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| 1 | 联合分析血小板特异性抗体和瞬逝生物传感器技术检测血小板抗体的方法比较显示文摘目的应用联合分析血小板特异性抗体(specificpplateletantibodies,SASPA)和瞬逝生物传感器技术(evanescentbiosensortechnology,EVA)分别检测血小板特异性同种抗体和自身抗体,对两者进行方法学比较。方法收集94例存在HPA-1a、HPA-Sb、HLA-I和自身抗体的患者血浆标本,制备血小板膜糖蛋白-血小板特异性抗体复合物,分别用SASPA和EVA方法对复合物进行检测,对SASPA检测所得平均荧光强度值(MFI)和EVA检测所得斜率值(Slope)作统计学分析和比较。结果SASPA方法对HPA-1a、HPA-Sb、HLA-I和自身抗体检测的敏感度分别为74.1%、86.9%、86.9%和40.9%,EVA方法的敏感度分别为88.9%、78.3%、60.9%和72.7%。人类血小板抗原(HPA)-1a抗体检测中,MFI与Slope表现为强相关性,相关性系数为r=0.95(P〈0.05)。结论SASPA和EVA技术对传统的单克隆抗体特异性血小板抗原固定实验(MAIPA)作了继承和改良,SASPA方法可以用极少量的血小板同时检测多种血小板特异性抗体,提高了检测效率;EVA方法将血小板裂解后的实验时间缩短为10min,极大地简化了操作过程,减少了检测时间。SASPA和EVA检测方法的建立对临床血小板免疫相关疾病的诊断和血小板输血领域的发展具有深远意义。 | 宋文倩 Torsten J Schulze Margit Baade Harald Kluter Peter Bugert | 2017 | 国际免疫学杂志2017，40，1： | 3 |
| 2 | The peroxisome proliferator-activated receptor-α (PPAR-α) agonist, AVE8134, attenuates the progression of heart failure and increases survival in rats显示文摘 | Wolfgang LINZ Paulus WOHLFART Manuel BAADE Kristin BREITSCHOPF EugenFALK Hans-Ludwig SCHAFER Martin GERL Werner KRAMER Hartmut RUTTEN | 2009 | Acta Pharmacologica Sinica2009，30，7： | 3 |
| 3 | Telephone ad- ministration of the SF-36 health survey:validatibn studies and population norms for adults in Queensland显示文摘 | Watson EK Firman DW Baade PD | 1996 | Aust N Z J Public Health1996，20，4： | 1 |
| 4 | Cancer statistics in China, 2015显示文摘 | Chen W Zheng R Baade PD | 2016 | CA Cancer J Clin2016，66，2： | 1 |
| 5 | Cancer statistics in China,2015显示文摘 | Chen W Zheng R Baade PD | 2016 | CA Cancer J Clin2016，66，2： | 1 |
| 6 | Dynamic contact mechan- ics of radial tears of the lateral meniscus:implications for treatment 显示文摘 | Bedi A Kelly N Baad M | 2012 | Arthroscopy2012，28，3： | 1 |
| 7 | Cancer statistics in China, 2015 显示文摘 | CHEN W ZHENG R BAADE P D | 2016 | CA Cancer J Clin2016，66，2： | 1 |
| 8 | Cancer statistics in China, 2015显示文摘 | Chen W Zheng R Baade PD | 2016 | CA Cancer J Clin2016，66，2： | 1 |
| 9 | Trends in incidence of childhood cancer in Australia, 1983 -2006显示文摘 | Baade PD Youlden DR Valery PC | 2010 | Br J Cancer2010，102，3： | 1 |
| 10 | Cancer statistics in China, 2015 显示文摘 | Chen W Zheng R Baade PD | 2016 | CA Cancer J Clin2016，66，2： | 1 |
| 11 | Polymerization of acrylamide in dispersion with paraffinic and aromatic liquids as oil phase显示文摘 | Baade W Reichert K H | 1986 | Makromol Chem: Rapid Commun1986，7，： | 1 |
| 12 | The role of biodiversity for element cycling and trophic interactions:An experimental approach in a grassland community显示文摘 | Roscher C Schumacher J Baade J | | 0，，： | 1 |
| 13 | Cancer statistics in Chi- na,2015显示文摘 | Chen W Zheng R Baade PD | 2016 | CA Cancer J Clin2016，66，2： | 1 |
| 14 | Cancer statistics in China, 2015显示文摘 | Chen W Zheng R Baade PD | 2016 | CA Cancer J Clin2016，66，2： | 1 |
| 15 | Interleukin-21 is a growth and survival factor for human myeloma cells 显示文摘 | Brerme AT Baade Ro T Waage A | 2002 | Blood2002，99，10： | 1 |
| 16 | Kinetics of the dispersion poly- merization of acrylamide显示文摘 | Baade W Reichert K H | 1984 | Eur Polym J1984，20，5： | 1 |
| 17 | Cancer statistics in China,2015显示文摘 | Chen W Zheng R Baade PD | 2016 | CA Cancer J Clin2016，66，2： | 1 |
| 18 | Cancer statistics in China, 2015显示文摘 | Chen W Zheng R Baade PD | 2016 | CA Cancer J Clin2016，66，2： | 1 |
| 19 | Mechanism, kinetics and modeling of the inverse-microsuspension homopolymerization of acrylamide显示文摘 | Hunkeler D Hamielec A E Baade W | 1989 | Polymer1989，30，： | 1 |
| 20 | The International Epidemiology of Lung Cancer: Geographical Distribution and Secular Trends显示文摘 | Danny R. Youlden Susanna M. Cramb Peter D. Baade | 2008 | Journal of Thoracic Oncology2008，，8： | 1 |
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