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| 1 | A Randomized, Prospective, Double-Blind, Placebo-Controlled Trial of Terlipressin for Type 1 Hepatorenal Syndrome显示文摘 | Arun J. Sanyal Thomas Boyer Guadalupe Garcia–Tsao Frederick Regenstein Lorenzo Rossaro Beate Appenrodt Andres Blei Veit Gülberg Samuel Sigal Peter Teuber | 2008 | Gastroenterology2008，，5： | 3 |
| 2 | Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome:A multicenter retrospective study显示文摘BACKGROUND Single-nucleotide polymorphisms(SNPs)of the serotonin type 3 receptor subunit(HTR3)genes have been associated with psychosomatic symptoms,but it is not clear whether these associations exist in irritable bowel syndrome(IBS).AIM To assess the association of HTR3 polymorphisms with depressive,anxiety,and somatization symptoms in individuals with IBS.METHODS In this retrospective study,623 participants with IBS were recruited from five specialty centers in Germany,Sweden,the United States,the United Kingdom,and Ireland.Depressive,anxiety,and somatization symptoms and sociodemographic characteristics were collected.Four functional SNPs—HTR3A c.-42C>T,HTR3B c.386A>C,HTR3C c.489C>A,and HTR3E c.*76G>A—were genotyped and analyzed using the dominant and recessive models.We also performed separate analyses for sex and IBS subtypes.SNP scores were calculated as the number of minor alleles of the SNPs above.The impact of HTR3C c.489C>A was tested by radioligand-binding and calcium influx assays.RESULTS Depressive and anxiety symptoms significantly worsened with increasing numbers of minor HTR3C c.489C>A alleles in the dominant model(F_(depressive)=7.475,P_(depressive)=0.006;F_(anxiety)=6.535,P_(anxiety)=0.011).A higher SNP score(range 0-6)was linked to a worsened depressive symptoms score(F=7.710,P-linear trend=0.006)in IBS.The potential relevance of the HTR3C SNP was corroborated,showing changes in the expression level of 5-HT3AC variant receptors.CONCLUSION We have provided the first evidence that HTR3C c.489C>A is involved in depressive and anxiety symptoms in individuals with IBS.The SNP score indicated that an increasing number of minor alleles is linked to the worsening of depressive symptoms in IBS. | Sabrina Berens Yuanjun Dong Nikola Fritz Jutta Walstab Mauro D'Amato Tenghao Zheng Verena Wahl Felix Boekstegers Justo Lorenzo Bermejo Cristina Martinez Stefanie Schmitteckert Egbert Clevers Felicitas Engel Annika Gauss Wolfgang Herzog Robin Spiller Miriam Goebel-Stengel Hubert Mönnikes Viola Andresen Frieling Thomas Jutta Keller Christian Pehl Christoph Stein-Thöringer Gerard Clarke Timothy G Dinan Eamonn M Quigley Gregory Sayuk Magnus Simrén Jonas Tesarz Gudrun Rappold Lukas van Oudenhove Rainer Schaefert Beate Niesler | 2022 | World Journal of Gastroenterology2022，28，21： | 2 |
| 3 | A Randomized, Prospective, Double-Blind, Placebo-Controlled Trial of Terlipressin for Type 1 Hepatorenal Syndrome显示文摘 | Arun J. Sanyal Thomas Boyer Guadalupe Garcia–Tsao Frederick Regenstein Lorenzo Rossaro Beate Appenrodt Andres Blei Veit Gülberg Samuel Sigal Peter Teuber | 2008 | Gastroenterology2008，，5： | 2 |
| 4 | Prograte turbulence following s in patient s with idiopathic dilated cardiomyopathy显示文摘 | GRIMM W SCHMIDT G nostic significance of heart vent rieular premature beat MAISCH B | 2003 | J Cardiovasc Electrophysiol2003，14，： | 1 |
| 5 | Ceftiofur Sodium Monoclonal antibody development and cross - reactivity studies with structurally related cephalosporins显示文摘 | Beate G R Sandra A B Carol K H | 1996 | J Agric Food Chem1996，44，： | 1 |
| 6 | Choroidal metastases and choroidal melanomas:comparison of ultrasonographic findings显示文摘 | Beate Sobottka Torsten Schlote Hans G Krumpaszky | 1998 | Br J Ophthalmol1998，82，： | 1 |
| 7 | Prediction of maize single- cross hybrid performance:support vector machine regression versus best linear prediction 显示文摘 | Machout S De Beats B Haesaert G | 2010 | Theor Appl Genet2010，120，2： | 1 |
| 8 | Measuring gene expression by quantitative proteome analysis显示文摘 | Steven P G Beate Rist Ruedi Aebersold | | 0，，： | 1 |
| 9 | Detection and differentiation of virulent and avirulent strains of Newcastle disease virus by real-time PCR显示文摘 | Nidzworski D Lukasz R Beats G | | 0，，： | 1 |
| 10 | Ceftiofur sodium mono-clonal antibody development and cross reactivity studies withstructurally related cephalosporins显示文摘 | Beate G R Sandra A B Carol K H | 1996 | J Agric Food Chem1996，44，： | 1 |
| 11 | Effect of HLA in- compatibility on graft - versus - host disease, relapse, and surviv- al after marrow transplantation for patients with leukemia or lym- phoma显示文摘 | ANASETTI C BEAT'I'Y P G STORB R | 1990 | HumImmunol1990，29，2： | 1 |
| 12 | Correlation between Point Mutations in NS2 and the Viabilityand Cytopathogenicity of Bovine Viral Diarrhea Virus Strain Oregon Analyzed with an Infectious cDNA Clone显示文摘 | Beate M Kummerer Meyers G | 2000 | Virol2000，74，： | 1 |
| 13 | On the microporous mature of mesoporous molecular sieves 显示文摘 | GOLTNER G Christine SMARSLY Berned BERTON beate | 2001 | Chemistry of Materials2001，，13： | 1 |
| 14 | Correlation between Point Mutations in NS2 and the Viability and Cytopathogenicity of Bovine Viral Diarrhea Virus Strain Oregon Analyzed with an Infectious cDNA Clone 显示文摘 | Beate M Kummerer B Meyers G | 2000 | Journal of Virology2000，74，： | 1 |
| 15 | Accelerated wa- ter quality improvement during oligotrophication in peria/pine lakes 显示文摘 | Beat Moiler Ren6 G~iehter Alfred Wriest | 2014 | Environmental Science & Technology2014，，48： | 1 |
| 16 | Purification and analysis of synthetic, triple-helical' minicollagens' by revervsed phase high performance liquid chromatography显示文摘 | Fields Cynthia G Grab Beate Lauer Janelle L | 1995 | Analytic Biochemistry1995，231，1： | 1 |
| 17 | Correlation between Point Mutations in NS2 and the Viabilityand Cytopathogenicity of Bovine Viral Diarrhea Virus Strain Oregon Analyzed with an Infectious cDNA Clone显示文摘 | Beate M Kummerer Myers G | 2000 | Virol2000，74，： | 1 |
| 18 | HLA ‐typing, clinical, and immunological characterization of youth with type 2 diabetes mellitus phenotype from the German/Austrian DPV database显示文摘 | Wendy L Awa Bernard O Boehm Silke Rosinger Peter Achenbach Anette G Ziegler Stephanie Krause Thomas Meissner Susanne Wiegand Thomas Reinehr Thomas Kapellen Beate Karges Thomas Eiermann Edith Schober Reinhard W Holl | 2013 | Pediatr Diabetes2013，，8： | 1 |
| 19 | Platelet activating factor antagonism reduces the systemic inflammatory response in a murine model of acute pancreatitis显示文摘 | John C Karen ET Beat G | 2001 | J Surg Res2001，99，： | 1 |
| 20 | Insiturheological investigation of the coagulation aqueous alumina suspensions 显示文摘 | Beate B Martink M H Ludwig J G | 2001 | Am Ceram Sac2001，84，8： | 1 |
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