factors,duration of the window on-offstatuses,and cause of window control ac-tions,among others.In addition,Spearman Correlation Coefficient was used to analyze the ranks of the candidate motivations for window operating behaviors.The preliminary results show that influenced by the personnel com-position,type of air conditioner and adjustable degree of windows,the window operating behaviors of different office buildings have larger discrepancies than that in the same building.However,there were some common characteristics in the window regulation behaviors of the three open-plan offices:they were generally influenced by the coupling of environmental factors,schedule factors,and equipment factors.This study reveals that when expand the research object from a single building to multiple buildings,more difficulties and challenges would be involved into behavior research. | Jiawen Ren Xin Zhou Jingjing An Da Yan Xing Shi Xing Jin Shaoyan Zheng | 2021 | Energy and Built Environment2021，2，2： | 0 |
| 11 | CACA Guidelines for Holistic Integrative Management of Breast Cancer显示文摘Purpose:Breast cancer is now the most common malignant tumor worldwide.About one-fourth of female cancer patients all over the world sufer from breast cancer.And about one in six female cancer deaths worldwide is caused by breast cancer.In terms of absolute numbers of cases and deaths,China ranks frst in the world.The CACA Guidelines for Holistic Integrative Management of Breast Cancer were edited to help improve the diagnosis and comprehensive treatment in China.Methods:The Grading of Recommendations Assessment,Development and Evaluation(GRADE)was used to classify evidence and consensus.Results:The CACA Guidelines for Holistic Integrative Management of Breast Cancer include the epidemiology of breast cancer,breast cancer screening,breast cancer diagnosis,early breast cancer treatment,advanced breast cancer treatment,follow-up,rehabilitation,and traditional Chinese medicine treatment of breast cancer patients.Conclusion:We to standardize the diagnosis and treatment of breast cancer in China through the formulation of the CACA Guidelines. | Jiong Wu Daiming Fan Zhimin Shao Binghe Xu Guosheng Ren Zefei Jiang Yongsheng Wang Feng Jin Jin Zhang Qingyuan Zhang Fei Ma Jinli Ma Zhonghua Wang Shusen Wang Xiaojia Wang Shu Wang Haibo Wang Tao Wang Xiang Wang Jing Wang Jia Wang Biyun Wang Li Fu Hongyuan Li Yehui Shi Lu Gan Yunjiang Liu Jian Liu Zhenzhen Liu Qiang Liu Qiang Sun Wenwu Cheng Keda Yu Zhongsheng Tong Xinhong Wu Chuangui Song Jianguo Zhang Jian Zhang Junjie Li Bin Li Man Li Huiping Li Wentao Yang Hongjian Yang Benlong Yang Hong Bu Juping Shen Zhenzhou Shen Yiding Chen Ceshi Chen Da Pang Zhimin Fan Ying Zheng Xiaoli Yu Guangyu Liu Xichun Hu Yiqun Ling Jinhai Tang Yongmei Yin Cuizhi Geng Peng Yuan Yajia Gu Cai Chang Xuchen Cao Yuan Sheng Yuanxi Huang Jian Huang Weijun Peng Xiaohua Zeng Yuntao Xie Ning Liao Committee of Breast Cancer Society,Chinese Anti-Cancer Association | 2022 | Holistic Integrative Oncology2022，1，1： | 0 |
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