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| 1 | Proposal of an ultrasonographic classification for hepatic alveolar echinococcosis: Echinococcosis multilocularis Ulm classification-ultrasound显示文摘AIM: To establish an ultrasonographic classification based on a large sample of patients with confirmed hepatic alveolar echinococcosis(AE).METHODS: Clinical data and ultrasonography(US) findings of 185 patients(100 males; 85 females; mean age at diagnosis: 51.4 ± 17.6 years; mean age at time of US examination: 58.7 ± 18.2 years) were retrospectively reviewed with respect to the US morphology of hepatic AE lesions. The sonomorphological findings were grouped according to a five-part classification scheme.RESULTS: Application of the new classification resulted in the following distribution of sonomorphological patterns among the patients examined: hailstorm(54.1%); pseudocystic(13.5%); ossification(13.0%); hemangioma-like(8.1%); and metastasis-like(6.5%). Only 4.9% of lesions could not be assigned to a sonomorphological pattern.CONCLUSION: The sonomorphological classification proposed in the present study facilitates the diagnosis,interpretation and comparison of hepatic alveolar echinococcosis in routine practice and in the context of scientific studies. | Wolfgang Kratzer Beate Gruener Tanja EM Kaltenbach Sarina Ansari-Bitzenberger Peter Kern Michael Fuchs Richard A Mason Thomas FE Barth Mark M Haenle Andreas Hillenbrand Suemeyra Oeztuerk Tilmann Graeter | 2015 | World Journal of Gastroenterology2015，21，43： | 16 |
| 2 | Radiofrequency ablation of liver tumors: Actual limitations and potential solutions in the future显示文摘Over the past decade,radiofrequency ablation(RFA) has evolved into an important therapeutical tool for the treatment of non resectable primary and secondary liver tumors.The clinical benefit of RFA is represented in several clinical studies.They underline the safety and feasibility of this new and modern concept in treating liver tumors.RFA has proven its clinical impact not only in hepatocellular carcinoma(HCC) but also in metastatic disease such as colorectal cancer(CRC).Due to the increasing number of HCC and CRC,RFA might play an even more important role in the future.Therefore,the refinement of RFA technology is as important as the evaluation of data of prospective randomized trials that will help define guidelines for good clinical practice in RFA application in the future.The combination of hepatic resection and RFA extends the feasibility of open surgical procedures in patients with extensive tumors.Adverse effects of RFA such as biliary tract damage,liver failure and local recurrence remain an important task today but overall the long term results of RFA application in treating liver tumors are promising.Incomplete ablation of liver tumors due to insufficient technology of ablation needles,tissue cooling by the neighbouring blood vessels,large tumor masses and ablation of tumors in close vicinity to heat sensitive organs remain difficult tasks for RFA.Future solutions to overcome these limitations of RFA will include refinement of ultrasonographic guidance(accuracy of probe placement),improvements in needle technology(e.g.needles preventing charring)and intraductal cooling techniques. | Beat M Künzli Paolo Abitabile Christoph A Maurer | 2011 | World Journal of Hepatology2011，3，1： | 15 |
| 3 | Influence of antibiotic-regimens on intensive-care unit-mortality and liver-cirrhosis as risk factor显示文摘AIM: To assess the rate of infection, appropriateness of antimicrobial-therapy and mortality on intensive care unit(ICU). Special focus was drawn on patients with liver cirrhosis.METHODS: The study was approved by the local ethical committee. All patients admitted to the Internal Medicine-ICU between April 1, 2007 and December 31, 2009 were included. Data were extracted retrospectively from all patients using patient charts and electronic documentations on infection, microbiological laboratory reports, diagnosis and therapy. Due to the large hepatology department and liver transplantation center, special interest was on the subgroup of patients with liver cirrhosis. The primary statistical-endpoint was the evaluation of the influence of appropriate versusinappropriate antimicrobial-therapy on in-hospitalmortality.RESULTS: Charts of 1979 patients were available. The overall infection-rate was 53%. Multiresistantbacteria were present in 23% of patients with infection and were associated with increased mortality(p < 0.000001). patients with infection had significantly increased in-hospital-mortality(34% vs 17%, p < 0.000001). Only 9% of patients with infection received inappropriate initial antimicrobial-therapy, no influence on mortality was observed. Independent risk-factors for in-hospital-mortality were the presence of septicshock, prior chemotherapy for malignoma and infection with pseudomonas spp. Infection and mortality-rate among 175 patients with liver-cirrhosis was significantly higher than in patients without liver-cirrhosis. Infection increased mortality 2.24-fold in patients with cirrhosis. patients with liver cirrhosis were at an increased risk to receive inappropriate initial antimicrobial therapy.CONCLUSION: The results of the present study report the successful implementation of early-goal-directed therapy. Liver cirrhosis patients are at increased risk of infection, mortality and to receive inappropriate therapy. Increasing burden are multiresistant-bacteria. | Mireen Friedrich-Rust Beate Wanger Florian Heupel Natalie Filmann Reinhard Brodt Volkhard AJ Kempf Johanna Kessel Thomas A Wichelhaus Eva Herrmann Stefan Zeuzem Joerg Bojunga | 2016 | World Journal of Gastroenterology2016，22，16： | 6 |
| 4 | Liver resections can be performed safely without Pringle maneuver: A prospective study显示文摘AIM To evaluate liver resections without Pringle maneuver, i.e., clamping of the portal triad. METHODS Between 9/2002 and 7/2013, 175 consecutive liver resections(n = 101 major anatomical and n = 74 large atypical > 5 cm) without Pringle maneuver were performed in 127 patients(143 surgeries). Accompanying, 37 wedge resections(specimens < 5 cm) and 43 radiofrequency ablations were performed. Preoperative volumetric calculation of the liver remnant preceeded all anatomical resections. The liver parenchyma was dissected by waterjet. The median central venous pressure was 4 mmH g(range: 5-14). Data was collected prospectively. RESULTS The median age of patients was 60 years(range: 16-85). Preoperative chemotherapy was used in 70 cases(49.0%). Liver cirrhosis was present in 6.3%, and liver steatosis of ≥ 10% in 28.0%. Blood loss was median 400 mL(range 50-5000 mL). Perioperative blood transfusions were given in 22/143 procedures(15%). The median weight of anatomically resected liver specimens was 525 g(range: 51-1850 g). One patient died postoperatively. Biliary leakages(n = 5) were treated conservatively. Temporary liver failure occurred in two patients.CONCLUSION Major liver resections without Pringle maneuver are feasible and safe. The avoidance of liver inflow clamping might reduce liver damage and failure, and shorten the hospital stay. | Christoph A Maurer Mikolaj Walensi Samuel A Kaser Beat M Künzli Rene Lotscher Anne Zuse | 2016 | World Journal of Hepatology2016，8，24： | 6 |
| 5 | Do you want to participate in a clinical study as a healthy control?-Risk or benefit?显示文摘A healthy woman volunteered to participate as 'healthy control' in a study.An increased level of procalcitonin(PCT) was detected and remained elevated on follow-up measurements.As calcitonin levels were elevated as well,thyroid ultrasound was performed which revealed nodes in both thyroid lobes,one of them showing metabolic activity in positron emission tomography-computed tomography scan.To exclude a malignant thyroid cancer despite the negative findings in a fine needle aspiration the patient underwent thyroidectomy and a medullary thyroid carcinoma(MTC) was detected in the right lobe.MTC is a rare endocrine tumor with a poor prognosis once having spread,therefore early detection remains a priority for the outcome.Screening parameter is serum calcitonin,in absence of infection the pro-hormone PCT can be used as a screening parameter as well with high sensitivity. | Hanna Giessen Christian A Nebiker Matthias Bruehlmeier Stefan Spreitzer Beat Mueller Philipp Schuetz | 2017 | World Journal of Clinical Cases2017，5，12： | 2 |
| 6 | The role of mitochondrial transition pore, and its modulation, in traumatic brain injury and delayed neurodegeneration after TBI显示文摘 | Mazzeo AT Beat A Singh A | 2009 | Exp Neurol2009，218，2： | 1 |
| 7 | Ceftiofur Sodium Monoclonal antibody development and cross - reactivity studies with structurally related cephalosporins显示文摘 | Beate G R Sandra A B Carol K H | 1996 | J Agric Food Chem1996，44，： | 1 |
| 8 | 显示文摘 | Graber Christoph Beat The New UNESCO Convention onCultural Diversity: A Counterbalance to the WTO | 2006 | Journal of International Economic Law2006，9，3： | 1 |
| 9 | Noninvasive haemodynamic monitoring by transthoracicimpedance cardiography during different ventricular activation sequences in CRT patients显示文摘 | David A Beat S Robert B | 2010 | Cardiovascul Med2010，13，6： | 1 |
| 10 | Switching the photo induced energy and electron-transfer processes in BODIPY - phthalocyanine conjugates显示文摘 | Liu Jianyong Eugeny A E Beate R | 2009 | Chem Commun2009，，12： | 1 |
| 11 | The cell envelope-bound metalloprotease (camelysin) from Bacillus cereus is a possible pathogenic factor Biochimica et Biophysica Acta显示文摘 | Beate Fricke Katharina DrMler Ingo Willhardt a | 2001 | 1537:132-1462001，1537，： | 1 |
| 12 | The role of mitochondrial transition pore, and its modulation, in traumatic brain injury and delayed neurodegeneration after TBI显示文摘 | Mazzeo AT Beat A Singh A | 2009 | Exp Neurol2009，218，2： | 1 |
| 13 | Ceftiofur sodium mono-clonal antibody development and cross reactivity studies withstructurally related cephalosporins显示文摘 | Beate G R Sandra A B Carol K H | 1996 | J Agric Food Chem1996，44，： | 1 |
| 14 | The minipig ' dermatotoxicology: Methods and challenges 显示文摘 | Jorg A M Beate E Vogel | 2006 | Exp Toxicol Patho12006，57，： | 1 |
| 15 | Quantitative analysis of complex protein mixtures using isotope-coded affinity tags 显示文摘 | Gygi Steven P Rist Beate Gerber Scott A | 1999 | Nature Biotechnology1999，17，10： | 1 |
| 16 | The effects of disseminated meth- ane hydrate on the dynamic stiffness and damping of a sand 显示文摘 | Clayton C Priest J Beat A | 2005 | Geotechnique2005，55，6： | 1 |
| 17 | The role of mitochondrial transition pore, and its modulation,in traumatic brain injury and delayed neuro- degeneration after TBI显示文摘 | Mazzeo AT Beat A Singh A | 2009 | Exp Neurol2009，218，2： | 1 |
| 18 | Genome-Wide Association Study Identifies Variants Associated With Progression of Liver Fibrosis From HCV Infection显示文摘 | Etienne Patin Zoltán Kutalik Julien Guergnon Stéphanie Bibert Bertrand Nalpas Emmanuelle Jouanguy Mona Munteanu Laurence Bousquet Laurent Argiro Philippe Halfon Anne Boland Beat Müllhaupt David Semela Jean–Fran?ois Dufour Markus H. Heim Darius Moradpour A | 2012 | Gastroenterology2012，，5： | 1 |
| 19 | A pill in the sandwich:Covert medication in food and drink显示文摘 | Treloar A Beats B Philpot M | 2000 | Journal o1 the Royal Society of Medicine2000，93，： | 1 |
| 20 | Experi- mental verification of the fracture density and shear-wave splitting relationship using synthetic silica cemented sand- stones with a controlled fracture geometry 显示文摘 | TILLOTSON P SOTHCOT1 J BEAT A I | 2012 | Geophysical prospecting2012，60，3： | 1 |
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