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您的检索式：作者名="Andreas Weigert"
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| 1 | HVEM,a cosignaling molecular switch,and its interactions with BTLA,CD160 and LIGHT显示文摘Temporal and spatial expression of cosignaling receptors and their ligands regulates the early stages of T-cell activation(signal 1,T-cell receptor(TCR)signaling and signal 2,costimulation/coinhibition),clonal expansion and T-cell survival during their differentiation towards effector T cells.Once the inflammatory stimulus is eliminated,effector T cells return to homeostasis after undergoing a contraction phase by activation-induced cell death and the intervention of ligands for coinhibitory receptors,leaving a population of long-term memory T cells.The expression of ligands for coinhibitory receptors on hematopoietic cells and,more importantly,on non-hematopoietic cells of peripheral tissues is a key process in tuning the functional activity of effector T cells to prevent excess tissue inflammation that may lead to immunopathology and subsequent tissue dysfunction. | Jose Ignacio Rodriguez-Barbosa Pascal Schneider Andreas Weigert Kyung-Mi Lee Tae-Jin Kim Jose-Antonio Perez-Simon Maria-Luisa del Rio | 2019 | Cellular & Molecular Immunology2019，16，7： | 4 |
| 2 | Adiponectin and its receptors in rodent models of fatty liver disease and liver cirrhosis显示文摘AIM: To determine circulating and hepatic adiponectin in rodents with fatty liver disease or liver cirrhosis and investigate expression of the adiponectin receptors AdipoR1 on the mRNA and protein level and AdipoR2 on the mRNA level. METHODS: Fat fed rats were used as a model for fatty liver disease and bile duct ligation in mice to investigate cirrhotic liver. Expression of AdipoR1 and AdipoR2 mRNA was determined by real time RT-PCR. AdipoR1 protein was analysed by immunoblot. Adiponectin was measured by ELISA. RESULTS: Systemic adiponectin is reduced in fat- fed rats but is elevated in mice after bile duct ligation (BDL). Hepatic adiponectin protein is lower in steatotic liver but not in the liver of BDL-mice when compared to controls. Adiponectin mRNA was not detected in human liver samples or primary human hepatocytes nor in rat liver but recombinant adiponectin is taken up by isolated hepatocytes in-vitro. AdipoR1 mRNA and AdipoR1 protein levels are similar in the liver tissue of control and fat fed animals whereas AdipoR2 mRNA is induced. AdipoR2 mRNA and AdipoR1 mRNA and protein is suppressed in the liver of BDL-mice. CONCLUSION: Our studies show reduced circulating adiponectin in a rat model of fatty liver disease whereas circulating adiponectin is elevated in a mouse model of cirrhosis and similar fi ndings have been described in humans. Diminished hepatic expression of adiponectinreceptors was only found in liver cirrhosis. | Markus Neumeier Claus Hellerbrand Erwin Gbele Roland Buettner Cornelius Bollheimer Johanna Weigert Andreas Schffler Thomas S Weiss Monika Lichtenauer Jürgen Schlmerich Christa Buechler | 2006 | World Journal of Gastroenterology2006，12，34： | 4 |
| 3 | Systemic and hepatic vein galectin-3 are increased in patients with alcoholic liver cirrhosis and negatively correlate with liver function显示文摘 | Josef Wanninger Johanna Weigert Reiner Wiest Sabrina Bauer Thomas Karrasch Stefan Farkas Marcus N. Scherer Roland Walter Thomas S. Weiss Claus Hellerbrand Markus Neumeier Andreas Sch?ffler Christa Buechler | 2011 | Cytokine2011，，3： | 1 |
| 4 | Prostacyclin mediates neuropathic pain through interleukin 1β-expressing resident macrophages显示文摘 | Claus Dieter Schuh Sandra Pierre Andreas Weigert Benjamin Weichand Kai Altenrath Yannick Schreiber Nerea Ferreiros Dong Dong Zhang Jing Suo Elsa-Marie Treutlein Marina Henke Hana Kunkel Manuel Grez Rolf Nüsing Bernhard Brüne Gerd Geisslinger Klaus Scholic | 2013 | Pain2013，，： | 1 |
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