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| 1 | Quality of life:A critical outcome for all surgical treatmentsof gastric cancer显示文摘Surgery represents the main curative therapeutic modality for gastric cancer, and it is occasionally considered for palliation as well as prophylaxis. Most frequently, surgical outcomes are conveyed in terms of oncological outcomes such as recurrence and survival.However, quality of life(Qo L) is also important and should be considered when making treatment decisions- including the extent of and approach to surgery. Measurement of Qo L usually involves the application of questionnaires. While there are multiple Qo L questionnaires validated for use in oncology patients, there are very few that have been validated for use in those with gastric cancer. In this review, we discuss and compare the current status of Qo L questionnaires in gastric cancer. More importantly, the impact of surgery for treatment, palliation and prophylaxis of gastric cancer on Qo L will be described. These data should inform the surgeon on the optimal approach to treating gastric cancer, taking into account oncological outcomes. Knowledge gaps are also identified, providing a roadmap for future studies. | Michael D McCall Peter J Graham Oliver F Bathe | 2016 | World Journal of Gastroenterology2016，22，3： | 7 |
| 2 | Increased catabolism and decreased unsaturation of ganglioside in patients with inflammatory bowel disease显示文摘AIM: To investigate whether accelerated catabolism of ganglioside and decreased ganglioside content contribute to the etiology of pro-inflammatory intestinal disease. METHODS: Intestinal mucosa from terminal ileum or colon was obtained from patients with ulcerative colitis or inflammatory Crohn's disease(n = 11) undergoing bowel resection and compared to control samples of normal intestine from patients with benign colon polyps(n = 6) and colorectal cancer(n = 12) in this observational case-control study. Gangliosides and phospholipids of intestinal mucosa were characterized by class and ceramide or fatty acid composition using liquid chromatography triple-quad mass spectrometry. Content and composition of ganglioside classes GM1, GM3, GD3, GD1 a, GT1 and GT3 were compared among subject groups. Content and composition of phospholipid classes phosphatidylcholine(PC) and phosphatidylethanolamine were compared among subject groups. Unsaturation index of individual ganglioside and phospholipid classes was computed and compared among subject groups. Ganglioside catabolism enzymes beta-hexosaminidase A(HEXA) and sialidase-3(NEU3) were measured in intestinal mucosa using western blot and compared among subject groups. RESULTS: Relative GM3 ganglioside content was 2-fold higher(P < 0.05) in intestine from patients with inflammatory bowel disease(IBD) compared to control intestine. The quantity of GM3 and ratio of GM3/GD3 was also higher in IBD intestine than control tissue(P < 0.05). Control intestine exhibited 3-fold higher(P < 0.01) relative GD1 a ganglioside content than IBD intestine. GD3 and GD1 a species of ganglioside containing three unsaturated bonds were present in control intestine, but were not detected in IBD intestine. The relative content of PC containing more than two unsaturated bonds was 30% lower in IBD intestine than control intestine(P < 0.05). The relative content of HEXA in IBD intestine was increased 1.7-fold(P < 0.05) and NEU3 was increased 8.3-fold(P < 0.01) compared to normal intestine. Intestinal mucosa in IBD is characterized by increased GM3 content, decreased GD1 a, and a reduction in polyunsaturated fatty acid constituents in GD3, GD1 a and PC.CONCLUSION: This study suggests a new paradigm by proposing that IBD occurs as a consequence of increased metabolism of specific gangliosides. | John J Miklavcic Glen K Shoemaker Vera C Mazurak M Tom Clandinin Tasha DL Hart Kareena L Schnabl Gordon M Lees Bodil MK Larsen Oliver F Bathe Alan BR Thomson M Tom Clandinin | 2015 | World Journal of Gastroenterology2015，21，35： | 3 |
| 3 | Effect of the stage of lactation in humans on carotenoid levels in milk, blood plasma and plasma lipoprotein fractions 显示文摘 | SCHWEIGERT F J BATHE K CHEN F | 2004 | Eur J Nutr2004，43，： | 1 |
| 4 | Influence of platelet size on outcome after myocardial infarction 显示文摘 | MARTIN J F BATH P M BURR M L | 1991 | Lancet1991，338，8780： | 1 |
| 5 | Influence of platelet size on outcome after myocardial infarction 显示文摘 | MARTIN J F BATH P M BURR M L | 1991 | Lanet1991，338，8780： | 1 |
| 6 | Transport of nitrite across fish gills 显示文摘 | Bath R N Eddy F B | 1980 | Journal of Experimental Zoology1980，214，1： | 1 |
| 7 | Floppy eyelid syndrome as an indicator of the presence of glaucoma in patients with obstructive sleep apnea显示文摘 | Muniesa M Sanchez-de-la-Torre M Huerva V Lumbierres M Bathe F | 2014 | Glau- coma2014，23，1： | 1 |
| 8 | Molecular diversity and routes of colonization of Candida albicans in a surgical intensive care unit ,as studied using microsatellite markers 显示文摘 | Stephan F Bath MS Desterke C | 2002 | Clin Infect Dis2002，35，12： | 1 |
| 9 | Effect of dextran on factor Ⅷ/von Willebrand factor structure and function显示文摘 | BatHe J del Rio F Lopez FM | 1985 | Thromb Haemost1985，54，3： | 1 |
| 10 | Extent of resection in the management of duodenal adenocarcinoma 显示文摘 | KAKLAMANOS I G BATHE O F FRANCESCHI D | 2000 | Am J Surg2000，179，1： | 1 |
| 11 | Low molecular weight heparin versus aspirin for acute ischemic stroke:a systematic review显示文摘 | Bath P Leonardi-Bee J Bath F | 2002 | J Stroke Cerebrovasc Diseases2002，11，2： | 1 |
| 12 | Noninvasive ventilatory support does not facilitate recovery from acute respiratory failure in chronic obstructive pulmonary disease 显示文摘 | Bathe F Togores B Rub IM | 1996 | Eur Respir J1996，9，6： | 1 |
| 13 | Splanchnie origin ofcytokines in a porcine model of mesenteric ischemia- reperfusion显示文摘 | Bathe O F Chow A W Phang P T | 1998 | Surgery1998，123，1： | 1 |
| 14 | Recreation Specialization among ATV Users and Its Relationship to Environmental Attitudes and Management Preferences on the Island of Newfoundland 显示文摘 | WAIGHT C F BATH A J | 2014 | Leisure Sciences2014，36，2： | 1 |
| 15 | Phase II study ofneoadjuvant5-FU+leucovorin+CPT--l] in patients withrespecatble liver metastases from colorectai adenocarcinom显示文摘 | Bathe OF Dowden Sutherland F | 2004 | BMc Cancer2004，4，： | 1 |
| 16 | Cases illustrative of the remedial effects of acupuncture显示文摘 | Bathe F | | North Am Med Surg J0，1，： | 1 |
| 17 | A genetic variant BDNF polymorphism alters extinction learning in both mouse and human显示文摘 | Soliman F Glatt CE Bath KG | 2010 | Science2010，327，5967： | 1 |
| 18 | A genetic variant BDNF polymorphism alters extinction learning in both mouse and human 显示文摘 | Soliman F Glatt CE Bath KG | 2010 | Science2010，327，5967： | 1 |
| 19 | A specific form of abomasal phytob-ezoar in goats and sheep显示文摘 | BATH G F BERGH T | | 0，，02： | 1 |
| 20 | Metastasectomy as a cytoreductive strategy for treatment of isolated pulmonary and hepatic metastases from breast cancer显示文摘 | BATHE O F KAKLAMANOS I G MOFFAT F L | | 0，，01： | 1 |
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