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| 1 | Combined carriership of TLR9 -1237C and CD14 -260T alleles enhances the risk of developing chronic relapsing pouchitis显示文摘AIM: To investigate the single nucleotide polymorphisms (SNPs) in genes involved in bacterial recognition and the susceptibility to pouchitis or pouchitis severity.METHODS: Analyses of CD14 -260C>T, CARD15/NOD2 3020insC, Toll-like receptor (TLR)4 +896A>G,TLR9 -1237T>C, TLR9+ 2848G>A, and IRAKM +22148G>A SNPs were performed in 157 ileal-pouch anal anastomosis (IPAA) patients (79 patients who did not develop pouchitis, 43 infrequent pouchitis patients,35 chronic relapsing pouchitis patients) and 224 Italian Caucasian healthy controls.RESULTS: No significant differences were found in SNP frequencies between controls and IPAA patients.However, a significant difference in carriership frequency of the TLR9-1237C allele was found between the infrequent pouchitis and chronic relapsing pouchitis groups [P = 0.028, odd's ratio (OR) = 3.2, 95%CI = 1.2-8.6].This allele uniquely represented a 4-locus TLR9 haplotype comprising both studied TLR9 SNPs in Caucasians.Carrier trait analysis revealed an enhanced combined carriership of the alleles TLR9 -1237C and CD14 -260T in the chronic relapsing pouchitis and infrequent pouchitis group (P = 0.018, OR = 4.1, 95%CI = 1.4 -12.3).CONCLUSION: There is no evidence that the SNPs predispose to the need for IPAA surgery. The significant increase of the combined carriership of the CD14 -260T and TLR9 -1237C alleles in the chronic relapsing pouchitis group suggests that these markers identify a subgroup of IPAA patients with a risk of developing chronic or refractory pouchitis. | KM Lammers S Ouburg SA Morré JBA Crusius P Gionchetti F Rizzello C Morselli E Caramelli R Conte G Poggioli M Campieri AS Pea | 2005 | World Journal of Gastroenterology2005，11，46： | 7 |
| 2 | 卒中介入治疗培训指南:国际多学会共识文件显示文摘1背景
缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞(emergent large vesselocclusion,ELVO)患者都会遗留长期残疾。事实上,这些颅内大动脉闭塞经常会导致大面积脑损伤,进而造成患者死亡或严重致残。 | Lavine SD Cockroft K Hoh B Bambakidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderman M Taylor A Krings T Orbach D Picard L Suh DC Zheng HQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N Matsumaru Y Yoshknura S Ezura M Fujinaka T Iihara K Ishii A Higashi T Hirohata M Hyodo A Ito Y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto Y Miyachi S Murayama Y Nagata I Nakahara I Nemoto S Niimi Y Oishi H Satomi J Satow T Sugiu K Tanaka M Terada T Yamagami H Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi TM Mack WJ McTaggart RA Meyers PM Mocco J Prestigiacomo CA Pride GL Rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩 孙瑞 郭芮兵 | 2017 | 国际脑血管病杂志2017，25，5： | 2 |
| 3 | Primary, nonsyndromic reflux and its nephropathy is genetically heterogeneous, with a locus on chromosome 1显示文摘 | Feather SA Malcolm S Woolf AS | 2000 | Am J Hum Genet2000，66，4： | 1 |
| 4 | Subcutaneous vs submuscular ulnar nerve transposition in moderate cubital tunnel syndrome显示文摘 | Jaddue DA Saloo SA Ssyed-Noor AS | 2009 | Open Orthop J2009，3，： | 1 |
| 5 | Anti-angiogenesis efficacy of the garlic ingredient alliin and antioxidants:role of nitric oxide and p53显示文摘 | Mousa AS Mousa SA | 2005 | Nutr Cancer2005，53，9： | 1 |
| 6 | Magnetic resonance imaging and confocal microscopy studies of magnetically labeled endothelial progenitor cells trafficking to sites of tumor angiogenesis 显示文摘 | Arbab AS Pandit SD Anderson SA | 2006 | Stem Cells2006，24，3： | 1 |
| 7 | Tissue Doppler E/E' ratio is a Powerful predictor of primary cardiac events in a hypertensive popula- tion:an ASCOT substudy显示文摘 | Sharp AS Tapp RJ Tliom SA | 2010 | Eur Heart J2010，31，6： | 1 |
| 8 | Muhilevel targeting of hematopoietic stem cell self-re- newal, differentiation and apoptosis for leukemia therapy 显示文摘 | TSIFTSOGLOU AS BONOVOLIAS ID TsIFrSOGLOU SA | 2009 | Pharmacol Ther2009，122，3： | 1 |
| 9 | Pattern of pathogens and their sensitivity isolated from superficial surgical site infections in a tertiary care hospital显示文摘 | Ali SA Tahir SM Memon AS | 2009 | J Ayub Med Coll Abbottabad2009，21，2： | 1 |
| 10 | Spondyloepiphyseal dysplasia tarda with progressive arthropathy: a rare disorder fre- quently diagnosed among Arabs 显示文摘 | Teebi AS A1 Awadi SA | 1986 | J Med Genet1986，23，2： | 1 |
| 11 | Internal iliac and ovarian artery ligation in the control of pelvic haemorrhage显示文摘 | Thavarasah AS Sivalingam N Almohdzar SA | 1989 | Aust NZ J Obstet Gynaecol1989，29，： | 1 |
| 12 | Effect of dex- medetomidine added to spinal bupivacaine for urological procedures 显示文摘 | A1-Mustafa MM Abu-Halaweh SA Aloweidi AS | 2009 | Saudi Med J2009，30，3： | 1 |
| 13 | Age and insulin-like growth factor-1 modulate N-methyl-D-aspardate receptor subtype expression in rats显示文摘 | Sonnag WE Bennett SA Khan AS | 2000 | Brain Res Bull2000，51，4： | 1 |
| 14 | Magnetic resonance imaging and confocal microscopy studies of magnetically labeled endothelial progenitor cells trafficking to sites of tumor angiogenesis 显示文摘 | Arbab AS Pandit SD Anderson SA | 2006 | Stern Cells2006，24，3： | 1 |
| 15 | Essential role for IL-10 in resistance to lipopolysaccharide-induced preterm labor in mice显示文摘 | Robertson SA Skinner RJ Care AS | 2006 | J Immunol2006，177，7： | 1 |
| 16 | Knockdown of occludin expression leads to diverse phenotypic alterations in epithelial cells 显示文摘 | Yu AS McCarthy KM Francis SA | 2005 | Am J Physiol Cell Physiol2005，288，： | 1 |
| 17 | Age and insulin-like growth factor-Ⅰ modulate N-methyl-D-aspardate receptor subtype expression in rats显示文摘 | Sonnag WE Bennett SA Khan AS | 2000 | Brain Res Bull2000，51，4： | 1 |
| 18 | Isolated right subcla- vian artery with interrupted aortic arch, ventricular septal defect, and left ventricular outflow tract obstruction显示文摘 | Te-Hoven AS Clur SA Andreu JP | 2015 | World J Pediatr Congenit Heart Surg2015，6，2： | 1 |
| 19 | Subcutaneous vs sub- muscular ulnar nerve uransposition in moderate cubita tunnel syn- drome 显示文摘 | Jaddue DA Saloo SA Sayed-Noor AS | 2009 | Open Orthop J2009，3，： | 1 |
| 20 | Dynamic contrast- enhanced MRI for prostate cancer localization 显示文摘 | Jackson AS Reinsberg SA Sohaib SA | 2009 | Br J Radial2009，2，： | 1 |
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