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| 1 | Hepatitis B virus,HBx mutants and their role in hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC)is one of the leading causes of death induced by cancer in the modern world and majority of the cases are related to chronic hepatitis B virus(HBV)infection.HBV-encoded X protein(HBx)is known to play a pivotal role in the pathogenesis of viral induced HCC.HBx is a multifunctional protein of17 kDa which modulates several cellular processes by direct or indirect interaction with a repertoire of host factors resulting in HCC.HBX might interfere with several cellular processes such as oxidative stress,DNA repair,signal transduction,transcription,protein degradation,cell cycle progression and apoptosis.A number of reports have indicated that HBx is one of the most common viral ORFs that is often integrated into the host genome and its sequence variants play a crucial role in HCC.By mutational or deletion analysis it was shown that carboxy terminal of HBx has a likely role in protein-protein interactions,transcriptional transactivation,DNA repair,cell,signaling and pathogenesis of HCC.The accumulated evidence thus far suggests that it is difficult to understand the mechanistic nature of HBx associated HCC,and HBx mediated transcriptional transactivation and signaling pathways may be a major determinant.This article addresses the role of HBx in the development of HCC with particular emphasis on HBx mutants and their putative targets. | Ashraf Ali Hany Abdel-Hafiz Mohd Suhail Amany Al-Mars Mohammad Khalid Zakaria Kaneez Fatima Sultan Ahmad Esam Azhar Adeel Chaudhary Ishtiaq Qadri | 2014 | World Journal of Gastroenterology2014，20，30： | 29 |
| 2 | Potential mechanisms of hepatitis B virus induced liver injury显示文摘Chronic active hepatitis(CAH) is acknowledged as an imperative risk factor for the development of liver injury and hepatocellular carcinoma.The histological end points of CAH are chronic inflammation,fibrosis and cirrhosis which are coupled with increased DNA synthesis in cirrhotic vs healthy normal livers.The potential mechanism involved in CAH includes a combination of processes leading to liver cell necrosis,inflammation and cytokine production and liver scaring(fibrosis).The severity of liver damage is regulated by Hepatitis B virus genotypes and viral components.The viral and cellular factors that contribute to liver injury are discussed in this article.Liver injury caused by the viral infection affects many cellular processes such as cell signaling,apoptosis,transcription,DNA repair which in turn induce radical effects on cell survival,growth,transformation and maintenance.The consequence of such perturbations is resulted in the alteration of bile secretion,gluconeogenesis,glycolysis,detoxification and metabolism of carbohydrates,proteins,fat and balance of nutrients.The identification and elucidation of the molecular pathways perturbed by the viral proteins are important in order to design effective strategy to minimize and/or restore the hepatocytes injury. | Mohd Suhail Hany Abdel-Hafiz Ashraf Ali Kaneez Fatima Ghazi A Damanhouri Esam Azhar Adeel GA Chaudhary Ishtiaq Qadri | 2014 | World Journal of Gastroenterology2014，20，35： | 12 |
| 3 | Characterization of lipid parameters in diabetic and non-diabetic atherosclerotic patients显示文摘背景 &在类脂化合物侧面不安和糖尿病之间的 ObjectiveThe 关系联系了复杂并发症长是兴趣的一个区域。Dyslipidemia 在糖尿病的病人是心血管的病态和死亡的一个有势力预言者。现在的学习的目的是在百和 76 个个人(45-75 年年龄) 参予了的糖尿病、非糖尿病的动脉粥样硬化患者 patients.MethodsFive 调查在老化和类脂化合物侧面之间的关系这研究。在这些之中, 192 正在有糖尿病 mellitus 和动脉粥样硬化的历史。个人们在健康的底上被分类(正常、非糖尿病的动脉粥样硬化,糖尿病的动脉粥样硬化) 并且年龄(45-55 年, 56-65 年,和 66-75 年) 。所有参加者受到象详细历史一样的过程,为 fasting 血糖的生物化学的分析,血红素 A1c,全部的胆固醇(TC ) , triglycerides (TG ) ,低密度的脂蛋白 --(LDL ) ,很低密度的脂蛋白(VLDL ) 和高密度的脂蛋白(HDL ) 。所有这些参数在所有三个年龄组的糖尿病、非糖尿病的动脉粥样硬化患者病人之间被比较。TC/HDL 和 LDL/HDL 也是有的 calculated.ResultsDiabetic 动脉粥样硬化患者个人(男性和女性) 与非糖尿病的动脉粥样硬化患者和正常控制个人相比的 HDL 的 TC, TG, LDL, VLDL 和底层高级。在所有三个年龄组之中,脂蛋白反常被观察比男性在女性更经常。在与年龄相比的糖尿病的动脉粥样硬化患者题目 TC/HDL 和 LDL/HDL 比率有重要增加,性别随两性的年龄的增加匹配非糖尿病的动脉粥样硬化患者和 dyslipidemia 增加的正常 control.ConclusionsDegree。女性是对糖尿病的 dyslipidemia 敏感的更多并且因此有与增加年龄开发动脉粥样硬化的更多的风险。 | Fatima Ali Hassan Jamil Sanam Saiqa Anwar Nadia Wajid | 2015 | Journal of Geriatric Cardiology2015，12，1： | 6 |
| 4 | Reverse vaccinology assisted designing of multiepitope-based subunit vaccine against SARS-CoV-2显示文摘Background:Coronavirus disease 2019(COVID-19)linked with severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)cause severe illness and life-threatening pneumonia in humans.The current COVID-19 pandemic demands an effective vaccine to acquire protection against the infection.Therefore,the present study was aimed to design a multiepitope-based subunit vaccine(MESV)against COVID-19.Methods:Structural proteins(Surface glycoprotein,Envelope protein,and Membrane glycoprotein)of SARS-CoV-2 are responsible for its prime functions.Sequences of proteins were downloaded from GenBank and several immunoinformatics coupled with computational approaches were employed to forecast B-and T-cell epitopes from the SARS-CoV-2 highly antigenic structural proteins to design an effective MESV.Results:Predicted epitopes suggested high antigenicity,conserveness,substantial interactions with the human leukocyte antigen(HLA)binding alleles,and collective global population coverage of 88.40%.Taken together,276 amino acids long MESV was designed by connecting 3 cytotoxic T lymphocytes(CTL),6 helper T lymphocyte(HTL)and 4 B-cell epitopes with suitable adjuvant and linkers.The MESV construct was non-allergenic,stable,and highly antigenic.Molecular docking showed a stable and high binding affinity of MESV with human pathogenic toll-like receptors-3(TLR3).Furthermore,in silico immune simulation revealed significant immunogenic response of MESV.Finally,MEV codons were optimized for its in silico cloning into the Escherichia coli K-12 system,to ensure its increased expression.Conclusion:The MESV developed in this study is capable of generating immune response against COVID-19.Therefore,if designed MESV further investigated experimentally,it would be an effective vaccine candidate against SARS-CoV-2 to control and prevent COVID-19. | Muhammad Tahir ul Qamar Farah Shahid Sadia Aslam Usman Ali Ashfaq Sidra Aslam Israr Fatima Muhammad Mazhar Fareed Ali Zohaib Ling-Ling Chen | 2020 | Infectious Diseases of Poverty2020，9，5： | 2 |
| 5 | Recent Insights into Signaling Responses to Cope Drought Stress in Rice显示文摘Drought is one of the hot topics needing urgent attention in the current era of climate change.It massively disturbs the rice growth and productivity and is becoming a serious threat.The drought avoidance strategies in rice include stomatal closure,cellular adaptation and changes in root development.Moreover,the endogenous plant hormones(abscisic acid and jasmonic acid)and reactive oxygen species have paramount importance in drought tolerance in rice.The drought tolerance induces modification in biochemical,molecular and physiological properties of plants.At the molecular level,expression of several transcription-factors is modulated which further determine the activation of drought responsive gene families.Mitogen activated protein kinases and Ca signaling pathways initiate an array of signaling cascade for mediating the gene expression in rice.Approaches,conventional breeding methods combined with modern emerging techniques such as genetic engineering,to improve rice drought tolerance were discussed.This review provided recent insights into major regulatory factors against drought stress,signaling mechanisms and molecular engineering strategies(including conventional transgenic and recent genome editing approaches)to induce drought tolerance in rice. | Muhammad Mahran ASLAM Muhammad Abdul Rehman RASHID Mohammad Aquil SIDDIQUI Muhammad Tahir KHAN Fozia FARHAT Shafquat YASMEEN Imtiaz Ahmad KHAN Shameem RAJA Fatima RASOOL Mahboob Ali SIAL ZHAO Yan | 2022 | Rice science2022，29，2： | 2 |
| 6 | Protective effect of capsaicin against methyl methanesulphonate induced toxicity in the third instar larvae of transgenic Drosophila melanogaster(hsp70-lacZ)Bg9显示文摘Capsaicin(trans-8-methyl-N-vanillyl-6-nonenamide) is the main component in hot peppers, including red chili peppers, alapenos, and habanero, belonging to the genus Capsicum. Capsaicin is a potent antioxidant that interferes with free radical activities. In the present study, the possible protective effect of capsaicin was studied against methyl methanesulphonate(MMS) induced toxicity in third instar larvae of transgenic Drosophila melanogaster(hsp70-lacZ)Bg^9. The third instar was allowed to feed on the diet having different doses of capsaicin and MMS separately and in combination. The results suggested that the exposure of third instar larvae to the diet having MMS alone showed significant hsp70 expression as well as tissue DNA and oxidative damage, whereas the larvae feed on the diet having MMS and capsaicin showed a decrease in the toxic effects for 48-h of exposure. In conclusion, capsaicin showed a dose-dependent decrease in the toxic effects induced by MMS in the third instar larvae of transgenic Drosophila melanogaster. | Saba Khanam Ambreen Fatima Rahul Smita Jyoti Fahad Ali Falaq Naz Barkha Shakya Yasir Hasan Siddique | 2017 | Chinese Journal of Natural Medicines2017，15，4： | 1 |
| 7 | Structural studies of vacuum gas oil distillate fractions of Kuwaiti Crude Oil by nuclear magnetic resonance显示文摘 | Ali Fatima Zahida Hameed Khan Nargis Ghaloum | 2004 | Energy & Fuels2004，18，6： | 1 |
| 8 | Evaluation of different detection methods of biofilm formation in the clinical isolates显示文摘 | Afreenish Hassan Javaid Usman Fatima Kaleem Maria Omair Ali Khalid Muhammad Iqbal | 2011 | Brazilian Journal of Infectious Diseases2011，，4： | 1 |
| 9 | Path lanning of mobile robot based on modification of vector field histogram using neuro-fuzzy algorithm 显示文摘 | ALI H H FATIMA B I | 2010 | International Journal of Advancements in Computing Technology2010，2，3： | 1 |
| 10 | Lung findings on thoracic high-resolution computed tomography in patients with ankylosing spondylitis. Correlations with disease duration, clinical findings and pulmonary function testing显示文摘 | Abdellah El Maghraoui Souad Chaouir Ahmed Abid Ahmed Bezza Fatima Tabache Lahsen Achemlal Ali Abouzahir Driss Ghafir Victor Ohayon Moulay Idriss Archane | 2004 | Clinical Rheumatology2004，，2： | 1 |
| 11 | Biomarkers for virus-induced hepatocellular carcinoma (HCC)显示文摘 | Shilu Mathew Ashraf Ali Hany Abdel-Hafiz Kaneez Fatima Mohd Suhail Govindaraju Archunan Nargis Begum Syed Jahangir Muhammad Ilyas Adeel G.A. Chaudhary Mohammad Al Qahtani Salem Mohamad Bazarah Ishtiaq Qadri | 2014 | Infection, Genetics and Evolution2014，，： | 1 |
| 12 | Racial Disparities in Tissue Plasminogen Activator Treatment Rate for Stroke: A Population-Based Study显示文摘 | Amie W. Hsia Dorothy F. Edwards Lewis B. Morgenstern Jeffrey J. Wing Nina C. Brown Regina Coles Sarah Loftin Andrea Wein Sara S. Koslosky Sabiha Fatima Brisa N. Sánchez Ali Fokar M. Chris Gibbons Nawar Shara Annapurni Jayam-Trouth Chelsea S. Kidwell | 2011 | Stroke2011，，8： | 1 |
| 13 | Extremely rare case of primary esophageal mucous associated lymphoid tissue lymphoma显示文摘SJ is a 37-year-old male who presented with one year history of dysphagia, odynophagia and 15 pounds weight loss. He underwent endoscopic evaluation which showed mid esophageal ulcers. It was thought that the cause of the ulcer was the multivitamins and the patient was asked to stop them. Furthermore Esomeprazole therapy was also initiated. Patient's symptoms persisted but he did not seek any medical attention until about one year later. Meanwhile the patient reported additional 15 pounds of weight loss. We repeated upper endoscopy again which showed evidence of two chronic non bleeding irregular friable ulcerations seen in the mid esophagus, 31 cm from the incisors. Biopsies and frozen section were taken and sent for assessment to the Pathology lab. Immunoperoxidase studies on frozen sections showed the presence of IgM and for most plasma cells IgG. The microscopic and histologic findings were consistent with mucous associated lymphoid tissue lymphoma with plasmocytic differentiation. Computed tomographic scan done showed no evidence of spread to adjacent structures. The patient was referred to oncology and several cycles of radiation and Rituximab therapy were initiated which cured the disease. Subsequent endoscopies with blind biopsies were done which were negative for any neoplastic process. | Ali Osama Malik Zahid Baig Aqeel Ahmed Nasar Qureshi Fatima Noor Malik | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，9： | 1 |
| 14 | Synthesis of 2,3-disubstituted pyrazines and quinoxalines by Heck cross-coupling reactions of 2,3-dichloropyrazine and 2,3-dichloroquinoxaline. Influence of the temperature on the product distribution显示文摘 | Imran Malik Munawar Hussain Asad Ali Serge-Mithérand Tengho Toguem Fatima Z. Basha Christine Fischer Peter Langer | 2010 | Tetrahedron2010，，9： | 1 |
| 15 | Relationship of the Manifestations of Tuberculosis to CD4 Cell Counts in Patients with HIV Infection显示文摘 | Nazish Fatima Abida Malik Parvez Anwar Khan Sana Ali Mohd. Shameem | 2012 | Journal of US-China Medical Science2012，9，4： | 0 |
| 16 | Modeling of Computer Virus Propagation with Fuzzy Parameters显示文摘Typically,a computer has infectivity as soon as it is infected.It is a reality that no antivirus programming can identify and eliminate all kinds of viruses,suggesting that infections would persevere on the Internet.To understand the dynamics of the virus propagation in a better way,a computer virus spread model with fuzzy parameters is presented in this work.It is assumed that all infected computers do not have the same contribution to the virus transmission process and each computer has a different degree of infectivity,which depends on the quantity of virus.Considering this,the parametersβandγbeing functions of the computer virus load,are considered fuzzy numbers.Using fuzzy theory helps us understand the spread of computer viruses more realistically as these parameters have fixed values in classical models.The essential features of the model,like reproduction number and equilibrium analysis,are discussed in fuzzy senses.Moreover,with fuzziness,two numerical methods,the forward Euler technique,and a nonstandard finite difference(NSFD)scheme,respectively,are developed and analyzed.In the evidence of the numerical simulations,the proposed NSFD method preserves the main features of the dynamic system.It can be considered a reliable tool to predict such types of solutions. | Reemah M.Alhebshi Nauman Ahmed Dumitru Baleanu Umbreen Fatima Fazal Dayan Muhammad Rafiq Ali Raza Muhammad Ozair Ahmad Emad E.Mahmoud | 2023 | Computers, Materials & Continua2023，，3： | 0 |
| 17 | Computational Algorithms for the Analysis of Cancer Virotherapy Model显示文摘Cancer is a common term for many diseases that can affect any part of the body.In 2020,ten million people will die due to cancer.A worldwide leading cause of death is cancer by the World Health Organization(WHO)report.Interaction of cancer cells,viral therapy,and immune response are identified in this model.Mathematical and computational modeling is an effective tool to predict the dynamics of cancer virotherapy.The cell population is categorized into three parts like uninfected cells(x),infected cells(y),virus-free cells(v),and immune cells(z).The modeling of cancerlike diseases is based on the law of mass action(the rate of change of reacting substances is directly proportional to the product of interacting substances).Positivity,boundedness,equilibria,threshold analysis,are part of deterministic modeling.Later on,a numerical analysis is designed by using the standard and non-standard finite difference methods.The non-standard finite difference method is developed to study the long-term behavior of the cancer model.For its efficiency,a comparison of the methods is investigated. | Ali Raza Dumitru Baleanu Muhammad Rafiq Syed Zaheer Abbas Abubakar Siddique Umer Javed Mehvish Naz Arooj Fatima Tayyba Munawar Hira Batool Zaighum Nazir | 2022 | Computers, Materials & Continua2022，，5： | 0 |
| 18 | Towards Cache-Assisted Hierarchical Detection for Real-Time Health Data Monitoring in IoHT显示文摘Real-time health data monitoring is pivotal for bolstering road services’safety,intelligence,and efficiency within the Internet of Health Things(IoHT)framework.Yet,delays in data retrieval can markedly hinder the efficacy of big data awareness detection systems.We advocate for a collaborative caching approach involving edge devices and cloud networks to combat this.This strategy is devised to streamline the data retrieval path,subsequently diminishing network strain.Crafting an adept cache processing scheme poses its own set of challenges,especially given the transient nature of monitoring data and the imperative for swift data transmission,intertwined with resource allocation tactics.This paper unveils a novel mobile healthcare solution that harnesses the power of our collaborative caching approach,facilitating nuanced health monitoring via edge devices.The system capitalizes on cloud computing for intricate health data analytics,especially in pinpointing health anomalies.Given the dynamic locational shifts and possible connection disruptions,we have architected a hierarchical detection system,particularly during crises.This system caches data efficiently and incorporates a detection utility to assess data freshness and potential lag in response times.Furthermore,we introduce the Cache-Assisted Real-Time Detection(CARD)model,crafted to optimize utility.Addressing the inherent complexity of the NP-hard CARD model,we have championed a greedy algorithm as a solution.Simulations reveal that our collaborative caching technique markedly elevates the Cache Hit Ratio(CHR)and data freshness,outshining its contemporaneous benchmark algorithms.The empirical results underscore the strength and efficiency of our innovative IoHT-based health monitoring solution.To encapsulate,this paper tackles the nuances of real-time health data monitoring in the IoHT landscape,presenting a joint edge-cloud caching strategy paired with a hierarchical detection system.Our methodology yields enhanced cache efficiency and data freshness.The corroborative numerical data accentuates the feasibility and relevance of our model,casting a beacon for the future trajectory of real-time health data monitoring systems. | Muhammad Tahir Mingchu Li Irfan Khan Salman AAl Qahtani Rubia Fatima Javed Ali Khan Muhammad Shahid Anwar | 2023 | Computers, Materials & Continua2023，77，11： | 0 |
| 19 | Optimization of Coronavirus Pandemic Model Through Artificial Intelligence显示文摘Artificial intelligence is demonstrated by machines,unlike the natural intelligence displayed by animals,including humans.Artificial intelligence research has been defined as the field of study of intelligent agents,which refers to any system that perceives its environment and takes actions that maximize its chance of achieving its goals.The techniques of intelligent computing solve many applications of mathematical modeling.The researchworkwas designed via a particularmethod of artificial neural networks to solve the mathematical model of coronavirus.The representation of the mathematical model is made via systems of nonlinear ordinary differential equations.These differential equations are established by collecting the susceptible,the exposed,the symptomatic,super spreaders,infection with asymptomatic,hospitalized,recovery,and fatality classes.The generation of the coronavirus model’s dataset is exploited by the strength of the explicit Runge Kutta method for different countries like India,Pakistan,Italy,and many more.The generated dataset is approximately used for training,validation,and testing processes for each cyclic update in Bayesian Regularization Backpropagation for the numerical treatment of the dynamics of the desired model.The performance and effectiveness of the designed methodology are checked through mean squared error,error histograms,numerical solutions,absolute error,and regression analysis. | Manal M.Alqarni Arooj Nasir Dumitru Baleanu Ali Raza Tahir Nawaz Cheema Nauman Ahmed Muhammad Rafiq Umbreen Fatima Emad E.Mahmoud | 2023 | Computers, Materials & Continua2023，，3： | 0 |
| 20 | In vitro-in vivo correlation study on nimesulide loaded hydroxypropylmethylcellulose microparticles显示文摘This study involves mathematical simulation model such as in vitro-in vivo correlation(IVIVC) development for various extended release formulations of nimesulide loaded hydroxypropylmethylcellulose(HPMC) microparticles(M1,M2 and M3 containing 1,2,and 3 g HPMC,respectively and 1 g drug in each) having variable release characteristics.In vitro dissolution data of these formulations were correlated to their relevant in vivo absorption profiles followed by predictability worth analysis of these Level A IVIVC.Nimaran was used as control formulation to validate developed formulations and their respective models.The regression coefficients of IVIVC plots for M1,M2,M3 and Nimaran were 0.834 9,0.831 2,0.927 2 and 0.898 1,respectively.The internal prediction error for all formulations was within limits,i.e.,<10%.A good IVIVC was found for controlled release nimesulide loaded HPMC floating M3 microparticles.In other words,this mathematical simulation model is best fit for biowaiver studies which involves study parameters as those adopted for M3 because the value of its IVIVC regression coefficient is the closest to 1 as compared to M1 and M2. | Shujaat Ali KHAN Mahmood AHMAD Ghulam MURTAZA Muhammad Naeem AAMIR Rozina KOUSAR Fatima RASOOL Shahiq-u-ZAMAN | 2010 | 药学学报2010，45，6： | 0 |
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