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| 1 | Relationship between adipose tissue dysfunction, vitamin D deficiency and the pathogenesis of non-alcoholic fatty liver disease显示文摘Non-alcoholic fatty liver disease(NAFLD)is the most common chronic liver disease worldwide.Its pathogenesis is complex and not yet fully understood.Over the years many studies have proposed various pathophysiological hypotheses,among which the currently most widely accepted is the'multiple parallel hits'theory.According to this model,lipid accumulation in the hepatocytes and insulin resistance increase the vulnerability of the liver to many factors that act in a coordinated and cooperative manner to promote hepatic injury,inflammation and fibrosis.Among these factors,adipose tissue dysfunction and subsequent chronic low grade inflammation play a crucial role.Recent studies have shown that vitamin D exerts an immune-regulating action on adipose tissue,and the growing wealth of epidemiological data is demonstrating that hypovitaminosis D is associated with both obesity and NAFLD.Furthermore,given the strong association between these conditions,current findings suggest that vitamin D may be involved in the relationship between adipose tissue dysfunction and NAFLD.The purpose of this review is to provide an overview of recent advances in the pathogenesis of NAFLD in relation to adipose tissue dysfunction,and in the pathophysiology linking vitamin D deficiency with NAFLD and adiposity,together with an overview of the evidence available on the clinical utility of vitamin D supplementation in cases of NAFLD. | Flavia A Cimini Ilaria Barchetta Simone Carotti Laura Bertoccini Marco G Baroni Umberto Vespasiani-Gentilucci Maria-Gisella Cavallo Sergio Morini | 2017 | World Journal of Gastroenterology2017，23，19： | 9 |
| 2 | Overview of studies of the vitamin D/vitamin D receptor system in the development of non-alcoholic fatty liver disease显示文摘Non-alcoholic fatty liver disease(NAFLD)is the most common chronic liver disease in the world.NAFLD is known to be associated with obesity,type 2 diabetes,metabolic syndrome and increased cardiovascular events:for these reasons,it is becoming a global public health problem and represents an important challenge in terms of prevention and treatment.The mechanisms behind the pathogenesis of NAFLD are multiple and have not yet been completely unraveled;consequently,at moment there are not effective treatments.In the past few years a large body of evidence has been assembled that attributes an important role in hepatic aberrant fat accumulation,inflammation and fibrosis,to the vitamin D/vitamin D receptor(VD/VDR)axis,showing a strong association between hypovitaminosis D and the diagnosis of NAFLD.However,the data currently available,including clinical trials with VD supplementation,still provides a contrasting picture.The purpose of this editorial is to provide an overview of recent advances in the pathogenesis of NAFLD in relation to VD/VDR.Based on recent data from literature,we focused in particular on the hypothesis that VDR itself,independently from its traditional ligand VD,may have a crucial function in promoting hepatic fat accumulation.This might also offer new possibilities for future innovative therapeutic approaches in the management of NAFLD. | Flavia Agata Cimini Ilaria Barchetta Simone Carotti Sergio Morini Maria Gisella Cavallo | 2019 | World Journal of Gastrointestinal Pathophysiology2019，10，2： | 4 |
| 3 | Noninvasive evaluation of flow reserve in the left anterior descending coronaey artery in pa- tients with cardiac syndrome X显示文摘 | Galuto L Sestito A Barchetta S | 2007 | Am J cardiol2007，99，10： | 1 |
| 4 | Noninvasive evaluation flow reserve in the left anterior descending coronary artery in pa- tients with cardiac syndrome X显示文摘 | Galiuto L Sestito A Barchetta S | 2007 | Am J Cardiol2007，99，10： | 1 |
| 5 | TSH levels are associated with vitamin D status and seasonality in an adult population of euthyroid adults显示文摘 | Barchetta I Baroni MG Leonetti F | 2015 | Clin Exp Med2015，15，3： | 1 |
| 6 | Noninvasive evaluation of flow reserve inthe left anterior descending coronary artery in patients with cardiac syndrome X显示文摘 | Galuto L Sestito A Barchetta S | 2007 | Am J Cardiol2007，99，10： | 1 |
| 7 | Altered glucose homeostasis is associated with increased serum Apelin levels in type 2 diabetes mellitus显示文摘 | Cavallo M G Sentinelli F Barchetta I | 2012 | PLoS One2012，7，12： | 1 |
| 8 | Noninvasive evaluation of flow reserve in the left anterior descending coronary artery in patients with cardiac syndrome X显示文摘 | Galiuto L Sestito A Barchetta S | 2007 | Am J Cardiol2007，99，10： | 1 |
| 9 | Altered glucose homeostasis is associated with increased serum apelin levels in type 2 diabetes mellitus显示文摘 | Cavallo MG Sentinelli F Barchetta I | 2012 | PLoS One2012，7，51： | 1 |
| 10 | Increased circulating osteopontin levels in adult patients with type 1 diabetes mellitus and association with dysmetabolic profile 显示文摘 | Barchetta I Alessandri C Bertoccini L | 2016 | European Journal of En- docrinology2016，174，2： | 1 |
| 11 | Noninvasive evaluation of flow reserve in the left anterior descending coronary artery in patients with cardiac syndrome X 显示文摘 | Galuto L Sestito A Barchetta S | 2007 | Am J Cardiol2007，99，10： | 1 |
| 12 | Strong association between non alcoholic fatty liver disease (NAFLD) and low 25 (OH) vi- tanain D levels in an adult population with normal serum liver en- zymes 显示文摘 | Barchetta I Angelico F Ben M | 2011 | BMC Med2011，9，： | 1 |
| 13 | Characterization of microvascular and myocardial damage within perfusion defect area at myocardial contrast echocardiography in the subacute phase of myocardial infarction显示文摘 | Leonarda Galiuto Gabriella Locorotondo Lazzaro Paraggio Alberto R. De Caterina Antonio M. Leone Elisa Fedele Sabrina Barchetta Italo Porto Luigi Natale Antonio G. Rebuzzi Lorenzo Bonomo Filippo Crea | 2012 | European Journal of Echocardiography2012，，2： | 1 |
| 14 | Altered glucose homeostasisis associated with increased serum apelin levels in type 2 diabetesmellitus显示文摘 | Cavallo MG Sentinelli F’Barchetta l | 2012 | PLoS 0ne2012，7，51： | 1 |
| 15 | Noninvasive evaluation of flow reserve in the left anterior descending coronary artery in pa- tients with cardiac syndrome X显示文摘 | Galiuto L Sastito A Barchetta S | 2007 | Am J Cardiol2007，99，： | 1 |
| 16 | Strong association between non alcoholic fatty liver disease (NAFLD) and low 25(OH) vitamin D levels in an adult population with normal serum liver enzymes显示文摘 | Barchetta I Angelico F Del Ben M | 2011 | BMC Med2011，9，： | 1 |
| 17 | Liver vitamin D receptor, CYP2R1, and CYP27A1 expression: relationship with liver histology and vitamin D3 levels in patients with nonalcoholic steatohepatitis or hepatitis C virus 显示文摘 | Barchetta I Carotti S Labbadia G | 2012 | Hepatology2012，56，6： | 1 |
| 18 | Subclinical vascular alterations in young adults with type 1 diabetes detected by arterial tonometry显示文摘 | Barchetta I Sperduti L Germanò G | | 0，，： | 1 |
| 19 | Strong association between non alcoholic fatty liver disease (NAFLD) and low 25 (OH) vitamin D levels in an adult population with normal serum liver enzymes 显示文摘 | Barchetta I Angelico F Del Ben M | 2011 | BMC Med2011，9，： | 1 |
| 20 | Noninvasive evaluation of flow reserve in the left anterior descending coronary artery in patients with cardiac syndromeX显示文摘 | Galiuto L Sestito A Barchetta S | 2007 | Am J Cardiol2007，99，： | 1 |
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