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| 1 | Differential regulations of blood pressure and perturbed metabolism by total ginsenosides and conventional antihypertensive agents in spontaneously hypertensive rats显示文摘 | Ji-ye AA Guang-ji WANG Hai-ping HAO Qing HUANG Yi-hong LU Bei YAN Wei-bin ZHA Lin-sheng LIU An KANG | 2010 | Acta Pharmacologica Sinica2010，31，8： | 14 |
| 2 | Lactate metabolism in human health and disease显示文摘The current understanding of lactate extends from its origins as a byproduct of glycolysis to its role in tumor metabolism,as identified by studies on the Warburg effect.The lactate shuttle hypothesis suggests that lactate plays an important role as a bridging signaling molecule that coordinates signaling among different cells,organs and tissues.Lactylation is a posttranslational modification initially reported by Professor Yingming Zhao’s research group in 2019.Subsequent studies confirmed that lactylation is a vital component of lactate function and is involved in tumor proliferation,neural excitation,inflammation and other biological processes.An indispensable substance for various physiological cellular functions,lactate plays a regulatory role in different aspects of energy metabolism and signal transduction.Therefore,a comprehensive review and summary of lactate is presented to clarify the role of lactate in disease and to provide a reference and direction for future research.This review offers a systematic overview of lactate homeostasis and its roles in physiological and pathological processes,as well as a comprehensive overview of the effects of lactylation in various diseases,particularly inflammation and cancer. | Xiaolu Li Yanyan Yang Bei Zhang Xiaotong Lin Xiuxiu Fu Yi An Yulin Zou Jian-Xun Wang Zhibin Wang Tao Yu | 2022 | Signal Transduction and Targeted Therapy2022，7，10： | 9 |
| 3 | Bone Metabolic Markers in Patients with Obstructive Sleep Apnea Syndrome显示文摘 | Yan Qiao Bei Wang Jiao-Jiao Yang Yan-Feng Fan Qian GUO Zhan-Jun Dou Ya-Qiong Huang Ting-Ting Feng Shu-Juan Wang Dong-Dong An Xiao-Ling Gao | 2018 | Chinese Medical Journal2018，，16： | 7 |
| 4 | Combination of 18F-fluorodeoxyglucose positron emission tomography/computed tomography and magnetic resonance imaging is an optimal way to evaluate rheumatoid arthritis in rats dynamically显示文摘 | ZHANG Wei-tao DU Xiang-ke HUO Tian-long WEI Zheng-mao HAO Chuan-xi AN Bei | 2013 | Chinese Medical Journal2013，，19： | 2 |
| 5 | Drug Resistance to HIV-1 Integrase Inhibitors among Treatment-naive Patients in Jiangsu, China显示文摘Integrase strand transfer inhibitors (In STIs) have been widely used in recent years because of their high genetic barrier to resistance.The World Health Organization (WHO) has recommended dolutegravir(DTG)-containing regimens as the preferred first-and second-line antiretroviral therapy (ART) regimens for people living with human immunodeficiency virus(HIV)[1]. | YIN Yue Qi LU Jing ZHOU Ying SHI Ling En YUAN De Fu CHEN Jian Shuang XU AN Yan HU Hai Yang ZHANG Zhi XU Xiao Qin FU Geng Feng WANG Bei | 2021 | Biomedical and Environmental Sciences2021，34，5： | 2 |
| 6 | Panda X-III: Searching for neutrinoless double beta decay with high pressure ^(136)Xe gas time projection chambers显示文摘Searching for the neutrinoless double beta decay(NLDBD)is now regarded as the topmost promising technique to explore the nature of neutrinos after the discovery of neutrino masses in oscillation experiments.Panda X-III(particle and astrophysical xenon experiment III)will search for the NLDBD of136Xe at the China Jin Ping Underground Laboratory(CJPL).In the first phase of the experiment,a high pressure gas Time Projection Chamber(TPC)will contain 200 kg,90%136Xe enriched gas operated at10 bar.Fine pitch micro-pattern gas detector(Microbulk Micromegas)will be used at both ends of the TPC for the charge readout with a cathode in the middle.Charge signals can be used to reconstruct the electron tracks of the NLDBD events and provide good energy and spatial resolution.The detector will be immersed in a large water tank to ensure~5 m of water shielding in all directions.The second phase,a ton-scale experiment,will consist of five TPCs in the same water tank,with improved energy resolution and better control over backgrounds. | Xun Chen Chang Bo Fu Javier Galan Karl Giboni Franco Giuliani Ling Hui Gu Ke Han Xiang Dong Ji Heng Lin Jiang Lai Liu Kai Xiang Ni Hiroki Kusano Xiang Xiang Ren Shao Bo Wang Yong Yang Dan Zhang Tao Zhang Li Zhao Xiang Ming Sun Shou Yang Hu Si Yu Jian Xing Long Li Xiao Mei Li Hao Liang Huan Qiao Zhang Ming Rui Zhao Jing Zhou Ya Jun Mao Hao Qiao Si Guang Wang Ying Yuan Meng Wang Amir N.Khan Neill Raper Jian Tang Wei Wang Jia Ning Dong Chang Qing Feng Cheng Li Jian Bei Liu Shu Bin Liu Xiao Lian Wang Dan Yang Zhu Juan F.Castel Susana Cebri'an Theopisti Dafni Javier G.Garza Igor G.Irastorza Francisco J.Iguaz Gloria Luz ′on Hector Mirallas Stephan Aune Eric Berthoumieux Yann Bedfer Denis Calvet Nicole d'Hose Alain Delbart Maria Diakaki Esther Ferrer-Ribas Andrea Ferrero Fabienne Kunne Damien Neyret Thomas Papaevangelou Franck Sabatie Maxence Vanderbroucke AnDi Tan Wick Haxton Yuan Mei Chinorat Kobdaj Yu-Peng Yan | 2017 | Science China(Physics,Mechanics & Astronomy)2017，60，6： | 2 |
| 7 | Comparative phylogeography of two sister species of snowcock: impacts of species-specific altitude preference and life history显示文摘Background: Phylogeographical patterns and population dynamics are usually interpreted by environmental disturbances and geographic barriers of the past. However, sister species may exhibit disparate patterns of genetic structures and population dynamics due to their habitat preference and altitude segregation. In this study, we tested how species-specific altitude habitat affected phylogeographical patterns in two sister snowcock species, Tibetan(Tetraogallus tibetanus) and Himalayan Snowcocks(T. himalayensis).Methods: A panel of seven microsatellite loci and a fragment of Mitochondrial DNA Control Region were used to investigate genetic structures and population dynamics in hope of revealing the underlying evolutionary processes through the identification of possible past demographic events.Results: Our results suggest that T. himalayensis showed a significant phylogeographical signal in mtDNA(FST microsatellite(F the glacial-interglacial cycles in the = 0.66, p < 0.001) and ST Pleistocene and followed demog= 0.11, p < 0.001) data and is stable duringraphic contraction until 0.003 million years(Mys) ago. The phylogeographical signal of T. tibetanus is lower than the level of genetic difference among populations in mtDNA(FST icrosatellite(F= 0.41, p < 0.001) and mST s been experien= 0.09, p < 0.001) data, likely benefiting from stable habitats over a long period of time. T. tibetanus hacing expansion since 0.09 Mys ago. However, an abnormally haplotype H9 from T. himalayensis clustering with T. tibetanus was spotted.Conclusion: Our results indicate that differences in habitat preference and altitude specialities were reflected in the genetic structure patterns and population dynamics of these two species. These dissimilarities in life history traits might have affected the dispersal and survival abilities of these two species differently during environmental fluctuations. The results of this study also enriched our knowledge on population differentiation and connectivity in high altitude mountain ecosystems. | Bei An Lixun Zhang Yutao Wang Sen Song | 2020 | Avian Research2020，11，1： | 1 |
| 8 | Mg-intercalation engineering of MnO_(2)electrode for high-performance aqueous magnesium-ion batteries显示文摘Rechargeable aqueous magnesium-ion batteries(MIBs)show great promise for low-cost,high-safety,and high-performance energy storage applications.Although manganese dioxide(MnO_(2))is considered as a potential electrode material for aqueous MIBs,the low electrical conductivity and unsatisfactory cycling performance greatly hinder the practical application of MnO_(2)electrode.To overcome these problems,herein,a novel Mg-intercalation engineering approach for MnO_(2)electrode to be used in aqueous MIBs is presented,wherein the structural regulation and electrochemical performance of the Mg-intercalation MnO_(2)(denoted as MMO)electrode were thoroughly investigated by density functional theory(DFT)calculations and in-situ Raman investigation.The results demonstrate that the Mg intercalation is essential to adjusting the charge/ion state and electronic band gap of MMO electrode,as well as the highly reversible phase transition of the MMO electrode during the charging-discharging process.Because of these remarkable characteristics,the MMO electrode can be capable of delivering a significant specific capacity of~419.8 mAh·g^(−1),while exhibiting a good cycling capability over 1000 cycles in 1 M aqueous MgCl_(2) electrolyte.On the basis of such MMO electrode,we have successfully developed a soft-packaging aqueous MIB with excellent electrochemical properties,revealing its huge application potential as the efficient energy storage devices. | Yue Zhao Bei Wang Minjie Shi Shibo An Liping Zhao Chao Yan | 2022 | International Journal of Minerals,Metallurgy and Materials2022，29，11： | 1 |
| 9 | Basic Fibroblast Growth Factor Protects C 17.2 Cells from Radiation‐Induced Injury through ERK 1/2显示文摘 | Ping Luan Hai‐Hong Zhou Bei Zhang An‐Ming Liu Lian‐Hong Yang Xue‐Ling Weng En‐Xiang Tao Jun Liu | 2012 | CNS Neurosci Ther2012，，： | 1 |
| 10 | Large area^(3)He tube array detector with modular design for multi‑physics instrument at CSNS显示文摘The multi-physics instrument(MPI)is the first user cooperative instrument at the China Spallation Neutron Source(CSNS).It was designed to explore the structures of complex materials at multiple scales based on the neutron total scattering technique.This imposes the requirements for the detector,including a high detection efficiency to reduce the measurement time and a large solid angle coverage to cover a wide range of momentum transfers.To satisfy these demands,a large-area array of 3He-filled linear position-sensitive detectors(LPSDs)was constructed,each with a diameter of 1 inch and pressure of 20 atm.It uses an orbicular layout of the detector and an eight-pack module design for the arrangement of 3He LPSDs,covering a range of scattering angles from 3°to 170°with a total detector area of approximately 7 m2.The detector works in air,which is separated from the vacuum environment to facilitate installation and maintenance.The characteristics of the MPI detector were investigated through Monte Carlo(MC)simulations using Geant4 and experimental measurements.The results suggest that the detectors are highly efficient in the wavelength range of the MPI,and an efficiency over 25%is achievable for above 0.1 A neutrons.A minimal position resolution of 6.4 mm full width at half maximum(FWHM)along the tube length was achieved at a working voltage of 2200 V,and a deviation below 2 mm between the real and measured positions was attained in the beam experiment.The detector module exhibited good consistency and an excellent counting rate capacity of up to 80 kHz,which satisfied the requirements of experiments with a high event rate.Observations of its operation over the past year have shown that the detector works steadily in sample experiments,which allows the MPI to serve the user program successfully. | Lin Zhu Jian‑Rong Zhou Yuan‑Guang Xia Liang Xiao Hong Luo Xiao‑Juan Zhou Wen‑Qin Yang Bei‑Ju Guan Xing‑Fen Jiang Yan‑Feng Wang Hong Xu Hai‑Yun Teng Li‑Xin Zeng Jia‑Jie Li Lei Hu Ke Zhou Yong‑Xiang Qiu Pei‑Xun Shen Jun Xu Li‑Jiang Liao Xiao‑Zhuang Wang Gui‑An Yang Huai‑Chan Chen Ju‑Ping Xu Zhi‑Duo Li Song‑Lin Wang Jian Zhuang Yu‑Bin Zhao Jun‑Rong Zhang Wen Yin Zhi‑Jia Sun Yuan‑Bo Chen | 2023 | Nuclear Science and Techniques2023，34，1： | 0 |
| 11 | Dietary lysozyme improves growth performance and intestinal barrier function of weaned piglets显示文摘Lysozyme(LZ)is a purely natural,nonpolluting and nonspecific immune factor,which has beneficial effects on the healthy development of animals.In this study,the influences of LZ on the growth performance and intestinal barrier of weaned piglets were studied.A total of 48 weaned piglets(Landrace×Yorkshire,22 d old)were randomly divided into a control group(basal diet)and a LZ group(0.1%LZ diet)for 19 d.The results showed that LZ could significantly improve the average daily gain(ADG,P<0.05)and average daily feed intake(ADFI,P<0.05).LZ also improved the intestinal morphology and significantly increased the expression of occludin in the jejunum(P<0.05).In addition,LZ down-regulated the expression of interleukin-1β(IL-1β,P<0.05)and tumor necrosis factor-a(TNF-a,P<0.05),and inhibited the expression of the genes in the nuclear factor-k-gene binding(NF-κB,P<0.05)signaling pathway.More importantly,the analysis of intestinal flora showed LZ increased the abundance of Firmicutes(P<0.05)and the ratio of Firmicutes to Bacteroidota(P=0.09)at the phylum level,and increased the abundance of Clostridium_sensu_stricto_1(P<0.05)and reduced the abundance of Olsenella and Prevotella(P<0.05)at the genus level.In short,this study proved that LZ could effectively improve the growth performance,relieve inflammation and improve the intestinal barrier function of weaned piglets.These findings provided an important theoretical basis for the application of LZ in pig production. | Yuying Wu Bei Cheng Longxiang Ji Xiangyun Lv Yingying Feng Liu’an Li Xin Wu | 2023 | Animal Nutrition2023，，3： | 0 |
| 12 | Starting a New Phase of Ecological Progress显示文摘 | Dong Fun WangLibin Gao Fing An Bei | 2017 | Qiu Shi2017，9，4： | 0 |
| 13 | THE EXCITED STATES AND VIBRATIONAL FREQUENCIES OF Bli_2~e(e=0,+1,-1)CLUSTERS显示文摘THEEXCITEDSTATESANDVIBRATIONALFREQUENCIESOFBli:(e=0,+1,-1)CLUSTERSTHEEXCITEDSTATESANDVIBRATIONALFREQUENCIESOFBli:(e=0,+1,-1)C... | Hua Bei ZHANG An Min TIAN and Guo Sen YAN (Department of Chemistry, Sichuan University ,Chengdu 610064) | 1995 | Chinese Chemical Letters1995，6，4： | 0 |
| 14 | Population structure and demographic history of the chukar partridge Alectoris chukar in China显示文摘 | Sen SONG Shijie BAO Ying WANG Xinkang BAO Bei AN Xiaoli WANG Naifa LIU | 2013 | Current Zoology2013，59，4： | 0 |
| 15 | Search for d-MPs without duplicates in two-terminal multistate networks based on MPs显示文摘The reliability evaluation of a multistate network is primarily based on d-minimal paths/cuts(d-MPs/d-MCs).However,being a nondeterminism polynomial hard(NP-hard)problem,searching for all d-MPs is a rather challenging task.In existing implicit enumeration algorithms based on minimal paths(MPs),duplicate d-MP candidates may be generated.An extra step is needed to locate and remove these duplicate d-MP candidates,which costs significant computational effort.This paper proposes an efficient method to prevent the generation of duplicate d-MP candidates for implicit enumeration algorithms for d-MPs.First,the mechanism of generating duplicate d-MP candidates in the implicit enumeration algorithms is discussed.Second,a direct and efficient avoiding-duplicates method is proposed.Third,an improved algorithm is developed,followed by complexity analysis and illustrative examples.Based on the computational experiments comparing with two existing algorithms,it is found that the proposed method can significantly improve the efficiency of generating d-MPs for a particular demand level d. | XU Bei FANG Yining BAI Guanghan ZHANG Yun’an TAO Junyong | 2022 | Journal of Systems Engineering and Electronics2022，33，6： | 0 |
| 16 | Study on the Correlation Between SFRP-5 Expression Level, Insulin Resistance, and Glycolipid Metabolism in Gestational Diabetes Mellitus显示文摘Objective:To investigate the correlation between serum secretory frizzled-related protein 5(SFRP-5)expression levels and insulin resistance and glucolipid metabolism in patients with gestational diabetes mellitus(GDM).Methods:Baseline data were collected from 58 patients with GDM and 51 healthy controls who were admitted Affiliated Hospital of Hebei University from May 2020 to June 2022.sSTRA5 concentrations in peripheral blood of pregnant women were measured,and SFRP-5 levels in patients with different GDM types and normal controls were analyzed by logistic regression models.Results:The levels of triglyceride(TG),total cholesterol(TC),low-density lipoprotein cholesterol(LDL-C),fasting blood glucose(FBG),fasting insulin(FINS),hemoglobin A1c(HbA1c),and homeostasis model assessment-estimated insulin resistance(HOMA-IR)were higher in the observation group than in the control group,with statistically significant differences(P<0.05),while the expression levels of high-density lipoprotein cholesterol(HDL-C)and serum SFRP-5 were lower than in the control group,with statistically significant differences(P<0.05);serum SFRP-5,TG,TC,FBG,and HOMA-IR were all risk factors for GDM(P<0.05).Conclusion:Elevated serum sSTRA5 may be involved in the regulation of insulin resistance in the body and the regulation of blood glucose in the body by affecting lipid metabolism and inflammatory response. | Bei Wang Chenyuan Cao Rui Li Yan An Fang Wang Yuxiang Huang Jinjin Qin | 2023 | Journal of Clinical and Nursing Research2023，7，2： | 0 |
| 17 | Influences of CeO_(2)morphology on enhanced performance of electro-Fenton for wastewater treatment显示文摘As a kind of rare-earth oxide,CeO_(2)has been considered as a great potential material for its abundant oxygen vacancies and catalysis activity in wastewater treatment.In this study,three ceria samples with different morphological structure were prepared,and their effect on contaminates degradation in electro-Fenton(E-Fenton)system was investigated.It is found that the morphology of CeO_(2)has great influence on promoting the performance of E-Fenton process.The rod-like CeO_(2)(R-CeO_(2))induced EFenton system shows higher azo dye X3 B removal and mineralization rates than cubs(C-CeO_(2))and octahedrons(O-CeO_(2)),and the degradation kinetic rate constants are 0.28,0.169 and 0.181 min^(-1)respectively,already surpass that of the blank one(0.120 min^(-1)).The H_(2)O_(2)generation capacity of R-CeO_(2)induced E-Fenton system is also superior to the others,and the corresponding Faraday current efficiency even increases to 166.2%at 2.5 min.Characterizations by scanning-transmission electron microscopy(STEM),X-ray diffraction(XRD),X-ray photoelectron spectroscopy(XPS),electron spin resonance(ESR),Raman spectroscopy were conducted to disclose the mystery behind this phenomenon.The results indicate that the difference of surface oxygen vacancy density in different shaped CeO_(2)acts as a magic driving force for the accelerated oxygen reduction,and then leads to the enhanced degradation efficiency of E-Fenton system.This work provides a new insight into the development and application of rare-earth elements based catalyst in E-Fenton technology. | Jingjing Hu Bei Wu Lei Chen Chengcheng Song Huifang Yang Fei Long Jie Sun Ru'an Chi | 2022 | Journal of Rare Earths2022，40，12： | 0 |
| 18 | Asymmetrical introgression patterns between rusty-necklaced partridge (Alectoris magna) and chukar partridge (Alectoris chukar) in China显示文摘The rusty-necklaced partridge(Alectoris magna)and the chukar partridge(Alectoris chukar)are the most common gamebirds in northern China.Previous comparisons of mitochondrial DNA(mtDNA)have revealed an introgression phenomenon between 2 species of partridge in the Liupan Mountain region of China.mtDNA is maternally inherited,making it difficult to determine the origin of parental genes.We assessed the genetic variation and gene flow between these 2 species of partridges using 8 microsatellite loci as neutral diagnostic markers in 171 samples from the hybrid zone.Our data revealed an extensive divergence of genetic structure between populations of rusty-necklaced partridges and chukar partridges.In this study,we found that 19 samples had been previously morphologically identified as rusty-necklaced partridge were genetically identified as hybrids through Bayesian analysis using STRUCTURE analysis.These hybrids exhibited a mosaic of alleles that were derived from both parental lineages.However,chukar partridges did not present the genotype of the rusty-necklaced partridge.Thus,our findings demonstrate that the hybridization between the 2 species was the result of asymmetrical introgression,with gene flow occurring only from the chukar partridge to the rusty-necklaced partridge.In addition,we also note the high linkage disequilibrium in populations of the rusty-necklaced partridge.These results indicate that although unidirectional introgression did not reduce genetic diversity of the Alectoris partridges,it affected the balance of gene flow between populations.The data from microsatellite DNA prompted our concern about the genetic integrity of the rusty-necklaced partridge. | Yanke CHEN Bei AN Naifa LIU | 2016 | Integrative Zoology2016，11，5： | 0 |
| 19 | Incubation strategies of the Black-necked Crane(Grus nigricollis) in relation to ambient temperature and time of day显示文摘Background: The behavior of cranes reflects many of their survival strategies, but little has been known of the incubation strategies of cranes, in which both parents share incubation duties, in response to cold temperatures in alpine environments. The lack of information may restrict the effective conservation of the threatened Black-necked Crane(Grus nigricollis), a biparental bird nesting in high elevation wetlands.Methods: We directly observed and used infrared video cameras from 2014 to 2015 to study the incubation behavior and quantitatively measured the frequency and details of egg turning behavior in the Black-necked Crane at the Yanchiwan National Nature Reserve in western Gansu Province, China.Results: At lower ambient temperatures in the morning, crane parents spent more time on the nest with less recess frequency and prolonged on-bout duration, while at higher temperatures around noon, the parents had more frequent recesses from incubation and shorter periods between nest exchanges. They adjusted the amount of time incubating by varying the recess frequency and the length of on-bout duration. Mean nest attendance and egg turning frequency of females were significantly higher than those of the males. The nest attendance and on-bout duration of females showed a significantly negative relationship with those of males. The two parents responded differently to the change of temperature. Females spent more time on the nest at lower morning temperatures, while males increased their time on the nest at higher temperatures after noon. Higher incubation recess frequency and egg turning frequency were observed at noon, probably because parents spent more time foraging, taking advantage of the lower egg cooling rate.Conclusion: Both Black-necked Crane parents in the alpine environment adjusted their behavior in response to the thermal requirements of eggs and the weather conditions experienced. Our findings demonstrate that parents of this species incubated in different but complementary ways and efficiently enhanced egg care in a dynamic environment, so as to maximize benefits from the warm portion of the day and the intense solar radiation while minimizing the cost of rewarming eggs and the risks of cooling eggs. | Lixun Zhang Bei An Meilin Shu Changming Zhao Xiaojun Yang Yila Suo Yongjun Se Xilite Dabu | 2017 | Avian Research2017，8，3： | 0 |
| 20 | Ground infrastructure monitoring in coastal areas usingtime-series inSAR technology:the case study of Pudong International Airport,Shanghai显示文摘Shanghai Pudong International Airport(PDIA),with its east side built along the coast with weak geological conditions,is prone to uneven foundation settlement due to the consolidation and compression of soil and erosion of coastal tides,affecting the safe operation of the airport.Therefore,it is crucial to conduct dynamic subsidence monitoring within the airport,especially in the runway area.29 scenes of ascending track Sentinel-1A radar images from August 2016 to June 2018 are selected to perform surface deformation inversion based on PS-InSAR and improved SBAS-InSAR for PDIA and its around coastal area.Through cross-validation,the reliability of the time-series InSAR technique for dynamic monitoring of surface deformation of coastal zone infrastructures is confirmed.The results show severely uneven settlement.By combining the monitoring results with the local geological and hydrological dataset,the driving factors of differential deformation of the infrastructures are analyzed,including stratigraphic geological conditions,ground loadings,foundation treatment methods,water erosion,and groundwater level changes.Finally,the time-series deformation characteristics and the causes of PDIA’s runway are emphasized based on the PS deformation results.This case provides a reference for the safety management of critical infrastructure in coastal areas using advanced InSAR technique. | Bei An Yanan Jiang Changcheng Wang Peng Shen Tianyi Song Chihao Hu Kui Liu | 2023 | International Journal of Digital Earth2023，16，1： | 0 |
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