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| 1 | Analysis of the delayed approach to the management of infected pancreatic necrosis显示文摘AIM: To analyze outcomes of delayed single-stage necrosectomy after early conservative management of patients with infected pancreatic necrosis (IPN) associated with severe acute pancreatitis (SAP). METHODS: Between January 1998 and December 2009, data from patients with SAP who developed IPN and were managed by pancreatic necrosectomy were analyzed. RESULTS: Fifty-nine of 61 pancreatic necrosectomies were performed by open surgery and 2 laparoscopically. In 55 patients, single-stage necrosectomy could be performed (90.2%). Patients underwent surgery at a median of 29 d (range 13-46 d) after diagnosis of acute pancreatitis. Sepsis and multiple organ failure accounted for the 9.8% mortality rate. Pancreatic fistulae (50.8%) predominantly accounted for the morbidity. The median hospital stay was 23 d, and the median interval for return to regular activities was 110 d.CONCLUSION: This series supports the concept of delayed single-stage open pancreatic necrosectomy for IPN. Advances in critical care, antibiotics and interventional radiology have played complementary role in improving the outcomes. | Nilesh Doctor Sujith Philip Vidhyachandra Gandhi Maharra Hussain Savio G Barreto | 2011 | World Journal of Gastroenterology2011，17，3： | 15 |
| 2 | Pioneering function of Isl1 in the epigenetic control of cardiomyocyte cell fate显示文摘Generation of widely differing and specialized cell types from a single totipotent zygote involves large-scale transcriptional changes and chromatin reorganization. Pioneer transcription factors play key roles in programming the epigenome and facilitating recruitment of additional regulatory factors during successive cell lineage specification and differentiation steps. Here we show that Isl1 acts as a pioneer factor driving cardiomyocyte lineage commitment by shaping the chromatin landscape of cardiac progenitor cells. Using an Isl1 hypomorphic mouse line which shows congenital heart defects, genome-wide profiling of Isl1 binding together with RNA- and ATAC-sequencing of cardiac progenitor cells and their derivatives, we uncover a regulatory network downstream of Isl1 that orchestrates cardiogenesis. Mechanistically, we show that Isl1 binds to compacted chromatin and works in concert with the Brg1-Baf60c-based SWI/SNF complex to promote permissive cardiac lineage-specific alterations in the chromatin landscape not only of genes with critical functions in cardiac progenitor cells, but also of cardiomyocyte structural genes that are highly expressed when Isl1 itself is no longer present. Thus, the Isl1/Brg1-Baf60c complex plays a crucial role in orchestrating proper cardiogenesis and in establishing epigenetic memory of cardiomyocyte fate commitment. | Rui Gao Xingqun Liang Sirisha Cheedipudi Julio Cordero Xue Jiang Qingquan Zhang Luca Caputo Stefan Günther Carsten Kuenne Yonggang Ren Shoumo Bhattacharya Xuejun Yuan Guillermo Barreto Yihan Chen Thomas Braun Sylvia M. Evans Yunfu Sun Gergana Dobreva | 2019 | Cell Research2019，29，6： | 5 |
| 3 | Extended pancreatic resections and lymphadenectomy:An appraisal of the current evidence显示文摘Surgery remains the mainstay of treatment for pancreatic ductal adenocarcinoma and complete removal of the cancer confers a definite survival advantage,especially in early disease.However,the majority of patients do not present with early disease,thus precluding the chance of a cure by standard pancreatoduodenectomy(PD),distal pancreatectomy or total pancreatectomy.For this reason,pancreatic surgeons have attempted to push the limits of resection over the last three decades.The aim of these resections has been to determine whether obtaining a complete resection by extending the limits of conventional resection in patients with advanced disease will yield the results seen with PD alone in early disease.This article revisits the data from such studies in an attempt to determine if the available literature supports the performance of extended resections for pancreatic cancer in terms of improvement of survival. | Shailesh V Shrikhande Savio G Barreto | 2010 | World Journal of Gastrointestinal Surgery2010，2，2： | 2 |
| 4 | Cell-type specificity of β-actin expression and its clinicopathological correlation in gastric adenocarcinoma显示文摘AIM:To investigate cell type specific distribution ofβ-actin expression in gastric adenocarcinoma and its correlation with clinicopathological parameters.METHODS:β-actin is a housekeeping gene,frequently used as loading control,but,differentially expresses in cancer.In gastric cancer,an overall increased expression ofβ-actin has been reported using tissue disruptive techniques.At present,no histological data is available to indicate its cell type-specific expression and distribution pattern.In the present study,we analyzedβ-actin expression and distribution in paired normal and tumor tissue samples of gastric adenocarcinoma patients using immunohistochemistry(IHC),a tissue non-disruptive technique as well as tissue disruptive techniques like reverse transcriptase-polymerase chain reaction(RT-PCR)and western blotting.Correlation ofβ-actin level with clinicopathological parameters was done using univariate analysis.RESULTS:The results of this study showed significant overexpression,at both mRNA and protein level in tumor tissues as confirmed by RT-PCR(1.47±0.13 vs2.36±0.16;P<0.001)and western blotting(1.92±0.26 vs 2.88±0.32;P<0.01).IHC revealed thatβ-actin expression is majorly distributed between epithelial and inflammatory cells of the tissues.Inflammatory cells showed a significantly higher expression compared to epithelial cells in normal(2.46±0.13 vs 5.92±0.23,P<0.001),as well as,in tumor tissues(2.79±0.24 vs6.71±0.14,P<0.001).Further,comparison of immunostaining between normal and tumor tissues revealed that both epithelial and inflammatory cells overexpressβ-actin in tumor tissues,however,significant difference was observed only in inflammatory cells(5.92±0.23vs 6.71±0.14,P<0.01).Moreover,combined expression in epithelial and inflammatory cells also showed significant increase(4.19±0.15 vs 4.75±0.14,P<0.05)in tumor tissues.In addition,univariate analysis showed a positive correlation ofβ-actin level of inflammatory cells with tumor grade(P<0.05)while epithelial cells exhibited negative correlation(P>0.05).CONCLUSION:In gastric cancer,β-actin showed an overall higher expression predominantly contributed by inflammatory or tumor infiltrating immune cells of the tissue microenvironment and correlates with tumor grade. | Shafqat A Khan Monica Tyagi Ajit K Sharma Savio G Barreto Bhawna Sirohi Mukta Ramadwar Shailesh V Shrikhande Sanjay Gupta | 2014 | World Journal of Gastroenterology2014，20，34： | 2 |
| 5 | Surgery for gallbladder cancer:The need to generate greater evidence显示文摘The outcomes for gallbladder cancer remain largely dismal to this day.Overall,the low incidence of gallbladder cancer around the world coupled with an even lower number of patients amenable to surgery at the time of presentation,has precluded the generation of evidence-based guidelines for the management of this cancer.However,while the incidence of the cancer may be decreasing in some parts of the world,in other countries such as India,Japan and Chile,gallbladder cancer continues to affect a sizeable population of patients.As such,there is a growing need to define what constitutes an adequate surgery for each stage of this cancer,based on sound evidence.This editorial provides a broad overview of the existing problems in the management of gallbladder cancer and appeals for multi-institutional studies aimed at answering some of the pertinent questions on the surgical management of gallbladder cancer. | Shailesh V Shrikhande Savio G Barreto | 2009 | World Journal of Gastrointestinal Surgery2009，1，1： | 2 |
| 6 | Transcranial ultrasound in clinical sonothrombolysis(TUCSON)trial显示文摘 | Molina CA Barreto AD Tsivgoulis G | 2009 | Ann Neurol2009，66，1： | 1 |
| 7 | GaDD45a promotes epige- netic gene aetivation by repair-mediated DNA demethylation 显示文摘 | Barreto G Schafer A Marhold J | 2007 | Nature2007，445，： | 1 |
| 8 | Synergistic effect of CPPU and benzyladenine on embryo rescue in six stenospermocarpic cultivars of grapevine显示文摘 | ANookaraju M S Barreto G S Karibasappa | 2007 | Vitis2007，46，4： | 1 |
| 9 | Influence of protein and fat content and cooking temperature on texture and sensory evaluation of bologna sausage显示文摘 | Colmenero F G Barreto G Mota N | 1995 | Lebensm- Wiss u-Technol1995，28，： | 1 |
| 10 | Binding properties and colour of Bologna sausage made with varying fat levels ,protein levels and cooking temperatures显示文摘 | CARBALLO J MOTA N BARRETO G | 1995 | Meat Science1995，41，3： | 1 |
| 11 | Synergistic effect of CPPU and benzyladenine on embryo rescue in six stenospermocarpic cultivars of grapevine显示文摘 | Nookaraju A Barreto M S Karibasappa G S | 2007 | Vitis2007，46，4： | 1 |
| 12 | A liquid-liquid extraction procedure followed by a low temperature purifi- cation step for the analysis of macrocyclic lactones in milk by liquid chromatography-tandem mass spectrometry and fluorescence detection显示文摘 | Sameness G Barreto F Hoff R B | 2011 | Anal Chim Acta2011，705，12： | 1 |
| 13 | Systematic review of diet in the pathogenesis of acute pancreatitis : a tale of too much or too little? 显示文摘 | THOMAS T MAH L BARRETO S G | 2012 | Saudi J Gastreenterol2012，18，5： | 1 |
| 14 | Binding properties and color of Bologna sausage made with varying fat levels, protein levels and cooking temperatures显示文摘 | CARBALLO J MOTA N BARRETO G | 1995 | Meat Science1995，41，3： | 1 |
| 15 | Environmental blue light prewnts stress in the fish Nile tilapia显示文摘 | Volpato G I Barreto R E | 2001 | Brazilian Journal of Me:lical and Biological Research2001，34，8： | 1 |
| 16 | Binding properties and colour of bologna sausage made with varying fat levels, protein levels and cooking temperatures 显示文摘 | Carballo J Mota N Barreto G | 1995 | Meat Science1995，41，3： | 1 |
| 17 | Environmental blue light prevents stressin the fish Nile tilapia显示文摘 | Volpato G L Barreto R E | 2001 | Brazilian Journal of Medical andBiological Research2001，34，8： | 1 |
| 18 | Pancreatic fistula afterpancreaticoduodenectomy : the impact of a standardized techniqueof pancreaticojejunostomy 显示文摘 | Shrikhande SV Barreto G Shukla PJ | 2008 | Langenbecks Arch Surg2008，393，1： | 1 |
| 19 | Development of Effervescent Tablets Containing Benznidazole Complexed with Cyclodextrin显示文摘 | MAXIMIANO F P COSTA G H Y DE SA BARRETO L C L | 2011 | Journal of Pharmacy and Pharmacology2011，63，6： | 1 |
| 20 | Frozenstorage of Bologna sausages as a function of fat content and of levels ofadded starch and egg white显示文摘 | COLMENERO F J BARRETO G FERNADEZ P | 1996 | Meat Science1996，42，3： | 1 |
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