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| 1 | HER2 therapies and gastric cancer:A step forward显示文摘Gastric cancer usually is diagnosed in advanced stages and thus current medical practice affords limited therapeutic options.However,recent studies established the role of human epidermal growth factor receptor 2(HER2)in clinical management.Trastuzumab,an antiHER2 monoclonal antibody,acquired a main role in advanced gastric cancer harboring HER2 overexpression and/or amplification improving survival to 17.1 mo according to trastuzumab for gastric cancer phaseⅢtrial results.Also,new promising drugs,such as c-Met inhibitors,are in development and assessment for this setting.Certainly,novel drugs will emerge in the next feel years for help oncologists improve clinical management of advanced gastric cancer providing higher survival and quality of life.In this mini-review we will discuss some issues in this regard and provide an actual overview of this setting. | Ramon Andrade de Mello Andrea Marin Marques António Araújo | 2013 | World Journal of Gastroenterology2013，19，37： | 7 |
| 2 | Association of nonalcoholic fatty liver disease and liver cancer显示文摘AIM:To investigate the association between nonalcoholic fatty liver disease(NAFLD) and liver cancer,and NAFLD prevalence in different liver tumors.METHODS:This is a retrospective study of the clinical,laboratory and histological data of 120 patients diagnosed with primary or secondary hepatic neoplasms and treated at a tertiary center where they underwent hepatic resection and/or liver transplantation,with subsequent evaluation of the explant or liver biopsy.The following criteria were used to exclude patients from the study:a history of alcohol abuse,hepatitis B or C infection,no tumor detected in the liver tissue examined by histological analysis,and the presence of chronic autoimmune hepatitis,hemochromatosis,Wilson's disease,or hepatoblastoma.The occurrence of NAFLD and the association with its known risk factors were studied.The risk factors considered were diabetes mellitus,impaired glucose tolerance,impaired fasting glucose,body mass index,dyslipidemia,and arterial hypertension.Presence of reticulin fibers in the hepatic neoplasms was assessed by histological analysis using slide-mounted specimens stained with either hematoxylin and eosin or Masson's trichrome and silver impregnation.Analysis of tumor-free liver parenchyma was carried out to determine the association between NAFLD and its histological grade.RESULTS:No difference was found in the association of NAFLD with the general population(34.2% and 30.0% respectively,95%CI:25.8-43.4).Evaluation by cancer type showed that NAFLD was more prevalent in patients with liver metastasis of colorectal cancer than in patients with hepatocellular carcinoma and intrahepatic cholangiocarcinoma(OR = 3.99,95%CI:1.78-8.94,P < 0.001 vs OR = 0.60,95%CI:0.18-2.01,P = 0.406 and OR = 0.70,95%CI:0.18-2.80,P = 0.613,respectively).There was a higher prevalence of liver fibrosis in patients with hepatocellular carcinoma(OR = 3.50,95%CI:1.06-11.57,P = 0.032).Evaluation of the relationship between the presence of NAFLD,nonalcoholic steatohepatitis,and liver fibrosis,and their risk factors,showed no significant statistical association for any of the tumors studied.CONCLUSION:NAFLD is more common in patients with liver metastases caused by colorectal cancer. | Perla Oliveira Schulz Fabio Goncalves Ferreira Maria de Fátima Araújo Nascimento Andrea Vieira Mauricio Alves Ribeiro André Ibrahim David Luiz Arnaldo Szutan | 2015 | World Journal of Gastroenterology2015，21，3： | 2 |
| 3 | Epidermal growth factor receptor and metastatic colorectal cancer:Insights into target therapies显示文摘Colorectal cancer(CRC)has high incidence and mortality worldwide.In 2012,CRC was the second most prevalent cancer among males(9%)and the third among females(8%).In recent decades,standard chemotherapies protocols combining 5-fluorouracil,leucovorin,irinotecan and oxaliplatin were important for improve survival in this set of patients.Further,biological drugs throughout epidermal growth factor receptor(EGFR)pathways showed interesting results in metastatic disease(mCRC)control when in association to standard chemotherapy regimens.Cetuximab and panitumumab are two cornerstones for mCRC treatment and are both approved in Europe and United States based on previous results phaseⅢtrials.This paper will briefly summarize those anti-EGFR therapies framework in mCRC and discusses some issues in this regard. | Ramon Andrade de Mello Andrea Marin Marques António Araújo | 2013 | World Journal of Gastroenterology2013，19，38： | 2 |
| 4 | Corrigendum to “PCR identification of Leishmania in diagnosis and control of canine leishmaniasis” [Vet. Parasitol. 144 (2007) 234–241]显示文摘 | Aparecida H.S. Gomes Isabelle M.R. Ferreira Maria L.S.R. Lima Elaine A. Cunha Andrea S. Garcia Maria F.L. Araújo Vera L. Pereira-Chioccola | 2007 | Veterinary Parasitology2007，，3： | 1 |
| 5 | The effect of splinting upon periodon- tal and palpal healing after autotransplantation of mature and immature permanent incisors in monkeys显示文摘 | Kristemon L Andrea sen JO | 1983 | Int J Oral Surg1983，12，4： | 1 |
| 6 | COL1A1 Sp1-binding site polymorphism as a risk factor for genital prolapse显示文摘 | Andrea Moura Rodrigues Manoel Jo?o Batista Castello Gir?o Ismael Dale Cotrim Guerreiro Silva Marair Gracio Ferreira Sartori Karina de Falco Martins Rodrigo de Aquino Castro | 2008 | International Urogynecology Journal2008，，11： | 1 |
| 7 | Application of Mid- and Near-Infrared Spectroscopy for the Control and Chemical Evaluation of Brine Solutions and Traditional Sea Salts显示文摘 | Andrea C. Galvis-Sánchez Inês C. Santos Raquel B. R. Mesquita Jo?o A. Lopes António O. S. S. Rangel Ivonne Delgadillo | 2013 | Food Analytical Methods2013，，2： | 1 |
| 8 | Ablation of PRDM16 and Beige Adipose Causes Metabolic Dysfunction and a Subcutaneous to Visceral Fat Switch显示文摘 | Paul Cohen Julia D. Levy Yingying Zhang Andrea Frontini Dmitriy P. Kolodin Katrin J. Svensson James C. Lo Xing Zeng Li Ye Melin J. Khandekar Jun Wu Subhadra C. Gunawardana Alexander S. Banks Jo?o Paulo G. Camporez Michael J. Jurczak Shingo Kajimura David | 2013 | Cell2013，，： | 1 |
| 9 | Impeding Macrophage Entry into Hypoxic Tumor Areas by Sema3A/Nrp1 Signaling Blockade Inhibits Angiogenesis and Restores Antitumor Immunity显示文摘 | Andrea Casazza Damya Laoui Mathias Wenes Sabrina Rizzolio Nicklas Bassani Marco Mambretti Sofie Deschoemaeker Jo A. Van Ginderachter Luca Tamagnone Massimiliano Mazzone | 2013 | Cancer Cell2013，，6： | 1 |
| 10 | Differential growth factor retention by platelet-rich plasma composites 显示文摘 | Rick C Jennifer Jo Andrea B | 2005 | Oral Maxillofac Surg2005，63，4： | 1 |
| 11 | Behavioral and cognitive effects of microwave exposure 显示文摘 | D'Andrea JA Adair ER de Lorge JO | 2003 | Bioeleetromagneties2003，6，： | 1 |
| 12 | Association between third mandibular molar impaction and degree of root development in adolescents 显示文摘 | Lauesen SR Andreas JO Gerds TA Christensen SSA | 2013 | Angle Orthod2013，83，1： | 1 |
| 13 | Analysis of the presence of cutaneous and mucosal papillomavirus types in ductal lavage fluid, milk and colostrum to evaluate its role in breast carcinogenesis显示文摘 | Massimiliano Cazzaniga Tarik Gheit Chiara Casadio Noureen Khan Debora Macis Francesco Valenti Mara Jo Miller Bakary S. Sylla Suminori Akiba Bernardo Bonanni Andrea Decensi Umberto Veronesi Massimo Tommasino | 2009 | Breast Cancer Research and Treatment2009，，3： | 1 |
| 14 | Influence of trans- dermal rotigotine on ovulation suppression by a combined oral contraceptive显示文摘 | Braun M Elshoff JP Andreas JO el al | 2009 | Br J Clin Pharmaco2009，68，3： | 1 |
| 15 | Influence of transdermal rotigotine on ovulation suppression by a combined oral contraceptive 显示文摘 | Braun M Elshoff JP Andreas JO | 2009 | Br J Clin Pharmacol2009，68，3： | 1 |
| 16 | A Blank Slate Layer-by-Layer deposition of hyaluronic acid and chitosan onto various surfaces显示文摘 | Tristan IC Andrea JO Geoffrey WS | 2006 | 0Biomacromolecules2006，7，5： | 1 |
| 17 | Differential growth factor retention by platelet-rich plasma composites显示文摘 | Rick C Jennifer Jo Andrea B | 2005 | Oral MaxillofacSurg2005，63，4： | 1 |
| 18 | Alba, Taste Perception: More than Meets the Tongue显示文摘 | Jo Andrea Hoegg JosephW | 2007 | Journal of Consumer Research2007，33，4： | 1 |
| 19 | Mdm2, p53, p21 and pAKT protein pathways in benign neoplasms of the salivary gland显示文摘 | Yonara Maria Freire Soares Marques Marina de Deus Moura de Lima Sérgio de Melo Alves Fernando Augusto Soares Vera Cavalcanti de Araújo Décio dos Santos Pinto Andrea Mantesso | 2007 | Oral Oncology2007，，9： | 1 |
| 20 | Twin Study Indicates Loss of Interaction Between Microbiota and Mucosa of Patients With Ulcerative Colitis显示文摘 | Patricia Lepage Robert H?sler Martina E. Spehlmann Ateequr Rehman Aida Zvirbliene Alexander Begun Stephan Ott Limas Kupcinskas Jo?l Doré Andreas Raedler Stefan Schreiber | 2011 | Gastroenterology2011，，1： | 1 |
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