5篇
您的检索式：作者名="Bellone S."
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| 1 | Ⅱ型表皮生长因子受体(HER2/neu)过度表达的种族差异:子宫浆液性乳头状癌的主要预后指标 | Santin A.D. Bellone S. Siegel E.R. 朱国栋 | 2005 | 世界核心医学期刊文摘(妇产科学分册)2005，0，7： | 2 |
| 2 | 采用HPV16/18型E7肽冲击的树突状细胞免疫复发性难治型宫颈癌显示文摘Objective. To evaluate the potential of human papillomavirus (HPV) type 16 and 18 E7 antigen-loaded autologous dendritic cells (DC) as a therapeutic cellular vaccine in a case series of cervical cancer patients harboring recurrent/metastatic disease refractory to standard treatment modalities. Methods. Autologous monocyte-derived DC were pulsed with recombinant HPV16 E7 or HPV18 E7 oncoproteins and administered to 4 cervical cancer patients. Vaccinations were followed by subcutaneous administration twice daily of low doses of human recombinant interleukin- 2 (1 × 106 IU/m2) from day 3 to day 7. Safety, toxicity, delayed type hypersensitivity reactions (DTH), clinical responses, and induction of serological and cellular immunity against HPV16/18 E7 were monitored. Results. The vaccine was well- tolerated in all patients and no local or systemic side effects or toxicity were recorded. Three out of four patients were found to be significantly immunocompromised before starting the vaccination treatment, as assessed by DTH with a panel of recall antigens. Specific humoral and cellular CD4+ T cell responses to the E7 vaccine were detected in 2 patients, as detected by ELISA and by IFN- γ ELISpot assays, respectively. Increased numbers of E7- specific IFN- γ secreting CD8+ T cells were detected in all patients after vaccination. Swelling and induration (i.e., a positive DTH response) to the intradermal injection of HPV E7 oncoprotein and/or irradiated autologous tumor cells were detected in two patients after six vaccinations. No objective clinical responses were observed. However, both patients who developed a positive DTH to the vaccine experienced a slow tumor progression (i.e., 13 months survival)while DTH unresponsive patients died within 5 months from the beginning of therapy. Conclusions. Autologous DC pulsed with HPV16/18 E7 proteins can induce systemic B and T cell responses in patients unresponsive to standard treatment modalities. However, treatment-induced immunosuppression may impose severe limitations on the efficacy of active vaccination strategies in late stage cervical cancer patients. DC-based vaccination trials are warranted in immunocompetent cervical cancer patients with early stage disease and/or limited tumor burden, and at significant risk for tumor recurrence or disease progression. | Santin A.D. Bellone S. Palmieri M. 李奎 | 2006 | 世界核心医学期刊文摘(妇产科学分册)2006，0，8： | 2 |
| 3 | Pharmacokinetics and Tissue Distribution of a Ribozyme Directed Against Hepatitis C Virus RNA Following Subcutaneous or Intravenous Administration in Mice显示文摘 | Patrice A. Lee Lawrence M. Blatt Karin S. Blanchard Karyn S. Bouhana Pamela A. Pavco Laurent Bellon Jennifer A. Sandberg | 2000 | Hepatology2000，，3： | 1 |
| 4 | Andesite and dacite genesis via contrasting processes: the geology and geochemistry of El Valle Volcano, Panama显示文摘 | Mare J. Defant Lee F. Clark Robert H. Stewart Mark S. Drummond Jelle Z. Boer René C. Maury Hervé Bellon Thomas E. Jackson Juan F. Restrepo | 1991 | Contributions to Mineralogy and Petrology1991，，3： | 1 |
| 5 | 确定子宫浆液性乳头状腺癌中HER2/neu基因的状态:免疫组化和荧光原位杂交的比较分析 | Santin A.D. Bellone S. Van Stedum S. 王颖 | 2005 | 世界核心医学期刊文摘(妇产科学分册)2005，0，11： | 0 |
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