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| 1 | A Review of Hepatitis B Virus and Hepatitis C Virus Immunopathogenesis显示文摘Despite the advances in therapy,hepatitis B virus(HBV)and hepatitis C virus(HCV)still represent a significant global health burden,both as major causes of cirrhosis,hepatocellular carcinoma,and death worldwide.HBV is capable of incorporating its covalently closed circular DNA into the host cell’s hepatocyte genome,making it rather difficult to eradicate its chronic stage.Successful viral clearance depends on the complex interactions between the virus and host’s innate and adaptive immune response.One encouraging fact on hepatitis B is the development and effective distribution of the HBV vaccine.This has significantly reduced the spread of this virus.HCV is a RNA virus with high mutagenic capacity,thus enabling it to evade the immune system and have a high rate of chronic progression.High levels of HCV heterogeneity and its mutagenic capacity have made it difficult to create an effective vaccine.The recent advent of direct acting antivirals has ushered in a new era in hepatitis C therapy.Sustained virologic response is achieved with DAAs in 85–99%of cases.However,this still leads to a large population of treatment failures,so further advances in therapy are still needed.This article reviews the immunopathogenesis of HBV and HCV,their properties contributing to host immune system avoidance,chronic disease progression,vaccine efficacy and limitations,as well as treatment options and common pitfalls of said therapy. | Corey Saraceni John Birk | 2021 | Journal of Clinical and Translational Hepatology2021，9，3： | 5 |
| 2 | The influence of internal surface treatments on tensile bond strength for two ceramic systems显示文摘 | Kiyan VH Saraceni CH da Silveira BL | 2007 | Oper Dent2007，32，5： | 1 |
| 3 | Spinal meningioma: chronicles of contemporary neurosurgical diagnosis and management 显示文摘 | Saraceni C Harrop JS | 2009 | Clin Neurol Neurosurg2009，111，3： | 1 |
| 4 | Syphilis in pregnancy and congenital syphilis in Amazonas State, Brazil: an evaluation using database linkage显示文摘 | Soeiro CM Miranda AE Saraceni V | 2014 | Cad Saude Publica2014，30，4： | 1 |
| 5 | Levomilnacipran(Fetzima) : A new serotonin - norepinephrine reuptake inhibitor forthe treat- ment of major depressive disorder显示文摘 | Saraceni MM Venci JV Gandhi MA | 2013 | J Pharm Pract2013，27，4： | 1 |
| 6 | Spinal meningioma:chronicles of contemporary neurosurgical diagnosis and management显示文摘 | Saraceni C Harr op JS | 2009 | Clin Neurol Neurosurg2009，111，3： | 1 |
| 7 | The impact of antiretrovirat therapy and isoniazid preventive therapy on tuberculosis incidence in HIV-infected patients in Rio de Janeiro, Brazil显示文摘 | Golub JE Saraceni V Cavalcante SC Pacheco AG Moulton LH King BS Efron A Moore RD Chaisson RE Durovni B | 2007 | AIDS2007，21，11： | 1 |
| 8 | Spinal meningioma: chronicles ofcontemporary neurosurgical diagnosis and management 显示文摘 | Saraceni C Harrop JS | 2009 | Clin Neurol Neurosurg2009，111，： | 1 |
| 9 | Extracorporeal shock wave therapy in early osteonecrosis of the femoral head: prospective clinical study with long-term follow-up显示文摘 | Maria Vulpiani Mario Vetrano Donatella Trischitta Laura Scarcello Federica Chizzi Giuseppe Argento Vincenzo Saraceni Nicola Maffulli Andrea Ferretti | 2012 | Archives of Orthopaedic and Trauma Surgery2012，，4： | 1 |
| 10 | Spinal meningioma:chronicles of contemporary neurosurgical diagnosis and management显示文摘 | Saraceni C Harrop J S | 2009 | Clin Neurol Neurosurg2009，111，3： | 1 |
| 11 | English as a Lingua Franca:Between form and function显示文摘 | Saraceni M | | 0，，02： | 1 |
| 12 | Spinal meningioma: chronicles of contemporary neurosurgical diagnosis and management 显示文摘 | Saraceni C Harrop JS | 2009 | Clin Neurol Neurosurg2009，111，3： | 1 |
| 13 | The influence of internal surface treatments on tensile bond strength for two ceramic systems 显示文摘 | Kiyan VH Saraceni CH da Silveira BL | 2007 | Oper Dent2007，32，5： | 1 |
| 14 | Syphilis in pregnancy and congenital syphilis in Amazonas State, Brazil:An evaluation using database linkage显示文摘 | Soeiro CM Miranda AE Saraceni V | 2014 | Cad Saude Publica2014，30，4： | 1 |
| 15 | The in- fluence of internal surface treatments on tensile bond strength for two ceramic systems 显示文摘 | Kiyan V H Saraceni C H da Silveira B L | 2007 | Oper Dent2007，32，5： | 1 |
| 16 | Comparison of two methods for cardiac output measurement in critically ill patients显示文摘 | Saraceni E Rossi S Persona P | 2011 | Br J Anaesth2011，106，10： | 1 |
| 17 | Extracorporeal shock wave therapy in early osteonecrosis of the femoral head: prospective clinical study with long-term follow-up显示文摘 | Maria Vulpiani Mario Vetrano Donatella Trischitta Laura Scarcello Federica Chizzi Giuseppe Argento Vincenzo Saraceni Nicola Maffulli Andrea Ferretti | 2012 | Archives of Orthopaedic and Trauma Surgery2012，，4： | 1 |
| 18 | Management of chronic pain in osteoporosis:challenges and solutions显示文摘 | Paolucci T Saraceni VM Piccinini G | 2016 | J Pain Res2016，9，： | 1 |
| 19 | Randomized Clinical Trial of Two Resin-Modified Glass Ionomer Materials:1-year Results显示文摘 | Perdig?o J Dutra-Corrêa M Saraceni S | | 0，，06： | 1 |
| 20 | The influence of internal surface treatments on tensile bond strength for two ceramic systems显示文摘 | Kiyan VH Saraceni CH da Silveira BL | 2007 | OperDent2007，32，5： | 1 |
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