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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Body composi-tion and net requirements of protein and energy for weight gain of nellore and crossbreed steers finished under grazing显示文摘 | Sant'Ana N F Fontes C A A Silva R S T | | 0，，04： | 1 |
| 3 | A dye sensitized TiO2 photovoltaic cell constructed with an elastomeric electrolyte显示文摘 | Ana F N Marco A De P | 2000 | Solar Energy Materials & Solar Cells2000，61，： | 1 |
| 4 | Compliance with hepatitis B virus vaccination and risk of occupational exposure to blood and other body fluids in intensive care department personnel in Brazil显示文摘 | Vania F.C Manso Kézia F Castro Sirley M Matos Ana Luiza N Junqueira Sandra B Souza Márcia M Sousa Regina M.B Martins Sheila A Teles | 2003 | AJIC: American Journal of Infection Control2003，，7： | 1 |
| 5 | Subcellular localisation of VEGF in different pituitary cells. Changes of its expression in oestrogen induced prolactinomas显示文摘 | Jorge Humberto Mukdsi Ana Lucía De Paul Silvina Gutiérrez Félix Daniel Roth Agustín Aoki Alicia Inés Torres | 2005 | Journal of Molecular Histology (-)2005，，8： | 1 |
| 6 | Microbleed Burden and Hematoma Expansion in Acute Intracerebral Hemorrhage显示文摘 | Martí-fàbregas Joan Delgado-mederos Raquel Granell Esther Morenas Rodríguez Estrella Marín Lahoz Juan Dinia Lavinia Carrera David Pérez De La Ossa Natalia Sanahuja Jordi Sobrino Tomás De Arce Ana María Alonso De Leci?ana María | 2013 | European Neurology . 2013 (3-4)2013，，3： | 1 |
| 7 | Eect of drying method and length ofstorage on tannin and total phenol concentrations in Pigeon pea seeds 显示文摘 | EDILENE C F ANA RITA A N GILBERTO B S | 2004 | Food Chemistry2004，86，： | 1 |
| 8 | Liquid-liquid equilibrium for the glycerol + alcohol + coconut biodiesel system at different temperatures and at- mospheric pressure 显示文摘 | Mesquita F M R Evangelista N S de Sant'Ana H B | 2012 | Journal of Chemical & Engineer- ingData2012，57，5： | 1 |
| 9 | Changes during the rip-ening of the very late season Spanish peach cultivar Calanda feasi-bility of using CIELAB coordinates as maturity indices显示文摘 | ANA F SARA R ANGEL I N ROSA O | 2005 | ScientiaHorticulturae2005，105，： | 1 |
| 10 | A dye sensitized TiO2 Photovoltaic cell constructed with an elastom eric electrolyte显示文摘 | ANA F N MAREO A D | 2000 | Solar Energy Materials & Solar Cells2000，61，： | 1 |
| 11 | Global spread of the hylEmf colonization virulence gene in mega plasmids of the Enterococcus faecium CC17 polyclonal sub cluster显示文摘 | Ana R F Ana P T Carla N | | 0，，06： | 1 |
| 12 | Analytical differentiation of cider inoculated with yeast (Saccharomyces cerevisiae) isolated from Asturian (Spain) apple juice显示文摘 | VALLES B S BENDRI N ANA RP TAscON N F | 2005 | Lebenson Wiss Teelmol2005，38，5： | 1 |
| 13 | Transport Characterisation of a PIM System Used for the Extraction of Pb(II ) using d-ehpa as Carrier显示文摘 | German S A Ana N B F Eduardo R de S M | 2005 | J Membr Sci2005，250，： | 1 |
| 14 | Characterization of waterborne polyurethane adhesives containing different amounts of ionic groups显示文摘 | P(e)rez-Limi(n)ana M A Arán-Aís F Torró-Palau A M | | 0，，06： | 1 |
| 15 | Nat Methods:利用CRISPR-Cas9组合筛选发现癌症弱点显示文摘导致癌症的基因突变也会削弱癌细胞,从而使得人们有机会开发选择性地杀死它们同时不影响正常细胞的药物。这一概念被称作”合成致死性(synthetic lethality)”,这是因为这些药物仅对发生突变的(或者说合成的)细胞是致命性的。在一项新的研究中。来自美国加州大学圣地亚哥分校、加州大学旧金山分校、斯坦福大学和癌细胞图谱项目(Cancer Cell Map Initiative)的研究人员开发出一种新的方法来寻找合成致死性的基因组合。 | John Paul Shen, Ana Bojorquez-Gomez, Katherine Licon, Kristin Klepper, Daniel Pekin, Alex N Beckett, Kyle Salinas Sanchez, Jason F Kreisberg, Trey Ideker John Paul Shen, Trey Ideker, Prashant Mali John Paul Shen, Dongxin Zhao, Dan Du, Assen Roguev, Jason F Kreisberg, Nevan Krogan, Lei Qi, Trey Ideker, Prashant Mali Dongxin Zhao, Chih-Chung Kuo, Prashant Mali Roman Sasik, Amanda Birmingham, Aaron N Chang, Trey Ideker Jens Luebeck, Alex Thomas Alex Thomas, Chih-Chung Kuo, Nathan E Lewis Dan Du Assen Roguev, Nevan Krogan Nathan E Lewis Lei Qi | 2017 | 现代生物医学进展2017，17，17： | 1 |
| 16 | Pretransplantation liver function impacts on the outcome of allogeneic hematopoietic stem cell transplantation:a study of 455 patients显示文摘 | Barba P Pi(n)ana JL Fernández-Avilés F | | 0，，： | 1 |
| 17 | What is the optimal level of vitamin D in non-dialysis chronic kidney disease population?显示文摘AIM To evaluate thresholds for serum 25(OH)D concentrations in relation to death, kidney progression and hospitalization in non-dialysis chronic kidney disease(CKD) population.METHODS Four hundred and seventy non-dialysis 3-5 stage CKD patients participating in OSERCE-2 study, a prospective, multicenter, cohort study, were prospectively evaluated and categorized into 3 groups according to 25(OH)D levels at enrollment(less than 20 ng/mL, between 20 and 29 ng/mL, and at or above 30 ng/mL), considering 25(OH)D between 20 and 29 ng/mL as reference group. Association between 25(OH)D levels and death(primary outcome), and time to first hospitalization and renal progression(secondary outcomes) over a 3-year followup, were assessed by Kaplan-Meier survival curves and Cox-proportional hazard models. To identify 25(OH)D levels at highest risk for outcomes, receiver operating characteristic(ROC) curves were performed.RESULTS Over 29 ± 12 mo of follow-up, 46(10%) patients dead, 156(33%) showed kidney progression, and 126(27%) were hospitalized. After multivariate adjustment, 25(OH)D < 20 ng/mL was an independent predictor of all-cause mortality(HR = 2.33; 95%CI: 1.10-4.91; P = 0.027) and kidney progression(HR = 2.46; 95%CI: 1.63-3.71; P < 0.001), whereas the group with 25(OH)D at or above 30 ng/mL did not have a different hazard for outcomes from the reference group. Hospitalization outcomes were predicted by 25(OH) levels(HR = 0.98; 95%CI: 0.96-1.00; P = 0.027) in the unadjusted Cox proportional hazards model, but not after multivariate adjusting. ROC curves identified 25(OH)D levels at highest risk for death, kidney progression, and hospitalization, at 17.4 ng/mL [area under the curve(AUC) = 0.60; 95%CI: 0.685-0.69; P = 0.027], 18.6 ng/mL(AUC = 0.65; 95%CI: 0.60-0.71; P < 0.001), and 19.0 ng/m L(AUC = 0.56; 95%CI: 0.50-0.62; P = 0.048), respectively.CONCLUSION25(OH)D < 20 ng/mL was an independent predictor of death and progression in patients with stage 3-5 CKD, with no additional benefits when patients reached the levels at or above 30 ng/m L suggested as optimal by CKD guidelines. | Pablo Molina JoséL Górriz Mariola D Molina Sandra Beltrán Belén Vizcaíno Verónica Escudero Julia Kanter Ana Iávila Jordi Bover Elvira Fernández Javier Nieto Secundino Cigarrán Enrique Gruss Gema Fernández-Juárez Alberto Martínez-Castelao Juan F Navarro-González Ramón Romero Luis M Pallardó | 2016 | World Journal of Nephrology2016，5，5： | 1 |
| 18 | Tetrahyroisoquinoline alkaloids and 2-deoxyribonolactones from Arlsrolochia arcuata 显示文摘 | Mauricio C F Ana Lucia M N Lucia M X L | 2003 | Phytochemistry2003，62，8： | 1 |
| 19 | Frequencies of GSTM1, GSTT1, and GSTP 1 polymorphisms in a Brazilian population显示文摘 | Ana Rossinil Davy C M Rapozol Lidia M F Amorim2 Jacyara M B Macedo1 Raquel Medina1 Jose F N Neto3 Claudia V M Gallol and Luis F R Pintol | 2002 | Genetics and Molecular Research2002，1，3： | 1 |
| 20 | 查看详情显示文摘 | Yolanda S Ramón M María D.M Fé1ix S. Ana M.C. Margarita P.and Salvador Gil | | 0，，： | 1 |
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