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| 1 | Benefit of combination β-blocker and endoscopic treatment to prevent variceal rebleeding: A meta-analysis显示文摘AIM: To determine whether the association of β-blockers with endoscopic treatment is superior to endoscopic treatment alone for the secondary prophylaxis of oesophageal variceal bleeding. METHODS: Randomised controlled trials comparing sclerotherapy (SCL) with SCL plus β-blockers (BB) or banding ligation (BL) with BL plus BB were identif ied.Main outcomes were overall and 6, 12 and 24 mo rebleeding rates, as well as overall and 6, 12 and 24 mo mortality. Two statistical methods were used: Yusuf-Peto, and Der Simonian and Laird. Inter-trial heterogeneity was systematically taken into account. RESULTS: Seventeen randomised controlled trials were included, 14 with SCL and 3 with BL. Combination β-blocker and endoscopic treatment signif icantly reduced rebleeding rates at 6, 12 and 24 mo and overall [odds ratio (OR): 2.20, 95% conf idence interval (CI): 1.69-2.85, P<0.0001] compared to endoscopic treatment alone. Mortality at 24 mo was signif icantly lower for the combined treatment group (OR: 1.83, 95% CI:1.16-2.90, P= 0.009), as well as overall mortality (OR: 1.43, 95% CI:1.03-1.98, P= 0.03). CONCLUSION: Combination therapy should thus be recommended as the fi rst line treatment for secondary prophylaxis of oesophageal variceal bleeding. | Natalie Funakoshi Frédérique Ségalas-Largey Yohan Duny Frédéric Oberti Jean-Christophe Valats Michael Bismuth Jean-Pierre Daurès Pierre Blanc | 2010 | World Journal of Gastroenterology2010，16，47： | 24 |
| 2 | Genotype phenotype classification of hepatocellular adenoma显示文摘Studies that compare tumor genotype with phenotype have provided the basis of a new histological/molecular classification of hepatocellular adenomas. Based on two molecular criteria (presence of a TCF1/HNF1α or β-catenin mutation), and an additional histological criterion (presence or absence of an inflammatory infiltrate), subgroups of hepatocellular adenoma can be defined and distinguished from focal nodular hyperplasia. Analysis of 96 hepatocellular adenomas performed by a French collaborative network showed that they can be divided into four broad subgroups: the fi rst one is defi ned by the presence of mutations in TCF1 gene inactivating the hepatocyte nuclear factor 1 (HNF1α); the second by the presence of β-catenin activating mutations; the category without mutations of HNF1α or β-catenin is further divided into 2 subgroups depending on the presence or absence of in? ammation. Therefore, the approach to the diagnosis of problematic benign hepatocytic nodules may be entering a new era directed by new molecular information. It is hoped that immunohistological tools will improve significantly diagnosis of liver biopsy in our ability to distinguish hepatocellular adenoma from focal nodular hyperplasia (FNH), and to delineate clinically meaningful entities within each group to define the best clinical management. The optimal care of patients with a liver nodule will benefit from the recent knowledge coming from molecular biology and the combined expertise of hepatologists, pathologists, radiologists, and surgeons. | Paulette Bioulac-Sage Jean Frédéric Blanc Sandra Rebouissou Charles Balabaud Jessica Zucman-Rossi | 2007 | World Journal of Gastroenterology2007，13，19： | 7 |
| 3 | A Hepatocellular Carcinoma 5-Gene Score Associated With Survival of Patients After Liver Resection显示文摘 | Jean–Charles Nault Aurélien De Reyniès Augusto Villanueva Julien Calderaro Sandra Rebouissou Gabrielle Couchy Thomas Decaens Dominique Franco Sandrine Imbeaud Francis Rousseau Daniel Azoulay Jean Saric Jean–Frédéric Blanc Charles Balabaud Paulette Bioulac | 2013 | Gastroenterology2013，，1： | 3 |
| 4 | Hemorrhage after pancreati- coduodenectomy : when is surgery still indicated 显示文摘 | Blanc T Cortes A Goere D | 2007 | 9 Am J Surg2007，194，1： | 1 |
| 5 | Ischemic colitis and recurrent venous thrombosis caused by familial protein S deficiency显示文摘 | Blanc P Bories P Donadio D | 1989 | Gastroenterol Clin Biol1989，13，11： | 1 |
| 6 | Differential response of p53 targe genes to p73 overexpression in SH-SYSY neuroblastoma cellline 显示文摘 | Goldschneider D Blanc E Raguenez G | 2004 | Cell Sci2004，117，2： | 1 |
| 7 | Outbreak of human liste- riosis associated with tomme cheese in northwest Switzerland, 2005 显示文摘 | BILLE J BLANC D S SCHMID H | 2006 | Euro Surveill2006，11，6： | 1 |
| 8 | Hard UV-eurable organo-mineral coatings for optical applications显示文摘 | Blanc D Last A Franc J | 2006 | Thin Solid Films2006，515，3： | 1 |
| 9 | Up- dating situation models during reading of news reports:evi- dence from empirical data and simulations显示文摘 | Blanc N Kendeou P van den Broek P Brouillet D | 2008 | Discourse Processes2008，，2： | 1 |
| 10 | Crown fragmentation assessment in tropieal trees: method, insights and perspectives 显示文摘 | RUTISHAUSER E BARTHILMY D BLANC L et oi | 2011 | For Ecol Manage2011，261，3： | 1 |
| 11 | Outbreak of human listeriosis associated with tomme cheese in northwest Switzerland, 2005 显示文摘 | Bille J Blanc D S Schmid H | 2006 | European Surveillance2006，11，6： | 1 |
| 12 | Outbreak of human listeriosis associated with tomme cheese in northwest Switzerland,2005显示文摘 | BILLE J BLANC D SCHMID H | 2006 | Eur Surveill2006，11，6： | 1 |
| 13 | Protective effects of glutamine dipeptide and alpha-tocopherol against ischemia-reperfusion injury in the isolated rat liver显示文摘 | Schuster H Blanc MC Bonnefont-Rousselot D | 2009 | Clin Nutr2009，28，3： | 1 |
| 14 | Double-Locus Sequence Typing Using clfB and spa, a Fast and Simple Method for Epidemiological Typing of Methicillin-Resistant Staphylococcus au- reus显示文摘 | Kuhn G Francioli P Blanc D S | 2007 | Journal of Clinical Microbiol2007，45，1： | 1 |
| 15 | Oxidized LDL modulates apoptosis of regulatory T cells in patients with ESRD 显示文摘 | Meier P Golshayan D Blanc E | 2009 | J Am Soc Nephrol2009，20，6： | 1 |
| 16 | Quality of life in older ages 显示文摘 | Netuveli G Blanc D | 2008 | Br Med Bull2008，85，： | 1 |
| 17 | Enhanced HIV infectivity and changesin GP120 conformation associated with viral incorporation of human leucocyte antigen class I molecules 显示文摘 | Cosma A Blanc D Braun J | 1999 | AIDS1999，13，15： | 1 |
| 18 | Cryptococcus neoformans Galactoxylomannan contains an epitope(s) that is cross-reactive with Aspergillus Galactomannan显示文摘 | Dalle F Charles PE Blanc K Caillot D Chavanet P Dromer F | | 0，，06： | 1 |
| 19 | MYCN enhances P-gp/MDR1 gene expression in the human metastatic neuroblastoma IGR-N-91 model显示文摘 | Blanc E Goldschneider D Ferrandis E | 2003 | Am J Pathol2003，163，1： | 1 |
| 20 | Genotyping of European isolates ofmethicillin-resistant Staphylococcus aureus by fluorescent amlplified-fragment length polymorphism analysis (FAFLP) and pulsed-field gel electrophoresis (PFGE)typing 显示文摘 | Grady R Blanc D Hauser P | 2001 | Med Microbiol2001，50，7： | 1 |
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