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| 1 | Photodynamic therapy vs radiofrequency ablation for Barrett's dysplasia: Efficacy,safety and cost-comparison显示文摘AIM:To compare effectiveness,safety,and cost of photodynamic therapy(PDT)and radiofrequency ablation(RFA)in treatment of Barrett’s dysplasia(BD).METHODS:Consecutive case series of patients undergoing either PDT or RFA treatment at single center by a single investigator were compared.Thirty-three patients with high-grade dysplasia(HGD)had treatment with porfimer sodium photosensitzer and 630 nm laser(130 J/cm),with maximum of 3 treatment sessions.Fifty-three patients with BD(47 with low-grade dysplasia-LGD,6 with HGD)had step-wise circumferential and focal ablation using the HALO system with maximum of 4 treatment sessions.Both groups received proton pump inhibitors twice daily.Endoscopic biopsies were acquired at 2 and 12 mo after enrollment,with 4-quadrant biopsies every 1 cm of the original BE extent.A complete histological resolution response of BD(CR-D)was defined as all biopsies at the last endoscopy session negative for BD.Fisher’s exact test was used to assess differences between the two study groups for primary outcomes.For all outcomes,a two-sided P value of less than 0.05 was considered to indicate statistical significance.RESULTS:Thirty(91%)PDT patients and 39(74%)RFA were men(P=0.05).The mean age was 70.7±12.2 and 65.4±12.7(P=0.10)year and mean length of BE was 5.4±3.2 cm and 5.7±3.2 cm(P=0.53)for PDT and RFA patients,respectively.The CR-D was(18/33)54.5%with PDT vs(47/53)88.7%with RFA(P=0.001).One patient with PDT had an esophageal perforation and was managed with non-surgical measures and no perforation was seen with RFA.PDT was five times more costly than RFA at our institution.The two groups were not randomized and had different BD grading are the limitations of the study.CONCLUSION:In our experience,RFA had higher rate of CR-D without any serious adverse events and was less costly than PDT for endoscopic treatment of BD. | Atilla Ertan Irum Zaheer Arlene M Correa Nirav Thosani Shanda H Blackmon | 2013 | World Journal of Gastroenterology2013，19，41： | 7 |
| 2 | Gastric, duodenal, and pancreatic somatostatin-like immunoreactivity during hypovolemic shock显示文摘 | David Wiles Oktay Yeginsu MD Ali Ozden MD Steve M. Covington MD Janet Rice PhD Atilla Ertan MD | 1988 | Digestive Diseases and Sciences1988，，7： | 2 |
| 3 | The Significance of 'Indefinite for Dysplasia' Grading in Barrett Metaplasia显示文摘 | Younes Mamoun Lauwers Gregory Y Ertan Atilla Ergun Gulchin Verm Ray Bridges Margaret Woods Karen Meriano Frank Schmulen Carl Johnson Craig Barroso Alberto Schwartz Jim McKechnie John Lechago Juan | 2011 | Archives of Pathology & Laboratory Medicine2011，，： | 1 |
| 4 | p53 Protein Accumulation Is a Specific Marker of Malignant Potential in Barrett’s Metaplasia显示文摘 | Mamoun Younes Atilla Ertan Lia V. Lechago Jacqueline R. Somoano Juan Lechago | 1997 | Digestive Diseases and Sciences1997，，4： | 1 |
| 5 | Role of self-expanding metal stents in patients with malignant colorectal obstruction: A systematic review and meta-analysis显示文摘AIM: To assess the safety and efficacy of self-expandable metal stents(SEMSs) for malignant colorectal obstruction. METHODS: Data regarding technical success, clinical success, and procedure related complications were collected from included studies. Der Simonian-Laird random effects model was used to generate the overall outcome. Thirty international studies with a total of 2058 patients with malignant colorectal obstruction were included. RESULTS: The technical and clinical success rates for SEMS placement were 94%(95%CI: 92-96) and 91%(95%CI: 88-93), respectively. Overall complication rate for SEMS was 23%(95%CI: 18-29). Stent migration8%(95%CI: 6-10) and stent obstruction 8%(95%CI: 6-11) were the most common complications, followed by perforation 5%(95%CI: 4%-7%). Surgical or endoscopic re-interventions were needed in 14%(95%CI: 10-18) of patients. Endoscopic repeat stent placement was required in 8%(95%CI: 6-10), while surgical intervention was needed in 6%(95%CI: 4-8).CONCLUSION: SEMS are effective when used as palliation or bridge to surgery for malignant colorectal obstruction with high technical and clinical success. About 14% of patients require repeat endoscopic or surgical intervention for stent failure or to manage stent related complications. | Nirav Thosani Subhas Banerjee Vikesh Khanijow Bhavana Rao Priyanka Priyanka Atilla Ertan Sushovan Guha | 2015 | World Journal of Meta-Analysis2015，3，6： | 0 |
| 6 | 腐植酸+黄腐酸缓解Cd对独行菜植株生长、生理和生化特性的不利影响显示文摘镉(Cd)是一种有毒的、流动性很强的重金属,可以被植物大量地吸附和吸收而没有任何明显的迹象。因此,对保护生物多样性和食品安全来说,在植物吸收之前稳定Cd是至关重要的。由于在其结构中含有大量的羧基和酚羟基,腐殖物质与重金属形成强烈的结合,这使它们成为完美的稳定剂。本研究的目的是确定在温室条件下,腐植酸和黄腐酸(HA+FA)的水平(0、3500、5250和7000 mg/L)对减轻独行菜(Lepidium sativum)受Cd(CdSO_(4)•8H_(2)O,0、100和200 Cd mg/kg)污染的Cd毒性的影响。我们的研究结果表明,Cd胁迫对独行菜的生长有负面影响,叶鲜重、叶干重、根鲜重和根干重、叶片相对含水量(LRWC)和除Cd外的矿物质含量均下降,膜渗透性(MP)和酶(CAT、SOD和POD)活性增加。然而,HA+FA的应用减少了Cd污染的不利影响。在200 mg/kg的Cd污染下,HA+FA的应用浓度为7000 mg/L时,与对照组相比,叶鲜重、叶干重、根鲜重、根干重、茎粗、叶面积、叶绿素读取值(CRV)、MP和LRWC值分别增加了262%、137%、550%、133%、92%、104%、34%、537%和32%。尽管在200 mg/L的镉污染下获得了最高的H2O2、丙二醛(MDA)、脯氨酸和蔗糖值,但HA+FA的应用浓度在200 mg/kg的Cd污染水平下,7000 mg/L的HA+FA成功地缓解了Cd胁迫的有害影响,使H2O2、MDA、脯氨酸和蔗糖值分别下降了66%、68%、70%和56%。浓度为7000 mg/L的HA+FA应用成功地缓解了Cd污染的负面影响,使N、P、K、Ca、Mg、Fe、Mn、Cu、Zn和B分别提高75%、23%、84%、87%、40%、85%、143%、1%、65%和115%。此外,HA+FA的应用浓度为7000 mg/L成功地减少了95%的Cd吸收和80%的Cl吸收。考虑到植物生长参数,当HA+FA浓度为7000 mg/L时,确定了最佳结果。我们已经证明,使用高比例的FA的腐殖质是非常关键的,FA的比例为10%,可以达到减轻重金属胁迫对植物生长不利影响的目的。总之,HA+FA的应用可以作为一种有效的解决方案,通过稳定土壤中的Cd,防止Cd从植物的根部转移到其嫩枝和叶片,从而减少植物对Cd的吸收。 | Ertan Yildirim Melek Ekinci Metin Turan Güleray Ağar Atilla Dursun Raziye Kul Zeynep Alim Sanem Argin 牛华琳(译) 庄琪(译) | 2023 | 腐植酸2023，，6： | 0 |
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