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| 1 | Boarding issue in a commercial flight for patients with cavitary pulmonary tuberculosis: A case report显示文摘BACKGROUND Several studies have demonstrated that airborne transmission of Mycobacterium tuberculosis bacteria from patients with active pulmonary tuberculosis(TB) to other passengers or crew members can occur during long flights. As such, non-infectious TB patients are usually allowed to undertake air travel after taking the appropriate anti-TB drugs. However, the global guidelines for air travel for patients with TB are inconsistent and insufficiently detailed with respect to cavitary pulmonary TB(CPTB).CASE SUMMARY Here, we report a case in which a patient with multiple CPTB was permitted air travel, following negative sputum acid-fast bacilli smear tests after administration of proper anti-TB medication. The patient’s culture results were pending.CONCLUSION This case revealed that more specific guidelines regulating air travel for patients with CPTB are necessary. | Woori Jo Chuiyong Pak Yangjin Jegal Kwang Won Seo | 2020 | World Journal of Clinical Cases2020，8，3： | 2 |
| 2 | Effects of cosmetics containing purified honeybee(Apis mellifera L.) venom on acne vulgaris显示文摘OBJECTIVE:Acne vulgaris is a chronic dermatologic problem with multiple factors involved in its pathogenesis.Alternative solutions to acne treatment were instigated by antibiotic resistance despite of its extensive use.Purified bee venom(PBV)has been proposed as a promising candidate for that purpose.The present study was designed to confirm the antibacterial effect of PBV and access the efficacy of cosmetics containing PBV in subjects with acne vulgaris.METHODS:The skin bacterium Propionibacterium acnes was incubated with PBV at various concentrations and bacterial growth was evaluated using the colony forming unit(CFU)assay.The mechanism of PBV employed in killing P.acnes was examined by scanning electron microscopy(SEM)and transmission electron microscopy(TEM).In addition,a total of 12 subjects were randomized in a double-blind,controlled trial to receive either cosmetics containing PBV or cosmetics without PBV for two weeks.Evaluations included lesion counts and skin microorganism.RESULTS:PBV exhibited antimicrobial activity in a concentration-dependent manner,reducing the number of P.acnes CFU by approximately 6 logs at a concentration of 0.5 mg.When PBV concentration was higher than 1.0 mg,no P.acnes colonies were spotted on an agar.TEM and SEM of untreated P.acnes illustrated the normal pleomorphic structure,whereas the PBVtreated bacterium lost the integrity of surface architecture.Significant difference(P=0.027)in the grading levels based on numbers of lesion counts for inflammatory and noninflammatory was observed in favour of the PBV group compared with the control group.In terms of average decrement of skin microorganism,subjects receiving cosmetics containing PBV experienced a significant 57.5%decrease of adenosine triphosphate levels,whereas participants receiving cosmetics without PBV experienced a nonsignificant decrease of 4.7%.CONCLUSION:These results show that the in vitro actions of antimicrobial activity of PBV were translated in vivo.Cosmetics containing PBV provided a certain degree of efficacy in terms of lesion counts and skin microorganism concentration compared with cosmetics without PBV in subjects with acne vulgaris.PBV may be a good candidate compound for developing therapeutic drug for the treatment of acne vulgaris. | Sang Mi Han Kwang Gill Lee Sok Cheon Pak | 2013 | Journal of Integrative Medicine2013，11，5： | 2 |
| 3 | Neural Cell Adhesion Molecule L1 Modulates Type I But Not Type II Inner Ear Spiral Ganglion Neurite Outgrowth in an In Vitro Alternate Choice Assay显示文摘 | Yves Brand Michael Sung Eduardo Chavez Eric Wei Kwang K. Pak Gary D. Housley Daniel Bodmer Allen F. Ryan | 2013 | Journal of Molecular Neuroscience2013，，3： | 1 |
| 4 | Electricfield effects on water clusters(n=3-5):Systematicab initio study of structures,enertics,andtransition states显示文摘 | Young Chiol Choi Chaeho Pak Kwang S Kim | 2006 | The Journal of ChemicalPhysics2006，124，09： | 1 |
| 5 | Neurotrophins differentially stimulate the growth of cochlear neurites on collagen surfaces and in gels显示文摘The electrodes of a cochlear implant are located far from the surviving neurons of the spiral ganglion, which results in decreased precision of neural activation compared to the normal ear. If the neurons could be induced to extend neurites toward the implant, it might be possible to stimulate more discrete subpopulations of neurons, and to increase the resolution of the device. However, a major barrier to neurite growth toward a cochlear implant is the fluid filling the scala tympani, which separates the neurons from the electrodes. The goal of this study was to evaluate the growth of cochlear neurites in three-dimensional extracellular matrix molecule gels, and to increase biocompatibility by using fibroblasts stably transfected to produce neurotrophin-3 and brain-derived neurotrophic factor. Spiral ganglion explants from neonatal rats were evaluated in cultures. They were exposed to soluble neurotrophins, cells transfected to secrete neurotrophins, and/or collagen gels. We found that cochlear neurites grew readily on collagen surfaces and in three-dimensional collagen gels. Co-culture with cells producing neurotrophin-3 resulted in increased numbers of neurites, and neurites that were longer than when explants were cultured with control fibroblasts stably transfected with green fluorescent protein. Brain-derived neurotrophic factor-producing cells resulted in a more dramatic increase in the number of neurites, but there was no significant effect on neurite length. It is suggested that extracellular matrix molecule gels and cells transfected to produce neurotrophins offer an opportunity to attract spiral ganglion neurites toward a cochlear implant. | Joanna Xie Kwang Pak Amaretta Evans Andy Kamgar-Parsi Stephen Fausti Lina Mullen Allen Frederic Ryan | 2013 | Neural Regeneration Research2013，8，17： | 0 |
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