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| 1 | Histotype-based prognostic classification of gastric cancer显示文摘AIM:To test the efficiency of a recently proposed histotype-based grading system in a consecutive series of gastric cancers.METHODS:Two hundred advanced gastric cancers operated upon in 1980-1987 and followed for a median 159 mo were investigated on hematoxylin-eosinstained sections to identify low-grade [muconodular,well differentiated tubular,diffuse desmoplastic and high lymphoid response (HLR)],high-grade (anaplastic and mucinous invasive) and intermediate-grade (ordinary cohesive,diffuse and mucinous) cancers,in parallel with a previously investigated series of 292 cases.In addition,immunohistochemical analyses for CD8,CD11 and HLA-DR antigens,pancytokeratin and podoplanin,as well as immunohistochemical and molecular tests for microsatellite DNA instability and in situ hybridization for the Epstein-Barr virus (EBV) EBER1 gene were performed.Patient survival was assessed with death rates per 100 person-years and with Kaplan-Meier or Cox model estimates.RESULTS:Collectively,the four low-grade histotypes accounted for 22% and the two high-grade histotypes for 7% of the consecutive cancers investigated,while the remaining 71% of cases were intermediate-grade cancers,with highly significant,stage-independent,survival differences among the three tumor grades (P=0.004 for grade 1 vs 2 and P=0.0019 for grade 2 vs grade 3),thus confirming the results in the original series.A combined analysis of 492 cases showed an improved prognostic value of histotype-based grading compared with the Lauren classification.In addition,it allowed better characterization of rare histotypes,particularly the three subsets of prognostically different mucinous neoplasms,of which 10 ordinary mucinous cancers showed stage-inclusive survival worse than that of 20 muconodular (P=0.037) and better than that of 21 high-grade (P<0.001) cases.Tumors with high-level microsatellite DNA instability (MSI-H) or EBV infection,together with a third subset negative for both conditions,formed the T8 cell-rich HLR group,the largest group among low-grade histotypes.Coexisting HLR proved to be a factor in improved prognosis in tumors with microsatellite instability (P=0.0015 vs HLR-/MSI-H tumors) or DR type human leukocyte antigen expression (P=0.033 vs HLR/HLA-DR+ tumors).CONCLUSION:Identification of lowand high-grade histotypes can improve the prognostic assessment of a substantial proportion of gastric cancers in routine diagnostic practice. | Anna Maria Chiaravalli Catherine Klersy Alessandro Vanoli Andrea Ferretti Carlo Capella Enrico Solcia | 2012 | World Journal of Gastroenterology2012，18，9： | 3 |
| 2 | Arthroscopic vs open ankle arthrodesis:A prospective case series with seven years follow-up显示文摘BACKGROUND The osteoarthritis of the ankle,although less common than other joints,is associated with severe functional limitation.Surgical options are ankle arthroscopic debridement,osteotomies,ankle arthrodesis and ankle arthroplasty.Ankle arthroplasty is increasingly used thanks to the new implants design,but ankle arthrodesis still represents the most used technique and it can be performed arthroscopically or with an open procedure.AIM To compare mid-term results of arthroscopic vs open ankle arthrodesis of patients affected by end-stage ankle arthritis.METHODS This study enrolled 23 patients,which underwent ankle arthrodesis.The patients were divided into 2 groups:group A(open procedure;n=11)and group B(arthroscopic procedure,n=12),the two groups were homogeneous with regard to age and body mass index(P=0.347).The American Orthopaedic Foot and Ankle score(AOFAS),Freiburg Ankle score(FAS)and visual analogue scale for pain intensity were evaluated preoperatively,at six months and at final follow-up of 7.6 years in group A and 7.3 years in group B(P=0.364).RESULTS Patients in the arthroscopic group showed better results at six-month follow-up compared to the open group at the AOFAS(group A,62.2;group B,78.5;P<0.05)and the FAS(group A,61.1;group B,70.3;P=0.015)scores.Pain relief was achieved in both groups at six-month follow-up(group A,1.4;group B,0.9;P=0.162).Both open and arthroscopic groups showed improved clinical outcomes from baseline to final follow-up(P>0.05).Hospital stay was shorter in group B than in group A(P=0.001).More complications were reported in the open group than in the arthroscopic group(P=0.459).CONCLUSION The arthroscopic and the open arthrodesis are valid and safe options for the treatment of ankle arthritis on the basis of clinical outcomes at 7 years follow-up.Moreover,the arthroscopic treatment shows faster improvement at six-month follow-up in comparison with the open group. | Federico Morelli Giorgio Princi Matteo Romano Cantagalli Marco Rossini Ludovico Caperna Daniele Mazza Andrea Ferretti | 2021 | World Journal of Orthopedics2021，12，12： | 3 |
| 3 | Chest pain caused by multiple exostoses of the ribs: A case report and a review of literature显示文摘The aim of this paper is to report an exceptional case of multiple internal exostoses of the ribs in a young patient affected by multiple hereditary exostoses(MHE) coming to our observation for chest pain as the only symptom of an intra-thoracic localization. A 16 years old patient with familiar history of MHE came to our observation complaining a left-sided chest pain. This pain had increased in the last months with no correlation to a traumatic event. The computed tomography(CT) scan revealed the presence of three exostoses located on the left third, fourth and sixth ribs, all protruding into the thoracic cavity, directly in contact with visceral pleura. Moreover, the apex of the one located on the sixth rib revealed to be only 12 mm away from pericardium. Patient underwent video-assisted thoracoscopy with an additional 4-cm mini toracotomy approach. At the last 1-year followup, patient was very satisfied and no signs of recurrence or major complication had occured. In conclusion, chest pain could be the only symptom of an intra-thoracic exostoses localization, possibly leading to serious complications. Thoracic localization in MHE must be suspected when patients complain chest pain. A chest CT scan is indicated to confirm exostoses and to clarify relationship with surrounding structures. Video-assisted thoracoscopic surgery can be considered a valuable option for exostoses removal, alone or in addiction to a mini-thoracotomy approach, in order to reduce thoracotomy morbidity. | Daniele Mazza Mattia Fabbri Cosma Calderaro Carlo Iorio Luca Labianca Camilla Poggi Francesco Turturro Antonello Montanaro Andrea Ferretti | 2017 | World Journal of Orthopedics2017，8，5： | 2 |
| 4 | Minimizing Internal Rotation Strength Deficit After Use of Semitendinosus for Anterior Cruciate Ligament Reconstruction:A Modified Harvesting Technique显示文摘 | Andrea Ferretti Antonio Vadal | 2008 | Arthroscopy:J Arthroscopic Related Surg2008，24，7： | 1 |
| 5 | Extracorporeal shock wave therapy in early osteonecrosis of the femoral head: prospective clinical study with long-term follow-up显示文摘 | Maria Vulpiani Mario Vetrano Donatella Trischitta Laura Scarcello Federica Chizzi Giuseppe Argento Vincenzo Saraceni Nicola Maffulli Andrea Ferretti | 2012 | Archives of Orthopaedic and Trauma Surgery2012，，4： | 1 |
| 6 | Real-Time Simulation of a Space Robotic Arm显示文摘 | Gianni Ferretti Gianantonio Magnani Paolo Porrati Gianpaolo Rizzi Paolo Rocco Andrea Rusconi | | 0，，： | 1 |
| 7 | Extracorporeal shock wave therapy in early osteonecrosis of the femoral head: prospective clinical study with long-term follow-up显示文摘 | Maria Vulpiani Mario Vetrano Donatella Trischitta Laura Scarcello Federica Chizzi Giuseppe Argento Vincenzo Saraceni Nicola Maffulli Andrea Ferretti | 2012 | Archives of Orthopaedic and Trauma Surgery2012，，4： | 1 |
| 8 | Intertrochanteric fractures: comparison between two different locking nails显示文摘 | Carmelo D'Arrigo Alessandro Carcangiu Dario Perugia Simone Scapel- lato Raffaella Alonzo Silvia Frontini Andrea Ferretti | 2012 | Zhongguo Gu Shang2012，36，12： | 1 |
| 9 | Efficient GW calculations in two dimensional materials through a stochastic integration of the screened potential显示文摘Many-body perturbation theory methods,such as the G0W0 approximation,are able to accurately predict quasiparticle(QP)properties of several classes of materials.However,the calculation of the QP band structure of two-dimensional(2D)semiconductors is known to require a very dense BZ sampling,due to the sharp q-dependence of the dielectric matrix in the long-wavelength limit(q→0).In this work,we show how the convergence of the QP corrections of 2D semiconductors with respect to the BZ sampling can be drastically improved,by combining a Monte Carlo integration with an interpolation scheme able to represent the screened potential between the calculated grid points.The method has been validated by computing the band gap of three different prototype monolayer materials:a transition metal dichalcogenide(MoS2),a wide band gap insulator(hBN)and an anisotropic semiconductor(phosphorene).The proposed scheme shows that the convergence of the gap for these three materials up to 50meV is achieved by using k-point grids comparable to those needed by DFT calculations,while keeping the grid uniform. | Alberto Guandalini Pino D’Amico Andrea Ferretti Daniele Varsano | 2023 | npj Computational Materials2023，，1： | 1 |
| 10 | Short-medium Term Tourist Services Demand Forecasting with Rough Set Theory显示文摘 | Emilio Celotto Andrea Ellero Paola Ferretti | 2012 | Procedia Economics and Finance2012，，： | 1 |
| 11 | Extracorporeal shock wave therapy in early osteonecrosis of the femoral head: prospective clinical study with long-term follow-up显示文摘 | Maria Vulpiani Mario Vetrano Donatella Trischitta Laura Scarcello Federica Chizzi Giuseppe Argento Vincenzo Saraceni Nicola Maffulli Andrea Ferretti | 2012 | Archives of Orthopaedic and Trauma Surgery2012，，4： | 1 |
| 12 | Liver-side of inflammatory bowel diseases:Hepatobiliary and druginduced disorders显示文摘Hepatobiliary disorders are among the most common extraintestinal manifestations in inflammatory bowel diseases(IBD),both in Crohn’s disease and ulcerative colitis(UC),and therefore represent a diagnostic challenge.Immunemediated conditions include primary sclerosing cholangitis(PSC)as the main form,variant forms of PSC(namely small-duct PSC,PSC-autoimmune hepatitis overlap syndrome and IgG4-related sclerosing cholangitis)and granulomatous hepatitis.PSC is by far the most common,presenting in up to 8%of IBD patients,more frequently in UC.Several genetic foci have been identified,but environmental factors are preponderant on disease pathogenesis.The course of the two diseases is typically independent.PSC diagnosis is based mostly on typical radiological findings and exclusion of secondary cholangiopathies.Risk of cholangiocarcinoma is significantly increased in PSC,as well as the risk of colorectal cancer in patients with PSC and IBD-related colitis.No disease-modifying drugs are approved to date.Thus,PSC management is directed against symptoms and complications and includes medical therapies for pruritus,endoscopic treatment of biliary stenosis and liver transplant for end-stage liver disease.Other nonimmune-mediated hepatobiliary disorders are gallstone disease,whose incidence is higher in IBD and reported in up to one third of IBD patients,non-alcoholic fatty liver disease,pyogenic liver abscess and portal vein thrombosis.Druginduced liver injury(DILI)is an important issue in IBD,since most IBD therapies may cause liver toxicity;however,the incidence of serious adverse events is low.Thiopurines and methotrexate are the most associated with DILI,while the risk related to anti-tumor necrosis factor-αand anti-integrins is low.Data on hepatotoxicity of newer drugs approved for IBD,like anti-interleukin 12/23 and tofacitinib,are still scarce,but the evidence from other rheumatic diseases is reassuring.Hepatitis B reactivation during immunosuppressive therapy is a major concern in IBD,and adequate screening and vaccination is warranted.On the other hand,hepatitis C reactivation does not seem to be a real risk,and hepatitis C antiviral treatment does not influence IBD natural history.The approach to an IBD patient with abnormal liver function tests is complex due to the wide range of differential diagnosis,but it is of paramount importance to make a quick and accurate diagnosis,as it may influence the therapeutic management. | Stefano Mazza Sara Soro Maria Chiara Verga Biagio Elvo Francesca Ferretti Fabrizio Cereatti Andrea Drago Roberto Grassia | 2021 | World Journal of Hepatology2021，13，12： | 1 |
| 13 | Towards high-throughput many-body perturbation theory: efficient algorithms and automated workflows显示文摘The automation of ab initio simulations is essential in view of performing high-throughput(HT)computational screenings oriented to the discovery of novel materials with desired physical properties.In this work,we propose algorithms and implementations that are relevant to extend this approach beyond density functional theory(DFT),in order to automate many-body perturbation theory(MBPT)calculations.Notably,an algorithm pursuing the goal of an efficient and robust convergence procedure for GW and BSE simulations is provided,together with its implementation in a fully automated framework.This is accompanied by an automatic GW band interpolation scheme based on maximally localized Wannier functions,aiming at a reduction of the computational burden of quasiparticle band structures while preserving high accuracy.The proposed developments are validated on a set of representative semiconductor and metallic systems. | Miki Bonacci Junfeng Qiao Nicola Spallanzani Antimo Marrazzo Giovanni Pizzi Elisa Molinari Daniele Varsano Andrea Ferretti Deborah Prezzi | 2023 | npj Computational Materials2023，，1： | 0 |
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