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| 1 | Preoperative therapy in locally advanced esophageal cancer显示文摘Esophageal cancer is an aggressive malignancy associated with dismal treatment outcomes. Presence of two distinct histopathological types distinguishes it from other gastrointestinal tract malignancies. Surgery is the cornerstone of treatment in locally advanced esophageal cancer(T2 or greater or node positive); however, a high rate of disease recurrence(systemic and loco-regional) and poor survival justifies a continued search for optimal therapy. Various combinations of multimodality treatment(preoperative/perioperative, or postoperative; radiotherapy, chemotherapy, or chemoradiotherapy) are being explored to lower disease recurrence and improve survival. Preoperative therapy followed by surgery is presently considered the standard of care in resectable locally advanced esophageal cancer as postoperative treatment may not be feasible for all the patients due to the morbidity of esophagectomy and prolonged recovery time limiting the tolerance of patient. There are wide variations in the preoperative therapy practiced across the centres depending upon the institutional practices, availability of facilities and personal experiences. There is paucity of literature to standardize the preoperative therapy. Broadly, chemoradiotherapy is the preferred neo-adjuvant modality in western countries whereas chemotherapy alone is considered optimal in the far East. The present review highlights the significant studies to assist in opting for the best evidence based preoperative therapy(radiotherapy, chemotherapy or chemoradiotherapy) for locally advanced esophageal cancer. | Pankaj Kumar Garg Jyoti Sharma Ashish Jakhetiya Aakanksha Goel Manish Kumar Gaur | 2016 | World Journal of Gastroenterology2016，22，39： | 13 |
| 2 | Neuroendocrine neoplasms of liver-A 5-year retrospective clinico-pathological study applying World Health Organization 2010 classification显示文摘AIM To study the clinicopathological characteristics of neuroendocrine neoplasms(NEN) on liver samples and apply World Health Organization(WHO) 2010 grading of gastroenteropancreatic(GEP) NEN.METHODS Clinicopathological features of 79 cases of NEN of the liver diagnosed between January 2011 to December 2015 were analyzed. WHO 2010 classification of GEP NEN was applied and the tumors were graded as G1, G2 or G3. Two more categories, D1/2(discordant 1/2) and D2/3(discordant 2/3) were also applied. The D1/2 grade tumors had a mitotic count of G1 and Ki-67 index of G2. The D2/3 tumors had a mitotic count of G2 and Ki-67 index of G3. The follow up details which were available till the end of the study period(December 2015) were collected.RESULTS Of the 79 tumors, 16 each were G1 and G2, and 18 were G3 tumors. Of the remaining 29 tumors, 13 were assigned to D1/2 and 16 were D2/3 grade. Male preponderance was noted in all tumors except for G2 neoplasms, which showed a slight female predilection. The median age at presentation was 47 years(range 10-82 years). The most common presentation was abdominal pain(81%). Pancreas(49%) was the most common site of primary followed by gastrointestinal tract(24.4%) and lungs(18%). Radiologically, 87% of the patients had multiple liver lesions. Histopathologically, necrosis was seen in only D2/3 and G3 tumors. Microvascular invasion was seen in all grades. Metastasis occurred in all grades of primary NEN and the grades of the metastatic tumors and their corresponding primary tumors were similar in 67% of the cases. Of the 79 patients, 36 had at least one follow up visit with a median duration of follow up of 8.5 mo(range: 1-50 mo). This study did not show any impact of the grade of tumor on the short term clinical outcome of these patients.CONCLUSION Liver biopsy is an important tool for clinicopathological characterization and grading of NEN, especially when the primary is not identified. Eighty-seven percent of the patients had multifocal liver lesions irrespective of the WHO grade, indicating a higher stage of disease at presentation. Follow up duration was inadequate to derive any meaningful conclusion on long term outcome in our study patients. | Deepak Kalyansingh Burad Thomas Alex Kodiatte Sayd Mohamed Rajeeb Ashish Goel Chundamannil Eapen Eapen Banumathi Ramakrishna | 2016 | World Journal of Gastroenterology2016，22，40： | 10 |
| 3 | The hemispheric asymmetry of solar activity during the last century and the solar dynamo显示文摘We believe the Babcock-Leighton process of poloidal field generation to be the main source of irregularity in the solar cycle.The random nature of this process may make the poloidal field in one hemisphere stronger than that in the other hemisphere at the end of a cycle.We expect this to induce an asymmetry in the next sunspot cycle.We look for evidence of this in the observational data and then model it theoretically with our dynamo code.Since actual polar field measurements exist only from the 1970s,we use the polar faculae number data recorded by Sheeley(1991,2008) as a proxy of the polar field and estimate the hemispheric asymmetry of the polar field in different solar minima during the major part of the twentieth century.This asymmetry is found to have a reasonable correlation with the asymmetry of the next cycle.We then run our dynamo code by feeding information about this asymmetry at the successive minima and compare the results with observational data.We find that the theoretically computed asymmetries of different cycles compare favorably with the observational data,with the correlation co-efficient being 0.73.Due to the coupling between the two hemispheres,any hemispheric asymmetry tends to get attenuated with time.The hemispheric asymmetry of a cycle ei-ther from observational data or from theoretical calculations statistically tends to be less than the asymmetry in the polar field(as inferred from the faculae data) in the preceding minimum.This reduction factor turns out to be 0.43 and 0.51 respectively in observational data and theoretical simulations. | Ashish Goel Arnab Rai Choudhuri | 2009 | Chinese Journal of Astronomy and Astrophysics2009，9，1： | 2 |
| 4 | Oblivious AQM and nash equilibria显示文摘 | Debojyoti Dutta Ashish Goel John Heidemann | | 0，，： | 1 |
| 5 | Endoscopic management of intraventricular neurocysticercosis显示文摘 | Rohit Kumar Goel Faiz Uddin Ahmad Ananth Kesav Vellimana Ashish Suri P. Sarat Chandra Rajinder Kumar Bhawani Shankar Sharma Ashok Kumar Mahapatra | 2007 | Journal of Clinical Neuroscience2007，，： | 1 |
| 6 | Obesity, and not obstructive sleep apnea, is responsible for metabolic abnormalities in a cohort with sleep-disordered breathing显示文摘 | S.K. Sharma Saket Kumpawat Ashish Goel Amit Banga Lakshmi Ramakrishnan Pradeep Chaturvedi | 2006 | Sleep Medicine2006，，1： | 1 |
| 7 | Matching output queueing with a combined input/output-queued switch 显示文摘 | Chuang S T Goel Ashish McKeown Nick | 1999 | IEEE J Select Areas Communications1999，17，6： | 1 |
| 8 | Idiopathic Non-Cirrhotic Intrahepatic Portal Hypertension (NCIPH)—Newer Insights into Pathogenesis and Emerging Newer Treatment Options显示文摘 | Ashish Goel Joshua E. Elias Chundamannil E. Eapen Banumathi Ramakrishna Elwyn Elias | 2014 | Journal of Clinical and Experimental Hepatology2014，，3： | 1 |
| 9 | Clinical profile and predictors of disease behavior and surgery in Indian patients with Crohn’s disease显示文摘 | Ashish Goel Amit Kumar Dutta Anna B. Pulimood Anu Eapen Ashok Chacko | 2013 | Indian Journal of Gastroenterology2013，，3： | 1 |
| 10 | Efficient computation of delay-sensitive routes from one source to all destinations显示文摘 | Goel Ashish Ramakrishnan K G Kataria Deepak Logothetis Dimitris | 2001 | IEEE INFOCOM 2001-The Conference on Computer Communications2001，4，1： | 1 |
| 11 | Common polymorphisms of protein tyrosine phosphate non-receptor type 2 gene are not associated with risk of Crohn’s disease in Indian显示文摘BACKGROUND Multiple genetic risk factors for Crohn’s disease(CD)have been identified.However,these observations are not consistent across different populations.The protein tyrosine phosphate non-receptor type 2(PTPN2)gene plays a role in various aspects of host defense including epithelial barrier function,autophagy,and innate and adaptive immune response.Two common polymorphisms in the PTPN2 gene(rs2542151 and rs7234029)have been associated with risk of CD in Western countries.AIM To evaluate the association of PTPN2 gene polymorphisms with risk of CD in Indian population.METHODS We conducted a prospective case-control study.Patients with CD were recruited,and their clinical and investigation details were noted.Controls were patients without organic gastrointestinal disease or other comorbid illnesses.Two common polymorphisms in the PTPN2 gene(rs2542151 and rs7234029)were assessed.DNA was extracted from peripheral blood samples of cases and controls and target DNA was amplified using specific sets of primers.The amplified fragments were digested with restriction enzymes and the presence of polymorphism was detected by restriction fragment length polymorphism.The frequency of alleles was determined.The frequencies of genotypes and alleles were compared between cases and controls to look for significant differences.RESULTS A total of 108 patients with CD(mean age 37.5±12.7 years,females 42.6%)and 100 controls(mean age 39.9±13.5 years,females 37%)were recruited.For the single nucleotide polymorphism(SNP)rs7234029,the overall frequency of G variant genotype(AG or GG)was noted to be significantly lower in the cases compared to controls(35.2%vs 50%,P=0.05).For the SNP rs2542151,the overall frequency of G variant genotype(GT or GG)was noted to be similar in cases compared to controls(43.6%vs 47%,P=0.73).There were no significant differences in minor allele(G)frequency for both polymorphisms between the cases and controls.Both the SNPs had no significant association with age of onset of illness,gender,disease location,disease behaviour,perianal disease,or extraintestinal manifestations of CD.CONCLUSION Unlike observation form the West,polymorphisms in the PTPN2 gene(rs7234029 and rs2542151)are not associated with an increased risk of developing CD in Indian patients. | Kaushik Chatterjee Amit Kumar Dutta Ashish Goel Rekha Aaron Vijayalekshmi Balakrishnan Ajith Thomas Anoop John Rajeeb Jaleel Deepu David Reuben Thomas Kurien SD Chowdhury Ebby George Simon AJ Joseph Prasanna Premkumar Anna B Pulimood | 2022 | World Journal of Gastrointestinal Pathophysiology2022，13，4： | 0 |
| 12 | Role of gemcitabine and cisplatin as neoadjuvant chemotherapy in muscle invasive bladder cancer: Experience over the last decade显示文摘Objective:Neoadjuvant chemotherapy followed by radical cystectomy is considered the standard of care for patients with muscle invasive bladder cancer.In the last decade,interest in neoadjuvant chemotherapy has slowly shifted from methotrexate,vinblastine,doxorubicin and cisplatin regime to gemcitabine and cisplatin regime.There are many publications on gemcitabine and cisplatin regime in literature which cover different aspects of treatment.This review aims to summarise the findings published so far on gemcitabine and cisplatin regime and present it in a concise manner.Methods:A systematic literature review was conducted searching the PubMeddatabase in December 2016 using the medical subject heading(MeSH)with the terms gemcitabine,cisplatin,chemotherapy,muscle invasive bladder cancer,and neoadjuvant.All relevant studies were included and results were analysed.Results:A total of 13 studies were included which published between 2007 and 2015.These 13 studies comprised of 754 subjects suffering from muscle invasive bladder cancer.The proportion of male patients ranged from 60%to 86.4%and the median age ranged from 54.2 to 77.3 years in various studies.Complete pathological response(pT0)was seen in 30.0%of patients and pathological downstaging( | Sunny Goel Rahul J.Sinha Ved Bhaskar Ruchir Aeron Ashish Sharma Vishwajeet Singh | 2019 | Asian Journal of Urology2019，6，3： | 0 |
| 13 | Clinical profile of febrile encephalopathy patients at a tertiary care hospital in India:A retrospective study显示文摘Objective:To investigate demography,etiology,and clinical profile and to analyze the outcomes of patients presenting with febrile encephalopathy at a tertiary care center in Eastern India.Methods:This retrospective,observational study included a total of 50 patients(>18 years)who presented with fever and encephalopathy.All patients underwent blood analysis;culture test for blood,urine,sputum,cerebrospinal fluid,and other body fluids;chest and abdominal ultrasonography;neuroimaging;polymerase chain reaction test,and other relevant tests as and when applicable.Results:The mean age of all enrolled patients was(58.0±16.0)years with male to female ratio of 1.27꞉1.Viral encephalitis was diagnosed in 16(32%)patients,sepsis-associated encephalitis in 14(28%),bacterial meningoencephalitis in 8(16%)and tuberculosis meningoencephalitis in 5(10%).The mean hospital stay was 10(4,17)days.At 6-month follow-up,10(20%)patients died,10(20%)patients recovered with sequelae(cognitive impairment,critical care neuropathy,etc.),and 30(60%)patients recovered without sequelae.A statistically significant association was noted between Glasgow Coma Scale(<8)and mortality rate(P=0.02).Conclusions:Primary central nervous system infection is the most frequent etiology of febrile encephalopathy and viral encephalitis is the most common etiological cause.Accurate,systematic,timely diagnosis and management are prime factors to reduce mortality and morbidity. | Sanjeev Sengupta Ashish Kumar Shukla Kunal Kishore Jitesh Goel Amlan Ghosh | 2023 | Journal of Acute Disease2023，12，4： | 0 |
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