6篇
您的检索式：作者名="Anirvan Ghosh"
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| 1 | Loss of CREST leads to neuroinflammatory responses and ALS-like motor defects in mice显示文摘Background:Amyotrophic lateral sclerosis(ALS)is a late onset neurodegenerative disease with fast progression.ALS has heavy genetic components in which a series of genetic mutations have been identified.In 2013,Mutations of the CREST gene(also known as SS18L1),which functions as a calcium-regulated transcriptional activator,were found in sporadic ALS patients.However,the pathogenic causality and mechanisms of ALS-associated mutations of CREST remain to be determined.Methods:In this study,we constructed CREST knockout and Q394X knock-in mice with CRISPR/Cas9 system.Using biochemical and imaging tools,we illustrated core pathological phenotypes in CREST mutant mice and claimed the possible pathogenic mechanisms.Furthermore,we also observed locomotion defects in CREST mutant mice with behavioural tests.Results:We demonstrate that ALS-related CREST-Q388X mutation exhibits loss-of-function effects.Importantly,the microglial activation was prevalent in CREST haploinsufficiency mice and Q394X mice mimicking the human CREST Q388X mutation.Furthermore,we showed that both CREST haploinsufficiency and Q394X mice displayed deficits in motor coordination.Finally,we identified the critical role of CREST-BRG1 complex in repressing the expression of immune-related cytokines including Ccl2 and Cxcl10 in neurons,via histone deacetylation,providing the molecular mechanisms underlying inflammatory responses within mice lack of CREST.Conclusion:Our findings indicate that elevated inflammatory responses in a subset of ALS may be caused by neuron-derived factors,suggesting potential therapeutic methods through inflammation pathways. | Cheng Cheng Kan Yang Xinwei Wu Yuefang Zhang Shifang Shan Aaron Gitler Anirvan Ghosh Zilong Qiu | 2019 | Translational Neurodegeneration2019，8，1： | 2 |
| 2 | On the determinationof basic dimensions of a cam with a translating roller-follo-wer 显示文摘 | Dasgupta Anirvan Ghosh Amitabha | 2004 | Journal of Mechanical Design Trans ASME2004，126，1： | 1 |
| 3 | On the determination of basic dimensions of a cam with a translating roller follower显示文摘 | DasGupta Anirvan Ghosh Amitabha | 2004 | Journal of Mechanical Design transaction of the ASME2004，126，1： | 1 |
| 4 | On the determination of basic dimensions of a cam with a translating roller-follower 显示文摘 | Dasgupta Anirvan Ghosh Amitabha | 2004 | Journal of Mechanical Design Trans ASME2004，126，1： | 1 |
| 5 | A Calcium-Dependent Switch in a CREST-BRG1 Complex Regulates Activity-Dependent Gene Expression显示文摘 | Zilong Qiu Anirvan Ghosh | 2008 | Neuron2008，，： | 1 |
| 6 | 全球网上超市逆流而上显示文摘一份新报告称,由于在经济萧条时消费者寻求廉价品,企业寻求新的出路,全球网上超市火了起来。 | Anirvan Ghosh 张含璞(译注) 高卫红(校) | 2011 | 英语世界2011，，8： | 0 |
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