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| 1 | Endoscopic transpapillary brush cytology and forceps biopsy in patients with hilar cholangiocarcinoma显示文摘AIM: To evaluate the sensitivity of brush cytology and forceps biopsy in a homogeneous patient group with hilar cholangiocarcinoma.METHODS: Brush cytology and forceps biopsy were routinely performed in patients with suspected malignant biliary strictures. Fifty-eight consecutive patients undergoing endoscopic retrograde cholangio-pancreatography (ERCP) including forceps biopsy and brush cytology in patients with hilar cholangiocarcinoma between 1995-2005.RESULTS: Positive results for malignancy were obtained in 24/58 patients (41.4%) by brush cytology and in 31/58 patients (53.4%) by forceps biopsy. The combination of both techniques brush cytology and forceps biopsy resulted only in a minor increase in diagnostic sensitivity to 60.3% (35/58 patients). In 20/58 patients (34.5%), diagnosis were obtained by both positive cytology and positive histology, in 11/58 (19%) by positive histology (negative cytology) and only 4/58 patients (6.9%) were confirmed by positive cytology (negative histology).CONCLUSION: Brush cytology and forceps biopsy have only limited sensitivity for the diagnosis of malignant hilar tumors. In our eyes, additional diagnostic techniques should be evaluated and should become routine in patients with negative cytological and histological findings. | Andreas Weber Claus von Weyhern Falko Fend Jochen Schneider Bruno Neu Alexander Meining Hans Weidenbach Roland M Schmid Christian Prinz | 2008 | World Journal of Gastroenterology2008，14，7： | 17 |
| 2 | Current Status and Future Challenges of Weather Radar Polarimetry: Bridging the Gap between Radar Meteorology/Hydrology/Engineering and Numerical Weather Prediction显示文摘After decades of research and development, the WSR-88 D(NEXRAD) network in the United States was upgraded with dual-polarization capability, providing polarimetric radar data(PRD) that have the potential to improve weather observations,quantification, forecasting, and warnings. The weather radar networks in China and other countries are also being upgraded with dual-polarization capability. Now, with radar polarimetry technology having matured, and PRD available both nationally and globally, it is important to understand the current status and future challenges and opportunities. The potential impact of PRD has been limited by their oftentimes subjective and empirical use. More importantly, the community has not begun to regularly derive from PRD the state parameters, such as water mixing ratios and number concentrations, used in numerical weather prediction(NWP) models.In this review, we summarize the current status of weather radar polarimetry, discuss the issues and limitations of PRD usage, and explore potential approaches to more efficiently use PRD for quantitative precipitation estimation and forecasting based on statistical retrieval with physical constraints where prior information is used and observation error is included. This approach aligns the observation-based retrievals favored by the radar meteorology community with the model-based analysis of the NWP community. We also examine the challenges and opportunities of polarimetric phased array radar research and development for future weather observation. | Guifu ZHANG Vivek N.MAHALE Bryan J.PUTNAM Youcun QI Qing CAO ANDrew D.BYRD Petar BUKOVCIC Dusan S.ZRNIC Jidong GAO Ming XUE Youngsun JUNG Heather D.REEVES Pamela L.HEINSELMAN AlexANDer RYZHKOV Robert D.PALMER Pengfei ZHANG Mark WEBER Greg M.MCFARQUHAR Berrien MOORE III Yan ZHANG Jian ZHANG J.VIVEKANANDAN Yasser AL-RASHID Richard L.ICE Daniel S.BERKOWITZ Chong-chi TONG Caleb FULTON Richard J.DOVIAK | 2019 | Advances in Atmospheric Sciences2019，36，6： | 9 |
| 3 | A Multicenter Analysis of Distal Pancreatectomy for Adenocarcinoma: Is Laparoscopic Resection Appropriate?显示文摘 | David A. Kooby William G. Hawkins C. Max Schmidt Sharon M. Weber David J. Bentrem Theresa W. Gillespie Johnita Byrd Sellers Nipun B. Merchant Charles R. Scoggins Robert C.G. Martin Hong Jin Kim Syed Ahmad Clifford S. Cho Alexander A. Parikh Carrie K. Chu | 2010 | Journal of the American College of Surgeons2010，，5： | 2 |
| 4 | Mucosal flora in inflammatory bowel disease显示文摘 | Alexander Swidsinski Axel Ladhoff Annelie Pernthaler Sonja Swidsinski Vera Loening-Baucke Marianne Ortner Jutta Weber Uwe Hoffmann Stefan Schreiber Manfred Dietel Herbert Lochs | 2002 | Gastroenterology2002，，1： | 2 |
| 5 | Should antibiotics be administered before arthroscopic knee surgery? A systematic review of the literature显示文摘AIM To explore the current evidence surrounding the administration of prophylactic antibiotics for arthroscopic knee surgery. METHODS Databases were searched from inception through May of 2018 for studies examining prophylactic antibiotic use and efficacy in knee arthroscopy. Studies with patient data were further assessed for types of arthroscopic procedures performed,number of patients in the study,use of antibiotics,and outcomes with the intention of performing a pooled analysis. Data pertaining to 'deep tissue infection' or 'septic arthritis' were included in our analysis. Reported data on superficial infection were not included in our data analysis. For the pooled analysis,a relative risk ratio was calculated and χ~2 tests were used to assess for statistical significance between rates of infection amongst the various patient groups. Post hoc power analyses were performed to compute the statistical power obtained from our sample sizes. Number needed to treat analyses were performed for statistically significant differences by dividing 1 by the difference between the infection rates of the antibiotic and no antibiotic groups. An alpha value of 0.05 was used for our analysis. Study heterogeneity was assessed by Cochrane's Q test as well as calculation of the I^2 value.RESULTS A total of 49682 patients who underwent knee ar-throscopy for a diverse set of procedures across 19 studies met inclusion critera for pooled analysis. For those not undergoing graft procedures,there were 27 cases of post-operative septic arthritis in 34487 patients(0.08%) who received prophylactic antibiotics and 16 cases in 10911(0.15%) who received none [risk ratio(RR) = 0.53,95% confidence interval(CI): 0.29-0.99,P = 0.05]. A sub-group analysis in which bony procedures were excluded was performed which found no significant difference in infection rates between patients that received prophylactic antibiotics and patients that did not(P > 0.05). All anterior cruciate ligament reconstruction studies used prophylactic antibiotics,but two studies investigating the effect of soaking the graft in vancomycin in addition to standard intravenous(IV) prophylaxis were combined for analysis. There were 19 cases in 1095 patients(1.74%) who received IV antibioitics alone and no infections in 2034 patients who received IV antibiotics and had a vancomycin soaked graft(RR = 0.01,95%CI: 0.001-0.229,P < 0.01).CONCLUSION Prophylactic antibiotics are effective in preventing septic arthritis following simple knee arthroscopy. In procedures involving graft implantation,graft soaking reduces the rate of infection. | John Carney Nathanael Heckmann Erik N Mayer Ram K Alluri Carleton Thomas Vangsness George F Hatch Ⅲ Alexander E Weber | 2018 | World Journal of Orthopedics2018，9，11： | 2 |
| 6 | Trends and challenges in the microbial production of lignocellulosic bioalcohol fuels显示文摘 | Christian Weber Alexander Farwick Feline Benisch Dawid Brat Heiko Dietz Thorsten Subtil Eckhard Boles | 2010 | Applied Microbiology and Biotechnology2010，，4： | 1 |
| 7 | Long-term outcome of endoscopic and/or percutaneous transhepatic therapy in patients with biliary stricture after orthotopic liver transplantation显示文摘 | Andreas Weber Christian Prinz Carlos Gerngro? Leopold Ludwig Wolfgang Huber Bruno Neu Matthias P. Ebert Alexander Meining Hans Weidenbach Roland M. Schmid Ewert Schulte-Frohlinde | 2009 | Journal of Gastroenterology2009，，12： | 1 |
| 8 | The modulation of Amyotrophic Lateral Sclerosis risk by Ataxin-2 intermediate polyglutamine expansions is a specific effect显示文摘 | Suzana Gispert Alexander Kurz Stefan Waibel Peter Bauer Inga Liepelt Christof Geisen Aaron D. Gitler Tim Becker Markus Weber Daniela Berg Peter M. Andersen Rejko Krüger Olaf Riess Albert C. Ludolph Georg Auburger | 2011 | Neurobiology of Disease2011，，1： | 1 |
| 9 | FDG PET imaging of locally advanced gastric carcinomas: correlation with endoscopic and histopathological findings显示文摘 | Alexander Stahl Katja Ott Wolfgang Weber Karen Becker Thomas Link J?rg-Rüdiger Siewert Markus Schwaiger Ulrich Fink | 2003 | European Journal of Nuclear Medicine and Molecular Imaging2003，，2： | 1 |
| 10 | FDG PET imaging of locally advanced gastric carcinomas: correlation with endoscopic and histopathological findings显示文摘 | Alexander Stahl Katja Ott Wolfgang Weber Karen Becker Thomas Link J?rg-Rüdiger Siewert Markus Schwaiger Ulrich Fink | 2003 | European Journal of Nuclear Medicine and Molecular Imaging2003，，2： | 1 |
| 11 | Primary pulmonary malignant meningioma with lymph node and liver metastasis in a centenary woman, an autopsy case显示文摘 | Catherine Weber Sophie Pautex Gilbert B. Zulian Marc Pusztaszeri Johannes Alexander Lobrinus | 2013 | Virchows Archiv2013，，4： | 1 |
| 12 | N-terminal B-type natriuretic peptide predicts extent of coronary artery disease and ischemia in patients with stable angina pectoris显示文摘 | Michael Weber Thorsten Dill Roman Arnold Matthias Rau Okan Ekinci Klaus D. Müller Alexander Berkovitsch Veselin Mitrovic Christian Hamm | 2004 | American Heart Journal2004，，4： | 1 |
| 13 | Recognition of pneumococcal peptidoglycan: an expanded, pivotal role for LPS binding protein显示文摘 | Weber J R Freyer D Alexander C | 2003 | Immunity2003，19，2： | 1 |
| 14 | The role of lipopolysac-charide-binding protein in modulating the innate immune response 显示文摘 | Weber J R Freyer D Alexander C | 2006 | Microbes Infect2006，8，3： | 1 |
| 15 | Lymphoplasmacytic sclerosing pancreatitis: Inflammatory mimic of pancreatic carcinoma显示文摘 | Sharon M. Weber M.D. Olcay Cubukcu- Dimopulo M.D. J. Alexander Palesty M.D. Arief Suriawinata M.D. David Klimstra M.D. Murray F. Brennan M.D. Kevin Conlon M.D | 2003 | Journal of Gastrointestinal Surgery2003，，1： | 1 |
| 16 | Modeling inherited metabolic disorders of the liver using human induced pluripotent stem cells显示文摘 | Rashid S Tamir Corbineau Sebastien Hannan Nick Marciniak Stefan J Miranda Elena Alexander Graeme Huang-Doran Isabel Griffin Julian Ahrlund-Richter Lars Skepper Jeremy Semple Robert Weber Anne Lomas David A Vallier Ludovic | 2010 | Journal of Clinical Investigation2010，，9： | 1 |
| 17 | Lymphoplasmacytic sclerosing pancreatitis: Inflammatory mimic of pancreatic carcinoma显示文摘 | Sharon M. Weber M.D. Olcay Cubukcu- Dimopulo M.D. J. Alexander Palesty M.D. Arief Suriawinata M.D. David Klimstra M.D. Murray F. Brennan M.D. Kevin Conlon M.D | 2003 | Journal of Gastrointestinal Surgery2003，，1： | 1 |
| 18 | Mucosal flora in inflammatory bowel disease显示文摘 | Alexander Swidsinski Axel Ladhoff Annelie Pernthaler Sonja Swidsinski Vera Loening-Baucke Marianne Ortner Jutta Weber Uwe Hoffmann Stefan Schreiber Manfred Dietel Herbert Lochs | 2002 | Gastroenterology2002，，1： | 1 |
| 19 | Recognition of pneu- mococcal peptidoglycan: An expanded, pivotal role for LPS bind- ingprotein显示文摘 | Weber J R Freyer D Alexander C | 2003 | Immunity2003，19，2： | 1 |
| 20 | The role of lipopo- lysaccharide-binding protein in modulating the innate immune re- sponse显示文摘 | Weber J R Freyer D Alexander C | 2006 | Microbes Infect2006，8，3： | 1 |
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