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| 1 | Updates in the pathophysiological mechanisms of Parkinson's disease: Emerging role of bone marrow mesenchymal stem cells显示文摘AIM: To explore the approaches exerted by mesenchymal stem cells(MSCs) to improve Parkinson's disease(PD) pathophysiology.METHODS: MSCs were harvested from bone marrowof femoral bones of male rats, grown and propagated in culture. Twenty four ovariectomized animals were classified into 3 groups: Group(1) was control, Groups(2) and(3) were subcutaneously administered with rotenone for 14 d after one month of ovariectomy for induction of PD. Then, Group(2) was left untreated, while Group(3) was treated with single intravenous dose of bone marrow derived MSCs(BM-MSCs). SRY gene was assessed by PCR in brain tissue of the female rats. Serum transforming growth factor beta-1(TGF-β1), monocyte chemoattractant protein-1(MCP-1) and brain derived neurotrophic factor(BDNF) levels were assayed by ELISA. Brain dopamine DA level was assayed fluorometrically, while brain tyrosine hydroxylase(TH) and nestin gene expression were detected by semi-quantitative real time PCR. Brain survivin expression was determined by immunohistochemical procedure. Histopathological investigation of brain tissues was also done.RESULTS: BM-MSCs were able to home at the injured brains and elicited significant decrease in serum TGF-β1(489.7 ± 13.0 vs 691.2 ± 8.0, P < 0.05) and MCP-1(89.6 ± 2.0 vs 112.1 ± 1.9, P < 0.05) levels associated with significant increase in serum BDNF(3663 ± 17.8 vs 2905 ± 72.9, P < 0.05) and brain DA(874 ± 15.0 vs 599 ± 9.8, P < 0.05) levels as well as brain TH(1.18 ± 0.004 vs 0.54 ± 0.009, P < 0.05) and nestin(1.29 ± 0.005 vs 0.67 ± 0.006, P < 0.05) genes expression levels. In addition to, producing insignificant increase in the number of positive cells for survivin(293.2 ± 15.9 vs 271.5 ± 15.9, P > 0.05) expression. Finally, the brain sections showed intact histological structure of the striatum as a result of treatment with BM-MSCs. CONCLUSION: The current study sheds light on the therapeutic potential of BM-MSCs against PD pathophysiology via multi-mechanistic actions. | Hanaa H Ahmed Ahmed M Salem Hazem M Atta Emad F Eskandar Abdel Razik H Farrag Mohamed A Ghazy Neveen A Salem Hadeer A Aglan | 2016 | World Journal of Stem Cells2016，8，3： | 9 |
| 2 | Antidiarrhoeal activity of some Egyptian medicinal plant extracts显示文摘 | Attia H Atta Samar M Mouneir | 2004 | Journal of Ethnopharmacology2004，，2： | 2 |
| 3 | Evaluation of some medicinal plant extracts for antidiarrhoeaI activity 显示文摘 | Atta A H Mouneir S M | 2005 | Phytother Res2005，19，6： | 1 |
| 4 | Antidiarrhoeal activity of some Egyptian medicinal plant extracts 显示文摘 | Atta A H Mouneir S M | 2004 | J Ethnopharmacol2004，92，30： | 1 |
| 5 | Effect of CAD-CAM porcelain veneers thickness on their cemented color 显示文摘 | Omar H Atta O E1-Mowafy O | 2010 | J Dent2010，382，： | 1 |
| 6 | The antinociceptive effect of some Egyptian medicinal plant extracts 显示文摘 | Atta A H EL-Sooud K A | 2004 | J Ethnopharmacol2004，95，23： | 1 |
| 7 | Antifungal Mac- rodiode Production By Streptomyces albidoflavus-143: Fermentation, Purification and Biological Activities 显示文摘 | Honssam M Atta E1-Sehrawi M H Bahobail A S | 2011 | Journal of American Sci- ence2011，7，3： | 1 |
| 8 | Multi-layer double coil micro-fabricated transformer 显示文摘 | | 2004 | Sensors and Actuators A2004，112，： | 1 |
| 9 | Depletion of trimethoprim and sulphadiazine from eggs of laying hens receiving trimethoprim/sulphadiazine combination显示文摘 | ATTA A H SAMIAA E Z | 2001 | Food Control2001，12，： | 1 |
| 10 | The decay of turbulence in thermally stratified flow 显示文摘 | LIRNHARD J H VON ATTA C W | 1990 | Journal of Fluid Mechanics1990，210，： | 1 |
| 11 | Crosslinked poly(octadecene-alt-maleic anhydride) copolymers as crude oil sorbers显示文摘 | ATTA A M EL-HAMOULY S H ALSABAGH A M | 2007 | J Appl Polym Sci2007，105，4： | 1 |
| 12 | Kinetics of cellgrowth and cyclosporin A production by Tolypocladiuminflatum when scaling up from shake flask to bioreactor 显示文摘 | El Enshasy H Abdel Fattah Y Atta A | 2008 | J Microbiol Biotechnol2008，18，1： | 1 |
| 13 | Putative role of carbon monoxide signaling pathway in penile erectile function 显示文摘 | Abdel Aziz MT Mostafa T Atta H | 2009 | J Sex Med2009，6，1： | 1 |
| 14 | Effect of levamisole hydrochloride on the immune response to Newcastle disease virus vaccine in chickens显示文摘 | Hassan A B Atta A H Soliman R T | 1989 | Indian Vet J1989，66，： | 1 |
| 15 | Some properties of extraeellular acetylxylan esterase produced by the yeast Rhodotorula mucilaginosa 显示文摘 | Lee H To R J l atta R K | 1987 | App Environ Micmbiol1987，53，12： | 1 |
| 16 | A sustainable approach to the recycling of rice straw through pelletization and controlled burning 显示文摘 | Ewida K T El-Salmawy H Atta N N | 2006 | Clean Technologies and Environmental Policy2006，8，3： | 1 |
| 17 | Oral phosphodiesterase5 inhibitors:effect of heme oxygenase inhibition on cGMP signalling in rat cavernous tissue显示文摘 | Abdel Aziz MT Mostafa T Atta H | 2007 | Andrologia2007，39，2： | 1 |
| 18 | Pharmacokinetics and tissue residues oI kitasamycin in healthy and diseased broilers显示文摘 | HASSAN A B ATTA A H SOLIMAN Z I | 1990 | Dtsch Tieriirztl Wochenschr1990，97，8： | 1 |
| 19 | Quality and sensory evaluation of meat from nilotic male kids fed on two different diets显示文摘 | ADAM A A G ATTA M ISMAIL S H A | 2010 | Journal of Animal and Veterinary Advances2010，9，15： | 1 |
| 20 | Comparative pharmacokinetics of doramectin and ivermectin in sheep显示文摘 | Atta A H Abo-Shihada M N | 2000 | J Vet Pharmacol Therap2000，23，： | 1 |
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