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| 1 | Pathogenesis of hepatocarcinogenesis in non-cirrhotic nonalcoholic fatty liver disease:Potential mechanistic pathways显示文摘Although hepatocellular carcinoma(HCC) primarily arises in the background of liver cirrhosis,the development of HCC in nonalcoholic fatty liver disease(NAFLD) without cirrhosis is increasingly recognized. The pathogenesis of NAFLD associated non-cirrhotic HCC is distinct from that of cirrhotic HCC because the metabolic syndrome(MS) along with obesity and insulin resistance(IR) underlie several unique mechanisms that promote tumorigenesis. IR associated with MS,NAFLD,and type 2 diabetes mellitus lead to the release of multiple pro-inflammatory cytokines,including tumor necrosis factor alpha,interleukin-6,leptin and resistin,as well as decreased amounts of adiponectin. These processes favor the development of hepatic steatosis and inflammation within the liver,which precede HCC development. Nevertheless,further investigation is necessary to elucidate the determinants for development of HCC in patients with NAFLD in the absence of cirrhosis. | Ryan B Perumpail Andy Liu Robert J Wong Aijaz Ahmed Stephen A Harrison | 2015 | World Journal of Hepatology2015，7，22： | 6 |
| 2 | Advances in alcoholic liver disease:An update on alcoholic hepatitis显示文摘Alcoholic hepatitis is a pro-inflammatory chronic liver disease that is associated with high short-term morbidity and mortality(25%-35% in one month) in the setting of chronic alcohol use. Histopathology is notable for micro- and macrovesicular steatosis, acute inflammation with neutrophil infiltration, hepatocellular necrosis, perivenular and perisinusoidal fibrosis, and Mallory hyaline bodies found in ballooned hepatocytes. Other findings include the characteristic eosinophilic fibrillar material(Mallory's hyaline bodies) found in ballooned hepatocytes. The presence of focal intense lobular infiltration of neutrophils is what typically distinguishes alcoholic hepatitis from other forms of hepatitis, in which the inflammatory infiltrate is primarily composed of mononuclear cells. Management consists of a multidisciplinary approach including alcohol cessation, fluid and electrolyte correction, treatment of alcohol withdrawal, and pharmacological therapy based on the severity of the disease. Pharmacological treatment for severe alcoholic hepatitis, as defined by Maddrey's discriminant factor ≥ 32, consists of either prednisolone or pentoxifylline for a period of four weeks. The body of evidence for corticosteroids has been greater than pentoxifylline, although there are higher risks of complications. Recently head-to-head trials between corticosteroids and pentoxifylline have been performed, which again suggests that corticosteroids should strongly be considered over pentoxifylline. | Randy Liang Andy Liu Ryan B Perumpail Robert J Wong Aijaz Ahmed | 2015 | World Journal of Gastroenterology2015，21，42： | 5 |
| 3 | Advances in cirrhosis: Optimizing the management of hepatic encephalopathy显示文摘Hepatic encephalopathy(HE) is a major complication of cirrhosis resulting in significant socioeconomic burden, morbidity, and mortality. HE can be further subdivided into covert HE(CHE) and overt HE(OHE). CHE is a subclinical, less severe manifestation of HE and requires psychometric testing for diagnosis. Due to the time consuming screening process and lack of standardized diagnostic criteria, CHE is frequently underdiagnosed despite its recognized role as a precursor to OHE. Screening for CHE with the availability of the Stroop test has provided a pragmatic method to promptly diagnose CHE. Management of acute OHE involves institution of lactulose, the preferred first-line therapy. In addition, prompt recognition and treatment of precipitating factors is critical as it may result in complete resolution of acute episodes of OHE. Treatment goals include improvement of daily functioning, evaluation for liver transplantation, and prevention of OHE recurrence. For secondary prophylaxis, intolerance to indefinite lactulose therapy may lead to non-adherence and has been identified as a precipitating factor for recurrent OHE. Rifaximin is an effective add-on therapy to lactulose for treatment and prevention of recurrent OHE. Recent studies have demonstrated comparable efficacy of probiotic therapy to lactulose use in both primary prophylaxis and secondary prophylaxis. | Andy Liu Ryan B Perumpail Radhika Kumari Zobair M Younossi Robert J Wong Aijaz Ahmed | 2015 | World Journal of Hepatology2015，7，29： | 3 |
| 4 | Steven Holl的冥思空间显示文摘Stever Holl(斯蒂文·霍尔)1947年出生于美国华盛顿州的布雷默顿,高中毕业后以优异的成绩考入西雅图的华盛顿州大学,1981年开始在美国哥伦比亚大学执教,并很快成为该学院的终身教授,颇具学者风范,就连他的建筑也常常带有哲思的深刻和诗的清新。90年代起,Holl便频频获奖,2001年被《时代》周刊评为美国最好的建筑师,现在的他已经是国际建筑界的一颗耀眼明星。 | 王环宇 Andy Ryan | 2007 | 建筑知识2007，27，6： | 2 |
| 5 | Sensitivity of transvaginal ultrasound screening for endometrial cancer in postmenopausal women: a case-control study within the UKCTOCS cohort显示文摘 | Ian Jacobs Aleksandra Gentry-Maharaj Matthew Burnell Ranjit Manchanda Naveena Singh Aarti Sharma Andy Ryan Mourad W Seif Nazar N Amso Gillian Turner Carol Brunell Gwendolen Fletcher Rani Rangar Kathy Ford Keith Godfrey Alberto Lopes David Oram Jonathan He | 2011 | Lancet Oncology2011，，1： | 2 |
| 6 | No evidence exists for methylation inactivation of the P16 tumor suppressor gene in ovarian carcinogenesis显示文摘 | Andy Ryan Rajai M Al-Jehani | 1998 | Gynecologic oncolngy1998，68，： | 1 |
| 7 | Use and perceived efficacy of complementary and alternative medicines after discontinuation of hormone therapy: a nested United Kingdom Collaborative Trial of Ovarian Cancer Screening cohort study显示文摘 | Aleksandra Gentry-Maharaj Chloe Karpinskyj Clara Glazer Matthew Burnell Andy Ryan Lindsay Fraser Anne Lanceley Ian Jacobs Myra S. Hunter Usha Menon | 2015 | Menopause2015，，4： | 1 |
| 8 | Safety of barricades in cemented paste-backfilled stopes显示文摘In underground mining,there has been an increasing use of'cemented paste'for the backfilling of stopes.As this cemented paste backfill(CPB)enters the stope as a fluid,shotcrete barricades are often used to retain the fill material during and after the filling operations.However,failures of barricades have been reported around the world in recent years.This paper presents an analytical solution based on the elastic thin plate theory for calibrating the design of shotcrete barricades in underground mines using CPB.This solution was used to determine the quantitative relationships between the lateral loading from the paste and the barricade response during the backfilling process.The results show that the proposed solution agrees well with in situ data.According to the actual barricade responses,the acceptable tensile stress and an analysis method of cracks development are proposed.The proposed solution has practical significance for underground mines. | Xu Zhao Andy Fourie Ryan Veenstra Chong-chong Qi | 2020 | International Journal of Minerals,Metallurgy and Materials2020，27，8： | 1 |
| 9 | 盛光的容器显示文摘“如果你有一个灵感.这是一个特别不可知的时刻,必须要记录下来。剩下的就是静静地微笑了。”——stevenHoll(斯蒂文·霍尔)。与其说他是一位建筑师.不如说他更像一位思想者.他的建筑彷佛总能在信手拈来之间.传达出不寻常的讯息。 | 王环宇 Andy Ryan | 2007 | 建筑知识2007，27，5： | 0 |
| 10 | 灵动楼梯显示文摘楼梯作为多层空间的垂直交通连接工具,是建筑物中必不可少的构件。在人们的脑海中,对于楼梯的记忆或映像,或许只存在这样一些类似的镜头:在夜黑风高的深夜,正巧你的目的地又是顶楼,要一步一步地费力走上去,这会儿在白天上上下下几次从不被留意的楼梯间。 | Steven Holl Architects 柿梓 Andy Ryan | 2008 | 缤纷2008，0，10： | 0 |
| 11 | 纳尔逊—阿特金斯美术馆 玻璃镜头显示文摘 | Steven Holl Chris Mcvoy Andy Ryan Kansas City Star | 2013 | 城市环境设计2013，，6： | 0 |
| 12 | 坎贝尔体育中心 地面成点,空间成线显示文摘坎贝尔体育中心位于西218大街与百老汇大街的拐角处,曼哈顿的最东端,百老汇与第十大道和地铁1号线的高架铁轨交叉处。中心成为哥伦比亚大学户外体育项目的核心——贝克体育综合设施的新门户。坎贝尔体育中心是继20世纪70年代建造的马塞勒斯·哈特利·道奇健身中心之后,哥伦比亚大学校园内的首个新建体育设施。它将成为新生的贝克体育综合设施的基石。 | Steven Holl Chris Mcvoy Andy Ryan | 2013 | 城市环境设计2013，，6： | 0 |
| 13 | Editorial for special issue on mitigating the impacts of mining显示文摘Dear readers,A special issue(SI)entitled'Mitigating the Impacts of Mining'has been successfully organized at International Journal of Minerals,Metallurgy and Materials(IJMMM).The primary reason for this SI lies in that this topic is gaining increasing attentions worldwide.A collection of high-quality papers will contribute to the sustainable development of the mining industry. | Chong-chong Qi Andy Fourie Qiu-song Chen Ryan Veenstra | 2020 | International Journal of Minerals,Metallurgy and Materials2020，27，8： | 0 |
| 14 | Neurotrophins differentially stimulate the growth of cochlear neurites on collagen surfaces and in gels显示文摘The electrodes of a cochlear implant are located far from the surviving neurons of the spiral ganglion, which results in decreased precision of neural activation compared to the normal ear. If the neurons could be induced to extend neurites toward the implant, it might be possible to stimulate more discrete subpopulations of neurons, and to increase the resolution of the device. However, a major barrier to neurite growth toward a cochlear implant is the fluid filling the scala tympani, which separates the neurons from the electrodes. The goal of this study was to evaluate the growth of cochlear neurites in three-dimensional extracellular matrix molecule gels, and to increase biocompatibility by using fibroblasts stably transfected to produce neurotrophin-3 and brain-derived neurotrophic factor. Spiral ganglion explants from neonatal rats were evaluated in cultures. They were exposed to soluble neurotrophins, cells transfected to secrete neurotrophins, and/or collagen gels. We found that cochlear neurites grew readily on collagen surfaces and in three-dimensional collagen gels. Co-culture with cells producing neurotrophin-3 resulted in increased numbers of neurites, and neurites that were longer than when explants were cultured with control fibroblasts stably transfected with green fluorescent protein. Brain-derived neurotrophic factor-producing cells resulted in a more dramatic increase in the number of neurites, but there was no significant effect on neurite length. It is suggested that extracellular matrix molecule gels and cells transfected to produce neurotrophins offer an opportunity to attract spiral ganglion neurites toward a cochlear implant. | Joanna Xie Kwang Pak Amaretta Evans Andy Kamgar-Parsi Stephen Fausti Lina Mullen Allen Frederic Ryan | 2013 | Neural Regeneration Research2013，8，17： | 0 |
| 15 | 收藏艺术品的艺术品——Nelson-Atkins艺术博物馆扩建新馆Bloch显示文摘Nelson-Atkins艺术博物馆是美国最著名的艺术博物馆之一,位于美国密苏里州的堪萨斯城。博物馆于1930年破土动工.1933年首次对外开放。由于当时正处于经济大萧条时期,全球艺术品市场涌现出大量的低价倾销的珍贵艺术品,而收购者很少,该馆因此在很短的时间内收购了大量的艺术品,奠定了在艺术博物馆中的地位。 | 王怀英 Andy Ryan(摄影) | 2007 | 中国室内装饰装修天地2007，，6： | 0 |
| 16 | 盛光的容器显示文摘'如果你有一个灵感,这是一个特别不可知的时刻,必须要记录下来。剩下的就是静静地微笑了。'——Steven Holl(斯蒂文·霍尔)。与其说他是一位建筑师,不如说他更像一位思想者,他彷佛总能在信手拈来之间,传达出不寻常的讯息。 | 王环宇 Andy Ryan | 2008 | 艺苑2008，，4： | 0 |
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