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| 1 | Non-invasive means of measuring hepatic fat content显示文摘Hepatic steatosis affects 20% to 30% of the general adult population in the western world. Currently, the technique of choice for determining hepatic fat deposition and the stage of fibrosis is liver biopsy. However, it is an invasive procedure and its use is limited, particularly in children. It may also be subject to sampling error. Non-invasive techniques such as ultrasound, computerised tomography (CT), magnetic resonance imaging (MRI) and proton magnetic resonance spectroscopy (1H MRS) can detect hepatic steatosis, but currently cannot distinguish between simple steatosis and steatohepatitis, or stage the degree of fibrosis accurately. Ultrasound is widely used to detect hepatic steatosis, but its sensitivity is reduced in the morbidly obese and also in those with small amounts of fatty infiltration. It has been used to grade hepatic fat content, but this is subjective. CT can detect hepatic steatosis, but exposes subjects to ionising radiation, thus limiting its use in longitudinal studies and in children. Recently, magnetic resonance (MR) techniques using chemical shift imaging have provided a quantitative assessment of the degree of hepatic fatty infiltration, which correlates well with liver biopsy results in the same patients. Similarly, in vivo 1H MRS is a fast, safe, non-invasive method forthe quantification of intrahepatocellular lipid (IHCL) levels. Both techniques will be useful tools in future longitudinal clinical studies, either in examining the natural history of conditions causing hepatic steatosis (e.g. non-alcoholic fatty liver disease), or in testing new treatments for these conditions. | Sanjeev R Mehta E Louise Thomas Jimmy D Bell Desmond G Johnston Simon D Taylor-Robinson | 2008 | World Journal of Gastroenterology2008，14，22： | 21 |
| 2 | Assessment of large aperture lightweight imaging concepts 显示文摘 | BELL K D BOUCHER R H | 1999 | IEEE1999，，： | 3 |
| 3 | Infectious hypodermal and hematopoietic necrosis, a newly recognized virus disease of penaeid shrimp显示文摘 | Lightner D V Redman R M Bell T A | 1983 | Invertebrate Pathology1983，42，： | 2 |
| 4 | Effects of purified dies containing different combinations of arachidonic and docosahexaenoic acid on survival, growth and fatty acid composition of juvenile turbot (Scophthalmus maximus) 显示文摘 | Castell J D Bell J G Tocher D R | 1994 | Aquaculture1994，1，： | 2 |
| 5 | Abundance and partitioning of OH in a hlgh-pressure magmatic system: Megacrysts from the Monastery kimberlite, South Africa显示文摘 | Bell D B Rossman G R Moore R O | 2004 | J Petrol2004，45，： | 1 |
| 6 | The resources for enhancing Alzheimerl s caregiver health (REACH): project design and baseline characteristics 显示文摘 | Wisniewski S R Belle S H Coon D W | 2003 | Psychol Aging2003，18，3： | 1 |
| 7 | Peritoneal implants of o- varian serous borderline tumors: histologie features and prognosis 显示文摘 | Bell D A Weinstock M A Scully R E | 1988 | Cancer1988，62，10： | 1 |
| 8 | Drum-boiler dynamics 显示文摘 | Astrom K J Bell R D | 2000 | Automatica2000，36，3： | 1 |
| 9 | Effects of essential fatty acid-deficient diets on growth, mortality, tissue histopathology and fatty acid compositions in juvenile turbot ( Scophthalmus maximus) 显示文摘 | BELL J G TOCHER D R FARNDALE B M | 1999 | Fish Physiol Biochem1999，20，3： | 1 |
| 10 | Urinary mutagenesis and fried red meat intake: Influence of cooking temperature, phenotype, and genotype of metabolizing enzymes in a con- trolled feeding study 显示文摘 | Peters U Sinha R Bell D A | 2004 | Environmental and Molecular Mu- tagenesis2004，43，1： | 1 |
| 11 | Effects of purified diets containing different combinations of arachidonic and docosahexaenoic acid on survival,growth and fatty acid composition of juvenile turbot (Scophthalmus maximus )显示文摘 | Castell J D Bell J G Tocher D R | 1994 | Aquaculture1994，128，： | 1 |
| 12 | Genomic structure of DNA encoding the lymphocyte homing receptor CD44 reveals at least 12 alternative spliced exons显示文摘 | Screaton G R Bell M V Jackson D G | 1992 | Proc Natl Acad Sci USA1992，89，12： | 1 |
| 13 | Management of laryngotracheal injuties associated with craniomaxillofacial trauma显示文摘 | Verscbuere D S Bell R B Bagberi S | 2006 | J Oral Maxillofac Surg2006，64，2： | 1 |
| 14 | Price Competition under Stockpiling and Flexible Con- sumption显示文摘 | BELL D R IYER G PADMANABHAN V | 2002 | Journal of Marketing Research2002，39，8： | 1 |
| 15 | Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small cell lung cancer to gefitinib显示文摘 | Lynch T J Bell D W Sordella R | 2004 | N Engl J Med2004，350，21： | 1 |
| 16 | An Exploration of the Technical Feasibility of Achieving CO2 Emission Reductions in Excess of 60% Within the UK Housing Stock by the Year 2050显示文摘 | Johnston D Lowe R Bell M | 2005 | Energy Policy2005，83，： | 1 |
| 17 | Behaviour of some trace elements in alluvial sediments, Zagerb water-well field atea,Croatia 显示文摘 | Vertacnik R D Redely C Bell J C | 1995 | Water Research1995，29，23： | 1 |
| 18 | Clearance of amyloid - beta peptide across the blood -brain barrier: implication for thera- pies in Alzheimer's disease显示文摘 | DEANE R BELL R D SAGARE A | 2009 | CNS Neurol Disord Drug Targets2009，8，1： | 1 |
| 19 | Oral and maxillofacial surgeons treating oral cancer: a preliminary report from the American Association of Oral and Maxillo- facial Surgeons Task Force on Oral Cancer显示文摘 | Kademani D Bell R B Schmidt B L | 2008 | Journal of Oral and Maxillofacial Surgery2008，66，10： | 1 |
| 20 | Development and application of molecular marker linkage maps in woody fruit crops显示文摘 | N F Weeden M Hemmatt D M Lawson M Lodhi R L Bell A G Manganaris B I Reischs S K Brown G N Ye | 1994 | Euphytica1994，77，12： | 1 |
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