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| 1 | Hybrid multi-chip assembly of optical communication engines by in situ 3D nanolithography显示文摘Three-dimensional(3D)nano-printing of freeform optical waveguides,also referred to as photonic wire bonding,allows for efficient coupling between photonic chips and can greatly simplify optical system assembly.As a key advantage,the shape and the trajectory of photonic wire bonds can be adapted to the mode-field profiles and the positions of the chips,thereby offering an attractive alternative to conventional optical assembly techniques that rely on technically complex and costly high-precision alignment.However,while the fundamental advantages of the photonic wire bonding concept have been shown in proof-of-concept experiments,it has so far been unclear whether the technique can also be leveraged for practically relevant use cases with stringent reproducibility and reliability requirements.In this paper,we demonstrate optical communication engines that rely on photonic wire bonding for connecting arrays of silicon photonic modulators to InP lasers and single-mode fibres.In a first experiment,we show an eight-channel transmitter offering an aggregate line rate of 448 Gbit/s by low-complexity intensity modulation.A second experiment is dedicated to a four-channel coherent transmitter,operating at a net data rate of 732.7 Gbit/s-a record for coherent silicon photonic transmitters with co-packaged lasers.Using dedicated test chips,we further demonstrate automated mass production of photonic wire bonds with insertion losses of(0.7±0.15)dB,and we show their resilience in environmental-stability tests and at high optical power.These results might form the basis for simplified assembly of advanced photonic multi-chip systems that combine the distinct advantages of different integration platforms. | Matthias Blaicher Muhammad Rodlin Billah Juned Kemal Tobias Hoose Pablo Marin-Palomo Andreas Hofmann Yasar Kutuvantavida Clemens Kieninger Philipp-Immanuel Dietrich Matthias Lauermann Stefan Wolf Ute Troppenz Martin Moehrle Florian Merget Sebastian Skacel Jeremy Witzens Sebastian Randel Wolfgang Freude Christian Koos | 2020 | Light(Science & Applications)2020，9，1： | 4 |
| 2 | Biophotonic sensors with integrated Si_(3)N_(4)-organic hybrid (SiNOH) lasers for point-of-care diagnostics显示文摘Early and efficient disease diagnosis with low-cost point-of-care devices is gaining importance for personalized medicine and public health protection.Within this context,waveguide-(WG)-based optical biosensors on the siliconnitride(Si_(3)N_(4))platform represent a particularly promising option,offering highly sensitive detection of indicative biomarkers in multiplexed sensor arrays operated by light in the visible-wavelength range.However,while passive Si_(3)N_(4)-based photonic circuits lend themselves to highly scalable mass production,the integration of low-cost light sources remains a challenge.In this paper,we demonstrate optical biosensors that combine Si_(3)N_(4)sensor circuits with hybrid on-chip organic lasers.These Si_(3)N_(4)-organic hybrid(SiNOH)lasers rely on a dye-doped cladding material that are deposited on top of a passive WG and that are optically pumped by an external light source.Fabrication of the devices is simple:The underlying Si_(3)N_(4)WGs are structured in a single lithography step,and the organic gain medium is subsequently applied by dispensing,spin-coating,or ink-jet printing processes.A highly parallel read-out of the optical sensor signals is accomplished with a simple camera.In our proof-of-concept experiment,we demonstrate the viability of the approach by detecting different concentrations of fibrinogen in phosphate-buffered saline solutions with a sensor-length(L-)-related sensitivity of S/L=0.16 rad nM^(-1)mm^(-1).To our knowledge,this is the first demonstration of an integrated optical circuit driven by a co-integrated low-cost organic light source.We expect that the versatility of the device concept,the simple operation principle,and the compatibility with cost-efficient mass production will make the concept a highly attractive option for applications in biophotonics and point-of-care diagnostics. | Daria Kohler Gregor Schindler Lothar Hahn Johannes Milvich Andreas Hofmann Kerstin Lange Wolfgang Freude Christian Koos | 2021 | Light(Science & Applications)2021，10，4： | 2 |
| 3 | Zea mays Annexins Modulate Cytosolic Free Ca^sup 2+^ and Generate a Ca^sup 2+^-Permeable Conductance(W)显示文摘 | Laohavisit Anuphon Mortimer Jennifer C Demidchik Vadim Coxon Katy M Stancombe Matthew A Macpherson Neil Brownlee Colin Hofmann Andreas Webb Alex A R Miedema Henk Battey Nicholas H Davies Julia M | 2009 | Plant Cell2009，，2： | 1 |
| 4 | Hybrid PET/MRI of Intracranial Masses: Initial Experiences and Comparison to PET/CT显示文摘 | Boss Andreas Bisdas Sotirios Kolb Armin Hofmann Matthias Ernemann Ulrike Claussen Claus D Pfannenberg Christina Pichler Bernd J Reimold Matthias Stegger Lars | 2010 | The Journal of Nuclear Medicine2010，，8： | 1 |
| 5 | In acute promyelocytic leukemia (APL) low BAALC gene expression identifies a patient group with favorable overall survival and improved relapse free survival显示文摘 | Florian Nolte Anna Hecht Mark Reinwald Daniel Nowak Verena Nowak Benjamin Hanfstein Andreas Faldum Thomas Büchner Karsten Spiekermann Cristina Sauerland Wolf-Karsten Hofmann Eva Lengfelder | 2012 | Leukemia Research2012，，： | 1 |
| 6 | Lung wedge resection improves outcome in stage I primary spontaneous pneumothorax显示文摘 | Martin Czerny Andreas Salat Tatjana Fleck Wolfgang Hofmann Daniel Zimpfer Franz Eckersberger Walter Klepetko Ernst Wolner Michael-Rolf Mueller | 2004 | The Annals of Thoracic Surgery2004，，5： | 1 |
| 7 | Pacemaker Channels and Sinus Node Arrhythmia显示文摘 | Juliane Stieber Franz Hofmann Andreas Ludwig | 2004 | Trends in Cardiovascular Medicine2004，，1： | 1 |
| 8 | A review of Palaeoarchaean felsic volcanism in the eastern Kaapvaal craton:Linking plutonic and volcanic records显示文摘In the Kaapvaal craton of southern Africa, as well as other Archaean cratons worldwide, the progression from dominant tonalite-trondhjemite-granodiorite(TTG) to granite-monzogranite-syenogranite(GMS)rock types is interpreted to reflect progressive reworking and differentiation of the continental crust.Here we re-evaluate the early Archaean evolution of the Kaapvaal craton and propose a unified view of the plutonic and volcanic records based on elemental and isotopic(Nd, Hf) data and zircon U-Pb ages.We also report new whole-rock major and trace element analyses, zircon U-Pb ages and Hf-in-zircon analyses of igneous clasts from a conglomerate of the 3.2 Ga Moodies Group of the Barberton Greenstone Belt. Many of these clasts are derived from shallow intrusive rocks of granitic composition, which are scarcely represented in outcrop. Despite alteration, the volcanic rocks can be classified based on their trace element contents into two main groups by comparison with plutonic rocks. One group has characteristics resembling TTGs: relatively low and fractionated rare earth element concentrations with no Eu anomaly and relatively low concentrations of high field strength elements(Nb mostly ≤12 ppm). The second group has GMS-like characteristics: less fractionated REE, marked negative Eu anomalies and HFSE-increasing trends with progressing fractionation(Nb ≤ 50 ppm or more, Th up to 30-40 ppm). In addition, igneous clasts of Moodies Group conglomerate have chemical, mineralogical and isotopic characteristics that link them to GMS. New analyses of some of these clasts indicate elevated high field strength elements(Nb up to 20 ppm) and_(εHf)(t)of zircon down to -3.5. These rocks imply the presence of an already differentiated felsic crust at >3.5 Ga, which has Nd and Hf model ages indicating mantle extraction ages extending back to the Eoarchaean. The combined record of plutonic and volcanic rocks of the Kaapvaal craton provides a more complex scenario than previously suggested and indicates that TTG and GMS-like felsic magmas were emplaced broadly coevally in multiple pulses between ~3.5 Ga and 3.2 Ga. | Andrea Agangi Axel Hofmann Marlina A.Elburg | 2018 | Geoscience Frontiers2018，9，3： | 1 |
| 9 | Continuous monitoring of bovine spongiform encephalopathy rapid test performance by weak positive tissue controls and quality control charts显示文摘 | Torsten Seuberlich Martin A. Hofmann Valerie Juillerat Patrick Boujon Andreas Zurbriggen Marcus G. Doherr | 2008 | Veterinary Microbiology2008，，3： | 1 |
| 10 | Principles of the therapy of bone infections in adult extremities显示文摘 | Andreas Heinrich Tiemann Gunther O. Hofmann | 2009 | Strategies in Trauma and Limb Reconstruction2009，，2： | 1 |
| 11 | Efficacy and safety of capecitabine in combination with docetaxel and mitomycin C in patients with pre-treated pancreatic, gallbladder, and bile duct carcinoma显示文摘 | Jens Kruth Johanna Nissen Thomas Ernst Melanie Kripp Nadine Lukan Kirsten Merx Wolf-Karsten Hofmann Andreas Hochhaus Ralf-Dieter Hofheinz | 2010 | Journal of Cancer Research and Clinical Oncology2010，，12： | 1 |
| 12 | 24- nor Ursodeoxycholic Acid Is Superior to Ursodeoxycholic Acid in the Treatment of Sclerosing Cholangitis in Mdr2 (Abcb4) Knockout Mice显示文摘 | Peter Fickert Martin Wagner Hanns–Ulrich Marschall Andrea Fuchsbichler Gernot Zollner Oleksiy Tsybrovskyy Kurt Zatloukal Jie Liu Michael P. Waalkes Cathleen Cover Helmut Denk Alan F. Hofmann Hartmut Jaeschke Michael Trauner | 2006 | Gastroenterology2006，，2： | 1 |
| 13 | The role of microRNA-196a and microRNA-196b as ERG regulators in acute myeloid leukemia and acute T-lymphoblastic leukemia显示文摘 | Ebru Coskun Eva Kristin von der Heide Cornelia Schlee Andrea Kühnl Nicola G?kbuget Dieter Hoelzer Wolf-Karsten Hofmann Eckhard Thiel Claudia D. Baldus | 2010 | Leukemia Research2010，，2： | 1 |
| 14 | Data Visualization With Multidimensional Scaling显示文摘 | Andreas Buja Deborah F Swayne Michael L Littman Nathaniel Dean Heike Hofmann Lisha Chen | 2008 | Journal of Computational and Graphical Statistics2008，，2： | 1 |
| 15 | Circulating levels of irisin in patients with anorexia nervosa and different stages of obesity – Correlation with body mass index显示文摘 | Andreas Stengel Tobias Hofmann Miriam Goebel-Stengel Ulf Elbelt Peter Kobelt Burghard F. Klapp | 2013 | Peptides2013，，： | 1 |
| 16 | Expression of inhibitors of apoptosis (IAP) proteins in non-small cell human lung cancer显示文摘 | Hans-Stefan Hofmann Andreas Simm Andreas Hammer Rolf-Edgar Silber Babett Bartling | | Journal of Cancer Research and Clinical Oncology0，，： | 1 |
| 17 | Ghrelin and NUCB2/nesfatin-1 are expressed in the same gastric cell and differentially correlated with body mass index in obese subjects显示文摘 | Andreas Stengel Tobias Hofmann Miriam Goebel-Stengel Vanessa Lembke Anne Ahnis Ulf Elbelt Nils W. G. Lambrecht Jürgen Ordemann Burghard F. Klapp Peter Kobelt | 2013 | Histochemistry and Cell Biology2013，，6： | 1 |
| 18 | Evidence for a plant-associated natural habitat for Cronobacter spp.显示文摘 | Michael Schmid Carol Iversen Iti Gontia Roger Stephan Andreas Hofmann Anton Hartmann Bhavanath Jha Leo Eberl Kathrin Riedel Angelika Lehner | 2009 | Research in Microbiology2009，，8： | 1 |
| 19 | Gel electrolytes based on ionic liquids for advanced lithium polymer batteries显示文摘 | Andreas Hofmann Michael Schulz Thomas Hanemann | 2012 | Electrochimica Acta2012，，： | 1 |
| 20 | Expression of inhibitors of apoptosis (IAP) proteins in non-small cell human lung cancer显示文摘 | Hans-Stefan Hofmann Andreas Simm Andreas Hammer Rolf-Edgar Silber Babett Bartling | 2002 | Journal of Cancer Research and Clinical Oncology2002，，10： | 1 |
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