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| 1 | Blood pressure management in acute stroke显示文摘Blood pressure(BP)is elevated in 75%or more of patients with acute stroke and is associated with poor outcomes.Whether to modulate BP in acute stroke has long been debated.With the loss of normal cerebral autoregulation,theoretical concerns are twofold:high BP can lead to cerebral oedema,haematoma expansion or haemorrhagic transformation;and low BP can lead to increased cerebral infarction or perihaematomal ischaemia.Published evidence from multiple large,high-quality,randomised trials is increasing our understanding of this challenging area,such that BP lowering is recommended in acute intracerebral haemorrhage and is safe in ischaemic stroke.Here we review the evidence for BP modulation in acute stroke,discuss the issues raised and look to on-going and future research to identify patient subgroups who are most likely to benefit. | Jason P Appleton Nikola Sprigg Philip M Bath | 2016 | Stroke & Vascular Neurology2016，1，2： | 7 |
| 2 | It is safe to use transdermal glyceryl trinitrate to lower blood pressure in patients with acute ischaemic stroke with carotid stenosis显示文摘Background There is concern that blood pressure(BP)lowering in acute stroke may compromise cerebral perfusion and worsen outcome in the presence of carotid stenosis.We assessed the effect of glyceryl trinitrate(GTN)in patients with carotid stenosis using data from the Efficacy of Nitric Oxide in Stroke(ENOS)Trial.Methods ENOS randomised 4011 patients with acute stroke and raised systolic BP(140-220 mm Hg)to transdermal GTN or no GTN within 48 hours of onset.Those on prestroke antihypertensives were also randomised to stop or continue their medication for 7 days.The primary outcome was the modified Rankin Scale(mRS)at day 90.Ipsilateral carotid stenosis was split:<30%;30-<50%;50-<70%;≥70%.Data are ORs with 95%CIs adjusted for baseline prognostic factors.results 2023(60.5%)ischaemic stroke participants had carotid imaging.As compared with<30%,≥70%ipsilateral stenosis was associated with an unfavourable shift in mRS(worse outcome)at 90 days(OR 1.88,95%CI 1.44 to 2.44,p<0.001).Those with≥70%stenosis who received GTN versus no GTN had a favourable shift in mRS(OR 0.56,95%CI 0.34 to 0.93,p=0.024).In those with 50-<70%stenosis,continuing versus stopping prestroke antihypertensives was associated with worse disability,mood,quality of life and cognition at 90 days.Clinical outcomes did not differ across bilateral stenosis groups.Conclusions Following ischaemic stroke,severe ipsilateral carotid stenosis is associated with worse functional outcome at 90 days.GTN appears safe in ipsilateral or bilateral carotid stenosis,and might improve outcome in severe ipsilateral carotid stenosis. | Jason P Appleton Lisa J Woodhouse Andrew Belcher Daniel Bereczki Eivind Berge Valeria Caso Hui Meng Chang Hanne K Christensen Ronan Collins John Gommans Ann C Laska George Ntaios Serefnur Ozturk Gillian M Sare Szabolcs Szatmari Yongjun Wang Joanna M Wardlaw Nikola Sprigg Philip M Bath for the ENOS investigators | 2019 | Stroke & Vascular Neurology2019，4，1： | 6 |
| 3 | PCR-SSCP comparison of 16S rDNA sequence diversity in soil DNA obtained using different isolation and purification methods 显示文摘 | Stach J E M Bathe S Clapp J P | 2001 | FEMS Microbiology Ecology2001，36，： | 2 |
| 4 | Serum S - 100 protein,relationship to clinical outcome in acute stroke显示文摘 | Abraha H D Butterworth R J Bath P M | 1997 | Ann Clin Biochem1997，34，4： | 1 |
| 5 | Interventions for deliberately alteringblood pressure in acute stroke显示文摘 | Geeganage C M Bath P M | 2009 | Stroke2009，40，8： | 1 |
| 6 | Influence of platelet size on outcome after myocardial infarction 显示文摘 | MARTIN J F BATH P M BURR M L | 1991 | Lancet1991，338，8780： | 1 |
| 7 | PCR-SSCP comparison of 16S rDNA sequence diversity in soil DNA obtained using different isolation and purification methods显示文摘 | STACH J E M BATHE S CLAPP J P | 2001 | FEMS Microbiol Ecol2001，36，23： | 1 |
| 8 | PCR-SSCP comparison of 16S rDNA sequence diversity in soil DNA obtained using different isolation and purification methods显示文摘 | Stach J E M Bathe S Clapp J P | 2001 | FEMS Microbiol Ecol2001，36，： | 1 |
| 9 | Influence of platelet size on outcome after myocardial infarction 显示文摘 | MARTIN J F BATH P M BURR M L | 1991 | Lanet1991，338，8780： | 1 |
| 10 | Relationship between therapeu-tic changes in blood pressure and outcomes in acute stroke:ametaregression显示文摘 | Geeganage C M Bath P M | 2009 | Hypertension2009，54，4： | 1 |
| 11 | Serum S-100protein,relationship to clinical outcome in acute stroke显示文摘 | Abraha H D Butterworth R J Bath P M | 1997 | Ann Cli Bioch1997，34，4： | 1 |
| 12 | PCR - SSCP comparison of 16S rDNA sequence diversity in soil DNA obtained using different i- solation and purification methods显示文摘 | Stach J E M Bathe S Clapp J P | 2001 | FEMS Microbiology Ecology2001，36，23： | 1 |
| 13 | Increased mono-eyte tissue factor expression in coronary disease显示文摘 | E W Leatham P M W Bath J A Tooze | 1995 | Br Heart J1995，73，： | 1 |
| 14 | Strain induced crystallization in stereoregular polynetworks显示文摘 | KUO C M BATHES K P MILLER R L | 1997 | Rub Chem and Tech1997，70，5： | 1 |
| 15 | Blood pressure and clinical outcomes in the International Stroke Trial显示文摘 | Leonardi-Bee J Bath P M W Phillips S J | 2002 | Stroke2002，33，5： | 1 |
| 16 | Polycystic kidney disease prevented by transgenic RNA interference显示文摘 | Bouillet P Robati M Bath M | 2005 | Cell Death Differ2005，12，7： | 1 |
| 17 | Prothrombotic megakary- ocyte and platelet changes in hypertension are reversed follow- ing treatment: a pilot study显示文摘 | Pathansali R Smith N M Bath P M | 2011 | Platelets2011，12，3： | 1 |
| 18 | Evaluation of the imaging properties of two generations of a CCD based system for digital chest radiography显示文摘 | Bath M Sund P Mansson L G | 2002 | Med Phys2002，29，： | 1 |
| 19 | Blood pressure and clinical out comesin the international stroketrial 显示文摘 | Leonardi-Bee J Bath P M Phillips S J | 2002 | Stroke2002，，33： | 1 |
| 20 | High blood pressure in acute stroke and subsequent outcome : A systematic review显示文摘 | Willmot M Leonard-Bee J Bath P M | 2004 | Hypertension2004，43，3： | 1 |
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