2篇
您的检索式：作者名="Ved Bhaskar"
|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Revisiting the role of mesenchymal stem cells in tuberculosis and other infectious diseases显示文摘Mesenchymal stem cells(MsCs)play diverse roles ranging from regeneration and wound healing to immune signaling.Recent investigations have indicated the crucial role of these multipotent stem cells in regulating various aspects of the immune system.MsCs express unique signaling molecules and secrete various soluble factors that play critical roles in modulating and shaping immune responses,and in some other cases,MSCs can also exert direct antimicrobial effects,thereby helping with the eradication of invading organisms.Recently,it has been demonstrated that MSCs are recruited at the periphery of the granuloma containing Mycobacterium tuberculosis and exert'Janus'-like functions by harboring pathogens and mediating host protective immune responses.This leads to the establishment of a dynamic balance between the host and the pathogen.MsCs function through various immunomodulatory factors such as nitric oxide(NO),IDO,and immunosuppressive cytokines.Recently,our group has shown that M.tb uses MSCs as a niche to evade host protective immune surveillance mechanisms and establish dormancy.MSCs also express a large number of ABC efflux pumps;therefore,dormant M.tb residing in MSCs are exposed to a suboptimal dose of drugs.Therefore,it is highly likely that drug resistance is coupled with dormancy and originates within MSCs.In this review,we discussed various immunomodulatory properties of MsCs,their interactions with important immune cells,and soluble factors.We also discussed the possible roles of MsCs in the outcome of multiple infections and in shaping the immune system,which may provide insight into therapeutic approaches using these cells in different infection models. | Annu Devi Isha Pahuja Shashi Prakash Singh Akanksha Verma Debapriya Bhattacharya Ashima Bhaskar Ved Prakash Dwivedi Gobardhan Das | 2023 | Cellular & Molecular Immunology2023，20，6： | 0 |
| 2 | Role of gemcitabine and cisplatin as neoadjuvant chemotherapy in muscle invasive bladder cancer: Experience over the last decade显示文摘Objective:Neoadjuvant chemotherapy followed by radical cystectomy is considered the standard of care for patients with muscle invasive bladder cancer.In the last decade,interest in neoadjuvant chemotherapy has slowly shifted from methotrexate,vinblastine,doxorubicin and cisplatin regime to gemcitabine and cisplatin regime.There are many publications on gemcitabine and cisplatin regime in literature which cover different aspects of treatment.This review aims to summarise the findings published so far on gemcitabine and cisplatin regime and present it in a concise manner.Methods:A systematic literature review was conducted searching the PubMeddatabase in December 2016 using the medical subject heading(MeSH)with the terms gemcitabine,cisplatin,chemotherapy,muscle invasive bladder cancer,and neoadjuvant.All relevant studies were included and results were analysed.Results:A total of 13 studies were included which published between 2007 and 2015.These 13 studies comprised of 754 subjects suffering from muscle invasive bladder cancer.The proportion of male patients ranged from 60%to 86.4%and the median age ranged from 54.2 to 77.3 years in various studies.Complete pathological response(pT0)was seen in 30.0%of patients and pathological downstaging( | Sunny Goel Rahul J.Sinha Ved Bhaskar Ruchir Aeron Ashish Sharma Vishwajeet Singh | 2019 | Asian Journal of Urology2019，6，3： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员