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| 1 | Digital Earth 2020:towards the vision for the next decade显示文摘This position paper is the outcome of a brainstorming workshop organised by the International Society for Digital Earth(ISDE)in Beijing in March 2011.It argues that the vision of Digital Earth(DE)put forward by Vice-President Al Gore 13 years ago needs to be re-evaluated in the light of the many developments in the fields of information technology,data infrastructures and earth observation that have taken place since.The paper identifies the main policy,scientific and societal drivers for the development of DE and illustrates the multi-faceted nature of a new vision of DE grounding it with a few examples of potential applications.Because no single organisation can on its own develop all the aspects of DE,it is essential to develop a series of collaborations at the global level to turn the vision outlined in this paper into reality. | Max Craglia Kees de Bie Davina Jackson Martino Pesaresi Gabor Remetey-Fulopp Changlin Wang Alessandro Annoni Ling Bian Fred Campbell Manfred Ehlers John van Genderen Michael Goodchild Huadong Guo Anthony Lewis Richard Simpson Andrew Skidmore Peter Woodgate | 2012 | International Journal of Digital Earth2012，5，1： | 8 |
| 2 | PrP^C-related signal transduction is influenced by copper, membrane integrity and the alpha cleavage site显示文摘铜绑定,抛锚膜的、细胞的 prion 蛋白质(PrPC ) 有二个组成的劈开地点生产不同 N 终端和 C 终端碎片(N1/C1 和 N2/C2 ) 。用表示也人的 PrPC,鼠标 PrPC 或鼠标 PrPC 的 RK13 房间带 3F4 epitope,这研究在 endoproteolytic 劈开和一个通常认为的 PrPC 函数上探索了 PrPC 主要顺序的影响,地图 kinase 信号 transduction,响应外长的铜与或没有使不安的膜环境。PrPC 主要顺序,特别在 N1/C1 劈开地点附近,看起来在这个地点和细胞外的调整信号的 kinase 1/2 (ERK1/2 ) phosphorylation 影响解朊作用的基础层次,与处理激活增加与基础 ERK1/2 表明一种反的关系。人的 PrPC 独自响应铜显示出增加的 N1/C1 劈开,由特定的 p38 和 JNK/SAPK phosphorylation 伴随了。到加扣押胆固醇的抗菌素 filipin 的铜的联合暴露导致了一只老鼠信号蛋白质 phosphorylation 的 PrPC 特定的实质的增加,由 N1/C1 劈开的增加伴随了。怀有人的 N1/C1 劈开地点的老鼠 PrPC 基础地并且响应铜假定更似人类的侧面并且改变了膜环境。我们的结果证明在 N1/C1 劈开地点附近的 PrPC 主要顺序影响在这个地点处理的 endoproteolytic,它显得连接了基础地并且响应铜印射 kinase 信号 transduction。进一步,主要顺序看起来响应外长的刺激在 PrPC 相关的信号 transduction 的忠实上授与 N1/C1 劈开和膜完整的相互的依赖。 | Cathryn L Haigh | 2009 | Cell Research2009，19，9： | 4 |
| 3 | Sofosbuvir and Ribavirin for Treatment of Compensated Recurrent Hepatitis C Virus Infection After Liver Transplantation显示文摘 | Michael Charlton Edward Gane Michael P. Manns Robert S. Brown Michael P. Curry Paul Y. Kwo Robert J. Fontana Richard Gilroy Lewis Teperman Andrew J. Muir John G. McHutchison William T. Symonds Diana Brainard Brian Kirby Hadas Dvory-Sobol Jill Denning Sara | 2014 | Gastroenterology2014，，： | 2 |
| 4 | Hepatitis C Virus Infects the Endothelial Cells of the Blood-Brain Barrier显示文摘 | Nicola F. Fletcher Garrick K. Wilson Jacinta Murray Ke Hu Andrew Lewis Gary M. Reynolds Zania Stamataki Luke W. Meredith Ian A. Rowe Guangxiang Luo Miguel A. Lopez–Ramirez Thomas F. Baumert Babette Weksler Pierre–Olivier Couraud Kwang Sik Kim Ignacio A. R | 2012 | Gastroenterology2012，，3： | 2 |
| 5 | Cultured circulating tumor cells and their derived xenografts for personalized oncology显示文摘Recent cancer research has demonstrated the existence of circulating tumor cells(CTCs)in cancer patient’s blood.Once identified,CTC biomarkers will be invaluable tools for clinical diagnosis,prognosis and treatment.In this review,we propose ex vivo culture as a rational strategy for large scale amplification of the limited numbers of CTCs from a patient sample,to derive enough CTCs for accurate and reproducible characterization of the biophysical,biochemical,gene expressional and behavioral properties of the harvested cells.Because of tumor cell heterogeneity,it is important to amplify all the CTCs in a blood sample for a comprehensive understanding of their role in cancer metastasis.By analyzing critical steps and technical issues in ex vivo CTC culture,we developed a cost-effective and reproducible protocol directly culturing whole peripheral blood mononuclear cells,relying on an assumed survival advantage in CTCs and CTC-like cells over the normal cells to amplify this specified cluster of cancer cells. | Ruoxiang Wang Gina CYChu Stefan Mrdenovic Alagappan A.Annamalai Andrew E.Hendifar Nicholas N.Nissen James S.Tomlinson Michael Lewis Nallasivam Palanisamy Hsian-Rong Tseng Edwin M.Posadas Michael R.Freeman Stephen J.Pandol Haiyen E.Zhau Leland W.K.Chung | 2016 | Asian Journal of Urology2016，3，4： | 2 |
| 6 | Comparison Between Angiography and Fractional Flow Reserve Versus Single-Photon Emission Computed Tomographic Myocardial Perfusion Imaging for Determining Lesion Significance in Patients With Multivessel Coronary Disease显示文摘 | Michael Ragosta Andrew H. Bishop Lewis C. Lipson Denny D. Watson Lawrence W. Gimple Ian J. Sarembock Eric R. Powers | 2007 | The American Journal of Cardiology2007，，7： | 2 |
| 7 | HealthAgents: distributed multi-agent brain tumor diagnosis and?prognosis显示文摘 | Horacio González-Vélez Mariola Mier Margarida Julià-Sapé Theodoros N. Arvanitis Juan M. García-Gómez Montserrat Robles Paul H. Lewis Srinandan Dasmahapatra David Dupplaw Andrew Peet Carles Arús Bernardo Celda Sabine Huffel Magí Lluch-Ariet | 2009 | Applied Intelligence2009，，3： | 1 |
| 8 | Detrital sedimentary rock classification and nomenclature for use in New Zealand 显示文摘 | Folk R L Andrews P B Lewis D W | 1970 | New Zealand Journal of Geology and Geophysics1970，13，4： | 1 |
| 9 | Household Demand in China显示文摘 | Lewis P & Andrews N | 1989 | Applied Economics1989，，79： | 1 |
| 10 | Phosphorylcholine-based polymers and their use in the prevention of biofouling显示文摘 | Andrew L. Lewis | 2000 | Colloids and Surfaces B: Biointerfaces2000，，3： | 1 |
| 11 | Detrital sedimentary rock classification and nomenclature for use in New Zealand显示文摘 | Folk R L Andrews P B Lewis D W | 1970 | New Zealand Journal of Geology and Geophysics1970，13，4： | 1 |
| 12 | Xaf1 can cooperate with TNFα in the induction of apoptosis, independently of interaction with XIAP显示文摘 | Yan Xia Rachel Novak Jennifer Lewis Colin S. Duckett Andrew C. Phillips | 2006 | Molecular and Cellular Biochemistry (-)2006，，1： | 1 |
| 13 | Detrital sedimentary rock classification and nomenclature for use in new zealand显示文摘 | Folk R L Andrews P B Lewis D W | 1970 | New Zealand Journal of Geology and Geophysics1970，13，： | 1 |
| 14 | Detrital sedimentary rock classification and nomenclature for use in New Zealand 显示文摘 | olk R L Andrews P B Lewis D W | 1970 | New Zealand Journal of Geology and Geophysics1970，13，4： | 1 |
| 15 | A parallel implementation of ant colony optimization显示文摘 | Andrew Lewis | 2002 | Journal of Parallel and Distributed Computing2002，62，9： | 1 |
| 16 | Gill damage in the freshwater fish G nathonemus, petersill (family:Mormyridae) exposed to selected pollutants:An ultrastructural study 显示文摘 | Aazemi B M Lewis J W Andrews E B | 1966 | Environmental technology1966，17，3： | 1 |
| 17 | Psychological therapies for chronic posttraumatic stress disorder(PTSD)in adults显示文摘 | Bisson JI Roberts NP Andrew M Cooper R Lewis C | 2013 | Cochrane Database Syst Rev2013，12，00： | 1 |
| 18 | A Phase I Study of FOLFIRINOX Plus IPI-926, a Hedgehog Pathway Inhibitor, for Advanced Pancreatic Adenocarcinoma显示文摘 | Andrew H. Ko Noelle LoConte Margaret A. Tempero Evan J. Walker R. Kate Kelley Stephanie Lewis Wei-Chou Chang Emily Kantoff Michael W. Vannier Daniel V. Catenacci Alan P. Venook Hedy L. Kindler | 2016 | Pancreas2016，，3： | 1 |
| 19 | Detrital sedimentary rock classification and nomenclature for use in New Zealand显示文摘 | Folk R L Andrews P B Lewis D W | | 0，，04： | 1 |
| 20 | A parallel implementation of ant colony optimization显示文摘 | Marcus Randall Andrew Lewis | 2002 | Journal of Parallel and Distributed Computing2002，62，9： | 1 |
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