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| 1 | Role of mi RNAs and their potential to be useful as diagnostic and prognostic biomarkers in gastric cancer显示文摘Alterations in epigenetic control of gene expression play an important role in many diseases, including gastric cancer. Many studies have identified a large number of upregulated oncogenic mi RNAs and downregulated tumour-suppressor mi RNAs in this type of cancer. In this review, we provide an overview of the role of mi RNAs, pointing to their potential to be useful as diagnostic and/or prognostic biomarkers in gastric cancer. Moreover, we discuss the influence of polymorphisms and epigenetic modifications on mi RNA activity. | Kelly Cristina da Silva Oliveira Taíssa Maíra Thomaz Araújo Camila Inagaki Albuquerque Gabriela Alcantara Barata Carolina Oliveira Gigek Mariana Ferreira Leal Fernanda Wisnieski Fernando Augusto Rodrigues Mello Junior André Salim Khayat Paulo Pimentel de Assumpcao Rommel Mário Rodriguez Burbano Marília Cardoso Smith Danielle Queiroz Calcagno | 2016 | World Journal of Gastroenterology2016，22，35： | 11 |
| 2 | Percutaneous radiofrequency ablation for early hepatocellular carcinoma: Risk factors for survival显示文摘AIM: To evaluate outcomes of radiofrequency ablation(RFA) therapy for early hepatocellular carcinoma(HCC) and identify survival- and recurrence-related factors. METHODS: Consecutive patients diagnosed with early HCC by computed tomography(CT) or magnetic resonance imaging(MRI)(single nodule of ≤ 5 cm, or multi-(up to 3) nodules of ≤ 3 cm each) and who underwent RFA treatment with curative intent between January 2010 and August 2011 at the Instituto do Cancer do Estado de S o Paulo, Brazil were enrolled in the study. RFA of the liver tumors(with 1.0 cm ablative margin) was carried out under CT-fluoro scan and ultrasonic image guidance of the percutaneous ablation probes. Procedure-related complications were recorded. At 1-mo post-RFA and 3-mo intervals thereafter, CT and MRI were performed to assess outcomes of complete response(absence of enhancing tissue at the tumor site) or incomplete response(enhancing tissue remaining at the tumor site). Overall survival and diseasefree survival rates were estimated by the Kaplan-Meier method and compared by the log rank test or simple Cox regression. The effect of risk factors on survival was assessed by the Cox proportional hazard model. RESULTS: A total of 38 RFA sessions were performed during the study period on 34 patients(age in years: mean, 63 and range, 49-84). The mean follow-up time was 22 mo(range, 1-33). The study population showed predominance of male sex(76%), less severe liver disease(Child-Pugh A, n = 26; Child-Pugh B, n = 8), and single tumor(65%). The maximum tumor diameters ranged from 10 to 50 mm(median, 26 mm). The initial(immediately post-procedure) rate of RFAinduced complete tumor necrosis was 90%. The probability of achieving complete response was significantly greater in patients with a single nodule(vs patients with multi-nodules, P = 0.04). Two patients experienced major complications, including acute pulmonary edema(resolved with intervention) and intestinal perforation(led to death). The 1- and 2-year overall survival rates were 82% and 71%, respectively. Sex, tumor size, initial response, and recurrence status influenced survival, but did not reach the threshold of statistical significance. Child-Pugh class and the model for end-stage liver disease score were identified as predictors of survival by simple Cox regression, but only Child-Pugh class showed a statistically significant association to survival in multiple Cox regression analysis(HR = 15; 95%CI: 3-76 mo; P = 0.001). The 1-and 2-year cumulative disease-free survival rates were 65% and 36%, respectively. CONCLUSION: RFA is an effective therapy for local tumor control of early HCC, and patients with preserved liver function are the best candidates. | Luciana Kikuchi Marcos Menezes Aline L Chagas Claudia M Tani Regiane SSM Alencar Marcio A Diniz Venncio AF Alves Luiz Augusto Carneiro D’Albuquerque Flair José Carrilho | 2014 | World Journal of Gastroenterology2014，20，6： | 5 |
| 3 | Pentoxifylline 通过 TNF- 合成和 TGF-1 基因表示的下面规定改进肝新生显示文摘 AIM:To investigate the mechanism of pentoxifylline(PTX)improvement in liver regeneration.RESULTS:Rats were randomized into 4 groups:Control rats;Sham-sham-operation rats;Saline-70% hepatectomy plus saline solution;PTX-70%hepatectomy plus PTX.At 2 and 6 h after hepatectomy,aspartate aminotransferase,alanine aminotransferase,tumor necrosis factor(TNF)-α and interleukin-6(IL-6)serum and hepatic tissue levels were determined.Tumor growth factor(TGF)-β1 gene expression in liver tissue was evaluated 24 h after hepatectomy by quantitative reverse transcriptase polymerase chain reaction analysis.Proliferation was analyzed by mitotic index and proliferating cell nuclear antigen(PCNA)staining 48 h after hepatectomy.RESULTS:TNF-α and IL-6 serum levels increased at 2 and 6 h after hepatectomy.At 2 h after hepatectomy serum PTX was reduced but not hepatic levels of TNF-α and IL-6.A decrease in liver TGF-β1 gene expression and an increase in mitotic index and PCNA after hepatectomy were observed in the PTX treatment group in comparison to the saline group.CONCLUSION:PTX improves liver regeneration by a mechanism related to down regulation of TNF-α production and TGF-β1 gene expression. | Rodrigo Bronze Martino Ana Maria Mendona Coelho Márcia Saldanha Kubrusly Regina Leito Sandra Nassa Sampietre Marcel Cerqueira Cesar Machado Telesforo Bacchella Luiz Augusto Carneiro D’Albuquerque | 2012 | World Journal of Gastrointestinal Surgery2012，4，6： | 2 |
| 4 | Appropriateness of outpatient gastrointestinal endoscopy in a non-academic hospital显示文摘AIM:To assess the appropriate use and the diagnostic yield of upper gastrointestinal endoscopy and colonoscopy in this subgroup of patients.METHODS:In total,789 consecutive outpatients referred for gastrointestinal(GI) endoscopy [381 for esophagogastroduodenoscopy(EGD) and 408 for colonoscopy] were prospectively enrolled in the study.The American Society for Gastrointestinal Endoscopy(ASGE) guidelines were used to assess the relationship between appropriateness and the presence of relevant endoscopic f indings.RESULTS:The overall inappropriate rate was 13.3%.The indications for EGD and colonoscopy were,respectively,appropriate in 82.7% and 82.6% of the exams,uncertain in 5.8% and 2.4% and inappropriate in 11.5% and 15%.The diagnostic yield was signif icant higher forEGDs and colonoscopies judged appropriate and uncertain when compared with those considered inappropriate(EGD:36.6% vs 36.4% vs 11.4%,P = 0.004;Colonoscopy:24.3% vs 20.0% vs 3.3%,P = 0.001).Of the 25 malignant lesions detected,all but one was detected in exams judged appropriate or uncertain.CONCLUSION:This study shows a good adherence to ASGE guidelines by the referring physicians and a significant increase of the diagnostic yield in appropriate examinations,namely in detecting neoplastic lesions.It underscores the importance that the appropriateness of the indication assumes in assuring high-quality GI endoscopic procedures. | Joo Mangualde Marie I Cremers Ana M Vieira Ricardo Freire lia Gamito Cristina Lobato Ana L Alves Fátima Augusto Ana P Oliveira | 2011 | World Journal of Gastrointestinal Endoscopy2011，3，10： | 2 |
| 5 | Astrocyte elevated gene-1 regulates hepatocellular carcinoma development and progression显示文摘 | Yoo Byoung Kwon Emdad Luni Su Zao-zhong Villanueva Augusto Chiang Derek Y Mukhopadhyay Nitai D Mills Alan Scott Waxman Samuel Fisher Robert A Llovet Josep M Fisher Paul B Sarkar Devanand | 2009 | Journal of Clinical Investigation2009，，3： | 2 |
| 6 | Decreased arginine and nitrite levels in nitrate reductasedeficient Arabidopsis thaliana plants impair nitric oxide synthesis and the hypersensitive response to Pseudomonas syringae显示文摘 | Modolo L V Augusto O Almeida I M G | 2006 | Plant Science2006，171，1： | 1 |
| 7 | Prognostic factors in advancedcancer Patients: evidence-based clinical recommendations-a study bythe Steering Committee of the European Association for palliativecare显示文摘 | Marco M Augusto C Cinzia B | 2015 | J Clin Oncol2015，23，25： | 1 |
| 8 | Microbial reduction of cyclohexanones显示文摘 | de Conti R M Porto A L M Augusto J | 2001 | Journal of Molecular Catalysis B:Enzymatic2001，11，4： | 1 |
| 9 | Contextual Factors and the Creativity of Frontline Employees:The Mediating Effects of Role Stress and Intrin- sic Motivation显示文摘 | Coelho F Augusto M Lages L F | 2011 | Journal of Retailing2011，87，1： | 1 |
| 10 | Familial isolated growth hormone deficiency is associated with increased systolic blood pressure 显示文摘 | Augusto J Regina M Salvatoti R | 2002 | J Clin Endocrinol Metab2002，87，5： | 1 |
| 11 | Job characteristics and the creativity of frontline service employees显示文摘 | Coelho F Augusto M | 2010 | Journal of Service Research2010，13，4： | 1 |
| 12 | Steviol effect, a glycoside of Stevia rebaudiana, on glucose clearances in rats 显示文摘 | Mehs M S Rocha S T Augusto A | 2009 | Brazilian Journal of Biology2009，69，2： | 1 |
| 13 | Using computational fluid dynamics (CFD) for the evaluation of beer pas-teurization: effect of orientation of cans显示文摘 | Augusto PED Pinheiro TF Cristianini M | 2010 | Food Science and Technology(Campinas)2010，30，4： | 1 |
| 14 | Pathogenesis of hepatocellular carcinoma and molecular therapies显示文摘 | Beatriz Mínguez Victoria Tovar Derek Chiang Augusto Villanueva Josep M Llovet | 2009 | Current Opinion in Gastroenterology2009，，3： | 1 |
| 15 | Numerical simulation of packed liquid food thermal process using computational fluid dynamics (CFD) 显示文摘 | Augusto P E D Cristianini M | 2011 | International Journal of Food Engineering2011，7，4： | 1 |
| 16 | Job characteristics and the cre-ativity of frontline service employees 显示文摘 | Coelho F Augusto M | 2010 | Journal of Service Research2010，13，4： | 1 |
| 17 | Steyaert and willy sansen a 12- bit intrinsic accuracy high- speed CMOS DAC显示文摘 | Jose Bastos Augusto M Marques Michel S J | 1998 | IEEE Journal of Solid--State Circuits1998，33，12： | 1 |
| 18 | Numerical simulation of packed liquid food thermal process using computational flu- id dynamics 显示文摘 | Augusto P E D Cristianini M | 2011 | International Journal of Food Engineer- ing2011，7，4： | 1 |
| 19 | Market orientation and new-to- the-world products: exploring the moderating effects of innova- tiveness, competitive strength,and environmental forces显示文摘 | AUGUSTO M COELHO F | 2007 | In- dustrial Marketing Management2007，38，： | 1 |
| 20 | Evaluation of geometric symmetry condition in numerical simulations of thermal process of packed liquid food by computational fluid dy- namics (CFD) 显示文摘 | Augusto P E D Cristianini M | 2010 | International Journal of Food Engi- neering2010，6，5： | 1 |
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