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| 1 | Spatial organization of bacterial flora in normal and inflamed intestine: A fluorescence in situ hybridization study in mice显示文摘AIM: To studythe role of intestinal flora in inflammatory bowel disease (IBD).METHODS: The spatial organization of intestinal flora was investigated in normal mice and in two models of murine colitis using fluorescence in situ hybridization.RESULTS: The murine small intestine was nearly bacteriafree. The normal colonic flora was organized in three distinct compartments (crypt, interlaced, and fecal), each with different bacterial compositions. Crypt bacteria were present in the cecum and proximal colon. The fecal compartment was composed of homogeneously mixed bacterial groups that directly contacted the colonic wall in the cecum but were separated from the proximal colonic wall by a dense interlaced layer. Beginning in the middle colon, a mucus gap of growing thickness physically separated all intestinal bacteria from contact with the epithelium. Colonic inflammation was accompanied with a depletion of bacteria within the fecal compartment, a reduced surface area in which feces had direct contact with the colonic wall, increased thickness and spread of the mucus gap, and massive increases of bacterial concentrations in the crypt and interlaced compartments. Adhesive and infiltrative bacteria were observed in inflamed colon only, with dominant Bacteroides species.CONCLUSION: The proximal and distal colons are functionally different organs with respect to the intestinal flora, representing a bioreactor and a Segregation device.The highly organized structure of the colonic flora, its specific arrangement in different colonic segments, and its specialized response to inflammatory stimuli indicate that the intestinal flora is an innate part of host immunity that is under complex control. | Alexander Swidsinski Vera Loening-Baucke Herbert Lochs Laura P.Hale | 2005 | World Journal of Gastroenterology2005，11，8： | 27 |
| 2 | Mucosal flora in inflammatory bowel disease显示文摘 | Alexander Swidsinski Axel Ladhoff Annelie Pernthaler Sonja Swidsinski Vera Loening-Baucke Marianne Ortner Jutta Weber Uwe Hoffmann Stefan Schreiber Manfred Dietel Herbert Lochs | 2002 | Gastroenterology2002，，1： | 2 |
| 3 | Mucosal flora in inflammatory bowel disease显示文摘 | Alexander Swidsinski Axel Ladhoff Annelie Pernthaler Sonja Swidsinski Vera Loening-Baucke Marianne Ortner Jutta Weber Uwe Hoffmann Stefan Schreiber Manfred Dietel Herbert Lochs | 2002 | Gastroenterology2002，，1： | 1 |
| 4 | Presence of a polymicrobial endometrial biofilm in patients with bac- terial vaginosis 显示文摘 | Alexander Swidsinski Hans Verstraelen Vera Loening-Baucke | 2013 | PLoS One2013，8，53： | 1 |
| 5 | Mucosal flora in inflammatory bowel disease显示文摘 | Alexander Swidsinski Axel Ladhoff Annelie Pernthaler Sonja Swidsinski Vera Loening-Baucke Marianne Ortner Jutta Weber Uwe Hoffmann Stefan Schreiber Manfred Dietel Herbert Lochs | 2002 | Gastroenterology2002，，1： | 1 |
| 6 | 腐植酸对健康志愿者结肠微生物的影响显示文摘为检测腐植酸对结肠固有微生物的影响,本试验通过跟随记录14名健康志愿者口服腐植酸(Activomin)45天的数据来研究其对结肠微生物的浓度和组成的影响。前10天,口服3次/天,800毫克/次,其后35天,口服3次/天,400毫克/次。 | Alexander Swidsinski Yvonne D?rffel Vera Loening-Baucke 王振武 | 2018 | 腐植酸2018，，2： | 1 |
| 7 | High prevalence of adherent-invasive Escherichia coli associated with ileal mucosa in Crohn’s disease显示文摘 | Arlette Darfeuille-Michaud Jér?me Boudeau Philippe Bulois Christel Neut Anne-Lise Glasser Nicolas Barnich Marie-Agnès Bringer Alexander Swidsinski Laurent Beaugerie Jean-Frédéric Colombel | 2004 | Gastroenterology2004，，2： | 1 |
| 8 | High prevalence of adherent-invasive Escherichia coli associated with ileal mucosa in Crohn’s disease显示文摘 | Arlette Darfeuille-Michaud Jér?me Boudeau Philippe Bulois Christel Neut Anne-Lise Glasser Nicolas Barnich Marie-Agnès Bringer Alexander Swidsinski Laurent Beaugerie Jean-Frédéric Colombel | 2004 | Gastroenterology2004，，2： | 1 |
| 9 | Mucosal flora in inflammatory bowel disease显示文摘 | Alexander Swidsinski Axel Ladhoff Annelie Pernthaler Sonja Swidsinski Vera Loening-Baucke Marianne Ortner Jutta Weber Uwe Hoffmann Stefan Schreiber Manfred Dietel Herbert Lochs | 2002 | Gastroenterology2002，，1： | 1 |
| 10 | Impact of humic acids on the colonic microbiome in healthy volunteers显示文摘AIM To test the effects of humic acids on innate microbial communities of the colon.METHODS We followed the effects of oral supplementation with humic acids(Activomin?) on concentrations and composition of colonic microbiome in 14 healthy volunteers for 45 d. 3 × 800 mg Activomin? were taken orally for 10 d followed by 3 × 400 mg for 35 d. Colonic microbiota were investigated using multicolor fluorescence in situ hybridization(FISH) of Carnoy fixated and paraffin embedded stool cylinders. Two stool samples were collected a week prior to therapy and one stool sample on days 10, 31 and 45. Forty-one FISH probes representing different bacterial groups were used.RESULTS The sum concentration of colonic microbiota increased from 20% at day 10 to 30% by day 31 and remained stable until day 45(32%) of humic acid supplementation(P < 0.001). The increase in the concentrations in each person was due to growth of preexisting groups. The individual microbial profile of the patients remained unchanged. Similarly, the bacterial diversity remained stable. Concentrations of 24 of the 35 substantial groups increased from 20% to 96%. Two bacterial groups detected with Bac303(Bacteroides) and Myc657(mycolic acid-containing Actinomycetes) FISH probes decreased(P > 0.05). The others remained unaffected. Bacterial groups with initially marginal concentrations(< 0.1 × 109/m L) demonstrated no response to humic acids. The concentrations of pioneer groups of Bifidobacteriaceae, Enterobacteriaceae and Clostridium difficile increased but the observed differences were statistically not significant.CONCLUSION Humic acids have a profound effect on healthy colonic microbiome and may be potentially interesting substances for the development of drugs that control the innate colonic microbiome. | Alexander Swidsinski Yvonne Dorffel Vera Loening-Baucke Christoph Gille Anne Reiβhauer Onder Goktas Monika Krüger Jürgen Neuhaus Wieland Schrodl | 2017 | World Journal of Gastroenterology2017，23，5： | 0 |
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