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| 1 | Sporadic versus hereditary gastrinomas of the duodenum and pancreas: Distinct clinico-pathological and epidemiological features显示文摘Gastrinomas are defined as gastrin secreting tumors that are associated with Zollinger-Ellison syndrome (ZES). ZES is characterized by elevated fasting gastrin serum levels, positive secretin stimulation test and clinical symptoms such as recurrent peptic ulcer disease, gastroesophageal re?ux disease and occasional diarrhea. Genetically, nonhereditary (sporadic) gastrinomas are distinguished from hereditary gastrinomas, which are associated with multiple endocrine neoplasia type 1 (MEN1) syndrome. In general, duodenal gastrinomas are small and solitary if they are sporadic and multiple as well as hereditary. The sporadic gastrinomas occur in the duodenum or in the pancreas while the hereditary gastrinomas almost all occur in the duodenum. Our series of 77 sporadic duodenal neuroendocrine tumors (NETs) includes 18 patients (23.4%) with gastrinomas and ZES. Of 535 sporadic NETs in the pancreas collected from the NET archives of the departments of pathology in Zürich, Switzerland, and Kiel, Germany, 24 patients (4.5%) suffered from sporadic pancreatic gastrinomas and ZES. These NETs have to be distinguished fromtumors with immunohistochemical positivity for gastrin but without evidence of ZES. An additional 19 patients suffered from MEN1 and ZES. These patients showed exclusively duodenal gastrinomas, but not pancreatic gastrinomas. The prognosis of sporadic and MEN1- associated duodenal gastrinomas is better than that of pancreatic gastrinomas, since they progress slowly to liver metastasis. In summary, sporadic and MEN1- associated gastrinomas in the duodenum and pancreas show different clinico-pathological and genetic features. The incidence of sporadic duodenal gastrin-producing tumors is increasing, possibly due to optimized diagnostic procedures. In contrast, pancreatic MEN1- associated gastrinomas seem to be extremely rare. A considerable subset of tumors with immunohistochemical expression of gastrin but without evidence of ZES should be designated as functionally inactive NETs expressing gastrin, but not as gastrinomas. | Martin Anlauf Nele Garbrecht Tobias Henopp Anja Schmitt Regina Schlenger Andreas Raffel Markus Krausch Oliver Gimm Claus F Eisenberger Wolfram T Knoefel Henning Dralle Paul Komminoth Philipp U Heitz Aurel Perren Günter Klppel | 2006 | World Journal of Gastroenterology2006，12，34： | 7 |
| 2 | How to Manage Functional Vitamin K Deficiency in CKD显示文摘 | Martin Busch Anja Stein Günter Stein | 2012 | American Journal of Kidney Diseases2012，，1： | 1 |
| 3 | Upregulation of connexin43 gap junctions between neointimal smooth muscle cells显示文摘 | Gabriele Plenz Yu-Shien Ko Hung-I Yeh Heike Eschert Jürgen R. Sindermann Anja Dorszewski Oliver Hofnagel Horst Robenek Günther Breithardt Nicholas J. Severs | 2004 | European Journal of Cell Biology2004，，10： | 1 |
| 4 | Is the medium the message? Perceptions of and reactions to crisis communication via twitter, blogs and traditional media显示文摘 | Friederike Schultz Sonja Utz Anja G?ritz | 2011 | Public Relations Review2011，，1： | 1 |
| 5 | Rapamyein prevents mesenteric neo-angiogenesis and reduces splanchnic blood flow in portal hypertensive mice 显示文摘 | ANJA M G ELINE V HANS V V | 2008 | Hepatol Res2008，38，： | 1 |
| 6 | Is the medium the message? Perceptions'of and reactions to crisis communication via twitter, blogs and traditional media 显示文摘 | FRIEDERIKE S SONJA U ANJA G | 2011 | Public Relations Review2011，37，： | 1 |
| 7 | Recent advances in membrane bioreactors ( MBRs ) : Membrane fouling and membrane material 显示文摘 | Meng F G Chae S R Anja D | 2009 | Water Res2009，43，6： | 1 |
| 8 | Migration of plasticizers from PVC gaskets of lids for glass jars into oily foods: Amount of gasket material in food contact, proportion of plasticizer migrating into food and compliance testing by simulation显示文摘 | Anja F Ni Koni G | 2006 | Food Science and Technology2006，17，： | 1 |
| 9 | Polyethylene glycols interact with membrane glycerophospholipids: is this part of their mechanism for hypothermic graft protection?显示文摘 | Delphine Dutheil Anja Underhaug Gjerde Isabelle Petit-Paris Gérard Mauco Holm Holmsen | 2009 | Journal of Chemical Biology2009，，1： | 1 |
| 10 | Transcription analysis of Arabidopsis membrane transporters and hormone pathways during developmental and in- duced leaf senescence显示文摘 | Van V D G Rainer S Anja S | 2006 | Plant Physiology2006，141，2： | 1 |
| 11 | Optimization of conditions for germination of cold-stored Arabidopsis thaliana pollen 显示文摘 | Firas B D Youssef C Anja G | 2009 | Plant Cell Rep2009，，28： | 1 |
| 12 | A conceptual framework for the definition of the optimal width of riparian forests 显示文摘 | Gerd S Simone B L R Anja G | 2002 | Agriculture Ecosystems and Environment2002，90，2： | 1 |
| 13 | Bank filtration in the sandylittoral zone of Lake Tegel(Berlin):structure and dynamics of thebiological active filter zone and clogging processes显示文摘 | Anja Hoffmann Günter Gunkel | 2011 | Limnologica-Ecology and Management of Inland Waters2011，41，1： | 1 |
| 14 | Nicotine and related alkaloids accumulation in constitutive salicylic acid producing tobacco plants显示文摘 | LAURENTIUS H N ANJA M G | 2002 | Plant Science2002，162，： | 1 |
| 15 | The extent and position of homoeologous recombination in a distant hybrid of Alstroemerica:a molecular cytogenetics assessment of first generation backcross progenies显示文摘 | Silvan A Kamstra Anja G J Kuipers Marjo J De Jeu M S Ramanna Evert Jacobsen | 1999 | Chromosoma1999，108，： | 1 |
| 16 | Nicotine andrelated alkaloids accumulation in constitutive salicylic acid producing tobacco plants显示文摘 | Laurentius H Nugroho Anja M G | 2002 | Plant Science2002，162，： | 1 |
| 17 | Highly sensitive immunoassay based on a monoclonal antibody specific for microcystins显示文摘 | Anne Zelk Anja Eikenberg Michael G Weller | 2001 | Analytica ChimicaActa2001，441，： | 1 |
| 18 | Endothelial HIF-2[alpha] regulates murine pathological angiogenesis and revascularization processes显示文摘 | Skuli Nicolas Majmundar Amar J Krock Bryan L Mesquita Rickson C Mathew Lijoy K Quinn Zachary L Runge Anja Liu Liping Kim Meeri N Liang Jiaming Schenkel Steven Yodh Arjun G Keith Brian Simon M Celeste | 2012 | EN2012，，4： | 1 |
| 19 | Challenges in the Technology Development for Additive Manufacturing in Space显示文摘Instead of foreseeing and preparing for all possible scenarios of machine failures,accidents,and other challenges arising in space missions,it appears logical to take advantage of the flexibility of additive manufacturing for“in-space manufacturing”(ISM).Manned missions into space rely on complicated equipment,and their safe operation is a great challenge.Bearing in mind the absolute distance for manned missions to the Moon and Mars,the supply of spare parts for the repair and replacement of lost equipment via shipment from Earth would require too much time.With the high flexibility in design and the ability to manufacture ready-to-use components directly from a computer-aided model,additive manufacturing technologies appear to be extremely attractive in this context.Moreover,appropriate technologies are required for the manufacture of building habitats for extended stays of astronauts on the Moon and Mars,as well as material/feedstock.The capacities for sending equipment and material into space are not only very limited and costly,but also raise concerns regarding environmental issues on Earth.Accordingly,not all materials can be sent from Earth,and strategies for the use of in-situ resources,i.e.,in-situ resource utilization(ISRU),are being envisioned.For the manufacturing of both complex parts and equipment,as well as for large infrastructure,appropriate technologies for material processing in space need to be developed. | Andrea Zocca Janka Wilbig Anja Waske Jens Günster Martinus Putra Widjaja Christian Neumann Mélanie Clozel Andreas Meyer Jifeng Ding Zuoxin Zhou Xiaoyong Tian | 2022 | Chinese Journal of Mechanical Engineering(Additive Manufacturing Frontiers)2022，1，1： | 1 |
| 20 | Geraniol 10-hydroxylase, a cytochrome P450 enzyme involved in terpenoid indole alkaloid biosynthesis 显示文摘 | Graziella Collu Nehir Unver Anja M G | 2001 | FEBS2001，508，： | 1 |
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