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| 1 | Progresses on microwave remote sensing of land surface parameters显示文摘Highly accurate observations at various scales on the land surface are urgently needed for the studies of many areas,such as hydrology,meteorology,and agriculture.With the rapid development of remote sensing techniques,remote sensing has had the capacity of monitoring many factors of the Earth's land surface.Especially,the space-borne microwave remote sensing systems have been widely used in the quantitative monitoring of global snow,soil moisture,and vegetation parameters with their all-weather,all-time observation capabilities and their sensitivities to the characteristics of land surface factors.Based on the electromagnetic theories and microwave radiative transfer equations,researchers have achieved great successes in the microwave remote sensing studies for different sensors in recent years.This article has systematically reviewed the progresses on five research areas including microwave theoretical modeling,microwave inversion on soil moisture,snow,vegetation and land surface temperatures.Through the further enrichment of remote sensing datasets and the development of remote sensing theories and inversion techniques,remote sensing including microwave remote sensing will play a more important role in the studies and applications of the Earth systems. | SHI JianCheng DU Yang DU JinYang JIANG LingMei CHAI LinNa MAO KeBiao XU Peng NI WenJian XIONG Chuan LIU Qiang LIU ChenZhou GUO Peng CUI Qian LI YunQing CHEN Jing WANG AnQi LUO HeJia WANG YinHui | 2012 | Science China Earth Sciences2012，55，7： | 24 |
| 2 | Elimination of senescent cells byβ-galactosidase-targeted prodrug attenuates inflammation and restores physical function in aged mice显示文摘Cellular senescence,a persistent state of cell cycle arrest,accumulates in aged organisms,contributes to tissue dysfunction,and drives age-related phenotypes.The clearance of senescent cells is expected to decrease chronic,low-grade inflammation and improve tissue repair capacity,thus attenuating the decline of physical function in aged organisms.However,selective and effective clearance of senescent cells of different cell types has proven challenging.Herein,we developed a prodrug strategy to design a new compound based on the increased activity of lysosomalβ-galactosidase(β-gal),a primary characteristic of senescent cells.Our prodrug SSK1 is specifically activated byβ-gal and eliminates mouse and human senescent cells independently of senescence inducers and cell types.In aged mice,our compound effectively cleared senescent cells in different tissues,decreased the senescence-and age-associated gene signatures,attenuated low-grade local and systemic inflammation,and restored physical function.Our results demonstrate that lysosomalβ-gal can be effectively leveraged to selectively eliminate senescent cells,providing a novel strategy to develop anti-aging interventions. | Yusheng Cai Huanhuan Zhou Yinhua Zhu Qi Sun Yin Ji Anqi Xue Yuting Wang Wenhan Chen Xiaojie Yu Longteng Wang Han Chen Cheng Li Tuoping Luo Hongkui Deng | 2020 | Cell Research2020，30，7： | 12 |
| 3 | Biomass-derived porous carbon highly efficient for removal of Pb(Ⅱ) and Cd(Ⅱ)显示文摘The utilization of abundant and renewable biomass to fabricate advanced functional materials is considered a promising route for environmental applications.Herein,Lignin-based porous carbon with layered graphene-like structure(LPC)is successfully synthesized and applied to efficiently remove Pb(Ⅱ)and Cd(Ⅱ).The as-synthesized LPC materials are systematically characterized and these results show that LPC has a porous graphene-like structure,facilitating the diffusion and immobilization of heavy metal ions.The influence of different reaction parameters(solution pH,initial concentration of metal ions,contact time and adsorbent amount)on the adsorption performance is investigated in details.The results demonstrate that LPC can achieve superior adsorption capacities of 250.5 mg·g^-1 for Pb(Ⅱ)and 126.4 mg·g^-1 for Cd(Ⅱ),which are far superior to the previously reported adsorbents.Pseudo-second order kinetics model and Freundlich isotherm model describe the adsorption process well.Furthermore,the exhausted LPC can be regenerated easily and exhibits the removal efficiency of 96%and 92%for Pb(Ⅱ)and Cd(Ⅱ)after five continuous runs,respectively.This study shows a sustainable strategy for the design of porous carbon material from na?ve biomass and highlights the great potential in wastewater treatment. | Anqi Wang Zhikeng Zheng Ruiqi Li Di Hu Yiran Lu Huixia Luo Kai Yan | 2019 | Green Energy & Environment2019，4，4： | 10 |
| 4 | Urbanization reduces resource use efficiency of phytoplankton community by altering the environment and decreasing biodiversity显示文摘Urbanization often exerts multiple effects on aquatic and terrestrial organisms,including changes in biodiversity,species composition and ecosystem functions.However,the impacts of urbanization on river phytoplankton in subtropical urbanizing watersheds remain largely unknown.Here,we explored the effects of urbanization on phytoplankton community structure(i.e.,biomass,community composition and diversity)and function(i.e.,resource use efficiency)in a subtropical river at watershed scale in southeast China over 6 years.A total of 318 phytoplankton species belonging into 120 genera and 7 phyla were identified from 108 samples.Bacillariophyta biomass showed an increasing trend with increasing urbanization level.The phytoplankton community shifted from Chlorophyta dominance in rural upstream waters to Bacillariophyta dominance in urbanized downstream waters.Furthermore,phytoplankton diversity and resource use efficiency(RUE=phytoplankton biomass/total phosphorus)were significantly decreased with increasing urbanization level from upstream to downstream.Phytoplankton RUE exhibited a significant positive correlation with species richness,but a negative correlation with phytoplankton evenness.The variation in environmental factors(turbidity,total nitrogen,NH_(4)^(+)-N,total phosphorus,PO_(4)^(3-)-P and percentage urbanized area)was significantly correlated with phytoplankton diversity and RUE.Overall,our results revealed the influence of urbanization on phytoplankton community structure and ecosystem function was due to its altering the environmental conditions.Therefore,human-driven urbanization may play crucial roles in shaping the structure and function of phytoplankton communities in subtropical rivers,and the mechanism of this process can provide important information for freshwater sustainable uses,watershed management and conservation. | Yigang Yang Huihuang Chen Mamun Abdullah Al Jean Claude Ndayishimiye Jun R Yang Alain Isabwe Anqi Luo Jun Yang | 2022 | Journal of Environmental Sciences2022，34，2： | 4 |
| 5 | Expansion of PmBEAT genes in the Prunus mume genome induces characteristic floral scent production显示文摘Prunus mume is the only plant in the genus Prunus of the Rosaceae family with a characteristic floral scent,and the main component of this scent is benzyl acetate.By contrast,benzyl acetate is not synthesized in Prunus persica flowers.Here,we searched for benzyl alcohol acetyltransferase(BEAT)genes based on genomic data from P.mume and P.persica and found 44 unique PmBEATs in P.mume.These genes,which were mainly detected in clusters on chromosomes,originated from gene duplication events during the species evolution of P.mume,and retroduplication and tandem duplication were the two dominant duplication patterns.The genes PmBEAT34,PmBEAT36 and PmBEAT37,which were generated by tandem duplication,were highly expressed in flowers,and their highest levels were detected during the blooming stage.In vitro,PmBEAT34,PmBEAT3,and PmBEAT37 all had benzyl alcohol acetyltransferase activity that was localized in the cytoplasm.Overexpression of the PmBEAT36 or PmBEAT37 genes increased benzyl acetate production in the petal protoplasts of P.mume,and interference in the expression of these genes slightly decreased the benzyl acetate content.In addition,light and temperature regulated the expression of the PmBEAT34,PmBEAT36 and PmBEAT37 genes.According to these results,we hypothesize that the expansion of the PmBEAT genes in the genome induce the characteristic floral scent of P.mume. | Fei Bao Anqi Ding Tengxun Zhang Le Luo Jia Wang Tangren Cheng Qixiang Zhang | 2019 | Horticulture Research2019，6，1： | 4 |
| 6 | Mechanical Behavior and Microstructure of Ultrasonic-Spot-Welded Al/Cu Dissimilar Joints with Zn Interlayer显示文摘The effect of Zn interlayer on the microstructural evolution and mechanical behavior of dissimilar ultrasonic-spot-welded Al/Cu joints was investigated.The tensile lap shear strength in relation to welding energy was analyzed.The experimental results show that two intermetallic compounds,Cu5Zn8 and Al2Cu,were generated at the interface of the ultrasonic-spotwelded Al/Cu joint with a Zn interlayer.The primary joining mechanisms of the joint included the intermetallic compound bonding and metallic bonding caused by solid shear plastic deformation.Meanwhile,with increasing welding energy,the plastic deformation of the material became more substantial.With increasing welding energy,the tensile lap shear strength of the joints first increased and then decreased for the ultrasonic-spot-welded Al/Cu joints with and without Zn interlayers.Under the energy input of 700 J,the bearing load capacity of the ultrasonic-spot-welded Al/Cu joints with a Zn interlayer improved signifi cantly due to the observed intermetallic compound(Cu5Zn8). | Chunjie Li Sansan Ao Anqi Wang Qi Wei Manpeng Wu Zhen Luo | 2020 | Transactions of Tianjin University2020，26，4： | 2 |
| 7 | Forensic parameters of 41 Y-STR loci in Shandong Han individuals and comparison with 42 other populations显示文摘The Y-chromosomal short tandem repeat polymorphisms(Y-STRs)are the male-specific markers.The characteristics of paternal lineages make it a valuable tool for tracing familial relationships[1-3].Y-STR analysis has been widely used for identifying genealogical DNA testing and to identify missing persons,assess paternal relationships,and investigate sexual assault cases[4,5]. | Anqi Chen Li Luo Ruiyang Tao Suhua Zhang Chengtao Li | 2022 | Forensic Sciences Research2022，7，4： | 0 |
| 8 | MtRGF3 peptide activates defense responses and represses the expressions of nodulation signaling genes in Medicago truncatula显示文摘Root meristem growth factors(RGFs)were first discovered in Arabidopsis thaliana and regulate root development,including primary root growth,lateral root formation and root gravitropism,etc.[1‒3].RGF belongs to a 13-amino-acid peptide family,which usually contains conserved aspartate(D1),tyrosine(Y2),proline(P9 and P10),histidine(H12)and asparagine(N13)residues.Among these residues,the second tyrosine residue(Y2)is modified by a sulfate group,and the tenth proline residue(P10)is hydroxylated[1‒3].The active peptide is processed from a precursor that consists of a signal peptide,a variant region and a conserved C-terminal domain.The peptide is recognized by the leucine rich repeat(LRR)receptor kinases(RGFR)and then regulates the activities of the AP transcription factors TLPs in A.[4‒6].Nine genes of AtRGF or AtGLV were identified in A.thaliana,and 15 corresponding genes were reported in the model legume Medicago truncatula[7]. | Qiong Li Dandan Shan Wenjia Zheng Yawen Wang Zhiyin Lin Huibo Jin Anqi Ding Junhui Yan Liangliang Yu Li Luo | 2023 | Acta Biochimica et Biophysica Sinica2023，55，8： | 0 |
| 9 | Pharmacological Effects and Molecular Mechanism of Osthole显示文摘Osthole has various pharmacological effects such as anti-cancer,anti-inflammation,prevention and treatment of cardiovascular diseases and neuroprotection.This paper reviews the advances in the research of the pharmacological effects and molecular mechanisms of osthole,in order to provide new ideas for further research and clinical application of osthole. | Yannan LI Wenshuang HOU Jinglong CAO Anqi WANG Yinghua LUO Chenghao JIN | 2023 | Medicinal Plant2023，14，2： | 0 |
| 10 | Urban water system theory and its model development and application显示文摘The urban water system theory is an extension of the basin water system science on an urban scale, providing a new systematic solution for the unbalanced human-water relationship and severe water challenges, such as waterlogging, black and odorous water, and ecological degradation caused by urbanization. Most existing studies on urban water systems have focused on individual water cycle processes linked with water supply and sewage treatment plants, but mutual feedback between the water cycle and its associated material circulation and water ecology, as well as human processes, still needs further exploration. In this paper, the concept, theory, and technical methodology of the urban water system were developed based on the water cycle and basin water system science. The Urban Water System 5.0(UWS 5.0) model was developed by integrating the Time Variant Gain rainfall-runoff Model with Urban water system(TVGM_Urban) in different underlying surface conditions for analyzing the natural-social water cycle processes and their associated water environmental and ecological processes and the influence of multiscale sponge measures. Herein, five major simulation functions were realized: rainfall-runoff-nonpoint source pollutant load,water and pollutant transportations through the drainage network system, terminal regulation and purification, socioeconomic water cycle, and water system assessment and regulation. The location for the case study used in this paper was Wuhan City. The findings showed that the entire urban water system should consider the built-up area and its associated rivers and lakes as the research object and explore the integrations among the urban natural-social water cycle and river regulations inside and outside of the city as well as the effects of socioeconomic development and sponge measures on the water quantity-quality-ecology processes. The UWS 5.0 model efficiently simulated the urban rainfall-runoff process, total nitrogen(TN) and total phosphorus(TP) concentrations in water bodies, and characteristic indicators of socioeconomic development. For the rainfall-runoff simulations, the correlation coefficient and Nash-Sutcliffe efficiency(NSE) fall under the excellent and good classes, respectively. For the TN and TP concentration simulations, results exhibited good bias and the correlation coefficients exceeded 0.90 for 78.1% of the sampled sites. The simulation of 18 socioeconomic indicators provided excellent bias, correlation coefficient, and NSE values of 100%, 83.3%, and 69.4% to total indicators, respectively. Based on the well-calibrated UWS 5.0 model, the source sponge,artificial enhancement, and source reduction-path interception-terminal treatment measures were optimized, which considerably mitigated waterlogging, black and odorous water, and lake eutrophication, respectively. The mitigation performance revealed that the maximum inundated area for a once-in-10-year rainfall event was reduced by 32.6%, the removal ratio of the black and odorous water area was 65%, the comprehensive trophic state index of water bodies was reduced by 37%, and the green development level of Wuhan City in 2020 increased from 0.56 to 0.67. This study is expected to advance the intersection and development of multidisciplinary fields(e.g., urban hydrology, environmental science, and ecology) and offer an important theoretical and technical basis for solving urban complex water issues and promoting green development of cities. | Jun XIA Yongyong ZHANG Dunxian SHE Shiyan ZHANG Jun YANG Mingquan LV Xiang ZHANG Anqi LUO Shengjun WU Yang LIU | 2024 | Science China Earth Sciences2024，67，3： | 0 |
| 11 | Research Progress on Biological Activity of Sciadopitysin显示文摘Sciadopitysin(SP)belongs to flavonoids.Recent studies showed that sciadopitysin has anti-tumor,anti-oxidation,treatment of osteoporosis,diabetic osteopathy,Alzheimer's disease and other effects.This study will review the biological activity and related action mechanism of the sciadopitysin in recent years,in order to provide theoretical basis and reference for the future research and drug development of the sciadopitysin. | Wenbo ZUO Yannan LI Hui XUE Tong ZHANG Yu ZHANG Anqi WANG Yue TENG Yinghua LUO Chenghao JIN | 2021 | Medicinal Plant2021，12，6： | 0 |
| 12 | Boosting the dimensionality of frequency entanglement using a reconfigurable microring resonator显示文摘Integrated quantum frequency combs(QFCs)based on microring resonators supplies as an essential resource for expanding the Hilbert-space dimensionality for high-dimensional quantum computing and information processing.In this work,we propose and demonstrate a reconfigurable ring resonator with tunable quality factors to efficiently increase the dimensionality of frequency entanglement,simultaneously,ensuring a high on-chip pair generation rate(PGR)and coincidence-to-accidental ratio(CAR).Our method exploits the asymmetric Mach-Zehnder interferometer instead of the traditional straight waveguide as the coupler of resonators which offer a tunable external coupling coefficient to modulate the quality factor to enlarge the QFCs’bandwidth and thus increase the dimensionality of frequency entanglement.We measured the QFCs’joint spectral intensity of 28 frequency pairs under various quality factors ranging from 16.6×10^(4) to 3.4×10^(4).Meanwhile,the measured Schmidt number increased from 11.01 to 24.77,denoting a huge expansion of the Hilbert-space dimensionality from 121 to a record number of 613 dimensions,which agrees well with our theoretical calculations.In addition,the PGR and CAR-another two key parameters for high-quality QFCs-were all measured under different quality factors to verify that our method can significantly increase the Schmidt number and CAR while maintaining a high PGR.In fact,bright QFCs with a total PGR of 4.3 MHz under a 0.48 mW pump power and a mean CAR of 1578 were simultaneously obtained at the highest Schmidt number.This method is widely applicable to other material-based ring resonators and can act as a general solution for high-dimensional QFCs. | Chao Wu Qilin Zheng Yingwen Liu Yang Wang Jiangfang Ding Pingyu Zhu Shichuan Xue Miaomiao Yu Weihong Luo Kaikai Zhang Anqi Huang Mingtang Deng Junjie Wu Ping Xu | 2023 | Science China(Physics,Mechanics & Astronomy)2023，66，5： | 0 |
| 13 | Mutations in the DNA polymerase binding pathway affect the immune microenvironment of patients with small-cell lung cancer and enhance the efficacy of platinum-based chemotherapy显示文摘Background:Small-cell lung cancer(SCLC)is characterized by its high malignancy and is associated with a poor prognosis.In the early stages of the disease,platinum-based chemotherapy is the recommended first-line treatment and has demonstrated efficacy.However,SCLC is prone to recurrence and is generally resistant to chemotherapy in its later stages.Methods:Here,we collected samples from SCLC patients who received platinum-based chemotherapy,performed genomic and transcriptomic analyses,and validated our results with publicly available data.Results:SCLC patients with DNA polymerase binding pathway mutations had an improved prognosis after platinum chemotherapy compared with patients without such mutations.Patients in the mutant(MT)group had higher infiltration of T cells,B cells,and M1 macrophages compared with patients without DNA polymerase binding pathway mutations.Conclusions:DNA polymerase binding pathway mutations can be used as prognostic markers for platinum-based chemotherapy in SCLC. | Anqi Lin Weiming Mou Lingxuan Zhu Tao Yang Chaozheng Zhou Jian Zhang Peng Luo | 2023 | Cancer Innovation2023，2，6： | 0 |
| 14 | Research Progress on Pharmacological Action of 5-O-methylvisammioside显示文摘5-O-methylvisammioside is a chemical derived from the dry root of Saposhnikovia divaricata,which has the functions of expelling pathogenic wind from body surface,removing dampness to relieve pain,and relieving convulsion.Recent studies have found that 5-O-methylvisammioside can play a variety of pharmacological effects such as anti-tumor,anti-inflammation,anti-virus and anti-depression through a variety of ways.The paper reviews the pharmacological action and mechanism of 5-O-methylvisammioside in recent years. | Jiazhu LI Anqi WANG Yue TENG Yuwei WANG Yinghua LUO Chenghao JIN | 2021 | Medicinal Plant2021，12，4： | 0 |
| 15 | Incorporating redox-sensitive nanogels into bioabsorbable nanofibrous membrane to acquire ROS-balance capacity for skin regeneration显示文摘Facing the high incidence of skin diseases,it is urgent to develop functional materials with high bioactivity for wound healing,where reactive oxygen species(ROS)play an important role in the wound healing process mainly via adjustment of immune response and neovasculation.In this study,we developed a kind of bioabsorbable materials with ROS-mediation capacity for skin disease therapy.Firstly,redox-sensitive poly(N-isopropylacrylamide-acrylic acid)(PNA)nanogels were synthesized by radical emulsion polymerization method using a disulfide molecule as crosslinker.The resulting nanogels were then incorporated into the nanofibrous membrane of poly(L-lactic acid)(PLLA)via airbrushing approach to offer bioabsorbable membrane with redox-sensitive ROS-balance capacity.In vitro biological evaluation indicated that the PNA-contained bioabsorbable membrane improved cell adhesion and proliferation compared to the native PLLA membrane.In vivo study using mouse wound skin model demonstrated that PNA-doped nanofibrous membranes could promote the wound healing process,where the disulfide bonds in them were able to adjust the ROS level in the wound skin for mediation of redox potential to achieve higher wound healing efficacy. | Shihao Zhang Yamin Li Xiaofeng Qiu Anqi Jiao Wei Luo Xiajie Lin Xiaohui Zhang Zeren Zhang Jiachan Hong Peihao Cai Yuhong Zhang Yan Wu Jie Gao Changsheng Liu Yulin Li | 2021 | Bioactive Materials2021，6，10： | 0 |
| 16 | CD209 signaling pathway as a biomarker for cisplatin chemotherapy response in small cell lung cancer显示文摘One of the bottlenecks in the clinical treatment of small cell lung cancer(SCLC)is its susceptibility to multidrug resistance.While SCLC is sensitive to platinum-based chemotherapy at the initial stage of treatment,it can rapidly become drug-resistant,allowing tumor growth to accelerate.A significant decrease in drug sensitivity after recurrence and multidrug resistance can seriously interfere with the effectiveness of treatment,making sensitivity maintenance one of the urgent challenges to be solved.Therefore,discovering prognostic markers for cisplatin chemotherapy and understanding the mechanisms of cisplatin resistance have great practical significance for improving the outcomes of sCLC patients. | Anqi Lin Hong Yang Jian Zhang Peng Luo | 2024 | Genes & Diseases2024，11，3： | 0 |
| 17 | Purification Process,Content Determination,Pharmacological Activity and Molecular Mechanism of Neogambogic Acid显示文摘Neogambogic acid is characterized by broad antitumor spectrum,good antitumor effect and low toxicity and side effects.This paper reviews the purification process,content determination and pharmacologic activity of neogambogic acid,in order to provide a theoretical reference for the research and application of neogambogic acid. | Tong ZHANG Jinglong CAO Wenshuang HOU Anqi WANG Yinghua LUO Chenghao JIN | 2023 | Plant Diseases and Pests2023，14，2： | 0 |
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