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| 1 | Liver injury in COVID-19:The hepatic aspect of the respiratory syndrome-what we know so far显示文摘The 2019 novel coronavirus disease(COVID-19)pandemic due to severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has posed a serious threat to global public health.Although primarily,the infection causes lung injury,liver enzyme abnormalities have also been reported to occur during the course of the disease.We conducted an extensive literature review using the PubMed database on articles covering a broad range of issues related to COVID-19 and hepatic injury.The present review summarizes available information on the spectrum of liver involvement,the possible mechanisms and risk factors of liver injury due to SARS-CoV-2 infection,and the prognostic significance of the presence of liver injury.Hopefully,this review will enable clinicians,especially the hepatologists,to understand and manage the liver derangements they may encounter in these patients better and provide guidance for further studies on the liver injury of COVID-19. | Prajna Anirvan Pankaj Bharali Mrinal Gogoi Paul J Thuluvath Shivaram P Singh Sanjaya K Satapathy | 2020 | World Journal of Hepatology2020，12，12： | 2 |
| 2 | Loss of CREST leads to neuroinflammatory responses and ALS-like motor defects in mice显示文摘Background:Amyotrophic lateral sclerosis(ALS)is a late onset neurodegenerative disease with fast progression.ALS has heavy genetic components in which a series of genetic mutations have been identified.In 2013,Mutations of the CREST gene(also known as SS18L1),which functions as a calcium-regulated transcriptional activator,were found in sporadic ALS patients.However,the pathogenic causality and mechanisms of ALS-associated mutations of CREST remain to be determined.Methods:In this study,we constructed CREST knockout and Q394X knock-in mice with CRISPR/Cas9 system.Using biochemical and imaging tools,we illustrated core pathological phenotypes in CREST mutant mice and claimed the possible pathogenic mechanisms.Furthermore,we also observed locomotion defects in CREST mutant mice with behavioural tests.Results:We demonstrate that ALS-related CREST-Q388X mutation exhibits loss-of-function effects.Importantly,the microglial activation was prevalent in CREST haploinsufficiency mice and Q394X mice mimicking the human CREST Q388X mutation.Furthermore,we showed that both CREST haploinsufficiency and Q394X mice displayed deficits in motor coordination.Finally,we identified the critical role of CREST-BRG1 complex in repressing the expression of immune-related cytokines including Ccl2 and Cxcl10 in neurons,via histone deacetylation,providing the molecular mechanisms underlying inflammatory responses within mice lack of CREST.Conclusion:Our findings indicate that elevated inflammatory responses in a subset of ALS may be caused by neuron-derived factors,suggesting potential therapeutic methods through inflammation pathways. | Cheng Cheng Kan Yang Xinwei Wu Yuefang Zhang Shifang Shan Aaron Gitler Anirvan Ghosh Zilong Qiu | 2019 | Translational Neurodegeneration2019，8，1： | 2 |
| 3 | On the determinationof basic dimensions of a cam with a translating roller-follo-wer 显示文摘 | Dasgupta Anirvan Ghosh Amitabha | 2004 | Journal of Mechanical Design Trans ASME2004，126，1： | 1 |
| 4 | On the determination of basic dimensions of a cam with a translating roller follower显示文摘 | DasGupta Anirvan Ghosh Amitabha | 2004 | Journal of Mechanical Design transaction of the ASME2004，126，1： | 1 |
| 5 | MIMO Capacity Through Correlated Channels in the Presence of Correlated Interrefers and Noise:A (Not So) Large N Analysis显示文摘 | Aris L Moustakas Steven H Simon Anirvan M Sengupta | 2003 | IEEE Transactions on Information Theory2003，49，10： | 1 |
| 6 | A framework for measuring international business cycles显示文摘 | Anirvan Banerji Lorene Hiris | 2001 | International Journal of Forecasting2001，，3： | 1 |
| 7 | Calcium signaling in neurons:molecular mechanisms and cellular consequences context显示文摘 | Anirvan G Michael E G | 1995 | Science1995，268，5208： | 1 |
| 8 | A framework for measuring international business cycles 显示文摘 | ANIRVAN B LORENE H | 2001 | International Journal of Forecasting2001，17，3： | 1 |
| 9 | Nonalcoholic Fatty Liver Disease(NAFLD)Name Change:Requiem or Reveille?显示文摘Nonalcoholic fatty liver disease(NAFLD)affects about a quarter of the world’s population and poses a major health and economic burden globally.Recently,there have been hasty attempts to rename NAFLD to metabolic-associated fatty liver disease(MAFLD)despite the fact that there is no scientific rationale for this.Quest for a“positive criterion”to diagnose the disease and destigmatizing the disease have been the main reasons put forth for the name change.A close scrutiny of the pathogenesis of NAFLD would make it clear that NAFLD is a heterogeneous disorder,involving different pathogenic mechanisms of which metabolic dysfunction-driven hepatic steatosis is only one.Replacing NAFLD with MAFLD would neither enhance the legitimacy of clinical practice and clinical trials,nor improve clinical care or move NAFLD research forward.Rather than changing the nomenclature without a strong scientific backing to support such a change,efforts should be directed at understanding NAFLD pathogenesis across diverse populations and ethnicities which could potentially help develop newer therapeutic options. | Shivaram P.Singh Prajna Anirvan Reshu Khandelwal Sanjaya K.Satapathy | 2021 | Journal of Clinical and Translational Hepatology2021，9，6： | 1 |
| 10 | A framework for measuring international business cycles显示文摘 | Anirvan Banerji Lorene Hiris | 2001 | International Journal of Forecasting2001，17，3： | 1 |
| 11 | On the determination of basic dimensions of a cam with a translating roller-follower 显示文摘 | Dasgupta Anirvan Ghosh Amitabha | 2004 | Journal of Mechanical Design Trans ASME2004，126，1： | 1 |
| 12 | A Calcium-Dependent Switch in a CREST-BRG1 Complex Regulates Activity-Dependent Gene Expression显示文摘 | Zilong Qiu Anirvan Ghosh | 2008 | Neuron2008，，： | 1 |
| 13 | Calcium signaling in neurons :Molecular mechanisms and cellular consequences显示文摘 | Anirvan G | 1995 | Science1995，268，14： | 1 |
| 14 | 全球网上超市逆流而上显示文摘一份新报告称,由于在经济萧条时消费者寻求廉价品,企业寻求新的出路,全球网上超市火了起来。 | Anirvan Ghosh 张含璞(译注) 高卫红(校) | 2011 | 英语世界2011，，8： | 0 |
| 15 | Association of non-alcoholic fatty liver disease and COVID-19: A literature review of current evidence显示文摘The coronavirus disease 2019(COVID-19)pandemic has swept through nations,crippled economies and caused millions of deaths worldwide.Many people diagnosed with COVID-19 infections are often found to develop liver injury,which,in a small portion of patients,progresses to severe liver disease.Liver injury in the form of elevated transaminases,hyperbilirubinemia and alterations in serum albumin has been observed to be higher in patients with severe forms of the disease.Those who already have insult to the liver from chronic disease,such as nonalcoholic fatty liver disease(NAFLD)may be at the greatest disadvantage.The severity of COVID-19 also seems to be driven by the presence of NAFLD and other co-morbidities.About 25%of the global population has NAFLD.With such a widespread prevalence of NAFLD,understanding the disease progression of COVID-19 and the occurrence of liver injury in this vulnerable population assumes great significance.In this review,we present an overview of COVID-19 infection in patients with NAFLD. | Prajna Anirvan Shivaram P Singh Alexa Giammarino Sanjaya K Satapathy | 2021 | World Journal of Hepatology2021，13，8： | 0 |
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