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| 1 | Contemporary meta-analysis of short-term probiotic consumption on gastrointestinal transit显示文摘AIM: To determine the efficacy of probiotic supplementation on intestinal transit time(ITT) in adults and to identify factors that influence these outcomes. METHODS: We conducted a systematic review of randomized controlled trials of probiotic supplementation that measured ITT in adults. Study quality was assessed using the Jadad scale. A random effects meta-analysis was performed with standardized mean difference(SMD) of ITT between probiotic and control groups as the primary outcome. Meta-regression and subgroup analyses examined the impact of moderator variables on SMD of ITT.RESULTS: A total of 15 clinical trials with 17 treatment effects representing 675 subjects were included in this analysis. Probiotic supplementation was moderately efficacious in decreasing ITT compared to control, with an SMD of 0.38(95%CI: 0.23-0.53, P < 0.001). Subgroup analyses demonstrated statistically greater reductions in ITT with probiotics in subjects with vs without constipation(SMD: 0.57 vs 0.22, P < 0.01) and in studies with high vs low study quality(SMD: 0.45 vs 0.00, P = 0.01). Constipation(R^2 = 38%, P < 0.01), higher study quality(R^2 = 31%, P = 0.01), older age(R^2 = 27%, P = 0.02), higher percentage of female subjects(R^2 = 26%, P = 0.02), and fewer probiotic strains(R^2 = 20%, P < 0.05) were predictive of decreased ITT with probiotics in meta-regression. Medium to large treatment effects were identified with B. lactis HN019(SMD: 0.67, P < 0.001) and B. lactis DN-173 010(SMD: 0.54, P < 0.01) while other probiotic strains yielded negligible reductions in ITT relative to control.CONCLUSION: Probiotic supplementation is moderately efficacious for reducing ITT in adults. Probiotics were most efficacious in constipated subjects, when evaluated in high-quality studies, and with certain probiotic strains. | Larry E Miller Angela K Zimmermann Arthur C Ouwehand | 2016 | World Journal of Gastroenterology2016，22，21： | 2 |
| 2 | 软骨寡聚基质蛋白在慢性胰腺炎损伤中退变腺泡细胞内的表达显示文摘目的 研究正常胰腺、慢性胰腺炎与胰腺癌组织中软骨寡聚基质蛋白 (cartilageoligomericmatrixprotein ,COMP)mRNA和蛋白表达水平的差异 ,揭示COMP在慢性胰腺炎样损伤中的意义。 方法 采用Northern印迹法、Western印迹法、原位杂交法与免疫组化方法对 14例慢性胰腺炎、14例胰腺癌及 15例正常胰腺组织进行分析。 结果 在慢性胰腺炎组织中和胰腺癌组织中类似慢性胰腺炎损伤的退变腺泡细胞胞浆内 ,存在高水平的COMPmRNA信号与免疫反应 ;而在胰腺癌细胞、正常胰腺组织的导管细胞与胰岛细胞的胞浆内 ,COMPmRNA信号与免疫反应微弱或缺如。结论 COMP在慢性胰腺炎及胰腺癌中类似慢性胰腺炎损伤的退变腺泡细胞内高表达 ,可能与慢性胰腺炎中腺泡细胞功能异常有关。 | 廖泉 赵玉沛 Jorg Kleeff 肖毅 Arthur Zimmermann Markus W.Buchler Helmut Friess | 2003 | 中华外科杂志2003，41，5： | 2 |
| 3 | Brain-Derived Neurotrophic Factor (BDNF) Is Upregulated and Associated with Pain in Chronic Pancreatitis显示文摘 | Zhao-Wen Zhu Helmut Friess Li Wang Arthur Zimmermann Markus W. B?chler | 2001 | Digestive Diseases and Sciences2001，，8： | 1 |
| 4 | Nerve Growth Factor and Its High-Affinity Receptor in Chronic Pancreatitis显示文摘 | Helmut Friess Zhao-Wen Zhu Fabio F. di Mola Christoph Kulli Hans U. Graber ?ke Andren-Sandberg Arthur Zimmermann Murray Korc Max Reinshagen Markus W. Büchler | 1999 | Annals of Surgery1999，，5： | 1 |
| 5 | Liver nodules resembling focal nodular hyperplasia after hepatic venous thrombosis显示文摘 | Martin K Schilling Arthur Zimmermann Claudio Redaelli | 2000 | Journal of Hepatology2000，33，4： | 1 |
| 6 | Brain-Derived Neurotrophic Factor (BDNF) Is Upregulated and Associated with Pain in Chronic Pancreatitis显示文摘 | Zhao-Wen Zhu Helmut Friess Li Wang Arthur Zimmermann Markus W. B?chler | 2001 | Digestive Diseases and Sciences2001，，8： | 1 |
| 7 | Nerve Growth Factor and Its High-Affinity Receptor in Chronic Pancreatitis显示文摘 | Helmut Friess Zhao-Wen Zhu Fabio F. di Mola Christoph Kulli Hans U. Graber ?ke Andren-Sandberg Arthur Zimmermann Murray Korc Max Reinshagen Markus W. Büchler | 1999 | Annals of Surgery1999，，5： | 1 |
| 8 | Hepatoblastoma with a low serum alpha-fetoprotein level at diagnosis: The SIOPEL group experience显示文摘 | Maretta De Ioris Laurence Brugieres Arthur Zimmermann Jean Keeling Penelope Brock Rudolf Maibach Jon Pritchard Liz Shafford Joszef Zsiros Piotr Czaudzerna Giorgio Perilongo | | European Journal of Cancer0，，： | 1 |
| 9 | Brain-Derived Neurotrophic Factor (BDNF) Is Upregulated and Associated with Pain in Chronic Pancreatitis显示文摘 | Zhao-Wen Zhu Helmut Friess Li Wang Arthur Zimmermann Markus W. B?chler | 2001 | Digestive Diseases and Sciences2001，，8： | 1 |
| 10 | Connective Tissue Growth Factor Gene Expression Alters Tumor Progression in Esophageal Cancer显示文摘 | Alexander Koliopanos Helmut Friess Fabio F. di Mola When-Hao Tang Darius Kubulus David Brigstock Arthur Zimmermann Markus W. Büchler | 2002 | World Journal of Surgery2002，，4： | 1 |
| 11 | Liver regeneration:the emergence of new path- ways显示文摘 | Arthur Zimmermann | 2002 | Med Sci Monit2002，8，3： | 1 |
| 12 | Herbal does not mean innocuous: Ten cases of severe hepatotoxicity associated with dietary supplements from Herbalife ? products显示文摘 | Alain M. Schoepfer Antoinette Engel Karin Fattinger Urs A. Marbet Dominique Criblez Juerg Reichen Arthur Zimmermann Carl M. Oneta | 2007 | Journal of Hepatology2007，，4： | 1 |
| 13 | Liver regeneration:the emergence of new pathways显示文摘 | Arthur Zimmermann | 2002 | Med Sci Monit2002，8，： | 1 |
| 14 | Connective Tissue Growth Factor Is a Regulator for Fibrosis in Human Chronic Pancreatitis显示文摘 | Fabio F. di Mola Helmut Friess Marcus E. Martignoni Pierluigi Di Sebastiano Arthur Zimmermann Paolo Innocenti Hans Graber Leslie I. Gold Murray Korc Markus W. Büchler | 1999 | Annals of Surgery1999，，： | 1 |
| 15 | Down-Regulation of DOC-2 in Colorectal Cancer Points to Its Role as a Tumor Suppressor in This Malignancy显示文摘 | J?rg Kleeff M.D. Yong Huang M.D. Samuel C. Mok M.D. Arthur Zimmermann M.D. Helmut Friess M.D. Markus W. Büchler M.D | 2002 | Diseases of the Colon & Rectum2002，，9： | 1 |
| 16 | Role of hepatic stellate cell/hepatocyte interaction and activation of hepatic stellate cells in the early phase of liver regeneration in the rat显示文摘 | Ayako Mabuchi Ian Mullaney Philip W Sheard Paul A Hessian Beth L Mallard Michael N Tawadrous Arthur Zimmermann Haruki Senoo Antony M Wheatley | 2004 | Journal of Hepatology2004，，6： | 1 |
| 17 | Apoptosis Inhibiting Factor Bcl-xL Might Be the Crucial Member of the Bcl-2 Gene Family in Colorectal Cancer显示文摘 | Christoph A. Maurer Helmut Friess Sabine S. Buhler Beatrice R. Wahl Hans Graber Arthur Zimmermann Markus W. Buchler | 1998 | Digestive Diseases and Sciences1998，，12： | 1 |
| 18 | Herbal does not mean innocuous: Ten cases of severe hepatotoxicity associated with dietary supplements from Herbalife ? products显示文摘 | Alain M. Schoepfer Antoinette Engel Karin Fattinger Urs A. Marbet Dominique Criblez Juerg Reichen Arthur Zimmermann Carl M. Oneta | 2007 | Journal of Hepatology2007，，4： | 1 |
| 19 | Concomitant Analysis of the Epidermal Growth Factor Receptor Family in Esophageal Cancer: Overexpression of Epidermal Growth Factor Receptor mRNA but Not of c-erbB-2 and c-erbB-3显示文摘 | Helmut Friess Akira Fukuda Wen-Hao Tang Adrian Eichenberger Neva Furlan Arthur Zimmermann Murray Korc Markus W. Büchler | 1999 | World Journal of Surgery1999，，10： | 1 |
| 20 | Randomized Placebo-Controlled Trial of Ursodeoxycholic Acid With Vitamin E in Nonalcoholic Steatohepatitis显示文摘 | Jean–Fran?ois Dufour Carl M. Oneta Jean–Jacques Gonvers Florian Bihl Andreas Cerny Jean–Michel Cereda Jean–Franco Zala Beat Helbling Michael Steuerwald Arthur Zimmermann | 2006 | Clinical Gastroenterology and Hepatology2006，，12： | 1 |
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