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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Atorvastatin Reduces the Expression of Prostaglandin E2 Receptors in Human Carotid Atherosclerotic Plaques and Monocytic Cells: Potential Implications for Plaque Stabilization显示文摘 | Almudena Gómez-Hernández Eva Sánchez-Galán José Luis Martín-Ventura Cristina Vidal Luis Miguel Blanco-Colio Mónica Ortego Melina Vega Javier Serrano Luis Ortega Gonzalo Hernández José Tunón Jesús Egido | 2006 | Journal of Cardiovascular Pharmacology2006，，1： | 1 |
| 3 | Mechanism and kinetics of sulfamethoxazole photocatalytic ozonation in water 显示文摘 | Femando J B Almudena A Juan F G | 2009 | Water Research2009，43，5： | 1 |
| 4 | SNP genotyping in melons: genetic variation, population structure, and linkage disequilibrium显示文摘 | Cristina Esteras Gelsomina Formisano Cristina Roig Aurora Díaz José Blanca Jordi Garcia-Mas María Luisa Gómez-Guillamón Ana Isabel López-Sesé Almudena Lázaro Antonio J. Monforte Belén Picó | 2013 | Theoretical and Applied Genetics2013，，5： | 1 |
| 5 | Resolution of inflammation: an integrated view显示文摘 | Almudena Ortega‐Gómez Mauro Perretti Oliver Soehnlein | 2013 | EMBO Mol Med2013，，5： | 1 |
| 6 | J Chroma A显示文摘 | Almudena M U Jose M G S Consuelo P | 2005 | 1089(1-2):31-382005，1089，12： | 1 |
| 7 | Distinct functions of chemokine receptor axes in the atherogenic mobilization and recruitment of classical monocytes显示文摘 | Oliver Soehnlein Maik Drechsler Yvonne D?ring Dirk Lievens Helene Hartwig Klaus Kemmerich Almudena Ortega‐Gómez Manuela Mandl Santosh Vijayan Delia Projahn Christoph D. Garlichs Rory R. Koenen Mihail Hristov Esther Lutgens Alma Zernecke Christian Weber | 2013 | EMBO Mol Med2013，，3： | 1 |
| 8 | Phenolic composition and magnitude of copigmentation in young and shortly aged red wines made from the cultivars, Cabernet Sauvignon, Cencibel, and Syrah 显示文摘 | Isidro H G Lorenzo E Almudena V | 2005 | Food Chemistry2005，92，： | 1 |
| 9 | Resolution of inflammation: an integrated view显示文摘 | Almudena Ortega‐Gómez Mauro Perretti Oliver Soehnlein | 2013 | EMBO Mol Med2013，，5： | 1 |
| 10 | Transferable force field for carbon dioxide adsorption in zeolites显示文摘 | Almudena G Conchi O A Jose B P | 2009 | J Phys Chem C2009，113，： | 1 |
| 11 | Intensive Treatment With Atorvastatin Reduces Inflammation in Mononuclear Cells and Human Atherosclerotic Lesions in One Month显示文摘 | Jose Luis Martín-Ventura Luis Miguel Blanco-Colio Almudena Gómez-Hernández Bego?a Mu?oz-García Melina Vega Javier Serrano Luis Ortega Gonzalo Hernández José Tu?ón Jesús Egido | 2005 | Stroke2005，，8： | 1 |
| 12 | Overexpression of COX-2, prostaglandin E synthase-1 and prostaglandinE receptors in blood mononuclear cells and plaque of patients with carotid atherosclero-sis: Regulation by nuclear factor-kB 显示文摘 | Almudena G'omez-Hern'andez Jose Luis Mart'n-Ventu- ra Eva S'anchez-Gal'an | 2006 | Atherosclerosis2006，187，1： | 1 |
| 13 | NF-κB Activation and Fas Ligand Overexpression in Blood and Plaques of Patients With Carotid Atherosclerosis: Potential Implication in Plaque Instability显示文摘 | José Luis Martín-Ventura Luis Miguel Blanco-Colio Bego?a Mu?oz-García Almudena Gómez-Hernández Ana Arribas Luis Ortega José Tu?ón Jesús Egido | 2004 | Stroke: Journal of the American Heart Association2004，，2： | 1 |
| 14 | Plasmid profiling and antibiotic resistance of Vibrio strains isolated from cultured penaeid shrimp 显示文摘 | ALMUDENA M A ALEJANDRA G G | 2002 | FEMS Microbiology Letters2002，213，1： | 1 |
| 15 | Anchoring of 10-phenylphenothiazine to mesoporous silica materials:A water compatible organic photocatalyst for the degradation of pollutants显示文摘The application of organic photocatalysts towards the oxidation of pollutants in water is hampered by different limitations such as their insolubility in the media.Herein,we report that the grafting of a photoorganocatalyst into mesoporous silica materials is an ideal approach to obtain effective catalysts.Thereby,the photocatalyst 10-phenylphenothiazine(PTH)was easily anchored into three different mesoporous silica-based materials(MSN,MSU-2 and SBA-15)with different particle sizes and pore sizes through an amide bond formation.The materials were characterized using IR analysis,solid-state X-ray diffraction,porosity and microscopy(SEM and TEM)techniques,showing that PTH is immobilized inside the pores of the materials and its optical properties are maintained after the anchoring.Although homogeneous PTH was inactive in water media,the three photocatalytic materials were active for the degradation of pollutants.SBA-15-AP-PTH exhibited the highest catalytic performance towards the degradation of acetaminophen and diclofenac under solar irradiation,finding in this manner a new strategy for the decontamination of pollutants. | Daniel González-Muñoz Almudena Gómez-Avilés Carmen B.Molina Jorge Bedia Carolina Belver Jose Alemán Silvia Cabrera | 2022 | Journal of Materials Science & Technology2022，，8： | 0 |
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