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| 1 | Endothelium-Mimicking Multifunctional Coating Modified Cardiovascular Stents via a Stepwise Metal-Catechol-(Amine)Surface Engineering Strategy显示文摘Stenting is currently the major therapeutic treatment for cardiovascular diseases.However,the nonbiogenic metal stents are inclined to trigger a cascade of cellular and molecular events including inflammatory response,thrombogenic reactions,smooth muscle cell hyperproliferation accompanied by the delayed arterial healing,and poor reendothelialization,thus leading to restenosis along with late stent thrombosis.To address prevalence critical problems,we present an endothelium-mimicking coating capable of rapid regeneration of a competently functioning new endothelial layer on stents through a stepwise metal(copper)-catechol-(amine)(MCA)surface chemistry strategy,leading to combinatorial endothelium-like functions with glutathione peroxidase-like catalytic activity and surface heparinization.Apart from the stable nitric oxide(NO)generating rate at the physiological level(2:2×10^(-10) mol/cm^(2)/min lasting for 60 days),this proposed strategy could also generate abundant amine groups for allowing a high heparin conjugation efficacy up to∼1μg/cm^(2),which is considerably higher than most of the conventional heparinized surfaces.The resultant coating could create an ideal microenvironment for bringing in enhanced antithrombogenicity,anti-inflammation,anti-proliferation of smooth muscle cells,re-endothelialization by regulating relevant gene expressions,hence preventing restenosis in vivo.We envision that the stepwise MCA coating strategy would facilitate the surface endothelium-mimicking engineering of vascular stents and be therefore helpful in the clinic to reduce complications associated with stenosis. | Ying Yang Peng Gao Juan Wang Qiufen Tu Long Bai Kaiqin Xiong Hua Qiu Xin Zhao Manfred FMaitz Huaiyu Wang Xiangyang Li Qiang Zhao Yin Xiao Nan Huang Zhilu Yang | 2020 | Research2020，，1： | 8 |
| 2 | Identification of powdery mildew resistance loci in wheat by integrating genome-wide association study(GWAS) and linkage mapping显示文摘Wheat powdery mildew(Blumeria graminis f.sp.tritici, Bgt) is a disease of increasing importance globally due to the adoption of high yielding varieties and modern sustainable farming technologies.Growing resistant cultivars is a preferred approach to managing this disease, and novel powdery mildew resistance genes are urgently needed for new cultivar development.A genome-wide association study was performed on a panel of 1292 wheat landraces and historical cultivars using 5011 single nucleotide polymorphism(SNP)markers.The association panel was evaluated for reactions to three Bgt inoculants, OKS(14)-B-3-1, OKS(14)-C-2-1, and Bgt15.Linkage disequilibrum(LD) analysis indicated that genome-wide LD decayed to 0.1 at 23 Mb, and population structure analysis revealed seven subgroups in the panel.Association analysis using a mixed linear model(MLM) identified three loci for powdery mildew resistance on chromosome 2 B, designated QPm.stars-2BL1,QPm.stars-2BL2, and QPm.stars-2BL3.To evaluate the efficacy of GWAS in gene discovery,QPm.stars-2BL2 was validated using F2 and F2:3 populations derived from PI420646 × OK1059060-126135-3.Linkage analysis delimited the powdery mildew resistance gene in PI 420646 to an interval where QPm.stars-2BL2 was located, lending credence to the GWAS results.QPm.stars-2BL1 and QPm.stars-2BL3, which were associated with four SNPs located at 457.7–461.7 Mb and two SNPs located at 696.6–715.9 Mb in the Chinese Spring reference IWGSC RefSeq v1.0, respectively, are likely novel loci for powdery mildew resistance and can be used in wheat breeding to improve powdery mildew resistance. | Genqiao Li Xiangyang Xu Chengcheng Tan Brett F.Carver Guihua Bai Xuewen Wang J.Michael Bonman Yanqi Wu Robert Hunger Christina Cowger | 2019 | The Crop Journal2019，7，3： | 2 |
| 3 | High thermoelectric performance of Yb 0.26 Co 4 Sb 12 / y GaSb nanocomposites originating from scattering electrons of low energy显示文摘 | Zhen Xiong Xihong Chen Xiangyang Huang Shengqiang Bai Lidong Chen | 2010 | Acta Materialia2010，，11： | 1 |
| 4 | Design of high-performance molybdenum alloys via doping metal oxide and carbide strengthening:A review显示文摘Metal oxide and carbide strengthening molybdenum(Mo)alloys have been designed as promising ad-vanced materials in refractory metals to solve some of the core engineering problems in superalloy ap-plications.Hence,there is a need to summarize the results obtained and evaluate the opportunities for preparing high-performance Mo alloys by strengthening metal oxides and carbides to improve the per-formance characteristics of Mo metal materials.This paper reviews the results of the reported work con-cerning the structure and properties of Mo alloys with different metal oxide and carbide strengthening methods added to Mo matrix.The influence of the doping of La 2 O 3 and Y 2 O 3 particles,ceramic Al 2 O 3 and ZrO 2 particles,and refractory TiC and ZrC carbides particles of Mo alloys are discussed.The impacts of particle morphology,size,distribution and volume fractions of oxide and carbide are analyzed,as well as the specific features of different doping techniques for obtaining high-performance Mo alloys mate-rials.This work will guide future research on the design of high-performance refractory Mo alloys by adding oxides and carbide particles,helping to solve the core issues in the field of superalloy application research. | Hairui Xing Ping Hu Chaojun He Xiangyang Zhang Jiayu Han Fan Yang Run Bai Wen Zhang Kuaishe Wang Alex AVolinsky | 2023 | Journal of Materials Science & Technology2023，，29： | 1 |
| 5 | Taraxerol inhibits LPS-induced inflammatory responses through suppression of TAK1 andAkt activation 显示文摘 | Yao Xiangyang Li Guilan Bai Qin | 2013 | International Immunopharmacology2013，15，2： | 1 |
| 6 | Discovery and bioassay of disubstituted β-elemene-NO donor conjugates:synergistic enhancement in the treatment of leukemia显示文摘Natural products are essential sources of antitumor drugs.One such molecule,β-elemene,is a potent antitumor compound extracted from Curcuma wenyujin.In the present investigation,a series of novel 13,14-disubstituted nitric oxide(NO)-donorβelemene derivatives were designed,withβ-elemene as the foundational compound,and subsequently synthesized to evaluate their therapeutic potential against leukemia.Notably,the derivative labeled as compound 13d demonstrated a potent anti-proliferative activity against the K562 cell line,with a high NO release.In vivo studies indicated that compound 13d could effectively inhibit tumor growth,exhibiting no discernible toxic manifestations.Specifically,a significant tumor growth inhibition rate of 62.9%was observed in the K562 xenograft tumor mouse model.The accumulated data propound the potential therapeutic application of compound 13d in the management of leukemia. | ZHU Junlong JIANG Xiaoying LUO Xinyu GAO Yuan ZHAO Rui LI Junjie CAI Hong DANG Xiawen YE Xiangyang BAI Renren XIE Tian | 2023 | Chinese Journal of Natural Medicines2023，21，12： | 1 |
| 7 | Production and verification of human papillomavirus type 18 vaccinein vitro显示文摘 | Shujie Liao Shixuan Wang Ling Xu Dongrui Deng Qian Xu Wei Wang Tao Zhu Xiangyang Bai Jianfeng Zhou Gang Xu Yunping Lu Li Meng Ding Ma | 2008 | Oncology Reports2008，，1： | 1 |
| 8 | Optimal Strategies for Distribution Network Reconfiguration Considering Uncertain Wind Power显示文摘The uncertainty of wind power can cause side-effects indistribution network reconfiguration.For reducing the impact from uncertainty in distribution network reconfiguration,the hard strategy of compressed air assisted wind turbine system(CAAWTS)and the soft strategy based on robust optimization are proposed in this paper.Since the energy storage capacity of CAAWTS is generally small,the performance of the hard strategy is limited.The soft strategy based on robust optimization by creating an uncertain set is applied to enhance the performance of the hard strategy.The proposed robust optimization model of distribution network reconfiguration is then solved by the maximum explicit method.Numerical examples show that the proposed hard and soft strategies can effectively solve the influences of uncertain wind power on the problem of distribution network reconfiguration,while the economic performance of the system can be improved. | Zhiwei Cui Xiaoqing Bai Peijie Li Bin Li Jie Cheng Xiangyang Su Yi Zheng | 2020 | CSEE Journal of Power and Energy Systems2020，6，3： | 0 |
| 9 | Research progress in geophysical exploration of the Antarctic ice sheet显示文摘The Antarctic ice sheet is an important target of Antarctic research.Thickness and structure,including intraice and subice,are closely related to the mass balance of the ice sheet,and play an important role in the study of global sea level and climate change.Subglacial topography is an important basis for studying ice sheet dynamics and ice sheet evolution.This paper briefly reviews the geophysical detection methods and research status of the Antarctic ice sheet:(1)Conventional methods such as ice radar are the main methods for studying the ice sheet today,and passive source seismic methods such as the receiver function method,H/V method and P-wave coda autocorrelation method have good development prospects;(2)the high-resolution(1 km)ice thickness and subglacial topographic database BEDMAP2 established based on various data has greatly improved the ability to detect internal isochronous layers,anisotropic layers,and temperature changes within ice and has advanced research on ice sheet evolution;and(3)ice radar,numerical simulation and core drilling are the main methods to study subglacial lakes and sediments.More than 400 subglacial lakes have been confirmed,and more than 12000 simulation results have been obtained.Research on the Antarctic ice sheet faces enormous challenges and is of great urgency.Aiming at hot issues,such as Antarctic geological evolution,glacial retreat,ice sheet melting and their relationships with global climate change,it is the frontier and trend of future Antarctic ice sheet research to carry out multidisciplinary and multicountry comprehensive geophysical exploration based on the traditional ice radar method combined with passive seismic methods,especially new technologies such as short-period dense array technology,unmanned aerial vehicles and artificial intelligence.This is expected to further promote Antarctic research. | Jinkai An Song Huang Xiangyang Chen Tao Xu Zhiming Bai | 2023 | Earthquake Research Advances2023，3，3： | 0 |
| 10 | In-situ grown Ni Co bimetal anchored on porous straw-derived biochar composites with boosted microwave absorption properties显示文摘With the gradually increasing protection awareness about electromagnetic pollution,the demand for absorbing materials with renewability and environmental friendliness has attracted widespread attention.In this work,composites consisting of straw-derived biochar combined with NiCo alloy were successfully fabricated through high-temperature carbonization and subsequent hydrothermal reaction.The electromagnetic parameters of the porous biocarbon/NiCo composites can be effectively modified by altering their NiCo content,and their improved absorbing performance can be attributed to the synergy effect of magnetic-dielectric characteristics.An exceptional reflection loss of-27.0 dB at 2.2 mm thickness and an effective absorption bandwidth of 4.4 GHz(11.7-16.1 GHz)were achieved.These results revealed that the porous biocarbon/NiCo composites could be used as a new generation absorbing material because of their low density,light weight,excellent conductivity,and strong absorption. | Yuanyuan Zhou Zhongyi Bai Xiangyang Yang Wei Liu Bingbing Fan Zhikai Yan Xiaoqin Guo | 2023 | International Journal of Minerals,Metallurgy and Materials2023，30，3： | 0 |
| 11 | Coverage Area Based Opportunistic Forwarding Algorithm in VANETs显示文摘The highly mobility of vehicles,intermittent communication between the vehicles and the requirements of real time applications are some of the main challenges of multi-hop message delivery in Vehicular Ad Hoc Networks(VANETs).There are also additional challenges,especially when the destination for the message delivery is a moving vehicle.In this paper,we propose a novel multi-hop message delivery method,called the Coverage Area-based oPportunistic message forwarding algorithm(CAP).The main idea of CAP is to cover the potential area of a moving target vehicle as much as possible with the reachable area of the required delivery messages,so that the message can be delivered successfully.Because the success ratio and overhead of the multi-hop message delivery are two important but incompatible parameters in CAP,two tunings are discussed in the algorithm in order to maintain the balance of the two parameters.The simulation results show that compared with other reference approaches,CAP provides an efficient message delivery with a higher success ratio and a shorter message delay. | Ding Yu Wang Wendong Gong Xiangyang Cui Yong Wang Bai | 2012 | China Communications2012，9，12： | 0 |
| 12 | Characterization of Rsg2.a3:A new greenbug resistance allele at the Rsg2 locus from wild barley(Hordeum vulgare ssp.spontaneum)显示文摘Greenbug(Schizaphis graminum Rondani)is a destructive insect pest that not only damages plants,but also serves as a vector for many viruses.Host plant resistance is the preferred strategy for managing greenbug.Two greenbug resistance genes,Rsg1 and Rsg2,have been reported in barley.To breed cultivars with effective resistance against various greenbug biotypes,additional resistance genes are urgently needed to sustain barley production.Wild barley accession WBDC053(PI 681777)was previously found to be resistant to several greenbug biotypes.In this study,a recombinant inbred line(RIL)population derived from Weskan×WBDC053 was evaluated for response to two greenbug biotypes(E and TX1)and genotyped using genotyping by sequencing(GBS).A set of 3347 high quality GBS-derived single nucleotide polymorphisms(SNPs)were then used to map the greenbug resistance gene in this wild barley accession.Linkage analysis placed the greenbug resistance gene in a 2.35 Mb interval(0-2,354,645 bp)in the terminal region of the short arm of chromosome 2H.This interval harbors 15 genes with leucine-rich-repeat(LRR)protein domains.An allelism test indicated that the greenbug resistance gene in WBDC053,designated Rsg2.a3,is likely allelic or closely linked to Rsg2.GBS-SNPs 2H_1318811and 2H_1839499 co-segregating with Rsg2.a3 in the RIL population were converted to Kompetitive allele specific PCR(KASP)markers KASP-Rsg2.a3-1 and KASP-Rsg2.a3-2,respectively.The two KASP markers can be used to select Rsg2.a3 and have the potential to tag Rsg2 in barley improvement programs. | Xiangyang Xu Dolores Mornhinweg Amy Bernardo Genqiao Li Ruolin Bian Brian J.Steffenson Guihua Bai | 2022 | The Crop Journal2022，10，6： | 0 |
| 13 | Cancer nanomedicine meets immunotherapy:opportunities and challenges显示文摘Cancer nanomedicines have shown promise in combination immunotherapy,thus far mostly preclinically but also already in clinical trials.Combining nanomedicines with immunotherapy aims to reinforce the cancer-immunity cycle,via potentiating key steps in the immune reaction cascade,namely antigen release,antigen processing,antigen presentation,and immune cell-mediated killing.Combination nano-immunotherapy can be realized via three targeting strategies,i.e.,by targeting cancer cells,targeting the tumor immune microenvironment,and targeting the peripheral immune system.The clinical potential of nano-immunotherapy has recently been demonstrated in a phase III trial in which nano-albumin paclitaxel(Abraxane■)was combined with atezolizumab(Tecentriq■)for the treatment of patients suffering from advanced triple-negative breast cancer.In the present paper,besides strategies and initial(pre)clinical success stories,we also discuss several key challenges in nano-immunotherapy.Taken together,nanomedicines combined with immunotherapy are gaining significant attention,and it is anticipated that they will play an increasingly important role in clinical cancer therapy. | Qingxue Sun Xiangyang Bai Alexandros Marios Sofias Roy van der Meel Eduardo Ruiz-Hernandez Gert Storm Wim EHennink Bruno De Geest Fabian Kiessling Hai-jun Yu Twan Lammers Yang Shi | 2020 | Acta Pharmacologica Sinica2020，41，7： | 0 |
| 14 | Space advanced technology demonstration satellite显示文摘The Space Advanced Technology demonstration satellite(SATech-01),a mission for low-cost space science and new technology experiments,organized by Chinese Academy of Sciences(CAS),was successfully launched into a Sun-synchronous orbit at an altitude of~500 km on July 27,2022,from the Jiuquan Satellite Launch Centre.Serving as an experimental platform for space science exploration and the demonstration of advanced common technologies in orbit,SATech-01 is equipped with 16 experimental payloads,including the solar upper transition region imager(SUTRI),the lobster eye imager for astronomy(LEIA),the high energy burst searcher(HEBS),and a High Precision Magnetic Field Measurement System based on a CPT Magnetometer(CPT).It also incorporates an imager with freeform optics,an integrated thermal imaging sensor,and a multi-functional integrated imager,etc.This paper provides an overview of SATech-01,including a technical description of the satellite and its scientific payloads,along with their on-orbit performance. | ZHANG XiaoFeng CHEN Wen ZHU XiaoCheng MENG Na HE JunWang BI XingZi ZHANG YongHe SHI Qi LI Fei LIU Rui FENG ZhengGong LIU Liu LI JinSong WU HaiChen XU DongXiao LI TaiJie HUANG JiangJiang LIU Shuo LI TianTong YU XianSheng GAO Yang ZHOU Heng BAN HanYu ZHANG YanLi ZHANG YueTing YANG YingQuan HE Tao DUAN XuLiang CHEN Xin WANG YaMin SUN AnTai ZHANG KuoXiang SUN Ying WANG YaoBin FAN ChengCheng XIONG ShaoLin LI XinQiao WEN XiangYang LING ZhiXing SUN XiaoJin ZHANG Chen BAI XianYong WANG ZhanShan DENG YuanYong TIAN Hui YANG JianFeng XUE HongBo SANG Peng LIU JinGuo ZHENG HuiLong ZHU Xiang HE JianWu LI Hui XU LuXiang XU ShuYan CHEN WenWu LIU ZhenDong WANG ZhaoLi MAO XiangLong GAO Rong LI ZongXuan DING GuoPeng WANG XinYu DOU RunJiang WENG LuBin LUO Hao WANG YaPing LIANG XianFeng FANG ZiRuo | 2024 | Science China(Technological Sciences)2024，67，1： | 0 |
| 15 | Metal records in lake/reservoir sediments adjacent to different pollution sources from Guizhou, southwestern China显示文摘 | Xiangyang BI Xinbin FENG Yuangen YANG Guangle QIU Xiaoli QIAN Weiyang BAI Zhongqing WEI Taoze LIU | 2006 | Chinese Journal Of Geochemistry2006，25，B08： | 0 |
| 16 | Development of diagnostic markers for a wheat leaf rust resistance gene Lr42 using RNA-sequencing显示文摘Wheat leaf rust is a prevalent foliar disease in wheat worldwide. Growing resistant cultivars is an effective strategy to minimize the impact of leaf rust on yield and grain quality. Lr42 is a leaf rust resistance gene identified from Aegilops tauschii and is still effective against current predominant leaf rust races in the United States and many other countries. In this study, we developed diagnostic DNA markers for Lr42 using the sequence polymorphisms of a differentially expressed gene(TaRPM1) encoding a putative NBARC protein in the Lr42 candidate region identified by RNA-sequencing of two near-isogenic lines contrasting in Lr42 alleles. Markers were designed based on a deletion mutation and a single nucleotide polymorphism(SNP) in the gene. Haplotype analyses of the newly developed markers in the three diversity panels demonstrated that they are diagnostic for Lr42, and superior to previously used markers in selection accuracy. These markers have the advantages of low cost and easy assay, and they are suitable for marker-assisted selection in breeding programs with either high-or low-throughput marker screening facilities. | Yang Liu Hui Chen Chunxin Li Lirong Zhang Mingqin Shao Yuhui Pang Xiangyang Xu Guihua Bai | 2021 | The Crop Journal2021，9，6： | 0 |
| 17 | Sensitivity of livelihood strategy to livestock production and marketization:An empirical analysis of grasslands in Inner Mongolia,China显示文摘Recent researches have primarily focused on the relationship between livelihood strategies and livelihood capital,with few empirical studies on the sensitivity of livelihood strategies to livestock production and marketization in Inner Mongolia Autonomous Region of China.This study used an income distribution approach to categorize livelihood strategies of the respondents(n=394)into three types,i.e.,herder livelihood strategy(LS1),petty-herder livelihood strategy(LS2),and non-herder livelihood strategy(LS3).Using the multinomial logistic regression model,we compared livestock production and marketization across the three livelihood strategies.Our findings showed that(1)livestock production and marketization tended to favor LS1;(2)an increase in the land asset(contracted and rented grassland)and off-take rate increased the probability of households choosing LS1;(3)stocking rate was higher for LS1;and(4)the higher critical market-related risks perceived by herders were animal price and hay and corn price.Moreover,higher livestock price acted as a deterrent to diversifying into other livelihood strategies(LS2 and LS3).Finally,this study advocates for policies that will promote the land transfer market,adopt modern techniques in animal husbandry,improve the medium for disseminating market information to herders,and provide incentives for long-term livelihood transformation. | Saheed Olaide JIMOH DING Wenqiang DONG Haibin BAI Haihua YIN Yanting LIU Huihui HOU Xiangyang | 2021 | Regional Sustainability2021，2，4： | 0 |
| 18 | Benzohydrazide Derivatives: Gelation and Application in Oil Spill Recovery显示文摘The synthesis and gelation properties of a series of organogelators containing a benzohydrazide unit and two alkoxy chams(oBn) were reported herein. oBn(n=8, 10, 12) could form stable gels in commercial fuels(e.g., diesel), which were characterized by low critical gelation concentrations(CGCs) and good mechanical properties (G'>10^5 Pa). The gelation process was further studied by field-emission scanning electron microscopy(FE-SEM), Fourier transform infrared spectroscopy(FTIR) and X-ray diffraction(XRD), etc. It was demonstrated that in these organogels, molecules self^assembled into fibrils 3D-network, where hydrogen bonding, van der Waals force and π-π interaction were confirmed as the driving forces. As compounds oBn(n=8, 10, 12) show very good gelation properties in diesel, their applications in oil spill treatment have also been tested. It was found tliat oBw could achieve rapid (<30 s) and effective oil removal at room temperature, being good candidates for oil spill treatment in the future. Also, the removal efficiency could be as high as 95%. | ZHANG Tianren ZHANG Chunxue CHE Xiangyang BAI Binglian LI Min WANG Haitao | 2019 | Chemical Research in Chinese Universities2019，35，5： | 0 |
| 19 | Expression and bioinformatic analysis of lymphoma-associated novel gene KIAA0372显示文摘The purpose of this study was to explore the differentially expressed genes in lymph-node cells(LNC)of lymphomas and reactive lymph node hyperplasia,and to perform an initial bioinformatic analysis on a novel gene,KIAA0372,which is highly expressed in the LNC of lymphomas.mRNA extracted from LNC of lymphomas and reactive lymph node hyperplasia were respectively marked with biotin and hybridized with Gene Expression Chips,resulting in differentially expressed genes.Initial bioinformatic analysis was then performed on a novel gene named KIAA0372,whose function has not yet been explored.Its structure and genomic location,its product’s physical and chemical properties,subcellular localization and functional domains,were also predicted.Further,a systematic evolution analysis was performed on similar proteins from among several species.Using Gene Expression Chips,many differentially expressed genes were uncovered.Efficient bioinformatic analysis has fundamentally determined that KIAA0372 is an extracellular protein which may be involved in TGF-b signaling.Microarray is an efficient and high throughput strategy for detection of differentially expressed genes.And KIAA0372 is thought to be a potential target for tumor research using bioinformatic analysis. | BAI Xiangyang TANG Duozhuang ZHU Tao SUN Lishi YAN Lingling LU Yunping ZHOU Jianfeng MA Ding | 2007 | Frontiers of Medicine2007，1，1： | 0 |
| 20 | Genomic location of Gb1, a unique gene conferring wheat resistance to greenbug biotype F显示文摘Greenbug(Schizaphis graminum, Rondani) is a serious insect pest in many wheat growing regions and has been infesting cereal crops in the USA for over a century. Continuous occurrence of new greenbug biotypes makes it essential to explore all greenbug resistant sources available to manage this pest. Gb1, a recessive greenbug resistance gene in DS28A, confers resistance to several economically important greenbug biotypes and is the only gene found to be resistant to greenbug biotype F. A set of 174 F_(2:3)lines from the cross DS28A × Custer was evaluated for resistance to greenbug biotype F in 2020 and 2022. Selective genotyping of the corresponding F_(2) population using single nucleotide polymorphism(SNP) markers generated by genotyping-by-sequencing(GBS) led to the identification of a candidate genomic region for Gb1. Thus, SSR markers previously mapped in this region were used to genotype the entire F2population,and kompetitive allele specific PCR(KASP) markers were also developed from SNPs in the target region.Gb1 was placed in the terminal region of the short arm of chromosome 1A, and its location was confirmed in a second population derived from the cross DS28A × PI 697274. The combined data analysis from the two mapping populations delimited Gb1 to a < 1 Mb interval between 13,328,200 and 14,241,426 bp on1AS. | Xiangyang Xu Genqiao Li Guihua Bai Brett FCarver Ruolin Bian Amy Bernardo JScott Armstrong | 2023 | The Crop Journal2023，11，5： | 0 |
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