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| 1 | Nat Genet:单细胞分析解开结直肠癌细胞的神秘面纱显示文摘结合单细胞基因组学和计算机技术,一个研究团队(包括来自杰克逊实验室(JAx)单细胞生物学主任Paul Robson博士在内)鉴定出了11种结直肠癌肿瘤的癌细胞组成及邻近的非癌细胞。这对于更好的肿瘤靶向诊断和治疗很重要。”使用单细胞测序。”JAX科学家、这篇发表在Nature Genetics上的文章共同第一作者Elise Courtois说道。”我们可以根据肿瘤中的细胞组成将结直肠癌进一步分类。因为每种亚型的肿瘤病人生存率存在差别,我们的方法将为肿瘤医生提供更多的关于肿瘤预后和治疗的信息。” | Huipeng Li, Elise T Courtois, Debarka Sengupta, Yuliana Tan Shyam Prabhakar Elise T Courtois, Yuliana Tan Paul Robson Debarka Sengupta Kok Hao Chen, Jolene Jie Lin Goh Paul Jongjoon Choi Say Li Kong, Axel M Hillmer Iain Beehuat Tan Clarinda Chua Iain Beehuat Tan Lim Kiat Hon Wah Siew Tan Mark Wong Lawrence J K Wee Iain Beehuat Tan Paul Robson Paul Robson Paul Robson | 2017 | 现代生物医学进展2017，17，15： | 37 |
| 2 | First performance evaluation of a dual-source CT (DSCT) system显示文摘 | Thomas G. Flohr Cynthia H. McCollough Herbert Bruder Martin Petersilka Klaus Gruber Christoph Sü? Michael Grasruck Karl Stierstorfer Bernhard Krauss Rainer Raupach Andrew N. Primak Axel Küttner Stefan Achenbach Christoph Becker Andreas Kopp Bernd M. Ohnes | 2006 | European Radiology2006，，6： | 3 |
| 3 | Tracing manufacturing processes using blockchain-based token compositions显示文摘Supply chain traceability is one of the most promising use cases to benefit from characteristics of blockchain,such as decentralization,immutability and transparency,not required to build prior trust relationships among entities.A plethora of supply chain traceability solutions based on blockchain has been proposed recently.However,current systems are limited to tracing simple goods that have not been part of the manufacturing process.We recommend a method that allows for the traceability of manufactured goods,including their components.Products are represented using non-fungible digital tokens that are created on a blockchain for each batch of manufactured products.To create a link between a product and the components that are needed to produce it,we propose“token recipes”that define the amount of tokenized goods required for minting a new token.As input tokens are automatically and transparently consumed when creating a product token,the physical process of producing a new item out of existing components is projected onto the ledger.This ultimately leads to the complete traceability of goods,including the origin of inputs.Evaluating the performance of the system,we show that a prototypical implementation for the Ethereum Virtual Machine(EVM)scales linearly with the amount of the input and goods tracked. | Martin Westerkamp Friedhelm Victor Axel Küpper | 2020 | Digital Communications and Networks2020，6，2： | 3 |
| 4 | Variable expression of cystatin C in cultured trans-differentiating rat hepatic stellate cells显示文摘瞄准:学习 C (CysC ) ,它由转变生长 factor-beta1 (TGF-beta1 ) 的规定和导出血小板的生长因素(PDGF ) 和有在这个特殊房间发信号的 TGF-beta1 的 CysC 的潜在的干扰打的 cystatin 的表示。方法:我们计算了 CysC 表达式在有教养, profibrogenic 肝的星形细胞和区分 trans 的 myofibroblasts 由北、西方弄污并且共焦的激光扫描显微镜学。结果:CysC 在 trans 区别期间显著地被增加。TGF-beta1 和 PDGF-BB 压制了 CysC 表示。而且, CysC 分泌物被处理与 TGF-beta1 导致。尽管 CysC 导致了 TGF 贝它的一种增加的有约束力的亲密关系,受体是由化学 cross-linking 估计了与打 III (beta-glycan )[125I ] 它没调制的 -TGF-beta1, 由评估 Smad2/3 磷酸化地位出现的 TGF-beta1 信号转导变异并且[CAGA ]-MLP-luciferase 记者基因试金。有趣地,流类型 III TGF 贝它受体 beta-glycan 在对待 CysC 的房间被减少。我们的数据显示那 CysC 表情起来在 trans 区别期间调整了。结论:在患肝疾病的病人的浆液的增加的 CysC 层次是至少部分由于在激活的肝的星形细胞的更高的表情。而且, TGF-beta1 影响 CysC 的分泌物,加亮在肝的纤维发生的前进的半胱氨酸朊酶的一个潜在地重要的角色。 | Axel M Gressner Birgit Lahme Steffen K Meurer Olav Gressner Raif Weiskirchen | 2006 | World Journal of Gastroenterology2006，12，5： | 2 |
| 5 | Interleukin-33 – cytokine of dual function or novel alarmin?显示文摘 | Guttorm Haraldsen Johanna Balogh Jürgen Pollheimer Jon Sponheim Axel M. Küchler | 2009 | Trends in Immunology2009，，5： | 1 |
| 6 | A Rapid and Reliable Enzyme Immunoassay PCR-Based Screening Method to Identify EBV-Carrying Gastric Carcinomas显示文摘 | Axel Z H Elma K K | 2002 | Mod Pathol2002，15，8： | 1 |
| 7 | Tumor necrosis factor-α contributes to ischemia and reperfusion induced endothelial activation in isolated hearts显示文摘 | Christian K Helmut H Axel G | 1999 | Cirs Res1999，84，： | 1 |
| 8 | Genetic diversity within a range of cultivars and landraces of flax as revealed by RAPDs显示文摘 | Ong B Axel D Richards K | 2002 | Genetic Resources and Crop Volution2002，49，2： | 1 |
| 9 | Nuclear Interleukin-33 Is Generally Expressed in Resting Endothelium but Rapidly Lost upon Angiogenic or Proinflammatory Activation显示文摘 | Axel M. Küchler Jürgen Pollheimer Johanna Balogh Jon Sponheim Linda Manley Dag R. Sorensen Paula M. De Angelis Helge Scott Guttorm Haraldsen | 2008 | The American Journal of Pathology2008，，4： | 1 |
| 10 | First performance evaluation of a dual-source CT (DSCT) system显示文摘 | Thomas G. Flohr Cynthia H. McCollough Herbert Bruder Martin Petersilka Klaus Gruber Christoph Süβ Michael Grasruck Karl Stierstorfer Bernhard Krauss Rainer Raupach Andrew N. Primak Axel Küttner Stefan Achenbach Christoph Becker Andreas Kopp Bernd M. Ohnes | 2006 | European Radiology2006，，2： | 1 |
| 11 | Comparison of exhaust emissions and their mutagenicity from the com- bustion of biodiesel, vegetable oil, gas - to - liquid and petrodiesel fuels显示文摘 | JURGEN K GERHARD K AXEL M | 2009 | Fuel2009，88，6： | 1 |
| 12 | Visualizing neuromodulation in vivo:TANGO-mapping of dopamine signaling reveals appetite control of sugar sensing显示文摘 | Inagaki Hidehiko K Ben-Tabou de-Leon S Wong AM Jagadish S Ishimoto H Barnea G Kitamoto T Axel R Anderson David J | | 0，，03： | 1 |
| 13 | Cooperation among strangers with limited information about reputation 显示文摘 | GARY E BOLTON ELENA K AXEL O | 2005 | Journal of Public Economics2005，89，1： | 1 |
| 14 | 4-and 5-level anterior fusions of the cervical spine:review of literature and clinical results显示文摘 | Heiko K Axel H Luis F | 2007 | Eurp Spine2007，16，12： | 1 |
| 15 | Randomized comparison of 64-Slice single-and dual-source computed tumography coronary angiography for the detection of coronary, artery disease显示文摘 | Stephan A Ulrike Rs Axel K | 2008 | J Am Coll Cardiol2008，1，： | 1 |
| 16 | Tumor necrosis factor - α contributes to ischemia and reperfusion - induced endothelial activation in isolated hearts 显示文摘 | Christian K Helmut H Axel G | 1999 | Circulation Research1999，84，4： | 1 |
| 17 | Neuroprotection of S(+) ketamine isomer in global forebrain ischemia显示文摘 | Axel H Oliver K | 2001 | Brain Research2001，904，： | 1 |
| 18 | Fairness versus efficiency: an experimental study of (mutual) gift giving 显示文摘 | Werner G Hattmut K Axel O | 2003 | Journal of Economic Behavior & Organzation2003，，50： | 1 |
| 19 | Decleration capacity of heart rate as a prelictor of mortality after myocardial infarction~ cohort study 显示文摘 | Axel B Jan W K Petra B | 2006 | Lancet2006，367，9523： | 1 |
| 20 | Interleukin-6 induces an epithelial-mesenehymal transition phenotype in human breast cancer cells显示文摘 | Sullivan N J Sasser A K Axel A E | | 0，，33： | 1 |
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