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| 1 | Distribution of HBV genotypes among HBV carriers in Benin:phylogenetic analysis and virological characteristics of HBV genotype E显示文摘AIM: To determine the distribution of Hepatitis B virus (HBV) genotypes in Benin, and to clarify the virological characteristics of the dominant genotype.METHODS: Among 500 blood donors in Benin, 21 HBsAg-positive donors were enrolled in the study. HBV genotypes were determined by enzyme immunoassay and restriction fragment length polymorphism. Complete genome sequences were determined by PCR and direct sequencing.RESULTS: HBV genotype E (HBV/E) was detected in 20/21 (95.2%), and HBV/A in 1/21 (4.8%). From the age-specific prevalence of HBeAg to anti-HBe seroconversion (SC) in 19 HBV/E subjects, SC was estimated to occur frequently in late teens in HBV/E.The comparison of four complete HBV/E genomes from HBeAg-positive subjects in this study and five HBV/E sequences recruited from the database revealed that HBV/E was distributed throughout West Africa with very low genetic divers ity (nucleotide homology 96.7-99.2%).Based on the sequences in the basic core promoter (BCP)to precore region of the nine HBV/E isolates compared to those of the other genotypes, a nucleotide substitution in the BCP, G1757A, was observed in HBV/E.CONCLUSION: HBV/E is predominant in the Republic of Benin, and SC is estimated to occur in late teens in HBV/E. The specific nucleotide substitution G1757A in BCP, which might influence the virological characteristics,is observed in HBV/E. | Kei Fujiwara Yasuhito Tanaka Etsuro Orito Tomoyoshi Ohno Takanobu Kato Kanji Sugihara Izumi Hasegawa Mayumi Sakurai Kiyoaki Ito Atsushi Ozasa Yuko Sakamoto Isao Arita Ahmed El-Gohary Agossou Benoit Sophie I Ogoundele-Akplogan Namiko Yoshihara Ryuzo Ueda Masashi Mizokami | 2005 | World Journal of Gastroenterology2005，11，41： | 3 |
| 2 | Iden- tification of homozygous deletions of tumor suppressor gene FAT in oral cancer using CGH - array显示文摘 | K Nakaya HD Yamagata N Arita K - i Nakashiro | 2007 | Oncogene2007，26，： | 1 |
| 3 | Industrial clusters,transactions costs and the institutional determinants of mne location behavior显示文摘 | MCCANN P ARITA T GORDON I R | | 0，，11： | 1 |
| 4 | Dispersion of phosphonic acids surface-modified titania nanocrystals in various organic solvents显示文摘 | Arita T Moriya K I Yoshimura T | 2010 | Ind Eng Chem Res2010，49，20： | 1 |
| 5 | Exploration and exploitation of offshore sand in Japan 显示文摘 | Arita M Morimoto I Mizuno A | 1985 | UN ESCAP CCOP Technical Bulletin1985，17，： | 1 |
| 6 | Initial results and clinical follow-up after balloon angioplasty for native coarctation显示文摘 | Nakano I Arita H | 1999 | Am J Cardiol1999，84，1： | 1 |
| 7 | Human monkeypox: a newly emerged orthopoxvirus zoonisis in the tropical rain forests ofAfrica显示文摘 | Arita I Jezek Z Khodakevich L et at | 1985 | Am J Trop Med Hyg1985，34，4： | 1 |
| 8 | Etiology of communityacquired pneumonia in hospitalized patients: a 3-year prospective study inJapan显示文摘 | Ishida T Hashimoto M Arita I | 1998 | Chest1998，114，6： | 1 |
| 9 | Generation of hiccupby electrical stimulation in medulla of cats显示文摘 | Arita H Oshima T Kita I | 1994 | NeurosciLett1994，175，12： | 1 |
| 10 | Human monkeypox: a newly emerged orthopoxvirus zoonosis in the tropical rain forests of Africa显示文摘 | Arita I Jezek Z Khodakevich L | 1985 | Am J Trop Med Hyg1985，34，4： | 1 |
| 11 | Etiology of community acquired pneumonia in hospitalized patienta a 3year prospective study in Japan显示文摘 | Hashimoto M Arita I | 1998 | Chest1998，114，6： | 1 |
| 12 | Novel modulator for endothelial adhesion molecules: adipoeyte-derived plasma protein adiponectin 显示文摘 | Oucb i N Kihara S Arita Y Maeda K Kuriyama H Okamoto Y | 1999 | Circulation1999，100，： | 1 |
| 13 | 显示文摘 | Arita I H Castano V M | 1995 | J Mater Sci: Mater Med1995，6，： | 1 |
| 14 | Human monkeypox: a newly emerged orthopoxvirus zoonosis in the tropical rain forests of Africa 显示文摘 | Arita I Jezek Z Khodakevich L | 1985 | Am J Trop Med Hyg1985，34，4： | 1 |
| 15 | Eviology of community-acquired pneumonia in hospitalized patients:a 3-year prospective study in Japan显示文摘 | Lishida T Hashimoto M Arita I | 1998 | Chest1998，114，6： | 1 |
| 16 | Blood pressure response to heart rate during exercise test and risk of future hypertension显示文摘 | Miyai N Arita M Miyashita K Morioka I Shiraishi T Nishio I | 2005 | Hypertension2005，39，： | 1 |
| 17 | Industrial clusters,transactions costs and the institutional determinants of MNE location behaviour显示文摘 | MCCANN P T ARITA I R GRODON | 2002 | International Business Review2002，11，6： | 1 |
| 18 | Outbreaks of monkeypox and serological surveys in non-human primates显示文摘 | Arita I Gispen R Kaher SS | 1972 | Bull WHO1972，46，5： | 1 |
| 19 | Exaggerated blood pressure response to exercise and risk of future hypertension in subjects with high-normal blood pressure显示文摘 | Arita M Morioka I | 2000 | J Am Coll Cardiol2000，36，： | 1 |
| 20 | Strain JTo107显示文摘 | SUGANO Y TERADA I ARITA M Purification and characterization of a novel enzyme α-neoagarooligosaccharide hydrolase from a marine bacterium Vibbrio sp | 1994 | J Bacteriol1994，176，22： | 1 |
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