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| 1 | Retrograde-viewing device improves adenoma detection rate in colonoscopies for surveillance and diagnostic workup显示文摘AIM:To determine which patients might benefit most from retrograde viewing during colonoscopy through subset analysis of randomized,controlled trial data.METHODS:The Third Eye Retroscope Randomized Clinical Evaluation(TERRACE) was a randomized,controlled,multicenter trial designed to evaluate the efficacy of a retrograde-viewing auxiliary imaging device that is used during colonoscopy to provide a second video image which allows viewing of areas on the proximal aspect of haustral folds and flexures that are difficult to see with the colonoscope's forward view.We performed a post-hoc analysis of the TERRACE data to determine whether certain subsets of the patient population would gain more benefit than others from use of the device.Subjects were patients scheduled for colonoscopy for screening,surveillance or diagnostic workup,and each underwent same-day tandem examinations with standard colonoscopy(SC) and Third Eye colonoscopy(TEC),randomized to SC followed by TEC or vice versa.RESULTS:Indication for colonoscopy was screening in 176/345 subjects(51.0%),surveillance after previous polypectomy in 87(25.2%) and diagnostic workup in 82(23.8%).In 4 subjects no indication was specified.Previously reported overall results had shown a net additional adenoma detection rate(ADR) with TEC of 23.2% compared to SC.Relative risk(RR) of missing adenomas with SC vs TEC as the initial procedure was 1.92(P = 0.029).Post-hoc subset analysis shows additional ADRs for TEC compared to SC were 4.4% for screening,35.7% for surveillance,55.4% for diagnostic and 40.7% for surveillance and diagnostic combined.The RR of missing adenomas with SC vs TEC was 1.11(P = 0.815) for screening,3.15(P = 0.014) for surveillance,8.64(P = 0.039) for diagnostic and 3.34(P = 0.003) for surveillance and diagnostic combined.Although a multivariate Poisson regression suggested gender as a possibly significant factor,subset analysis showed that the difference between genders was not statistically significant.Age,bowel prep quality and withdrawal time did not significantly affect the RR of missing adenomas with SC vs TEC.Mean sizes of adenomas detected with TEC and SC were similar at 0.59 cm and 0.56 cm,respectively(P = NS).CONCLUSION:TEC allows detection of significantly more adenomas compared to SC in patients undergoing surveillance or diagnostic workup,but not in screening patients(ClinicalTrials.gov Identifier:NCT01044732). | Peter D Siersema Amit Rastogi Anke M Leufkens Paul A Akerman Kassem Azzouzi Richard I Rothstein Frank P Vleggaar Alessandro Repici Giacomo Rando Patrick I Okolo Olivier Dewit Ana Ignjatovic Elizabeth Odstrcil James East Pierre H Deprez Brian P Saunders Anthony N Kalloo Bradley Creel Vikas Singh Anne Marie Lennon Daniel C DeMarco | 2012 | World Journal of Gastroenterology2012，18，26： | 6 |
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| 14 | Fatty acids and other compounds with nematicidal activity from cultures of Basidiomycetcs显示文摘 | STADLER M MAYER A ANKE H | 1994 | Planta Medics1994，60，2： | 1 |
| 15 | Zopfiellamides A and B,antimicrobial pyrrolidinone derivatives from the marine fungus Zopfiella latipes 显示文摘 | Daferner M Anke T Sterner O | 2002 | Tetrahedron2002，58，： | 1 |
| 16 | Secondary metabolites with nematicidal activity from nematophagous fungi and ascomycetes显示文摘 | ANKE H STADLER M MAYER A | 1995 | Can J Botany1995，72，： | 1 |
| 17 | Prognostic value of E-cadherin expression in 413 gastric carcinomas显示文摘 | Helmut E G Wolfram M Ank S | 1996 | Int J Cancer1996，69，： | 1 |
| 18 | The German Thuringia and Brandenburg trace elements ( Zn, Mn, Cu, Mo, I and Ni ) intake显示文摘 | Anke M | 1992 | Foreign Medical Sciences Medical Geography Analysis1992，13，4： | 1 |
| 19 | Prognostic value of E-cadherin expression in 413 gastric carcinomas显示文摘 | Helmut E Wolfram M Anke S | 1998 | Int J Cancer1998，69，2： | 1 |
| 20 | Characterzation of chitinases able to rescue somatic embryos of the temperature-sensitive carrot variantts11显示文摘 | Kragh Karsten M Hendriks Theo de Jong Anke J | | 0，，03： | 1 |
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