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| 1 | Plasma betatrophin levels in patients with liver cirrhosis显示文摘AIM: To investigate the plasma levels of betatrophin in patients with cirrhosis.METHODS: Forty patients diagnosed at the clinic with liver cirrhosis according to biological, ultrasonographic,or histological criteria were included.The severity of cirrhosis was classified according to Pugh's modification of Child's classification and MELD score. Insulin resistance(IR) was assessed by the Homeostasis Model Assessment. A total of 20 patients showed a MELD score higher than 14. The control group consisted in 15 sex-and aged-matched subjects.Fasting blood samples were obtained for subsequent analysis. Serum insulin was determined by Liaison automated immune chemiluminiscence assay(DiaSorin S.p.A.) using a sandwich assay. The sensitivity of the assay was 0.2 μU/mL. The intra and interassay variation coefficients were < 4% and < 10%,respectively. The normal values were between 2 and17 μU/mL. Human active betatrophin was analyzed by specific quantitative sandwich ELISA(Aviscera Bioscience). The sensitivity of the assay was 0.4 ng/mL, and the intra and interassay reproducibility were< 6% and < 10%, respectively.RESULTS: Plasma betatrophin levels were significantly increased in patients with cirrhosis compared with those in healthy subjects(P = 0.0001). Betatrophin levels were also associated with disease severity, being higher in Child-Pugh C patients compared to Child-Pugh B(P< 0.0005) and in patients who displayed a MELD score higher than 14 points compared to patients with lower punctuation(P = 0.01). In addition, we found a positive correlation between plasma betatrophin levels and the severity of cirrhosis according to Child-Pugh classification(r = 0.53; P < 0.01) or MELD score(r = 0.45; P <0.01). In the overall cohort, a moderate correlation between serum betatrophin and plasmatic bilirrubin(r= 0.39; P < 0.01) has been observed, as well as an inverse correlation between betatrophin and albumin(r =-0.41; P < 0.01) or prothrombin time(r =-0.44;P <0.01). Moreover, insulin resistance was observed in82.5% of the cirrhotic patients. In this group of patients,betatrophin levels were significantly higher than those in the group of patients without IR(P < 0.05).CONCLUSION: Plasma betatrophin is increased in patients with cirrhosis. This increase is related to the severity of cirrhosis, as well as with the emergence of insulin resistance. | Maria Teresa Arias-Loste Maria Teresa García-Unzueta Susana Llerena Paula Iruzubieta Angela Puente Joaquín Cabezas Carmen Alonso Antonio Cuadrado José Antonio Amado Javier Crespo Emilio Fábrega | 2015 | World Journal of Gastroenterology2015，21，37： | 9 |
| 2 | 遗传性肥胖与心房颤动的关系显示文摘观察性研究已经确定了体质量指数(body mass index,BMI)与心房颤动之间的关联。然而,从观察性研究中推断因果关系会受到混杂因素、逆因果关系和偏倚的影响。该研究的主要目的是应用BMI的遗传学预测因子评估BMI与心房颤动之间的因果关系。方法:纳入1987-2002年期间在美国、冰岛和荷兰实施的7个前瞻性人群队列研究中基线无心房颤动的欧洲血统个体51 646人, | 刘莉 叶鹏 Chatterjee NA Giulianini F Geelhoed B Lunetta KL Misialek JR Niemeijer MN Rienstra M Rose LM Smith AV Arking DE Ellinor PT Heeringa J Lin H Lubitz SA Soliman EZ Verweij N Alonso A Benjamin EJ Gudnason V Stricker BH van der Harst P Chasman DI Albert CM | 2017 | 中华高血压杂志2017，25，2： | 2 |
| 3 | Epidermoid splenic cysts and partial splenectomy显示文摘 | Seguel Ramírez F Alonso Calderón JL Ollero Caprani JM | | 0，，02： | 1 |
| 4 | Amino acid changes within the Bunyamwera virus nucleocapsid protein differentially affect the mRNA transcription and RNA replication activities of assembled ribonucleoprotein templates显示文摘 | Walter C T Bento D F C Alonso A G Barr J N | 2011 | J Gen Virol2011，92，1： | 1 |
| 5 | Operating parameters that af- fect the carrying capacity of column notation of a zinc sulfide miner- al显示文摘 | Salas A U Garibay R P Alonso F N | 2007 | Minerals Engineering2007，20，： | 1 |
| 6 | Phospholipase C and sphingomyelinase activities of the Clostridium perfringens α-toxin显示文摘 | Patricia Urbina Marietta Flores-Díaz Alberto Alape-Girón Alicia Alonso Félix M. Goni | 2009 | Chemistry and Physics of Lipids2009，，1： | 1 |
| 7 | Immobilization and stabilization of glutaryl acylase on amina ted sepabeads supports by the glutaraldehyde crosslinking method显示文摘 | Alonso N Lopez-Gallego F Betancor L | 2005 | JMol Catal B Enzymatic2005，35，： | 1 |
| 8 | Compartmentalization of ceramide signaling: physical foundations and biological effects 显示文摘 | KOLESNICK R N GONI F M ALONSO A | 2000 | J Cell Physiol2000，184，3： | 1 |
| 9 | Anthocyanin pigments in strawberry显示文摘 | Fátima Lopes da Silva María Teresa Escribano-Bailón José Joaquín Pérez Alonso Julián C. Rivas-Gonzalo Celestino Santos-Buelga | 2005 | LWT - Food Science and Technology2005，，2： | 1 |
| 10 | Shape optimization for path synthesis of crank-rocker mechanisms using a wavelet-based neural network 显示文摘 | GALAN-MAR ALONSO F J DEL-CASTILLO J M | 2009 | Mechanism and Machine Theory2009，44，6： | 1 |
| 11 | Microbleed Burden and Hematoma Expansion in Acute Intracerebral Hemorrhage显示文摘 | Martí-fàbregas Joan Delgado-mederos Raquel Granell Esther Morenas Rodríguez Estrella Marín Lahoz Juan Dinia Lavinia Carrera David Pérez De La Ossa Natalia Sanahuja Jordi Sobrino Tomás De Arce Ana María Alonso De Leci?ana María | 2013 | European Neurology . 2013 (3-4)2013，，3： | 1 |
| 12 | Capillary liquid chromatographic determination of neutral phenolic compounds in apple juices显示文摘 | Gomis D B Phalomino N F Alonso J J M | 2001 | Analy tica Chimica Acta2001，426，： | 1 |
| 13 | The interaction of phosphatidylcholine bilayers with Triton X-100显示文摘 | Go(n)i F M Urbaneja M A Arrondo J L Alonso A Durrani A A Chapman D | | 0，，： | 1 |
| 14 | The porcine 2A10 antigen is homolo- gous to human CD163 and related to macrophage dif ferentiation显示文摘 | Sanchez C Domanech N Vazquez J Alonso F Ezquerra A Domlnguez J | 1999 | Immunol1999，162，： | 1 |
| 15 | Signal transduction mechanism of biased ligands at histamine H2receptors显示文摘 | Alonso N Monczor F Echeverria E | 2014 | The Biochemical Journal2014，459，： | 1 |
| 16 | Reduction in the rates of restenosis after coronary angioplasty with simvastatin and probucol显示文摘 | Merchán Herrera A López Mínguez J Alonso Ruiz F | 1999 | Rev Esp Cardiol1999，52，10： | 1 |
| 17 | Immobilization and stabilization of glutaryl acylase on aminated sepabeads supports by the glutaraldehyde crosslink- ing method显示文摘 | Alonso N L6pez - Gallego F Betancor L | 2005 | Journal of Molecular Ca- talysis B : Enzymatic2005，35，13： | 1 |
| 18 | Ground reaction curves for rock masses exhibiting strain-softening behaviour显示文摘 | Alonso E Alejano LR Varas F Fdez-Manín G Carranza-Torres C | | 0，，13： | 1 |
| 19 | MIND-BEST: Web server for drugs and target discovery; design, synthesis, and assay of MAO-B inhibitors and theoretical-experimental study of G3PDH protein from Triehomonas gallinae显示文摘 | Gonzalez-Diaz H Prado-Prado F Garcia-Mera X Alonso N Abeijon P Caamano O | 2011 | J Proteome Res2011，10，4： | 1 |
| 20 | Microscreening toxicity system based on hying magnetic yeast and gradient chips显示文摘 | Garcia -Alonso J Fakhrullin R F Paunov V N | 2011 | Analytical and Bioanalytical Chemistry2011，400，4： | 1 |
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