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| 1 | Minimally invasive surgery for gastric cancer: A comparison between robotic, laparoscopic and open surgery显示文摘AIM To investigate the role of minimally invasive surgery for gastric cancer and determine surgical, clinical, and oncological outcomes.METHODS This is a propensity score-matched case-control study, comparing three treatment arms: robotic gastrectomy(RG), laparoscopic gastrectomy(LG), open gastrectomy(OG). Data collection started after sharing a specific study protocol. Data were recorded through a tailored and protected web-based system. Primary outcomes: harvested lymph nodes, estimated blood loss, hospital stay, complications rate. Among the secondary outcomes, there are: operative time, R0 resections, POD of mobilization, POD of starting liquid diet and soft solid diet. The analysis includes the evaluation of type and grade of postoperative complications. Detailed information of anastomotic leakages is also provided.RESULTS The present analysis was carried out of 1026 gastrectomies. To guarantee homogenous distribution of cases, patients in the RG, LG and OG groups were 1:1:2 matched using a propensity score analysis with a caliper = 0.2. The successful matching resulted in a total sample of 604 patients(RG = 151; LG = 151; OG = 302). The three groups showed no differences in all baseline patients characteristics, type of surgery(P = 0.42) and stage of the disease(P = 0.16). Intraoperative blood loss was significantly lower in the LG(95.93 ± 119.22) and RG(117.91 ± 68.11) groups compared to the OG(127.26 ± 79.50, P = 0.002). The mean number of retrieved lymph nodes was similar between the RG(27.78 ± 11.45), LG(24.58 ± 13.56) and OG(25.82 ± 12.07) approach. A benefit in favor of the minimally invasive approaches was found in the length of hospital stay(P < 0.0001). A similar complications rate was found(P = 0.13). The leakage rate was not different(P = 0.78) between groups.CONCLUSION Laparoscopic and robotic surgery can be safely performed and proposed as possible alternative to open surgery. The main highlighted benefit is a faster postoperative functional recovery. | Amilcare Parisi Daniel Reim Felice Borghi Ninh T Nguyen Feng Qi Andrea Coratti Fabio Cianchi Maurizio Cesari Francesca Bazzocchi Orhan Alimoglu Johan Gagnière Graziano Pernazza Simone D'Imporzano Yan-Bing Zhou Juan-Santiago Azagra Olivier Facy Steven T Brower Zhi-Wei Jiang Lu Zang Arda Isik Alessandro Gemini Stefano Trastulli Alexander Novotny Alessandra Marano Tong Liu Mario Annecchiarico Benedetta Badii Giacomo Arcuri Andrea Avanzolini Metin Leblebici Denis Pezet Shou-Gen Cao Martine Goergen Shu Zhang Giorgio Palazzini Vito D'Andrea Jacopo Desiderio | 2017 | World Journal of Gastroenterology2017，23，13： | 17 |
| 2 | Diagnosis of gastrointestinal bleeding: A practical guide for clinicians显示文摘Gastrointestinal bleeding is a common problem encountered in the emergency department and in the primary care setting. Acute or overt gastrointestinal bleeding is visible in the form of hematemesis, melena or hematochezia. Chronic or occult gastrointestinal bleeding is notapparent to the patient and usually presents as positive fecal occult blood or iron deficiency anemia. Obscure gastrointestinal bleeding is recurrent bleeding when the source remains unidentified after upper endoscopy and colonoscopic evaluation and is usually from the small intestine. Accurate clinical diagnosis is crucial and guides definitive investigations and interventions. This review summarizes the overall diagnostic approach to gastrointestinal bleeding and provides a practical guide for clinicians. | Bong Sik Matthew Kim Bob T Li Alexander Engel Jaswinder S Samra Stephen Clarke Ian D Norton Angela E Li | 2014 | World Journal of Gastrointestinal Pathophysiology2014，5，4： | 13 |
| 3 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 4 | Twenty proteins containing a C terminal SOCS box form five structural classes 显示文摘 | Hilton D J Richardson R T Alexander W S | 1998 | Proc Natl Acad Sci1998，95，1： | 2 |
| 5 | 脊髓损伤后残存自主神经功能载录国际标准显示文摘近年来,脊髓损伤神经学分类园际标准(International Stand- ards for the Neurological Classification of Spinal Cord Injury, ISNCSCI)被用来记载脊髓损伤后运动和感觉功能的损害,目前该标准已是第六版。1992年第一份国际认可的标准出版时,曾进行了较大的修订,修订内容包括完全性损伤与不完全性损伤的定义, | MS Alexander AB Jackson W Donovan DE Graves SL Elliott A Krassioukov AW Sheel I Estoresl B Green A Gousse NL Braekett D Cardenas M Kennelly A-K Karlason F Biering-Sorensen K Krogh T Linsenmeyer R Marino J Ditunno CJ Mathias I Perkash G Creasey G Schilero J Wecht B Schurch V Dietz J Sonksen S Stiens D Bodner LA Wuermser J-J Wyndaele 周谋望 刘楠 S Charlifue | 2010 | 中华物理医学与康复杂志2010，32，4： | 2 |
| 6 | Factors in tonsillectomy mortalily显示文摘 | Alexander D W Graff T D Kelley E | 1965 | Arch Otolaryngol1965，82，4： | 1 |
| 7 | Interferon regulatory factor 1 tryptophan 11 to arginine point mutation abolishes DNA binding 显示文摘 | Eason Donna D Shepherd Alexander T | 1999 | Biochimica et Biophysica Acta ( BBA )/Gene Structure and Expression1999，1446，12： | 1 |
| 8 | Genetically null mice reveal a central role for epidermal growth factor receptor in the differentiation of the hair follicle and normal hair development显示文摘 | Hansen L A Alexander N Hogan M E Sundberg J P Dlugosz A Threadgill D W Magnuson T Yuspa S H | | 0，，06： | 1 |
| 9 | Formation of eutectic inter- metallic rosettes by entrapment of liquid droplets during cel- lular columnar growth显示文摘 | Alexander D T L Greer A L | 2004 | Acta Mater2004，52，： | 1 |
| 10 | Human parathyroid hormone 1-34 reverses bone loss in ovariectomized mice显示文摘 | Alexander JM Bab I Fish S Muller R Uchiyama T Gronowicz G Nahounou M Zhao Q White DW Chorev M Gazit D Rosenblatt M | | 0，，： | 1 |
| 11 | Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways显示文摘 | Larsen C P Elwood E T Alexander D Z | 1996 | Nature1996，381，6581： | 1 |
| 12 | Twenty proteins containing a C-terminal SOCS box form five structural classes显示文摘 | Hilton D J Richardson R T Alexander W S | 1998 | Proc Natl Acad Sci1998，95，1： | 1 |
| 13 | The elec- tro-deoxidation of dense titanium dioxide precursors in molten calcium chloride giving a new reaction pathway 显示文摘 | Alexander D T L Schwandt C Fray D J | 2011 | Electrochimica Acta2011，56，9： | 1 |
| 14 | Origin of water and mantle-crust interactions on Mars inferred from hydrogen isotopes and volatile element abundances of olivine-hosted melt inclusions of primitive shergottites 显示文摘 | USUI T ALEXANDER C M O D WANG J | 2012 | Earth and Planetary Science Letters2012，，： | 1 |
| 15 | Microstructural kinetics of phase transformations during electrochemical reduction of titanium dioxide in molten calcium chloride显示文摘 | ALEXANDER D T L SCHWANDT C FRAY D J | 2006 | Acta Materialia2006，54，11： | 1 |
| 16 | Twenty proteins containing a C-terminal SOCS box form five structural classes显示文摘 | Hilton D j Richardson R T Alexander W S | 1998 | Proc Natl Acad Sci U S A1998，95，： | 1 |
| 17 | Solid-state intermetalle phase transformation in 3XXX aluminium alloys显示文摘 | ALEXANDER D T L GREER A L | 2002 | Acta Mate- rialia2002，50，10： | 1 |
| 18 | Building Sister Chromatid Cohesion: Smc3 Acetylation Counteracts an Antiestablishment Activity显示文摘 | Benjamin D. Rowland Maurici B. Roig Tatsuya Nishino Alexander Kurze Pelin Uluocak Ajay Mishra Frédéric Beckou?t Philippa Underwood Jean Metson Richard Imre Karl Mechtler Vittorio L. Katis Kim Nasmyth | 2009 | Molecular Cell2009，，6： | 1 |
| 19 | The active form of leflunomide, HMR1726,facilitates TNF-a and IL-17 Induced MMP-1 and MMP-3 expression显示文摘 | ALEXANDER D FRIEDRICH B ABRUZZESE T | 2006 | Cell Physi- ol Biochem2006，17，12： | 1 |
| 20 | Intraarterial versus intravenous adrimaycin in the rabbit VX2 tumor system 显示文摘 | Alexander T Swistel M D James R | 1984 | Cancer1984，53，6： | 1 |
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